ATF7

Functionⁱ

Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.

Isoform 4 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.

Isoform 5 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	7 – 31	C2H2-typePROSITE-ProRule annotationAdd BLAST		25

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA binding transcription factor activity
Source: ProtInc
Non-traceable author statementⁱ
- 1694576
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 23382074
metal ion binding Source: UniProtKB-KW
mitogen-activated protein kinase binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10376527
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 8288576
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 8288576
transcription factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10376527

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 8288576
regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 8288576
transcription, DNA-templated Source: UniProtKB-KW
viral process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Host-virus interaction, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

SIGNORⁱ	P17544

SIGNORⁱ

P17544

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclic AMP-dependent transcription factor ATF-7 Short name: cAMP-dependent transcription factor ATF-7 Alternative name(s): Activating transcription factor 7 Transcription factor ATF-A
Gene namesⁱ	Name:ATF7 Synonyms:ATFA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170653.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:792 ATF7
MIMⁱ	606371 gene
neXtProtⁱ	NX_P17544

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	9	C → A: Severely reduced TAF12-mediated enhancement of transcriptional activity. 1 Publication	1
Mutagenesisⁱ	14	C → A: Greatly reduced JNK2- or adenovirus E1A-mediated transactivation. Abolishes adenovirus 2 E1A-mediated transactivation; when associated with A-51; A-53 and G-112. 1 Publication	1
Mutagenesisⁱ	22	D → K: No effect on binding adenovirus 2 E1A. Abolishes ATF7-mediated E1A responsiveness. 1 Publication	1
Mutagenesisⁱ	27	H → N: No effect on binding adenovirus 2 E1A. Abolishes ATF7-mediated E1A responsiveness. 1 Publication	1
Mutagenesisⁱ	33	M → D: Severely reduced TAF12-induced transcriptional activity; when associated with S-35. 1 Publication	1
Mutagenesisⁱ	35	L → S: Severely reduced TAF12-induced transcriptional activity; when associated with D-33. 1 Publication	1
Mutagenesisⁱ	51	T → A: Severely reduced TAF12-induced transcriptional activity. No effect on MAPK9-mediated phosphorylation; when associated with A-53. Greatly reduces MAPK9- and adenovirus E1A-mediated transactivation; when associated with A-53 and G-112. Abolishes adenovirus 2 E1A-mediated transactivation; when associated with A-14; A-53 and G-112. 3 Publications	1
Mutagenesisⁱ	51	T → D: Completely abolishes MAPK9- and adenovirus E1A-mediated transactivation; when associated with D-53. 3 Publications	1
Mutagenesisⁱ	53	T → A: Severely reduced TAF12-induced transcriptional activity. No effect on MAPK9-mediated phosphorylation; when associated with A-51. Greatly reduces MAPK9- and adenovirus E1A-mediated transactivation; when associated with A-51 and G-112. Abolishes adenovirus 2 E1A-mediated transactivation; when associated with A-14; A-51 and G-112. 3 Publications	1
Mutagenesisⁱ	53	T → D: Completely abolishes MAPK9- and adenovirus E1A-mediated transactivation; when associated with D-51. 3 Publications	1
Mutagenesisⁱ	112	T → G: Some reduction in transactivation but, completely abolishes MAPK9-mediated activation. Abolishes MAPK9-mediated and greatly reduces adenovirus E1A-mediated transactivation; when associated with A-51 and A-53. Abolishes adenovirus 2 E1A-mediated transactivation; when associated with A-14; A-51 and A-53. 2 Publications	1
Mutagenesisⁱ	118	K → R: Abolishes sumoylation. Exclusive nucleoplasmic location. Increase in binding the E-selectin promoter. 1 Publication	1
Mutagenesisⁱ	156	T → A: No effect on transactivation; when associated with A-158. 1 Publication	1
Mutagenesisⁱ	158	T → A: No effect on transactivation; when associated with A-156. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11016
Open Targets More...OpenTargetsⁱ	ENSG00000170653
PharmGKBⁱ	PA25092

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00852 Pseudoephedrine

DrugBankⁱ

DB00852 Pseudoephedrine

Polymorphism and mutation databases

BioMutaⁱ	ATF7
DMDMⁱ	12643393

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076592	1 – 494	Cyclic AMP-dependent transcription factor ATF-7Add BLAST		494

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	51	Phosphothreonine; by MAPK111 Publication	1
Modified residueⁱ	53	Phosphothreonine1 Publication	1
Modified residueⁱ	112	Phosphothreonine1 Publication	1
Cross-linkⁱ	118	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)2 Publications
Modified residueⁱ	424	PhosphoserineCombined sources	1
Modified residueⁱ	434	PhosphoserineCombined sources	1

Post-translational modificationⁱ

On EGF stimulation, phosphorylated first on Thr-53 allowing subsequent phosphorylation on Thr-51. This latter phosphorylation prevents sumoylation, increases binding to TAF12 and enhances transcriptional activity.1 Publication

Sumoylation delays nuclear localization and inhibits transactivation activity through preventing binding to TAF12. RANBP2 appears to be the specific E3 ligase.

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P17544
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P17544
PaxDbⁱ	P17544
PeptideAtlas More...PeptideAtlasⁱ	P17544
PRIDEⁱ	P17544
ProteomicsDBⁱ	53487 53488 [P17544-2] 53489 [P17544-3] 53490 [P17544-4] 53491 [P17544-5] 53492 [P17544-6]

PTM databases

iPTMnetⁱ	P17544
PhosphoSitePlusⁱ	P17544

Expressionⁱ

Tissue specificityⁱ

Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000170653
CleanExⁱ	HS_ATF7
ExpressionAtlasⁱ	P17544 baseline and differential
Genevisibleⁱ	P17544 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003384

HPAⁱ

HPA003384

Interactionⁱ

Subunit structureⁱ

Homodimer; binds DNA as homodimer. Heterodimer; heterodimerizes with other members of ATF family and with JUN family members. Interacts with JNK2; the interaction does not phosphorylate ATF7 but acts as a docking site for other ATF-associated partners such as JUN family members. Interacts (via its transactivation domain) with TAF12 (isoforms TAFII15 and TAFII20); the interaction potentiates the transactivation activity (isoform TAFII20 only) and is inhibited by ATF7 sumoylation. Interacts with TAF4; the interaction inhibits the TAF12-dependent transactivation. Interacts with MAPK9; the interaction does not phosphorylate ATF7 but acts as a docking site for ATF7-associated partners such as JUN.6 Publications

(Microbial infection) Interacts with adenovirus 2 E1A; the interaction enhances the ATF7-mediated viral transactivation activity which requires the zinc-binding domains of both E1A and ATF7.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ATF3	P18847	2	EBI-765623,EBI-712767
CCDC155	Q8N6L0	3	EBI-765623,EBI-749265
FAM9B	Q8IZU0	3	EBI-765623,EBI-10175124
FCER2	P06734	3	EBI-765623,EBI-10199985
FOS	P01100	4	EBI-765623,EBI-852851
FOSL2	P15408	2	EBI-765623,EBI-3893419
HBZ	P0C746	2	EBI-765623,EBI-10890294	From Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A).
JUN	P05412	6	EBI-765623,EBI-852823
JUNB	P17275	2	EBI-765623,EBI-748062
JUND	P17535	2	EBI-765623,EBI-2682803
MDV005	Q9DGW5	2	EBI-765623,EBI-10889526	From Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987).
OCIAD1	Q9NX40	2	EBI-765623,EBI-2683029
TMEM239	Q8WW34	3	EBI-765623,EBI-9675724

Show more details

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 23382074
mitogen-activated protein kinase binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10376527
transcription factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 10376527

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116206, 40 interactors
CORUMⁱ	P17544
ELMⁱ	P17544
IntActⁱ	P17544, 30 interactors
Molecular INTeraction database More...MINTⁱ	P17544
STRINGⁱ	9606.ENSP00000329212

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P17544
SMRⁱ	P17544
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	343 – 406	bZIPPROSITE-ProRule annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 296	Transactivation domainAdd BLAST	296
Regionⁱ	336 – 494	Essential for binding adenovirus 2 E1AAdd BLAST	159
Regionⁱ	345 – 365	Basic motifPROSITE-ProRule annotationAdd BLAST	21
Regionⁱ	371 – 399	Leucine-zipperPROSITE-ProRule annotationAdd BLAST	29

Sequence similaritiesⁱ

Belongs to the bZIP family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	7 – 31	C2H2-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1414 Eukaryota ENOG4111CH5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000020106
HOGENOMⁱ	HOG000220894
HOVERGENⁱ	HBG004300
InParanoidⁱ	P17544
KEGG Orthology (KO) More...KOⁱ	K09045
OMAⁱ	EDCMERR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AO8
PhylomeDBⁱ	P17544

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR016378 TF_CRE-BP1-typ IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
PIRSFⁱ	PIRSF003153 ATF2_CRE-BP1, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit SM00355 ZnF_C2H2, 1 hit
SUPFAMⁱ	SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit PS00028 ZINC_FINGER_C2H2_1, 1 hit PS50157 ZINC_FINGER_C2H2_2, 1 hit

Sequences (6)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 3 (identifier: P17544-1) [UniParc]FASTA Add to basket

Also known as: ATF-A1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ 
        60         70         80         90        100
TPTPTRFLKN CEEVGLFNEL ASSFEHEFKK AADEDEKKAR SRTVAKKLVA 
       110        120        130        140        150
AAGPLDMSLP STPDIKIKEE EPVEVDSSPP DSPASSPCSP PLKEKEVTPK 
       160        170        180        190        200
PVLISTPTPT IVRPGSLPLH LGYDPLHPTL PSPTSVITQA PPSNRQMGSP 
       210        220        230        240        250
TGSLPLVMHL ANGQTMPVLP GPPVQMPSVI SLARPVSMVP NIPGIPGPPV 
       260        270        280        290        300
NSSGSISPSG HPIPSEAKMR LKATLTHQVS SINGGCGMVV GTASTMVTAR 
       310        320        330        340        350
PEQSQILIQH PDAPSPAQPQ VSPAQPTPST GGRRRRTVDE DPDERRQRFL 
       360        370        380        390        400
ERNRAAASRC RQKRKLWVSS LEKKAEELTS QNIQLSNEVT LLRNEVAQLK 
       410        420        430        440        450
QLLLAHKDCP VTALQKKTQG YLESPKESSE PTGSPAPVIQ HSSATAPSNG 
       460        470        480        490 
LSVRSAAEAV ATSVLTQMAS QRTELSMPIQ SHVIMTPQSQ SAGR

Length:494

Mass (Da):52,967

Last modified:January 24, 2001 - v2

Checksum:ⁱ511EAF79C6503300

GO

Isoform 1 (identifier: P17544-2) [UniParc]FASTA Add to basket

Also known as: ATF-A

The sequence of this isoform differs from the canonical sequence as follows:
89-99: Missing.
125-145: Missing.

« Hide

        10         20         30         40         50
MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ 
        60         70         80         90        100
TPTPTRFLKN CEEVGLFNEL ASSFEHEFKK AADEDEKKAA AGPLDMSLPS 
       110        120        130        140        150
TPDIKIKEEE PVEEVTPKPV LISTPTPTIV RPGSLPLHLG YDPLHPTLPS 
       160        170        180        190        200
PTSVITQAPP SNRQMGSPTG SLPLVMHLAN GQTMPVLPGP PVQMPSVISL 
       210        220        230        240        250
ARPVSMVPNI PGIPGPPVNS SGSISPSGHP IPSEAKMRLK ATLTHQVSSI 
       260        270        280        290        300
NGGCGMVVGT ASTMVTARPE QSQILIQHPD APSPAQPQVS PAQPTPSTGG 
       310        320        330        340        350
RRRRTVDEDP DERRQRFLER NRAAASRCRQ KRKLWVSSLE KKAEELTSQN 
       360        370        380        390        400
IQLSNEVTLL RNEVAQLKQL LLAHKDCPVT ALQKKTQGYL ESPKESSEPT 
       410        420        430        440        450
GSPAPVIQHS SATAPSNGLS VRSAAEAVAT SVLTQMASQR TELSMPIQSH 
       460 
VIMTPQSQSA GR

Show »

Length:462

Mass (Da):49,650

Checksum:ⁱ92AB6DF8D2A954CD

GO

Isoform 2 (identifier: P17544-3) [UniParc]FASTA Add to basket

Also known as: ATF-A-delta

The sequence of this isoform differs from the canonical sequence as follows:
125-145: Missing.

« Hide

        10         20         30         40         50
MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ 
        60         70         80         90        100
TPTPTRFLKN CEEVGLFNEL ASSFEHEFKK AADEDEKKAR SRTVAKKLVA 
       110        120        130        140        150
AAGPLDMSLP STPDIKIKEE EPVEEVTPKP VLISTPTPTI VRPGSLPLHL 
       160        170        180        190        200
GYDPLHPTLP SPTSVITQAP PSNRQMGSPT GSLPLVMHLA NGQTMPVLPG 
       210        220        230        240        250
PPVQMPSVIS LARPVSMVPN IPGIPGPPVN SSGSISPSGH PIPSEAKMRL 
       260        270        280        290        300
KATLTHQVSS INGGCGMVVG TASTMVTARP EQSQILIQHP DAPSPAQPQV 
       310        320        330        340        350
SPAQPTPSTG GRRRRTVDED PDERRQRFLE RNRAAASRCR QKRKLWVSSL 
       360        370        380        390        400
EKKAEELTSQ NIQLSNEVTL LRNEVAQLKQ LLLAHKDCPV TALQKKTQGY 
       410        420        430        440        450
LESPKESSEP TGSPAPVIQH SSATAPSNGL SVRSAAEAVA TSVLTQMASQ 
       460        470 
RTELSMPIQS HVIMTPQSQS AGR

Show »

Length:473

Mass (Da):50,860

Checksum:ⁱ6CB9C4D7A0128AA9

GO

Isoform 4 (identifier: P17544-4) [UniParc]FASTA Add to basket

Also known as: ATF-A0

The sequence of this isoform differs from the canonical sequence as follows:
89-99: Missing.
146-321: Missing.

« Hide

        10         20         30         40         50
MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ 
        60         70         80         90        100
TPTPTRFLKN CEEVGLFNEL ASSFEHEFKK AADEDEKKAA AGPLDMSLPS 
       110        120        130        140        150
TPDIKIKEEE PVEVDSSPPD SPASSPCSPP LKEKSPAQPT PSTGGRRRRT 
       160        170        180        190        200
VDEDPDERRQ RFLERNRAAA SRCRQKRKLW VSSLEKKAEE LTSQNIQLSN 
       210        220        230        240        250
EVTLLRNEVA QLKQLLLAHK DCPVTALQKK TQGYLESPKE SSEPTGSPAP 
       260        270        280        290        300
VIQHSSATAP SNGLSVRSAA EAVATSVLTQ MASQRTELSM PIQSHVIMTP 

QSQSAGR

Show »

Length:307

Mass (Da):33,681

Checksum:ⁱ01665BFA649C6CA1

GO

Isoform 5 (identifier: P17544-5) [UniParc]FASTA Add to basket

Also known as: ATF-4

The sequence of this isoform differs from the canonical sequence as follows:
100-494: AAAGPLDMSL...MTPQSQSAGR → VFRPRLFLLCFGIIFLIG

« Hide

        10         20         30         40         50
MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ 
        60         70         80         90        100
TPTPTRFLKN CEEVGLFNEL ASSFEHEFKK AADEDEKKAR SRTVAKKLVV 
       110 
FRPRLFLLCF GIIFLIG

Show »

Length:117

Mass (Da):13,278

Checksum:ⁱ15298D193695ACED

GO

Isoform 6 (identifier: P17544-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
89-99: Missing.

« Hide

        10         20         30         40         50
MGDDRPFVCN APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RTDSVIIADQ 
        60         70         80         90        100
TPTPTRFLKN CEEVGLFNEL ASSFEHEFKK AADEDEKKAA AGPLDMSLPS 
       110        120        130        140        150
TPDIKIKEEE PVEVDSSPPD SPASSPCSPP LKEKEVTPKP VLISTPTPTI 
       160        170        180        190        200
VRPGSLPLHL GYDPLHPTLP SPTSVITQAP PSNRQMGSPT GSLPLVMHLA 
       210        220        230        240        250
NGQTMPVLPG PPVQMPSVIS LARPVSMVPN IPGIPGPPVN SSGSISPSGH 
       260        270        280        290        300
PIPSEAKMRL KATLTHQVSS INGGCGMVVG TASTMVTARP EQSQILIQHP 
       310        320        330        340        350
DAPSPAQPQV SPAQPTPSTG GRRRRTVDED PDERRQRFLE RNRAAASRCR 
       360        370        380        390        400
QKRKLWVSSL EKKAEELTSQ NIQLSNEVTL LRNEVAQLKQ LLLAHKDCPV 
       410        420        430        440        450
TALQKKTQGY LESPKESSEP TGSPAPVIQH SSATAPSNGL SVRSAAEAVA 
       460        470        480 
TSVLTQMASQ RTELSMPIQS HVIMTPQSQS AGR

Note: No experimental confirmation available.

Show »

Length:483

Mass (Da):51,757

Checksum:ⁱ07080BC24FED635B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	12	P → T in AAH42363 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_000594	89 – 99	Missing in isoform 1, isoform 4 and isoform 6. 3 PublicationsAdd BLAST	11
Alternative sequenceⁱVSP_042469	100 – 494	AAAGP…QSAGR → VFRPRLFLLCFGIIFLIG in isoform 5. 1 PublicationAdd BLAST	395
Alternative sequenceⁱVSP_000595	125 – 145	Missing in isoform 1 and isoform 2. 1 PublicationAdd BLAST	21
Alternative sequenceⁱVSP_034543	146 – 321	Missing in isoform 4. 1 PublicationAdd BLAST	176

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X52943 mRNA Translation: CAA37118.1 X57197 mRNA Translation: CAA40483.1 AK298853 mRNA Translation: BAG60976.1 AC023509 Genomic DNA No translation available. AC073594 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW96723.1 CH471054 Genomic DNA Translation: EAW96724.1 BC042363 mRNA Translation: AAH42363.1 BC136302 mRNA Translation: AAI36303.1 BC140006 mRNA Translation: AAI40007.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44906.1 [P17544-6] CCDS58238.1 [P17544-5]
PIRⁱ	S12741
NCBI Reference Sequences More...RefSeqⁱ	NP_001123532.1, NM_001130060.1 [P17544-2] NP_001193611.1, NM_001206682.1 [P17544-5] NP_001193612.1, NM_001206683.1 [P17544-5] NP_006847.1, NM_006856.2 [P17544-6] XP_005268644.1, XM_005268587.3 [P17544-6] XP_016874211.1, XM_017018722.1 [P17544-6]
UniGeneⁱ	Hs.12286 Hs.633602

Genome annotation databases

Ensemblⁱ	ENST00000420353; ENSP00000399465; ENSG00000170653 [P17544-6] ENST00000456903; ENSP00000387406; ENSG00000170653 [P17544-6] ENST00000548118; ENSP00000456858; ENSG00000170653 [P17544-5] ENST00000548446; ENSP00000449938; ENSG00000170653 [P17544-1] ENST00000591397; ENSP00000465192; ENSG00000170653 [P17544-5]
GeneIDⁱ	11016
KEGGⁱ	hsa:11016
UCSC genome browser More...UCSCⁱ	uc001sdz.4 human [P17544-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P17544	ATF7 isoform 4		PANTR		494
Activating transcription factor 7		PANPA		494
Cyclic AMP-dependent transcription factor ATF-7 (Fragment)		HUMAN		78
Cyclic AMP-dependent transcription factor ATF-7 (Fragment)		HUMAN		79
ATF7 isoform 5 (Fragment)		PANTR		79
+2
P17544-5	ATF7 isoform 1		PANTR		117
Activating transcription factor 7		PANPA		117
Activating transcription factor 7		GORGO		117
P17544-6	ATF7 isoform 2		PANTR		483
Activating transcription factor 7		GORGO		483

Protein	Similar proteins		Species	Score	Length
P17544	ATF7 isoform 4		PANTR		494
Activating transcription factor 7		PANPA		494
Cyclic AMP-dependent transcription factor ATF-7 (Fragment)		HUMAN		78
Cyclic AMP-dependent transcription factor ATF-7 (Fragment)		MYOBR		551
Activating transcription factor 7 (Fragment)		MUSPF		148
+206
P17544-2	UPI0005F53407		MACNE		473
UPI00083C2F34		RHIBE		473
UPI0004C0824F		CALAN		467
UPI00042BE686		CHEMY		462
UPI0003318CF6		SORAR		462
+11
P17544-3	UPI0005F53407		MACNE		473
UPI00083C2F34		RHIBE		473
UPI0004C0824F		CALAN		467
UPI00042BE686		CHEMY		462
UPI0003318CF6		SORAR		462
+11
P17544-5	ATF7 isoform 1		PANTR		117
Activating transcription factor 7		PANPA		117
Activating transcription factor 7		GORGO		117
ATF7 isoform 1		PONAB		117
Activating transcription factor 7		COLAP		117
+12

Protein	Similar proteins		Species	Score	Length
P17544	ATF7 isoform 4		PANTR		494
Activating transcription factor 7		PANPA		494
Cyclic AMP-dependent transcription factor ATF-7 (Fragment)		HUMAN		78
Cyclic AMP-dependent transcription factor ATF-7 (Fragment)		MYOBR		551
Activating transcription factor 7 (Fragment)		MUSPF		148
+461
P17544-2	UPI0005F53407		MACNE		473
UPI00083C2F34		RHIBE		473
UPI0004C0824F		CALAN		467
UPI00046BADB0		EPTFU		462
UPI00042BE686		CHEMY		462
+74
P17544-3	UPI0005F53407		MACNE		473
UPI00083C2F34		RHIBE		473
UPI0004C0824F		CALAN		467
UPI00046BADB0		EPTFU		462
UPI00042BE686		CHEMY		462
+74
P17544-4	Cyclic AMP-dependent transcription factor ATF-7 (Fragment)		GAVST		310
Cyclic AMP-dependent transcription factor ATF-7 (Fragment)		Struthio camelus australis		323
Cyclic AMP-dependent transcription factor ATF-7 (Fragment)		NIPNI		310
Cyclic AMP-dependent transcription factor ATF-7 (Fragment)		Dalmatian pelican		310
Cyclic AMP-dependent transcription factor ATF-7 (Fragment)		CATAU		310
+15
P17544-5	ATF7 isoform 1		PANTR		117
Activating transcription factor 7		PANPA		117
Activating transcription factor 7		GORGO		117
UPI00045D60AE		Orycteropus afer afer		117
Uncharacterized protein		NOMLE		117
+16

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X52943 mRNA Translation: CAA37118.1 X57197 mRNA Translation: CAA40483.1 AK298853 mRNA Translation: BAG60976.1 AC023509 Genomic DNA No translation available. AC073594 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW96723.1 CH471054 Genomic DNA Translation: EAW96724.1 BC042363 mRNA Translation: AAH42363.1 BC136302 mRNA Translation: AAI36303.1 BC140006 mRNA Translation: AAI40007.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44906.1 [P17544-6] CCDS58238.1 [P17544-5]
PIRⁱ	S12741
NCBI Reference Sequences More...RefSeqⁱ	NP_001123532.1, NM_001130060.1 [P17544-2] NP_001193611.1, NM_001206682.1 [P17544-5] NP_001193612.1, NM_001206683.1 [P17544-5] NP_006847.1, NM_006856.2 [P17544-6] XP_005268644.1, XM_005268587.3 [P17544-6] XP_016874211.1, XM_017018722.1 [P17544-6]
UniGeneⁱ	Hs.12286 Hs.633602

3D structure databases

ProteinModelPortalⁱ	P17544
SMRⁱ	P17544
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116206, 40 interactors
CORUMⁱ	P17544
ELMⁱ	P17544
IntActⁱ	P17544, 30 interactors
Molecular INTeraction database More...MINTⁱ	P17544
STRINGⁱ	9606.ENSP00000329212

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00852 Pseudoephedrine

DrugBankⁱ

DB00852 Pseudoephedrine

PTM databases

iPTMnetⁱ	P17544
PhosphoSitePlusⁱ	P17544

Polymorphism and mutation databases

BioMutaⁱ	ATF7
DMDMⁱ	12643393

Proteomic databases

EPDⁱ	P17544
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P17544
PaxDbⁱ	P17544
PeptideAtlas More...PeptideAtlasⁱ	P17544
PRIDEⁱ	P17544
ProteomicsDBⁱ	53487 53488 [P17544-2] 53489 [P17544-3] 53490 [P17544-4] 53491 [P17544-5] 53492 [P17544-6]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11016
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000420353; ENSP00000399465; ENSG00000170653 [P17544-6] ENST00000456903; ENSP00000387406; ENSG00000170653 [P17544-6] ENST00000548118; ENSP00000456858; ENSG00000170653 [P17544-5] ENST00000548446; ENSP00000449938; ENSG00000170653 [P17544-1] ENST00000591397; ENSP00000465192; ENSG00000170653 [P17544-5]
GeneIDⁱ	11016
KEGGⁱ	hsa:11016
UCSC genome browser More...UCSCⁱ	uc001sdz.4 human [P17544-1]

Organism-specific databases

CTDⁱ	11016
DisGeNET More...DisGeNETⁱ	11016
EuPathDBⁱ	HostDB:ENSG00000170653.18
GeneCardsⁱ	ATF7
H-InvDBⁱ	HIX0201838
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:792 ATF7
Human Protein Atlas More...HPAⁱ	HPA003384
MIMⁱ	606371 gene
neXtProtⁱ	NX_P17544
Open Targets More...OpenTargetsⁱ	ENSG00000170653
PharmGKBⁱ	PA25092
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1414 Eukaryota ENOG4111CH5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000020106
HOGENOMⁱ	HOG000220894
HOVERGENⁱ	HBG004300
InParanoidⁱ	P17544
KEGG Orthology (KO) More...KOⁱ	K09045
OMAⁱ	EDCMERR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AO8
PhylomeDBⁱ	P17544

Enzyme and pathway databases

SIGNORⁱ	P17544

SIGNORⁱ

P17544

Miscellaneous databases

ChiTaRSⁱ	ATF7 human
GeneWikiⁱ	ATF7
GenomeRNAiⁱ	11016
Protein Ontology More...PROⁱ	PR:P17544
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170653
CleanExⁱ	HS_ATF7
ExpressionAtlasⁱ	P17544 baseline and differential
Genevisibleⁱ	P17544 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP IPR016378 TF_CRE-BP1-typ IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
PIRSFⁱ	PIRSF003153 ATF2_CRE-BP1, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit SM00355 ZnF_C2H2, 1 hit
SUPFAMⁱ	SSF57667 SSF57667, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit PS00028 ZINC_FINGER_C2H2_1, 1 hit PS50157 ZINC_FINGER_C2H2_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ATF7_HUMAN
Accessionⁱ	P17544Primary (citable) accession number: P17544 Secondary accession number(s): A5D6Y4 , B2RMP1, B4DQL4, Q13814, Q8IVR8, Q9UD83
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	January 24, 2001
	Last modified:	July 18, 2018
	This is version 188 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P17544 (ATF7_HUMAN)

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Cyclic AMP-dependent transcription factor ATF-7

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<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

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