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Protein

Luciferin 2-monooxygenase

Gene
N/A
Organism
Vargula hilgendorfii (Sea firefly) (Cypridina hilgendorfii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

60 kcal/mol are required for the blue emission of light (460 nm) due to the oxidation of luciferin via a dioxetanone intermediate, in which the excited state oxyluciferin bound to luciferase is the emitter.

Catalytic activityi

Cypridina luciferin + O2 = oxidized Cypridina luciferin + CO2 + light.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase, Monooxygenase, Oxidoreductase, Photoprotein
Biological processLuminescence

Enzyme and pathway databases

BRENDAi1.13.12.6 1799

Names & Taxonomyi

Protein namesi
Recommended name:
Luciferin 2-monooxygenase (EC:1.13.12.6)
Alternative name(s):
Cypridina-type luciferase
OrganismiVargula hilgendorfii (Sea firefly) (Cypridina hilgendorfii)
Taxonomic identifieri6674 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaOligostracaOstracodaMyodocopaMyodocopidaCypridinoideaCypridinidaeVargula

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 11Sequence analysisAdd BLAST11
ChainiPRO_000002162612 – 555Luciferin 2-monooxygenaseAdd BLAST544

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi408N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The cysteine residues presumably exist in intramolecular disulfide bridges.
The N-terminus is blocked.

Keywords - PTMi

Disulfide bond, Glycoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 297VWFD 1PROSITE-ProRule annotationAdd BLAST217
Domaini320 – 525VWFD 2PROSITE-ProRule annotationAdd BLAST206

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 82Cys-richAdd BLAST44

Keywords - Domaini

Repeat, Signal

Family and domain databases

InterProiView protein in InterPro
IPR001846 VWF_type-D
PfamiView protein in Pfam
PF00094 VWD, 2 hits
SMARTiView protein in SMART
SM00216 VWD, 2 hits
PROSITEiView protein in PROSITE
PS51233 VWFD, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17554-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIIILSVIL AYCVTDNCQD ACPVEAEPPS STPTVPTSCE AKEGECIDTR
60 70 80 90 100
CATCKRDILS DGLCENKPGK TCCRMCQYVI ECRVEAAGYF RTFYGKRFNF
110 120 130 140 150
QEPGKYVLAR GTKGGDWSVT LTMENLDGQK GAVLTKTTLE VAGDVIDITQ
160 170 180 190 200
ATADPITVNG GADPVIANPF TIGEVTIAVV EIPGFNITVI EFFKLIVIDI
210 220 230 240 250
LGGRSVRIAP DTANKGLISG ICGNLEMNDA DDFTTDADQL AIQPNINKEF
260 270 280 290 300
DGCPFYGNPS DIEYCKGLME PYRAVCRNNI NFYYYTLSCA FAYCMGGEER
310 320 330 340 350
AKHVLFDYVE TCAAPETRGT CVLSGHTFYD TFDKARYQFQ GPCKEILMAA
360 370 380 390 400
DCYWNTWDVK VSHRDVESYT EVEKVTIRKQ STVVDLIVDG KQVKVGGVDV
410 420 430 440 450
SIPYSSENTS IYWQDGDILT TAILPEALVV KFNFKQLLVV HIRDPFDGKT
460 470 480 490 500
CGICGNYNQD STDDFFDAEG ACALTPNPPG CTEEQKPEAE RLCNNLFDSS
510 520 530 540 550
IDEKCNVCYK PDRIARCMYE YCLRGQQGFC DHAWEFKKEC YIKHGDTLEV

PPECQ
Length:555
Mass (Da):61,627
Last modified:August 1, 1990 - v1
Checksum:i2FB150371A80A0DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25666 mRNA Translation: AAA30332.1
PIRiA33723

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25666 mRNA Translation: AAA30332.1
PIRiA33723

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi1.13.12.6 1799

Family and domain databases

InterProiView protein in InterPro
IPR001846 VWF_type-D
PfamiView protein in Pfam
PF00094 VWD, 2 hits
SMARTiView protein in SMART
SM00216 VWD, 2 hits
PROSITEiView protein in PROSITE
PS51233 VWFD, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLUCI_VARHI
AccessioniPrimary (citable) accession number: P17554
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: June 20, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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