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Protein

T-cell acute lymphocytic leukemia protein 1

Gene

TAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
SignaLinkiP17542
SIGNORiP17542

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell acute lymphocytic leukemia protein 1
Short name:
TAL-1
Alternative name(s):
Class A basic helix-loop-helix protein 17
Short name:
bHLHa17
Stem cell protein
T-cell leukemia/lymphoma protein 5
Gene namesi
Name:TAL1
Synonyms:BHLHA17, SCL, TCL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162367.11
HGNCiHGNC:11556 TAL1
MIMi187040 gene
neXtProtiNX_P17542

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi6886
MalaCardsiTAL1
OpenTargetsiENSG00000162367
Orphaneti99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBiPA36326

Polymorphism and mutation databases

DMDMi134305

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274541 – 331T-cell acute lymphocytic leukemia protein 1Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei172PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity).By similarity
Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP17542
PaxDbiP17542
PeptideAtlasiP17542
PRIDEiP17542
ProteomicsDBi53484
53485 [P17542-2]
53486 [P17542-3]

PTM databases

iPTMnetiP17542
PhosphoSitePlusiP17542

Miscellaneous databases

PMAP-CutDBiP17542

Expressioni

Tissue specificityi

Leukemic stem cell.

Gene expression databases

BgeeiENSG00000162367 Expressed in 163 organ(s), highest expression level in liver
CleanExiHS_TAL1
GenevisibleiP17542 HS

Organism-specific databases

HPAiCAB017805
HPA047866
HPA073983

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Interacts with SBNO2; this interaction inhibits TAL1 occupancy of the DCSTAMP promoter, leading to the activation of the DCSTAMP promoter by the transcription factor MITF.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112749, 49 interactors
CORUMiP17542
DIPiDIP-40640N
ELMiP17542
IntActiP17542, 30 interactors
MINTiP17542
STRINGi9606.ENSP00000294339

Structurei

Secondary structure

1331
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP17542
SMRiP17542
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini187 – 239bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi89 – 132Pro-richAdd BLAST44
Compositional biasi263 – 274Poly-GlyAdd BLAST12

Domaini

The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000113414
HOVERGENiHBG005018
InParanoidiP17542
KOiK09068
OMAiQELCPGS
OrthoDBiEOG091G0ESI
PhylomeDBiP17542
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Note: The splicing pattern is cell-lineage dependent.
Isoform PP42-TAL1 (identifier: P17542-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTERPPSEAA RSDPQLEGRD AAEASMAPPH LVLLNGVAKE TSRAAAAEPP
60 70 80 90 100
VIELGARGGP GGGPAGGGGA ARDLKGRDAA TAEARHRVPT TELCRPPGPA
110 120 130 140 150
PAPAPASVTA ELPGDGRMVQ LSPPALAAPA APGRALLYSL SQPLASLGSG
160 170 180 190 200
FFGEPDAFPM FTTNNRVKRR PSPYEMEITD GPHTKVVRRI FTNSRERWRQ
210 220 230 240 250
QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA KLLNDQEEEG
260 270 280 290 300
TQRAKTGKDP VVGAGGGGGG GGGGAPPDDL LQDVLSPNSS CGSSLDGAAS
310 320 330
PDSYTEEPAP KHTARSLHPA MLPAADGAGP R
Length:331
Mass (Da):34,271
Last modified:November 1, 1991 - v2
Checksum:i33BBE31589DBB7C7
GO
Isoform PP39-TAL1 (identifier: P17542-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.

Show »
Length:306
Mass (Da):31,617
Checksum:i4457C743678771FE
GO
Isoform PP22-TAL1 (identifier: P17542-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-175: Missing.

Show »
Length:156
Mass (Da):16,548
Checksum:i5BC0D5F12E261CDE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0021541 – 175Missing in isoform PP22-TAL1. CuratedAdd BLAST175
Alternative sequenceiVSP_0021531 – 25Missing in isoform PP39-TAL1. CuratedAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61108 mRNA Translation: AAA36600.1
M61103 Genomic DNA No translation available.
M61104 Genomic DNA No translation available.
M61105 Genomic DNA No translation available.
M63572 Genomic DNA No translation available.
M63589, M63576, M63584 Genomic DNA Translation: AAA36599.1
AL135960 Genomic DNA Translation: CAB72103.1
CH471059 Genomic DNA Translation: EAX06875.1
CH471059 Genomic DNA Translation: EAX06876.1
CH471059 Genomic DNA Translation: EAX06877.1
X58621 Genomic DNA Translation: CAA41476.1 Sequence problems.
X58622 Genomic DNA Translation: CAA41477.1
M29038 mRNA Translation: AAA36598.1
X51990 mRNA Translation: CAA36246.1
CCDSiCCDS547.1 [P17542-1]
PIRiA36358
I38253
RefSeqiNP_001274276.1, NM_001287347.2 [P17542-1]
NP_001277332.1, NM_001290403.1 [P17542-1]
NP_001277333.1, NM_001290404.1 [P17542-1]
NP_001277334.1, NM_001290405.1 [P17542-1]
NP_001277335.1, NM_001290406.1
NP_003180.1, NM_003189.5 [P17542-1]
XP_005271217.1, XM_005271160.4 [P17542-1]
XP_016857676.1, XM_017002187.1 [P17542-1]
XP_016857677.1, XM_017002188.1 [P17542-1]
XP_016857678.1, XM_017002189.1 [P17542-1]
XP_016857679.1, XM_017002190.1 [P17542-1]
XP_016857680.1, XM_017002191.1 [P17542-1]
UniGeneiHs.705618
Hs.737706

Genome annotation databases

EnsembliENST00000294339; ENSP00000294339; ENSG00000162367 [P17542-1]
ENST00000371884; ENSP00000360951; ENSG00000162367 [P17542-1]
GeneIDi6886
KEGGihsa:6886
UCSCiuc001cqx.4 human [P17542-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M61108 mRNA Translation: AAA36600.1
M61103 Genomic DNA No translation available.
M61104 Genomic DNA No translation available.
M61105 Genomic DNA No translation available.
M63572 Genomic DNA No translation available.
M63589, M63576, M63584 Genomic DNA Translation: AAA36599.1
AL135960 Genomic DNA Translation: CAB72103.1
CH471059 Genomic DNA Translation: EAX06875.1
CH471059 Genomic DNA Translation: EAX06876.1
CH471059 Genomic DNA Translation: EAX06877.1
X58621 Genomic DNA Translation: CAA41476.1 Sequence problems.
X58622 Genomic DNA Translation: CAA41477.1
M29038 mRNA Translation: AAA36598.1
X51990 mRNA Translation: CAA36246.1
CCDSiCCDS547.1 [P17542-1]
PIRiA36358
I38253
RefSeqiNP_001274276.1, NM_001287347.2 [P17542-1]
NP_001277332.1, NM_001290403.1 [P17542-1]
NP_001277333.1, NM_001290404.1 [P17542-1]
NP_001277334.1, NM_001290405.1 [P17542-1]
NP_001277335.1, NM_001290406.1
NP_003180.1, NM_003189.5 [P17542-1]
XP_005271217.1, XM_005271160.4 [P17542-1]
XP_016857676.1, XM_017002187.1 [P17542-1]
XP_016857677.1, XM_017002188.1 [P17542-1]
XP_016857678.1, XM_017002189.1 [P17542-1]
XP_016857679.1, XM_017002190.1 [P17542-1]
XP_016857680.1, XM_017002191.1 [P17542-1]
UniGeneiHs.705618
Hs.737706

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YPAX-ray2.80A180-253[»]
2YPBX-ray2.87A180-253[»]
ProteinModelPortaliP17542
SMRiP17542
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112749, 49 interactors
CORUMiP17542
DIPiDIP-40640N
ELMiP17542
IntActiP17542, 30 interactors
MINTiP17542
STRINGi9606.ENSP00000294339

PTM databases

iPTMnetiP17542
PhosphoSitePlusiP17542

Polymorphism and mutation databases

DMDMi134305

Proteomic databases

MaxQBiP17542
PaxDbiP17542
PeptideAtlasiP17542
PRIDEiP17542
ProteomicsDBi53484
53485 [P17542-2]
53486 [P17542-3]

Protocols and materials databases

DNASUi6886
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294339; ENSP00000294339; ENSG00000162367 [P17542-1]
ENST00000371884; ENSP00000360951; ENSG00000162367 [P17542-1]
GeneIDi6886
KEGGihsa:6886
UCSCiuc001cqx.4 human [P17542-1]

Organism-specific databases

CTDi6886
DisGeNETi6886
EuPathDBiHostDB:ENSG00000162367.11
GeneCardsiTAL1
H-InvDBiHIX0029300
HGNCiHGNC:11556 TAL1
HPAiCAB017805
HPA047866
HPA073983
MalaCardsiTAL1
MIMi187040 gene
neXtProtiNX_P17542
OpenTargetsiENSG00000162367
Orphaneti99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBiPA36326
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000113414
HOVERGENiHBG005018
InParanoidiP17542
KOiK09068
OMAiQELCPGS
OrthoDBiEOG091G0ESI
PhylomeDBiP17542
TreeFamiTF315153

Enzyme and pathway databases

ReactomeiR-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
SignaLinkiP17542
SIGNORiP17542

Miscellaneous databases

ChiTaRSiTAL1 human
GeneWikiiTAL1
GenomeRNAii6886
PMAP-CutDBiP17542
PROiPR:P17542
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162367 Expressed in 163 organ(s), highest expression level in liver
CleanExiHS_TAL1
GenevisibleiP17542 HS

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAL1_HUMAN
AccessioniPrimary (citable) accession number: P17542
Secondary accession number(s): D3DQ24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1991
Last modified: September 12, 2018
This is version 188 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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