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Protein

Fumarate reductase iron-sulfur subunit

Gene

frdB

Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor.1 Publication

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi57Iron-sulfur 1 (2Fe-2S)1
Metal bindingi62Iron-sulfur 1 (2Fe-2S)1
Metal bindingi65Iron-sulfur 1 (2Fe-2S)1
Metal bindingi77Iron-sulfur 1 (2Fe-2S)1
Metal bindingi151Iron-sulfur 2 (4Fe-4S)1
Metal bindingi154Iron-sulfur 2 (4Fe-4S)1
Metal bindingi157Iron-sulfur 2 (4Fe-4S)1
Metal bindingi161Iron-sulfur 3 (3Fe-4S)1
Metal bindingi208Iron-sulfur 3 (3Fe-4S)1
Metal bindingi214Iron-sulfur 3 (3Fe-4S)1
Metal bindingi218Iron-sulfur 2 (4Fe-4S)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport, Tricarboxylic acid cycle
Ligand2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciWSUC273121:G1GTD-798-MONOMER

Protein family/group databases

TCDBi3.D.10.1.3 the prokaryotic succinate dehydrogenase (sdh) family

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate reductase iron-sulfur subunit (EC:1.3.5.1)
Gene namesi
Name:frdB
Ordered Locus Names:WS0830
OrganismiWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Taxonomic identifieri273121 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella
Proteomesi
  • UP000000422 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001587081 – 239Fumarate reductase iron-sulfur subunitAdd BLAST239

Interactioni

Subunit structurei

Part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur protein, and cytochrome b-556.

Protein-protein interaction databases

STRINGi273121.WS0830

Structurei

Secondary structure

1239
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP17596
SMRiP17596
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17596

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 952Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST91
Domaini142 – 1714Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd BLAST30

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105E33 Bacteria
COG0479 LUCA
HOGENOMiHOG000160590
KOiK00245
OMAiESWIHTN
OrthoDBiPOG091H02OF

Family and domain databases

Gene3Di1.10.1060.10, 1 hit
3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
PF13183 Fer4_8, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit

Sequencei

Sequence statusi: Complete.

P17596-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRMLTIRVF KYDPQSAVSK PHFQEYKIEE APSMTIFIVL NMIRETYDPD
60 70 80 90 100
LNFDFVCRAG ICGSCGMMIN GRPSLACRTL TKDFEDGVIT LLPLPAFKLI
110 120 130 140 150
KDLSVDTGNW FNGMSQRVES WIHAQKEHDI SKLEERIEPE VAQEVFELDR
160 170 180 190 200
CIECGCCIAA CGTKIMREDF VGAAGLNRVV RFMIDPHDER TDEDYYELIG
210 220 230
DDDGVFGCMT LLACHDVCPK NLPLQSKIAY LRRKMVSVN
Length:239
Mass (Da):27,165
Last modified:August 1, 1990 - v1
Checksum:i24D1992489B8FFD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000662 Genomic DNA Translation: CAA04215.1
BX571659 Genomic DNA Translation: CAE09941.1
PIRiC44954
RefSeqiWP_011138738.1, NC_005090.1

Genome annotation databases

EnsemblBacteriaiCAE09941; CAE09941; WS0830
KEGGiwsu:WS0830

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000662 Genomic DNA Translation: CAA04215.1
BX571659 Genomic DNA Translation: CAE09941.1
PIRiC44954
RefSeqiWP_011138738.1, NC_005090.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E7PX-ray3.10B/E/H/K1-239[»]
1QLBX-ray2.33B/E1-239[»]
2BS2X-ray1.78B/E1-239[»]
2BS3X-ray2.19B/E1-239[»]
2BS4X-ray2.76B/E1-239[»]
ProteinModelPortaliP17596
SMRiP17596
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273121.WS0830

Protein family/group databases

TCDBi3.D.10.1.3 the prokaryotic succinate dehydrogenase (sdh) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE09941; CAE09941; WS0830
KEGGiwsu:WS0830

Phylogenomic databases

eggNOGiENOG4105E33 Bacteria
COG0479 LUCA
HOGENOMiHOG000160590
KOiK00245
OMAiESWIHTN
OrthoDBiPOG091H02OF

Enzyme and pathway databases

BioCyciWSUC273121:G1GTD-798-MONOMER

Miscellaneous databases

EvolutionaryTraceiP17596

Family and domain databases

Gene3Di1.10.1060.10, 1 hit
3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
PF13183 Fer4_8, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFRDB_WOLSU
AccessioniPrimary (citable) accession number: P17596
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: February 28, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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