UniProtKB - P17583 (CYNX_ECOLI)
Protein
Cyanate transport protein CynX
Gene
cynX
Organism
Escherichia coli (strain K12)
Status
Functioni
This protein is part of an active transport system that transports exogenous cyanate into E.coli cells.
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- cyanate catabolic process Source: EcoCyc
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:CYNX-MONOMER |
Protein family/group databases
TCDBi | 2.A.1.17.1, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Cyanate transport protein CynX |
Gene namesi | Name:cynX Ordered Locus Names:b0341, JW0332 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- plasma membrane Source: EcoCyc
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 3 – 23 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 34 – 54 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 68 – 88 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 89 – 109 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 122 – 142 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 153 – 173 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 204 – 224 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 235 – 255 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 263 – 283 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 287 – 307 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 322 – 342 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 354 – 374 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000205707 | 1 – 384 | Cyanate transport protein CynXAdd BLAST | 384 |
Proteomic databases
PaxDbi | P17583 |
PRIDEi | P17583 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4263183, 8 interactors |
STRINGi | 511145.b0341 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Cyanate porter (TC 2.A.1.17) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2807, Bacteria |
HOGENOMi | CLU_038046_4_0_6 |
InParanoidi | P17583 |
PhylomeDBi | P17583 |
Family and domain databases
InterProi | View protein in InterPro IPR004747, Cyan_transport IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00896, CynX, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
P17583-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLVLVLIGL NMRPLLTSVG PLLPQLRQAS GMSFSVAALL TALPVVTMGG
60 70 80 90 100
LALAGSWLHQ HVSERRSVAI SLLLIAVGAL MRELYPQSAL LLSSALLGGV
110 120 130 140 150
GIGIIQAVMP SVIKRRFQQR TPLVMGLWSA ALMGGGGLGA AITPWLVQHS
160 170 180 190 200
ETWYQTLAWW ALPAVVALFA WWWQSAREVA SSHKTTTTPV RVVFTPRAWT
210 220 230 240 250
LGVYFGLING GYASLIAWLP AFYIEIGASA QYSGSLLALM TLGQAAGALL
260 270 280 290 300
MPAMARHQDR RKLLMLALVL QLVGFCGFIW LPMQLPVLWA MVCGLGLGGA
310 320 330 340 350
FPLCLLLALD HSVQPAIAGK LVAFMQGIGF IIAGLAPWFS GVLRSISGNY
360 370 380
LMDWAFHALC VVGLMIITLR FAPVRFPQLW VKEA
Sequence cautioni
The sequence AAB18065 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 27 | R → A in AAA23627 (PubMed:3049588).Curated | 1 | |
Sequence conflicti | 336 – 384 | APWFS…WVKEA → PRGFLACCVVSAAIT (PubMed:3049588).CuratedAdd BLAST | 49 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M23219 Genomic DNA Translation: AAA23627.1 U73857 Genomic DNA Translation: AAB18065.1 Different initiation. U00096 Genomic DNA Translation: AAC73444.1 AP009048 Genomic DNA Translation: BAE76123.1 |
PIRi | E64761, BVECCX |
RefSeqi | NP_414875.1, NC_000913.3 |
Genome annotation databases
EnsemblBacteriai | AAC73444; AAC73444; b0341 BAE76123; BAE76123; BAE76123 |
GeneIDi | 946770 |
KEGGi | ecj:JW0332 eco:b0341 |
PATRICi | fig|511145.12.peg.349 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M23219 Genomic DNA Translation: AAA23627.1 U73857 Genomic DNA Translation: AAB18065.1 Different initiation. U00096 Genomic DNA Translation: AAC73444.1 AP009048 Genomic DNA Translation: BAE76123.1 |
PIRi | E64761, BVECCX |
RefSeqi | NP_414875.1, NC_000913.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4263183, 8 interactors |
STRINGi | 511145.b0341 |
Protein family/group databases
TCDBi | 2.A.1.17.1, the major facilitator superfamily (mfs) |
Proteomic databases
PaxDbi | P17583 |
PRIDEi | P17583 |
Genome annotation databases
EnsemblBacteriai | AAC73444; AAC73444; b0341 BAE76123; BAE76123; BAE76123 |
GeneIDi | 946770 |
KEGGi | ecj:JW0332 eco:b0341 |
PATRICi | fig|511145.12.peg.349 |
Organism-specific databases
EchoBASEi | EB0174 |
Phylogenomic databases
eggNOGi | COG2807, Bacteria |
HOGENOMi | CLU_038046_4_0_6 |
InParanoidi | P17583 |
PhylomeDBi | P17583 |
Enzyme and pathway databases
BioCyci | EcoCyc:CYNX-MONOMER |
Miscellaneous databases
PROi | PR:P17583 |
Family and domain databases
InterProi | View protein in InterPro IPR004747, Cyan_transport IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00896, CynX, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CYNX_ECOLI | |
Accessioni | P17583Primary (citable) accession number: P17583 Secondary accession number(s): P71308, P75695, Q2MC83 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families