UniProtKB - P17563 (SBP1_MOUSE)
Protein
Methanethiol oxidase
Gene
Selenbp1
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).By similarity1 Publication
Catalytic activityi
- EC:1.8.3.41 Publication
Kineticsi
- KM=5 nM for methanethiol1 Publication
: Organosulfur degradation Pathwayi
This protein is involved in Organosulfur degradation.1 PublicationView all proteins of this organism that are known to be involved in Organosulfur degradation.
GO - Molecular functioni
- methanethiol oxidase activity Source: UniProtKB-EC
- selenium binding Source: MGI
GO - Biological processi
- brown fat cell differentiation Source: MGI
- protein transport Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Protein transport, Transport |
Ligand | Selenium |
Names & Taxonomyi
Protein namesi | Recommended name: Methanethiol oxidase1 Publication (EC:1.8.3.41 Publication)Short name: MTO1 Publication Alternative name(s): 56 kDa selenium-binding protein Short name: SBP56 Short name: SP56 Selenium-binding protein 1 |
Gene namesi | Name:Selenbp1 Synonyms:Lpsb |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96825, Selenbp1 |
Subcellular locationi
Cytoplasm and Cytosol
- cytosol By similarity
Nucleus
- Nucleus By similarity
Other locations
- Membrane By similarity; Peripheral membrane protein By similarity
Note: May associate with Golgi membrane (By similarity). May associate with the membrane of autophagosomes (By similarity).By similarity
Cytosol
- cytosol Source: UniProtKB-SubCell
Nucleus
- fibrillar center Source: MGI
- nucleolus Source: MGI
Other locations
- membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Membrane, NucleusPathology & Biotechi
Disruption phenotypei
SELENBP1 knockout results in accumulation of dimethylsulfoxide in the plasma. Methanethiol oxidase activity measured in tissues from knockout mice is significantly lower that in normal tissues.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000174634 | 2 – 472 | Methanethiol oxidaseAdd BLAST | 471 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 111 | PhosphoserineBy similarity | 1 | |
Modified residuei | 467 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
The N-terminus is blocked.By similarity
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P17563 |
jPOSTi | P17563 |
MaxQBi | P17563 |
PaxDbi | P17563 |
PeptideAtlasi | P17563 |
PRIDEi | P17563 |
ProteomicsDBi | 255462 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00623845 P17563 |
SWISS-2DPAGEi | P17563 |
PTM databases
iPTMneti | P17563 |
PhosphoSitePlusi | P17563 |
SwissPalmi | P17563 |
Expressioni
Tissue specificityi
Highly expressed in liver, kidney and, to a lesser extent, lung.
Gene expression databases
Bgeei | ENSMUSG00000068874, Expressed in colon and 244 other tissues |
Genevisiblei | P17563, MM |
Interactioni
Subunit structurei
Interacts with USP33.
By similarityProtein-protein interaction databases
BioGRIDi | 203156, 10 interactors |
IntActi | P17563, 2 interactors |
MINTi | P17563 |
STRINGi | 10090.ENSMUSP00000088349 |
Miscellaneous databases
RNActi | P17563, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the selenium-binding protein family.Curated
Phylogenomic databases
eggNOGi | KOG0918, Eukaryota |
GeneTreei | ENSGT00390000014244 |
HOGENOMi | CLU_032512_0_0_1 |
InParanoidi | P17563 |
OMAi | SMDDRYL |
OrthoDBi | 483905at2759 |
PhylomeDBi | P17563 |
TreeFami | TF315241 |
Family and domain databases
InterProi | View protein in InterPro IPR008826, Se-bd |
PANTHERi | PTHR23300, PTHR23300, 1 hit |
Pfami | View protein in Pfam PF05694, SBP56, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P17563-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATKCTKCGP GYSTPLEAMK GPREEIVYLP CIYRNTGTEA PDYLATVDVD
60 70 80 90 100
PKSPQYSQVI HRLPMPYLKD ELHHSGWNTC SSCFGDSTKS RNKLILPGLI
110 120 130 140 150
SSRIYVVDVG SEPRAPKLHK VIEASEIQAK CNVSSLHTSH CLASGEVMVS
160 170 180 190 200
TLGDLQGNGK GSFVLLDGET FEVKGTWEKP GDAAPMGYDF WYQPRHNVMV
210 220 230 240 250
STEWAAPNVF KDGFNPAHVE AGLYGSRIFV WDWQRHEIIQ TLQMTDGLIP
260 270 280 290 300
LEIRFLHDPS ATQGFVGCAL SSNIQRFYKN AEGTWSVEKV IQVPSKKVKG
310 320 330 340 350
WMLPEMPGLI TDILLSLDDR FLYFSNWLHG DIRQYDISNP QKPRLAGQIF
360 370 380 390 400
LGGSIVRGGS VQVLEDQELT CQPEPLVVKG KRIPGGPQMI QLSLDGKRLY
410 420 430 440 450
ATTSLYSAWD KQFYPDLIRE GSMMLQIDVD TVNGGLKLNP NFLVDFGKEP
460 470
LGPALAHELR YPGGDCSSDI WI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RHN2 | D6RHN2_MOUSE | Methanethiol oxidase | Selenbp1 | 123 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 270 – 272 | LSS → SAP in AAA40104 (PubMed:2225343).Curated | 3 | |
Sequence conflicti | 305 – 306 | EM → GV in AAA40104 (PubMed:2225343).Curated | 2 | |
Sequence conflicti | 453 | P → A in AAA40104 (PubMed:2225343).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M32032 mRNA Translation: AAA40104.1 BC011202 mRNA Translation: AAH11202.1 |
CCDSi | CCDS38540.1 |
PIRi | S27878 |
RefSeqi | NP_033176.2, NM_009150.3 |
Genome annotation databases
Ensembli | ENSMUST00000090839; ENSMUSP00000088349; ENSMUSG00000068874 |
GeneIDi | 20341 |
KEGGi | mmu:20341 |
UCSCi | uc008qhf.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M32032 mRNA Translation: AAA40104.1 BC011202 mRNA Translation: AAH11202.1 |
CCDSi | CCDS38540.1 |
PIRi | S27878 |
RefSeqi | NP_033176.2, NM_009150.3 |
3D structure databases
SMRi | P17563 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203156, 10 interactors |
IntActi | P17563, 2 interactors |
MINTi | P17563 |
STRINGi | 10090.ENSMUSP00000088349 |
PTM databases
iPTMneti | P17563 |
PhosphoSitePlusi | P17563 |
SwissPalmi | P17563 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00623845 P17563 |
SWISS-2DPAGEi | P17563 |
Proteomic databases
EPDi | P17563 |
jPOSTi | P17563 |
MaxQBi | P17563 |
PaxDbi | P17563 |
PeptideAtlasi | P17563 |
PRIDEi | P17563 |
ProteomicsDBi | 255462 |
Genome annotation databases
Ensembli | ENSMUST00000090839; ENSMUSP00000088349; ENSMUSG00000068874 |
GeneIDi | 20341 |
KEGGi | mmu:20341 |
UCSCi | uc008qhf.1, mouse |
Organism-specific databases
CTDi | 8991 |
MGIi | MGI:96825, Selenbp1 |
Phylogenomic databases
eggNOGi | KOG0918, Eukaryota |
GeneTreei | ENSGT00390000014244 |
HOGENOMi | CLU_032512_0_0_1 |
InParanoidi | P17563 |
OMAi | SMDDRYL |
OrthoDBi | 483905at2759 |
PhylomeDBi | P17563 |
TreeFami | TF315241 |
Miscellaneous databases
BioGRID-ORCSi | 20341, 0 hits in 33 CRISPR screens |
ChiTaRSi | Selenbp1, mouse |
PROi | PR:P17563 |
RNActi | P17563, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000068874, Expressed in colon and 244 other tissues |
Genevisiblei | P17563, MM |
Family and domain databases
InterProi | View protein in InterPro IPR008826, Se-bd |
PANTHERi | PTHR23300, PTHR23300, 1 hit |
Pfami | View protein in Pfam PF05694, SBP56, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SBP1_MOUSE | |
Accessioni | P17563Primary (citable) accession number: P17563 Secondary accession number(s): Q91X87 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | May 29, 2007 | |
Last modified: | April 7, 2021 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families