T-cell acute lymphocytic leukemia protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis."
    McCormack M.P., Hall M.A., Schoenwaelder S.M., Zhao Q., Ellis S., Prentice J.A., Clarke A.J., Slater N.J., Salmon J.M., Jackson S.P., Jane S.M., Curtis D.J.
    Blood 108:2248-2256(2006) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: BHF-UCLInferred from direct assayⁱ
  • "LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis."
    Hu X., Li X., Valverde K., Fu X., Noguchi C., Qiu Y., Huang S.
    Proc. Natl. Acad. Sci. U.S.A. 106:10141-10146(2009) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
• E-box binding Source: BHF-UCLInferred from direct assayⁱ
  • "NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia."
    Kusy S., Gerby B., Goardon N., Gault N., Ferri F., Gerard D., Armstrong F., Ballerini P., Cayuela J.M., Baruchel A., Pflumio F., Romeo P.H.
    J. Exp. Med. 207:2141-2156(2010) [PubMed] [Europe PMC] [Abstract]
• enzyme binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis."
    Hu X., Li X., Valverde K., Fu X., Noguchi C., Qiu Y., Huang S.
    Proc. Natl. Acad. Sci. U.S.A. 106:10141-10146(2009) [PubMed] [Europe PMC] [Abstract]
• histone deacetylase binding Source: BHF-UCLInferred from physical interactionⁱ
  • "LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis."
    Hu X., Li X., Valverde K., Fu X., Noguchi C., Qiu Y., Huang S.
    Proc. Natl. Acad. Sci. U.S.A. 106:10141-10146(2009) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: Ensembl
• RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "GATA-1 forms distinct activating and repressive complexes in erythroid cells."
    Rodriguez P., Bonte E., Krijgsveld J., Kolodziej K.E., Guyot B., Heck A.J.R., Vyas P., de Boer E., Grosveld F., Strouboulis J.
    EMBO J. 24:2354-2366(2005) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region DNA binding Source: BHF-UCL

GO - Biological processⁱ

• angiogenesis Source: Ensembl
• astrocyte fate commitment Source: Ensembl
• basophil differentiation Source: BHF-UCL <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Expression of tal-1 and GATA-binding proteins during human hematopoiesis."
    Mouthon M.A., Bernard O., Mitjavila M.T., Romeo P.H., Vainchenker W., Mathieu-Mahul D.
    Blood 81:647-655(1993) [PubMed] [Europe PMC] [Abstract]
• cell fate commitment Source: BHF-UCL
• definitive hemopoiesis Source: Ensembl
• embryonic hemopoiesis Source: UniProtKB
• erythrocyte differentiation Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.7

    "The SCL gene product: a positive regulator of erythroid differentiation."
    Aplan P.D., Nakahara K., Orkin S.H., Kirsch I.R.
    EMBO J. 11:4073-4081(1992) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• erythrocyte maturation Source: Ensembl
• hemangioblast cell differentiation Source: Ensembl
• hematopoietic stem cell differentiation Source: Ensembl
• hemopoiesis Source: BHF-UCL
• locomotory behavior Source: Ensembl
• megakaryocyte development Source: Ensembl
• megakaryocyte differentiation Source: BHF-UCLInferred from expression patternⁱ
  • "Expression of tal-1 and GATA-binding proteins during human hematopoiesis."
    Mouthon M.A., Bernard O., Mitjavila M.T., Romeo P.H., Vainchenker W., Mathieu-Mahul D.
    Blood 81:647-655(1993) [PubMed] [Europe PMC] [Abstract]
• negative regulation of erythrocyte differentiation Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: Ensembl
• platelet formation Source: Ensembl
• positive regulation of cell division Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia."
    Kusy S., Gerby B., Goardon N., Gault N., Ferri F., Gerard D., Armstrong F., Ballerini P., Cayuela J.M., Baruchel A., Pflumio F., Romeo P.H.
    J. Exp. Med. 207:2141-2156(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of chromatin assembly or disassembly Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia."
    Kusy S., Gerby B., Goardon N., Gault N., Ferri F., Gerard D., Armstrong F., Ballerini P., Cayuela J.M., Baruchel A., Pflumio F., Romeo P.H.
    J. Exp. Med. 207:2141-2156(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of erythrocyte differentiation Source: UniProtKBInferred from direct assayⁱ
  • "Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1."
    Lausen J., Pless O., Leonard F., Kuvardina O.N., Koch B., Leutz A.
    J. Biol. Chem. 285:5338-5346(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mitotic cell cycle Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia."
    Kusy S., Gerby B., Goardon N., Gault N., Ferri F., Gerard D., Armstrong F., Ballerini P., Cayuela J.M., Baruchel A., Pflumio F., Romeo P.H.
    J. Exp. Med. 207:2141-2156(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein complex assembly Source: BHF-UCLInferred from direct assayⁱ
  • "NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia."
    Kusy S., Gerby B., Goardon N., Gault N., Ferri F., Gerard D., Armstrong F., Ballerini P., Cayuela J.M., Baruchel A., Pflumio F., Romeo P.H.
    J. Exp. Med. 207:2141-2156(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein tyrosine kinase activity Source: Ensembl
• positive regulation of signaling receptor activity Source: Ensembl
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • "Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1."
    Lausen J., Pless O., Leonard F., Kuvardina O.N., Koch B., Leutz A.
    J. Biol. Chem. 285:5338-5346(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia."
    Kusy S., Gerby B., Goardon N., Gault N., Ferri F., Gerard D., Armstrong F., Ballerini P., Cayuela J.M., Baruchel A., Pflumio F., Romeo P.H.
    J. Exp. Med. 207:2141-2156(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of cell population proliferation Source: Ensembl
• regulation of hematopoietic stem cell differentiation Source: Reactome
• regulation of mast cell differentiation Source: Ensembl
• regulation of stem cell population maintenance Source: Ensembl
• regulation of transcription by RNA polymerase II Source: BHF-UCL
• spinal cord association neuron differentiation Source: Ensembl
• transcription by RNA polymerase II Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• enzyme binding Source: BHF-UCLInferred from physical interactionⁱ
  • "LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis."
    Hu X., Li X., Valverde K., Fu X., Noguchi C., Qiu Y., Huang S.
    Proc. Natl. Acad. Sci. U.S.A. 106:10141-10146(2009) [PubMed] [Europe PMC] [Abstract]
• histone deacetylase binding Source: BHF-UCLInferred from physical interactionⁱ
  • "LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis."
    Hu X., Li X., Valverde K., Fu X., Noguchi C., Qiu Y., Huang S.
    Proc. Natl. Acad. Sci. U.S.A. 106:10141-10146(2009) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: Ensembl
• RNA polymerase II transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "GATA-1 forms distinct activating and repressive complexes in erythroid cells."
    Rodriguez P., Bonte E., Krijgsveld J., Kolodziej K.E., Guyot B., Heck A.J.R., Vyas P., de Boer E., Grosveld F., Strouboulis J.
    EMBO J. 24:2354-2366(2005) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MTERPPSEAA RSDPQLEGRD AAEASMAPPH LVLLNGVAKE TSRAAAAEPP 
        60         70         80         90        100
VIELGARGGP GGGPAGGGGA ARDLKGRDAA TAEARHRVPT TELCRPPGPA 
       110        120        130        140        150
PAPAPASVTA ELPGDGRMVQ LSPPALAAPA APGRALLYSL SQPLASLGSG 
       160        170        180        190        200
FFGEPDAFPM FTTNNRVKRR PSPYEMEITD GPHTKVVRRI FTNSRERWRQ 
       210        220        230        240        250
QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA KLLNDQEEEG 
       260        270        280        290        300
TQRAKTGKDP VVGAGGGGGG GGGGAPPDDL LQDVLSPNSS CGSSLDGAAS 
       310        320        330 
PDSYTEEPAP KHTARSLHPA MLPAADGAGP R                     

        10         20         30         40         50
MAPPHLVLLN GVAKETSRAA AAEPPVIELG ARGGPGGGPA GGGGAARDLK 
        60         70         80         90        100
GRDAATAEAR HRVPTTELCR PPGPAPAPAP ASVTAELPGD GRMVQLSPPA 
       110        120        130        140        150
LAAPAAPGRA LLYSLSQPLA SLGSGFFGEP DAFPMFTTNN RVKRRPSPYE 
       160        170        180        190        200
MEITDGPHTK VVRRIFTNSR ERWRQQNVNG AFAELRKLIP THPPDKKLSK 
       210        220        230        240        250
NEILRLAMKY INFLAKLLND QEEEGTQRAK TGKDPVVGAG GGGGGGGGGA 
       260        270        280        290        300
PPDDLLQDVL SPNSSCGSSL DGAASPDSYT EEPAPKHTAR SLHPAMLPAA 

DGAGPR                                                 

        10         20         30         40         50
MEITDGPHTK VVRRIFTNSR ERWRQQNVNG AFAELRKLIP THPPDKKLSK 
        60         70         80         90        100
NEILRLAMKY INFLAKLLND QEEEGTQRAK TGKDPVVGAG GGGGGGGGGA 
       110        120        130        140        150
PPDDLLQDVL SPNSSCGSSL DGAASPDSYT EEPAPKHTAR SLHPAMLPAA 

DGAGPR                                                 

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
3. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot