UniProtKB - P17542 (TAL1_HUMAN)
T-cell acute lymphocytic leukemia protein 1
TAL1
Functioni
GO - Molecular functioni
- chromatin binding Source: MGI
- DNA-binding transcription factor activity Source: BHF-UCL
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- E-box binding Source: BHF-UCL
- enzyme binding Source: BHF-UCL
- histone deacetylase binding Source: BHF-UCL
- protein dimerization activity Source: InterPro
- RNA polymerase II transcription factor binding Source: BHF-UCL
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- transcription regulatory region sequence-specific DNA binding Source: BHF-UCL
GO - Biological processi
- angiogenesis Source: Ensembl
- astrocyte fate commitment Source: Ensembl
- basophil differentiation Source: BHF-UCL
- cell fate commitment Source: BHF-UCL
- definitive hemopoiesis Source: Ensembl
- embryonic hemopoiesis Source: UniProtKB
- erythrocyte differentiation Source: BHF-UCL
- erythrocyte maturation Source: Ensembl
- hemangioblast cell differentiation Source: Ensembl
- hematopoietic stem cell differentiation Source: Ensembl
- hemopoiesis Source: BHF-UCL
- locomotory behavior Source: Ensembl
- megakaryocyte development Source: Ensembl
- megakaryocyte differentiation Source: BHF-UCL
- negative regulation of erythrocyte differentiation Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- platelet formation Source: Ensembl
- positive regulation of cell division Source: BHF-UCL
- positive regulation of chromatin assembly or disassembly Source: BHF-UCL
- positive regulation of erythrocyte differentiation Source: UniProtKB
- positive regulation of mitotic cell cycle Source: BHF-UCL
- positive regulation of protein-containing complex assembly Source: BHF-UCL
- positive regulation of protein tyrosine kinase activity Source: Ensembl
- positive regulation of signaling receptor activity Source: Ensembl
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of cell population proliferation Source: Ensembl
- regulation of hematopoietic stem cell differentiation Source: Reactome
- regulation of mast cell differentiation Source: Ensembl
- regulation of stem cell population maintenance Source: Ensembl
- regulation of transcription by RNA polymerase II Source: BHF-UCL
- spinal cord association neuron differentiation Source: Ensembl
- transcription by RNA polymerase II Source: Ensembl
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Differentiation, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P17542 |
Reactomei | R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-9616222, Transcriptional regulation of granulopoiesis |
SignaLinki | P17542 |
SIGNORi | P17542 |
Names & Taxonomyi
Protein namesi | Recommended name: T-cell acute lymphocytic leukemia protein 1Short name: TAL-1 Alternative name(s): Class A basic helix-loop-helix protein 17 Short name: bHLHa17 Stem cell protein T-cell leukemia/lymphoma protein 5 |
Gene namesi | Name:TAL1 Synonyms:BHLHA17, SCL, TCL5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11556, TAL1 |
MIMi | 187040, gene |
neXtProti | NX_P17542 |
VEuPathDBi | HostDB:ENSG00000162367.11 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nuclear chromatin Source: BHF-UCL
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
Other locations
- transcription regulator complex Source: BHF-UCL
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 6886 |
MalaCardsi | TAL1 |
OpenTargetsi | ENSG00000162367 |
Orphaneti | 99861, Precursor T-cell acute lymphoblastic leukemia |
PharmGKBi | PA36326 |
Miscellaneous databases
Pharosi | P17542, Tbio |
Genetic variation databases
BioMutai | TAL1 |
DMDMi | 134305 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127454 | 1 – 331 | T-cell acute lymphocytic leukemia protein 1Add BLAST | 331 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 12 | PhosphoserineCombined sources | 1 | |
Modified residuei | 122 | PhosphoserineCombined sources | 1 | |
Modified residuei | 172 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
MassIVEi | P17542 |
MaxQBi | P17542 |
PaxDbi | P17542 |
PeptideAtlasi | P17542 |
PRIDEi | P17542 |
ProteomicsDBi | 53484 [P17542-1] 53485 [P17542-2] 53486 [P17542-3] |
PTM databases
iPTMneti | P17542 |
PhosphoSitePlusi | P17542 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000162367, Expressed in liver and 177 other tissues |
Genevisiblei | P17542, HS |
Organism-specific databases
HPAi | ENSG00000162367, Tissue enhanced (bone) |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2.
Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3.
Interacts with SBNO2; this interaction inhibits TAL1 occupancy of the DCSTAMP promoter, leading to the activation of the DCSTAMP promoter by the transcription factor MITF.
By similarityBinary interactionsi
Hide detailsP17542
GO - Molecular functioni
- enzyme binding Source: BHF-UCL
- histone deacetylase binding Source: BHF-UCL
- protein dimerization activity Source: InterPro
- RNA polymerase II transcription factor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 112749, 50 interactors |
CORUMi | P17542 |
DIPi | DIP-40640N |
ELMi | P17542 |
IntActi | P17542, 30 interactors |
MINTi | P17542 |
STRINGi | 9606.ENSP00000294339 |
Miscellaneous databases
RNActi | P17542, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P17542 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 187 – 239 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 89 – 132 | Pro-richAdd BLAST | 44 | |
Compositional biasi | 263 – 274 | Poly-GlyAdd BLAST | 12 |
Domaini
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000159889 |
HOGENOMi | CLU_059203_0_0_1 |
InParanoidi | P17542 |
OMAi | HSDPPLE |
OrthoDBi | 1453623at2759 |
PhylomeDBi | P17542 |
TreeFami | TF315153 |
Family and domain databases
CDDi | cd00083, HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
IDEALi | IID00543 |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR040238, TAL-like |
PANTHERi | PTHR13864, PTHR13864, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTERPPSEAA RSDPQLEGRD AAEASMAPPH LVLLNGVAKE TSRAAAAEPP
60 70 80 90 100
VIELGARGGP GGGPAGGGGA ARDLKGRDAA TAEARHRVPT TELCRPPGPA
110 120 130 140 150
PAPAPASVTA ELPGDGRMVQ LSPPALAAPA APGRALLYSL SQPLASLGSG
160 170 180 190 200
FFGEPDAFPM FTTNNRVKRR PSPYEMEITD GPHTKVVRRI FTNSRERWRQ
210 220 230 240 250
QNVNGAFAEL RKLIPTHPPD KKLSKNEILR LAMKYINFLA KLLNDQEEEG
260 270 280 290 300
TQRAKTGKDP VVGAGGGGGG GGGGAPPDDL LQDVLSPNSS CGSSLDGAAS
310 320 330
PDSYTEEPAP KHTARSLHPA MLPAADGAGP R
The sequence of this isoform differs from the canonical sequence as follows:
1-25: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-175: Missing.
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002154 | 1 – 175 | Missing in isoform PP22-TAL1. CuratedAdd BLAST | 175 | |
Alternative sequenceiVSP_002153 | 1 – 25 | Missing in isoform PP39-TAL1. CuratedAdd BLAST | 25 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000294339; ENSP00000294339; ENSG00000162367 [P17542-1] ENST00000371884; ENSP00000360951; ENSG00000162367 [P17542-1] |
GeneIDi | 6886 |
KEGGi | hsa:6886 |
UCSCi | uc001cqx.4, human [P17542-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2YPA | X-ray | 2.80 | A | 180-253 | [»] | |
2YPB | X-ray | 2.87 | A | 180-253 | [»] | |
SMRi | P17542 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112749, 50 interactors |
CORUMi | P17542 |
DIPi | DIP-40640N |
ELMi | P17542 |
IntActi | P17542, 30 interactors |
MINTi | P17542 |
STRINGi | 9606.ENSP00000294339 |
PTM databases
iPTMneti | P17542 |
PhosphoSitePlusi | P17542 |
Genetic variation databases
BioMutai | TAL1 |
DMDMi | 134305 |
Proteomic databases
MassIVEi | P17542 |
MaxQBi | P17542 |
PaxDbi | P17542 |
PeptideAtlasi | P17542 |
PRIDEi | P17542 |
ProteomicsDBi | 53484 [P17542-1] 53485 [P17542-2] 53486 [P17542-3] |
Protocols and materials databases
Antibodypediai | 4499, 733 antibodies |
DNASUi | 6886 |
Genome annotation databases
Ensembli | ENST00000294339; ENSP00000294339; ENSG00000162367 [P17542-1] ENST00000371884; ENSP00000360951; ENSG00000162367 [P17542-1] |
GeneIDi | 6886 |
KEGGi | hsa:6886 |
UCSCi | uc001cqx.4, human [P17542-1] |
Organism-specific databases
CTDi | 6886 |
DisGeNETi | 6886 |
GeneCardsi | TAL1 |
HGNCi | HGNC:11556, TAL1 |
HPAi | ENSG00000162367, Tissue enhanced (bone) |
MalaCardsi | TAL1 |
MIMi | 187040, gene |
neXtProti | NX_P17542 |
OpenTargetsi | ENSG00000162367 |
Orphaneti | 99861, Precursor T-cell acute lymphoblastic leukemia |
PharmGKBi | PA36326 |
VEuPathDBi | HostDB:ENSG00000162367.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000159889 |
HOGENOMi | CLU_059203_0_0_1 |
InParanoidi | P17542 |
OMAi | HSDPPLE |
OrthoDBi | 1453623at2759 |
PhylomeDBi | P17542 |
TreeFami | TF315153 |
Enzyme and pathway databases
PathwayCommonsi | P17542 |
Reactomei | R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-9616222, Transcriptional regulation of granulopoiesis |
SignaLinki | P17542 |
SIGNORi | P17542 |
Miscellaneous databases
BioGRID-ORCSi | 6886, 15 hits in 901 CRISPR screens |
ChiTaRSi | TAL1, human |
GeneWikii | TAL1 |
GenomeRNAii | 6886 |
Pharosi | P17542, Tbio |
PROi | PR:P17542 |
RNActi | P17542, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162367, Expressed in liver and 177 other tissues |
Genevisiblei | P17542, HS |
Family and domain databases
CDDi | cd00083, HLH, 1 hit |
Gene3Di | 4.10.280.10, 1 hit |
IDEALi | IID00543 |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR040238, TAL-like |
PANTHERi | PTHR13864, PTHR13864, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TAL1_HUMAN | |
Accessioni | P17542Primary (citable) accession number: P17542 Secondary accession number(s): D3DQ24 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | November 1, 1991 | |
Last modified: | February 10, 2021 | |
This is version 204 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references