UniProtKB - P17544 (ATF7_HUMAN)
Cyclic AMP-dependent transcription factor ATF-7
ATF7
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 7 – 31 | C2H2-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- enzyme binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- mitogen-activated protein kinase binding Source: UniProtKB
- RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
- transcription factor binding Source: UniProtKB
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription, DNA-templated Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Host-virus interaction, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
SIGNORi | P17544 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclic AMP-dependent transcription factor ATF-7Short name: cAMP-dependent transcription factor ATF-7 Alternative name(s): Activating transcription factor 7 Transcription factor ATF-A |
Gene namesi | Name:ATF7 Synonyms:ATFA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:792 ATF7 |
MIMi | 606371 gene |
neXtProti | NX_P17544 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
- nucleoplasm 1 Publication
Note: Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery.
Nucleus
- nuclear chromatin Source: NTNU_SB
- nuclear periphery Source: UniProtKB
- nucleoplasm Source: UniProtKB-SubCell
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 9 | C → A: Severely reduced TAF12-mediated enhancement of transcriptional activity. 1 Publication | 1 | |
Mutagenesisi | 14 | C → A: Greatly reduced JNK2- or adenovirus E1A-mediated transactivation. Abolishes adenovirus 2 E1A-mediated transactivation; when associated with A-51; A-53 and G-112. 1 Publication | 1 | |
Mutagenesisi | 22 | D → K: No effect on binding adenovirus 2 E1A. Abolishes ATF7-mediated E1A responsiveness. 1 Publication | 1 | |
Mutagenesisi | 27 | H → N: No effect on binding adenovirus 2 E1A. Abolishes ATF7-mediated E1A responsiveness. 1 Publication | 1 | |
Mutagenesisi | 33 | M → D: Severely reduced TAF12-induced transcriptional activity; when associated with S-35. 1 Publication | 1 | |
Mutagenesisi | 35 | L → S: Severely reduced TAF12-induced transcriptional activity; when associated with D-33. 1 Publication | 1 | |
Mutagenesisi | 51 | T → A: Severely reduced TAF12-induced transcriptional activity. No effect on MAPK9-mediated phosphorylation; when associated with A-53. Greatly reduces MAPK9- and adenovirus E1A-mediated transactivation; when associated with A-53 and G-112. Abolishes adenovirus 2 E1A-mediated transactivation; when associated with A-14; A-53 and G-112. 3 Publications | 1 | |
Mutagenesisi | 51 | T → D: Completely abolishes MAPK9- and adenovirus E1A-mediated transactivation; when associated with D-53. 3 Publications | 1 | |
Mutagenesisi | 53 | T → A: Severely reduced TAF12-induced transcriptional activity. No effect on MAPK9-mediated phosphorylation; when associated with A-51. Greatly reduces MAPK9- and adenovirus E1A-mediated transactivation; when associated with A-51 and G-112. Abolishes adenovirus 2 E1A-mediated transactivation; when associated with A-14; A-51 and G-112. 3 Publications | 1 | |
Mutagenesisi | 53 | T → D: Completely abolishes MAPK9- and adenovirus E1A-mediated transactivation; when associated with D-51. 3 Publications | 1 | |
Mutagenesisi | 112 | T → G: Some reduction in transactivation but, completely abolishes MAPK9-mediated activation. Abolishes MAPK9-mediated and greatly reduces adenovirus E1A-mediated transactivation; when associated with A-51 and A-53. Abolishes adenovirus 2 E1A-mediated transactivation; when associated with A-14; A-51 and A-53. 2 Publications | 1 | |
Mutagenesisi | 118 | K → R: Abolishes sumoylation. Exclusive nucleoplasmic location. Increase in binding the E-selectin promoter. 1 Publication | 1 | |
Mutagenesisi | 156 | T → A: No effect on transactivation; when associated with A-158. 1 Publication | 1 | |
Mutagenesisi | 158 | T → A: No effect on transactivation; when associated with A-156. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 11016 |
OpenTargetsi | ENSG00000170653 |
PharmGKBi | PA25092 |
Miscellaneous databases
Pharosi | P17544 |
Chemistry databases
DrugBanki | DB00852 Pseudoephedrine |
Polymorphism and mutation databases
BioMutai | ATF7 |
DMDMi | 12643393 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076592 | 1 – 494 | Cyclic AMP-dependent transcription factor ATF-7Add BLAST | 494 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 51 | Phosphothreonine; by MAPK111 Publication | 1 | |
Modified residuei | 53 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 112 | Phosphothreonine1 Publication | 1 | |
Cross-linki | 118 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)2 Publications | ||
Modified residuei | 424 | PhosphoserineCombined sources | 1 | |
Modified residuei | 434 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P17544 |
jPOSTi | P17544 |
MassIVEi | P17544 |
MaxQBi | P17544 |
PaxDbi | P17544 |
PeptideAtlasi | P17544 |
PRIDEi | P17544 |
ProteomicsDBi | 53487 [P17544-1] 53488 [P17544-2] 53489 [P17544-3] 53490 [P17544-4] 53491 [P17544-5] 53492 [P17544-6] |
PTM databases
iPTMneti | P17544 |
PhosphoSitePlusi | P17544 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000170653 Expressed in 191 organ(s), highest expression level in popliteal artery |
ExpressionAtlasi | P17544 baseline and differential |
Genevisiblei | P17544 HS |
Organism-specific databases
HPAi | HPA003384 |
Interactioni
Subunit structurei
Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members.
Interacts with JNK2; the interaction does not phosphorylate ATF7 but acts as a docking site for other ATF-associated partners such as JUN family members.
Interacts (via its transactivation domain) with TAF12 (isoforms TAFII15 and TAFII20); the interaction potentiates the transactivation activity (isoform TAFII20 only) and is inhibited by ATF7 sumoylation.
Interacts with TAF4; the interaction inhibits the TAF12-dependent transactivation.
Interacts with MAPK9; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN.
6 Publications(Microbial infection) Interacts with adenovirus 2 E1A; the interaction enhances the ATF7-mediated viral transactivation activity which requires the zinc-binding domains of both E1A and ATF7.
2 PublicationsBinary interactionsi
GO - Molecular functioni
- enzyme binding Source: UniProtKB
- mitogen-activated protein kinase binding Source: UniProtKB
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGridi | 116206, 43 interactors |
CORUMi | P17544 |
ELMi | P17544 |
IntActi | P17544, 37 interactors |
MINTi | P17544 |
STRINGi | 9606.ENSP00000399465 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 343 – 406 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 296 | Transactivation domainAdd BLAST | 296 | |
Regioni | 336 – 494 | Essential for binding adenovirus 2 E1AAdd BLAST | 159 | |
Regioni | 345 – 365 | Basic motifPROSITE-ProRule annotationAdd BLAST | 21 | |
Regioni | 371 – 399 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 29 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 7 – 31 | C2H2-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG1414 Eukaryota ENOG4111CH5 LUCA |
GeneTreei | ENSGT00940000155261 |
HOGENOMi | HOG000220894 |
InParanoidi | P17544 |
KOi | K09045 |
OMAi | TELSMPM |
OrthoDBi | 978850at2759 |
PhylomeDBi | P17544 |
Family and domain databases
InterProi | View protein in InterPro IPR004827 bZIP IPR016378 TF_CRE-BP1-typ IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfami | View protein in Pfam PF00170 bZIP_1, 1 hit |
PIRSFi | PIRSF003153 ATF2_CRE-BP1, 1 hit |
SMARTi | View protein in SMART SM00338 BRLZ, 1 hit SM00355 ZnF_C2H2, 1 hit |
SUPFAMi | SSF57667 SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit PS00028 ZINC_FINGER_C2H2_1, 1 hit PS50157 ZINC_FINGER_C2H2_2, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ
60 70 80 90 100
TPTPTRFLKN CEEVGLFNEL ASSFEHEFKK AADEDEKKAR SRTVAKKLVA
110 120 130 140 150
AAGPLDMSLP STPDIKIKEE EPVEVDSSPP DSPASSPCSP PLKEKEVTPK
160 170 180 190 200
PVLISTPTPT IVRPGSLPLH LGYDPLHPTL PSPTSVITQA PPSNRQMGSP
210 220 230 240 250
TGSLPLVMHL ANGQTMPVLP GPPVQMPSVI SLARPVSMVP NIPGIPGPPV
260 270 280 290 300
NSSGSISPSG HPIPSEAKMR LKATLTHQVS SINGGCGMVV GTASTMVTAR
310 320 330 340 350
PEQSQILIQH PDAPSPAQPQ VSPAQPTPST GGRRRRTVDE DPDERRQRFL
360 370 380 390 400
ERNRAAASRC RQKRKLWVSS LEKKAEELTS QNIQLSNEVT LLRNEVAQLK
410 420 430 440 450
QLLLAHKDCP VTALQKKTQG YLESPKESSE PTGSPAPVIQ HSSATAPSNG
460 470 480 490
LSVRSAAEAV ATSVLTQMAS QRTELSMPIQ SHVIMTPQSQ SAGR
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ESA4 | K7ESA4_HUMAN | Cyclic AMP-dependent transcription ... | ATF7 | 163 | Annotation score: | ||
F8VWG7 | F8VWG7_HUMAN | Cyclic AMP-dependent transcription ... | ATF7 | 78 | Annotation score: | ||
K7EKZ7 | K7EKZ7_HUMAN | Cyclic AMP-dependent transcription ... | ATF7 | 79 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | P → T in AAH42363 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000594 | 89 – 99 | Missing in isoform 1, isoform 4 and isoform 6. 3 PublicationsAdd BLAST | 11 | |
Alternative sequenceiVSP_042469 | 100 – 494 | AAAGP…QSAGR → VFRPRLFLLCFGIIFLIG in isoform 5. 1 PublicationAdd BLAST | 395 | |
Alternative sequenceiVSP_000595 | 125 – 145 | Missing in isoform 1 and isoform 2. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_034543 | 146 – 321 | Missing in isoform 4. 1 PublicationAdd BLAST | 176 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52943 mRNA Translation: CAA37118.1 X57197 mRNA Translation: CAA40483.1 AK298853 mRNA Translation: BAG60976.1 AC023509 Genomic DNA No translation available. AC073594 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW96723.1 CH471054 Genomic DNA Translation: EAW96724.1 BC042363 mRNA Translation: AAH42363.1 BC136302 mRNA Translation: AAI36303.1 BC140006 mRNA Translation: AAI40007.1 |
CCDSi | CCDS44906.1 [P17544-6] CCDS58238.1 [P17544-5] |
PIRi | S12741 |
RefSeqi | NP_001123532.1, NM_001130060.1 [P17544-2] NP_001193611.1, NM_001206682.1 [P17544-5] NP_001193612.1, NM_001206683.1 [P17544-5] NP_006847.1, NM_006856.2 [P17544-6] XP_005268644.1, XM_005268587.3 XP_016874211.1, XM_017018722.1 |
Genome annotation databases
Ensembli | ENST00000420353; ENSP00000399465; ENSG00000170653 [P17544-6] ENST00000456903; ENSP00000387406; ENSG00000170653 [P17544-6] ENST00000548118; ENSP00000456858; ENSG00000170653 [P17544-5] ENST00000548446; ENSP00000449938; ENSG00000170653 [P17544-1] ENST00000591397; ENSP00000465192; ENSG00000170653 [P17544-5] |
GeneIDi | 11016 |
KEGGi | hsa:11016 |
UCSCi | uc001sdz.4 human [P17544-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52943 mRNA Translation: CAA37118.1 X57197 mRNA Translation: CAA40483.1 AK298853 mRNA Translation: BAG60976.1 AC023509 Genomic DNA No translation available. AC073594 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW96723.1 CH471054 Genomic DNA Translation: EAW96724.1 BC042363 mRNA Translation: AAH42363.1 BC136302 mRNA Translation: AAI36303.1 BC140006 mRNA Translation: AAI40007.1 |
CCDSi | CCDS44906.1 [P17544-6] CCDS58238.1 [P17544-5] |
PIRi | S12741 |
RefSeqi | NP_001123532.1, NM_001130060.1 [P17544-2] NP_001193611.1, NM_001206682.1 [P17544-5] NP_001193612.1, NM_001206683.1 [P17544-5] NP_006847.1, NM_006856.2 [P17544-6] XP_005268644.1, XM_005268587.3 XP_016874211.1, XM_017018722.1 |
3D structure databases
SMRi | P17544 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 116206, 43 interactors |
CORUMi | P17544 |
ELMi | P17544 |
IntActi | P17544, 37 interactors |
MINTi | P17544 |
STRINGi | 9606.ENSP00000399465 |
Chemistry databases
DrugBanki | DB00852 Pseudoephedrine |
PTM databases
iPTMneti | P17544 |
PhosphoSitePlusi | P17544 |
Polymorphism and mutation databases
BioMutai | ATF7 |
DMDMi | 12643393 |
Proteomic databases
EPDi | P17544 |
jPOSTi | P17544 |
MassIVEi | P17544 |
MaxQBi | P17544 |
PaxDbi | P17544 |
PeptideAtlasi | P17544 |
PRIDEi | P17544 |
ProteomicsDBi | 53487 [P17544-1] 53488 [P17544-2] 53489 [P17544-3] 53490 [P17544-4] 53491 [P17544-5] 53492 [P17544-6] |
Protocols and materials databases
ABCDi | P17544 |
DNASUi | 11016 |
Genome annotation databases
Ensembli | ENST00000420353; ENSP00000399465; ENSG00000170653 [P17544-6] ENST00000456903; ENSP00000387406; ENSG00000170653 [P17544-6] ENST00000548118; ENSP00000456858; ENSG00000170653 [P17544-5] ENST00000548446; ENSP00000449938; ENSG00000170653 [P17544-1] ENST00000591397; ENSP00000465192; ENSG00000170653 [P17544-5] |
GeneIDi | 11016 |
KEGGi | hsa:11016 |
UCSCi | uc001sdz.4 human [P17544-1] |
Organism-specific databases
CTDi | 11016 |
DisGeNETi | 11016 |
GeneCardsi | ATF7 |
HGNCi | HGNC:792 ATF7 |
HPAi | HPA003384 |
MIMi | 606371 gene |
neXtProti | NX_P17544 |
OpenTargetsi | ENSG00000170653 |
PharmGKBi | PA25092 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1414 Eukaryota ENOG4111CH5 LUCA |
GeneTreei | ENSGT00940000155261 |
HOGENOMi | HOG000220894 |
InParanoidi | P17544 |
KOi | K09045 |
OMAi | TELSMPM |
OrthoDBi | 978850at2759 |
PhylomeDBi | P17544 |
Enzyme and pathway databases
SIGNORi | P17544 |
Miscellaneous databases
ChiTaRSi | ATF7 human |
GeneWikii | ATF7 |
GenomeRNAii | 11016 |
Pharosi | P17544 |
PROi | PR:P17544 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170653 Expressed in 191 organ(s), highest expression level in popliteal artery |
ExpressionAtlasi | P17544 baseline and differential |
Genevisiblei | P17544 HS |
Family and domain databases
InterProi | View protein in InterPro IPR004827 bZIP IPR016378 TF_CRE-BP1-typ IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfami | View protein in Pfam PF00170 bZIP_1, 1 hit |
PIRSFi | PIRSF003153 ATF2_CRE-BP1, 1 hit |
SMARTi | View protein in SMART SM00338 BRLZ, 1 hit SM00355 ZnF_C2H2, 1 hit |
SUPFAMi | SSF57667 SSF57667, 1 hit |
PROSITEi | View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit PS00028 ZINC_FINGER_C2H2_1, 1 hit PS50157 ZINC_FINGER_C2H2_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATF7_HUMAN | |
Accessioni | P17544Primary (citable) accession number: P17544 Secondary accession number(s): A5D6Y4 Q9UD83 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | January 24, 2001 | |
Last modified: | November 13, 2019 | |
This is version 201 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot