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Entry version 193 (08 May 2019)
Sequence version 2 (01 Nov 1991)
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Protein

T-cell acute lymphocytic leukemia protein 1

Gene

TAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P17542

SIGNOR Signaling Network Open Resource

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SIGNORi
P17542

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
T-cell acute lymphocytic leukemia protein 1
Short name:
TAL-1
Alternative name(s):
Class A basic helix-loop-helix protein 17
Short name:
bHLHa17
Stem cell protein
T-cell leukemia/lymphoma protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAL1
Synonyms:BHLHA17, SCL, TCL5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11556 TAL1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
187040 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P17542

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
6886

MalaCards human disease database

More...
MalaCardsi
TAL1

Open Targets

More...
OpenTargetsi
ENSG00000162367

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
99861 Precursor T-cell acute lymphoblastic leukemia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36326

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TAL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
134305

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001274541 – 331T-cell acute lymphocytic leukemia protein 1Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei172PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity).By similarity
Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

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MaxQBi
P17542

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P17542

PeptideAtlas

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PeptideAtlasi
P17542

PRoteomics IDEntifications database

More...
PRIDEi
P17542

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53484
53485 [P17542-2]
53486 [P17542-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P17542

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P17542

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P17542

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Leukemic stem cell.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000162367 Expressed in 163 organ(s), highest expression level in liver

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P17542 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017805
HPA047866
HPA073983

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Interacts with SBNO2; this interaction inhibits TAL1 occupancy of the DCSTAMP promoter, leading to the activation of the DCSTAMP promoter by the transcription factor MITF.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112749, 50 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P17542

Database of interacting proteins

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DIPi
DIP-40640N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P17542

Protein interaction database and analysis system

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IntActi
P17542, 30 interactors

Molecular INTeraction database

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MINTi
P17542

STRING: functional protein association networks

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STRINGi
9606.ENSP00000294339

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1331
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YPAX-ray2.80A180-253[»]
2YPBX-ray2.87A180-253[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P17542

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini187 – 239bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi89 – 132Pro-richAdd BLAST44
Compositional biasi263 – 274Poly-GlyAdd BLAST12

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4029 Eukaryota
ENOG411227D LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159889

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000113414

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P17542

KEGG Orthology (KO)

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KOi
K09068

Identification of Orthologs from Complete Genome Data

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OMAi
EMPVIEL

Database of Orthologous Groups

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OrthoDBi
1292816at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P17542

TreeFam database of animal gene trees

More...
TreeFami
TF315153

Family and domain databases

Conserved Domains Database

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CDDi
cd00083 HLH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR040238 TAL-like

The PANTHER Classification System

More...
PANTHERi
PTHR13864 PTHR13864, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00010 HLH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00353 HLH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47459 SSF47459, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: The splicing pattern is cell-lineage dependent.
Isoform PP42-TAL1 (identifier: P17542-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTERPPSEAA RSDPQLEGRD AAEASMAPPH LVLLNGVAKE TSRAAAAEPP
60 70 80 90 100
VIELGARGGP GGGPAGGGGA ARDLKGRDAA TAEARHRVPT TELCRPPGPA
110 120 130 140 150
PAPAPASVTA ELPGDGRMVQ LSPPALAAPA APGRALLYSL SQPLASLGSG
160 170 180 190 200
FFGEPDAFPM FTTNNRVKRR PSPYEMEITD GPHTKVVRRI FTNSRERWRQ
210 220 230 240 250
QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA KLLNDQEEEG
260 270 280 290 300
TQRAKTGKDP VVGAGGGGGG GGGGAPPDDL LQDVLSPNSS CGSSLDGAAS
310 320 330
PDSYTEEPAP KHTARSLHPA MLPAADGAGP R
Length:331
Mass (Da):34,271
Last modified:November 1, 1991 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i33BBE31589DBB7C7
GO
Isoform PP39-TAL1 (identifier: P17542-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.

Show »
Length:306
Mass (Da):31,617
Checksum:i4457C743678771FE
GO
Isoform PP22-TAL1 (identifier: P17542-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.

Show »
Length:156
Mass (Da):16,548
Checksum:i5BC0D5F12E261CDE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0021541 – 175Missing in isoform PP22-TAL1. CuratedAdd BLAST175
Alternative sequenceiVSP_0021531 – 25Missing in isoform PP39-TAL1. CuratedAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M61108 mRNA Translation: AAA36600.1
M61103 Genomic DNA No translation available.
M61104 Genomic DNA No translation available.
M61105 Genomic DNA No translation available.
M63572 Genomic DNA No translation available.
M63589, M63576, M63584 Genomic DNA Translation: AAA36599.1
AL135960 Genomic DNA Translation: CAB72103.1
CH471059 Genomic DNA Translation: EAX06875.1
CH471059 Genomic DNA Translation: EAX06876.1
CH471059 Genomic DNA Translation: EAX06877.1
X58621 Genomic DNA Translation: CAA41476.1 Sequence problems.
X58622 Genomic DNA Translation: CAA41477.1
M29038 mRNA Translation: AAA36598.1
X51990 mRNA Translation: CAA36246.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS547.1 [P17542-1]

Protein sequence database of the Protein Information Resource

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PIRi
A36358
I38253

NCBI Reference Sequences

More...
RefSeqi
NP_001274276.1, NM_001287347.2 [P17542-1]
NP_001277332.1, NM_001290403.1 [P17542-1]
NP_001277333.1, NM_001290404.1 [P17542-1]
NP_001277334.1, NM_001290405.1 [P17542-1]
NP_001277335.1, NM_001290406.1
NP_003180.1, NM_003189.5 [P17542-1]
XP_005271217.1, XM_005271160.4 [P17542-1]
XP_016857676.1, XM_017002187.1 [P17542-1]
XP_016857677.1, XM_017002188.1 [P17542-1]
XP_016857678.1, XM_017002189.1 [P17542-1]
XP_016857679.1, XM_017002190.1 [P17542-1]
XP_016857680.1, XM_017002191.1 [P17542-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000294339; ENSP00000294339; ENSG00000162367 [P17542-1]
ENST00000371884; ENSP00000360951; ENSG00000162367 [P17542-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6886

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6886

UCSC genome browser

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UCSCi
uc001cqx.4 human [P17542-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61108 mRNA Translation: AAA36600.1
M61103 Genomic DNA No translation available.
M61104 Genomic DNA No translation available.
M61105 Genomic DNA No translation available.
M63572 Genomic DNA No translation available.
M63589, M63576, M63584 Genomic DNA Translation: AAA36599.1
AL135960 Genomic DNA Translation: CAB72103.1
CH471059 Genomic DNA Translation: EAX06875.1
CH471059 Genomic DNA Translation: EAX06876.1
CH471059 Genomic DNA Translation: EAX06877.1
X58621 Genomic DNA Translation: CAA41476.1 Sequence problems.
X58622 Genomic DNA Translation: CAA41477.1
M29038 mRNA Translation: AAA36598.1
X51990 mRNA Translation: CAA36246.1
CCDSiCCDS547.1 [P17542-1]
PIRiA36358
I38253
RefSeqiNP_001274276.1, NM_001287347.2 [P17542-1]
NP_001277332.1, NM_001290403.1 [P17542-1]
NP_001277333.1, NM_001290404.1 [P17542-1]
NP_001277334.1, NM_001290405.1 [P17542-1]
NP_001277335.1, NM_001290406.1
NP_003180.1, NM_003189.5 [P17542-1]
XP_005271217.1, XM_005271160.4 [P17542-1]
XP_016857676.1, XM_017002187.1 [P17542-1]
XP_016857677.1, XM_017002188.1 [P17542-1]
XP_016857678.1, XM_017002189.1 [P17542-1]
XP_016857679.1, XM_017002190.1 [P17542-1]
XP_016857680.1, XM_017002191.1 [P17542-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YPAX-ray2.80A180-253[»]
2YPBX-ray2.87A180-253[»]
SMRiP17542
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112749, 50 interactors
CORUMiP17542
DIPiDIP-40640N
ELMiP17542
IntActiP17542, 30 interactors
MINTiP17542
STRINGi9606.ENSP00000294339

PTM databases

iPTMnetiP17542
PhosphoSitePlusiP17542

Polymorphism and mutation databases

BioMutaiTAL1
DMDMi134305

Proteomic databases

MaxQBiP17542
PaxDbiP17542
PeptideAtlasiP17542
PRIDEiP17542
ProteomicsDBi53484
53485 [P17542-2]
53486 [P17542-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6886
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294339; ENSP00000294339; ENSG00000162367 [P17542-1]
ENST00000371884; ENSP00000360951; ENSG00000162367 [P17542-1]
GeneIDi6886
KEGGihsa:6886
UCSCiuc001cqx.4 human [P17542-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6886
DisGeNETi6886

GeneCards: human genes, protein and diseases

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GeneCardsi
TAL1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0029300
HGNCiHGNC:11556 TAL1
HPAiCAB017805
HPA047866
HPA073983
MalaCardsiTAL1
MIMi187040 gene
neXtProtiNX_P17542
OpenTargetsiENSG00000162367
Orphaneti99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBiPA36326

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00940000159889
HOGENOMiHOG000113414
InParanoidiP17542
KOiK09068
OMAiEMPVIEL
OrthoDBi1292816at2759
PhylomeDBiP17542
TreeFamiTF315153

Enzyme and pathway databases

ReactomeiR-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
SignaLinkiP17542
SIGNORiP17542

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TAL1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TAL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6886
PMAP-CutDBiP17542

Protein Ontology

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PROi
PR:P17542

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162367 Expressed in 163 organ(s), highest expression level in liver
GenevisibleiP17542 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR040238 TAL-like
PANTHERiPTHR13864 PTHR13864, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAL1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17542
Secondary accession number(s): D3DQ24
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1991
Last modified: May 8, 2019
This is version 193 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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