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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

Gene

NDUFB7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

  • mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
  • mitochondrial respiratory chain complex I assembly Source: UniProtKB

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Alternative name(s):
Cell adhesion protein SQM1
Complex I-B18
Short name:
CI-B18
NADH-ubiquinone oxidoreductase B18 subunit
Gene namesi
Name:NDUFB7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000099795.6
HGNCiHGNC:7702 NDUFB7
MIMi603842 gene
neXtProtiNX_P17568

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4713
OpenTargetsiENSG00000099795
PharmGKBiPA31513

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

Polymorphism and mutation databases

BioMutaiNDUFB7
DMDMi12644140

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001188112 – 137NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7Add BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Disulfide bondi59 ↔ 90PROSITE-ProRule annotation
Disulfide bondi69 ↔ 80PROSITE-ProRule annotation
Modified residuei73PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiP17568
MaxQBiP17568
PaxDbiP17568
PeptideAtlasiP17568
PRIDEiP17568
ProteomicsDBi53493

PTM databases

iPTMnetiP17568
PhosphoSitePlusiP17568

Expressioni

Gene expression databases

BgeeiENSG00000099795 Expressed in 227 organ(s), highest expression level in apex of heart
CleanExiHS_NDUFB7
ExpressionAtlasiP17568 baseline and differential
GenevisibleiP17568 HS

Organism-specific databases

HPAiHPA002817

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.2 Publications

Protein-protein interaction databases

BioGridi110793, 39 interactors
ComplexPortaliCPX-577 Mitochondrial respiratory chain complex I
CORUMiP17568
IntActiP17568, 46 interactors
MINTiP17568
STRINGi9606.ENSP00000215565

Structurei

3D structure databases

ProteinModelPortaliP17568
SMRiP17568
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 98CHCHPROSITE-ProRule annotationAdd BLAST43

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi59 – 69Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi80 – 90Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Domaini

Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.1 Publication

Sequence similaritiesi

Belongs to the complex I NDUFB7 subunit family.Curated

Phylogenomic databases

eggNOGiKOG3468 Eukaryota
ENOG411230N LUCA
GeneTreeiENSGT00390000018759
HOGENOMiHOG000199343
HOVERGENiHBG001948
InParanoidiP17568
KOiK03963
OMAiVMRMKEY
OrthoDBiEOG091G10SJ
PhylomeDBiP17568
TreeFamiTF315152

Family and domain databases

InterProiView protein in InterPro
IPR008698 NADH_UbQ_OxRdtase_B18_su
PANTHERiPTHR20900 PTHR20900, 1 hit
PfamiView protein in Pfam
PF05676 NDUF_B7, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P17568-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAHLVRRYL GDASVEPDPL QMPTFPPDYG FPERKEREMV ATQQEMMDAQ
60 70 80 90 100
LRLQLRDYCA HHLIRLLKCK RDSFPNFLAC KQERHDWDYC EHRDYVMRMK
110 120 130
EFERERRLLQ RKKRREKKAA ELAKGQGPGE VDPKVAL
Length:137
Mass (Da):16,402
Last modified:January 23, 2007 - v4
Checksum:i2743716544288776
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R3B8M0R3B8_HUMAN
NADH dehydrogenase [ubiquinone] 1 b...
NDUFB7
70Annotation score:

Sequence cautioni

The sequence AAA35675 differs from that shown. Reason: Frameshift at several positions.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050591106R → G. Corresponds to variant dbSNP:rs3752220Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33374 mRNA Translation: AAA35675.1 Frameshift.
AF217091 mRNA Translation: AAF91223.1
AF112200 mRNA Translation: AAF17188.1
CR450354 mRNA Translation: CAG29350.1
CH471106 Genomic DNA Translation: EAW84436.1
BC002595 mRNA Translation: AAH02595.1
CCDSiCCDS12314.1
PIRiA34653
RefSeqiNP_004137.2, NM_004146.5
UniGeneiHs.532853

Genome annotation databases

EnsembliENST00000215565; ENSP00000215565; ENSG00000099795
GeneIDi4713
KEGGihsa:4713
UCSCiuc002mzg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33374 mRNA Translation: AAA35675.1 Frameshift.
AF217091 mRNA Translation: AAF91223.1
AF112200 mRNA Translation: AAF17188.1
CR450354 mRNA Translation: CAG29350.1
CH471106 Genomic DNA Translation: EAW84436.1
BC002595 mRNA Translation: AAH02595.1
CCDSiCCDS12314.1
PIRiA34653
RefSeqiNP_004137.2, NM_004146.5
UniGeneiHs.532853

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTCelectron microscopy3.70v3-124[»]
5XTDelectron microscopy3.70v1-137[»]
5XTHelectron microscopy3.90v3-124[»]
5XTIelectron microscopy17.40Bv/v3-124[»]
ProteinModelPortaliP17568
SMRiP17568
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110793, 39 interactors
ComplexPortaliCPX-577 Mitochondrial respiratory chain complex I
CORUMiP17568
IntActiP17568, 46 interactors
MINTiP17568
STRINGi9606.ENSP00000215565

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

PTM databases

iPTMnetiP17568
PhosphoSitePlusiP17568

Polymorphism and mutation databases

BioMutaiNDUFB7
DMDMi12644140

Proteomic databases

EPDiP17568
MaxQBiP17568
PaxDbiP17568
PeptideAtlasiP17568
PRIDEiP17568
ProteomicsDBi53493

Protocols and materials databases

DNASUi4713
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215565; ENSP00000215565; ENSG00000099795
GeneIDi4713
KEGGihsa:4713
UCSCiuc002mzg.4 human

Organism-specific databases

CTDi4713
DisGeNETi4713
EuPathDBiHostDB:ENSG00000099795.6
GeneCardsiNDUFB7
HGNCiHGNC:7702 NDUFB7
HPAiHPA002817
MIMi603842 gene
neXtProtiNX_P17568
OpenTargetsiENSG00000099795
PharmGKBiPA31513
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3468 Eukaryota
ENOG411230N LUCA
GeneTreeiENSGT00390000018759
HOGENOMiHOG000199343
HOVERGENiHBG001948
InParanoidiP17568
KOiK03963
OMAiVMRMKEY
OrthoDBiEOG091G10SJ
PhylomeDBiP17568
TreeFamiTF315152

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Miscellaneous databases

ChiTaRSiNDUFB7 human
GeneWikiiNDUFB7
GenomeRNAii4713
PROiPR:P17568
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099795 Expressed in 227 organ(s), highest expression level in apex of heart
CleanExiHS_NDUFB7
ExpressionAtlasiP17568 baseline and differential
GenevisibleiP17568 HS

Family and domain databases

InterProiView protein in InterPro
IPR008698 NADH_UbQ_OxRdtase_B18_su
PANTHERiPTHR20900 PTHR20900, 1 hit
PfamiView protein in Pfam
PF05676 NDUF_B7, 1 hit
PROSITEiView protein in PROSITE
PS51808 CHCH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNDUB7_HUMAN
AccessioniPrimary (citable) accession number: P17568
Secondary accession number(s): Q6ICN9, Q9UI16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 174 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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