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Protein

Chymotrypsinogen B

Gene

CTRB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Charge relay systemBy similarity1
Active sitei120Charge relay systemBy similarity1
Active sitei213Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processDigestion

Enzyme and pathway databases

ReactomeiR-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsinogen B (EC:3.4.21.1)
Cleaved into the following 3 chains:
Gene namesi
Name:CTRB1Imported
Synonyms:CTRBImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000168925.10
HGNCiHGNC:2521 CTRB1
MIMi118890 gene
neXtProtiNX_P17538

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1504
OpenTargetsiENSG00000168925

Chemistry databases

ChEMBLiCHEMBL4796
DrugBankiDB07899 (2S) N-ACETYL-L-ALANYL-ALPHAL-PHENYLALANYL-CHLOROETHYLKETONE
DB07749 2-ACETYLAMINO-4-METHYL-PENTANOIC ACID (1-FORMYL-2-PHENYL-ETHYL)-AMIDE
DB07668 3-(4-DIETHYLAMINO-2-HYDROXY-PHENYL)-2-METHYL-PROPIONIC ACID
DB06692 Aprotinin
DB08692 D-1-(4-CHLOROPHENYL)-2-(ACETAMIDO)ETHANE BORONIC ACID
DB08566 D-1-NAPHTHYL-2-ACETAMIDO-ETHANE BORONIC ACID
DB08693 L-1-(4-CHLOROPHENYL)-2-(ACETAMIDO)ETHANE BORONIC ACID
DB08565 L-1-NAPHTHYL-2-ACETAMIDO-ETHANE BORONIC ACID
DB08374 PHENYLALANYLMETHYLCHLORIDE
DB01963 Phenylethane Boronic Acid
DB03976 Phosphorylisopropane
DB01662 Trans-O-Hydroxy-Alpha-Methyl Cinnamate

Polymorphism and mutation databases

DMDMi117617

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000002763819 – 263Chymotrypsinogen BAdd BLAST245
ChainiPRO_000002763919 – 31Chymotrypsin B chain AAdd BLAST13
ChainiPRO_000002764034 – 164Chymotrypsin B chain BAdd BLAST131
ChainiPRO_0000027641167 – 263Chymotrypsin B chain CAdd BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi19 ↔ 140PROSITE-ProRule annotation
Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
Modified residuei93PhosphoserineBy similarity1
Disulfide bondi154 ↔ 219PROSITE-ProRule annotation
Disulfide bondi186 ↔ 200PROSITE-ProRule annotation
Disulfide bondi209 ↔ 238PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Phosphoprotein, Zymogen

Proteomic databases

PeptideAtlasiP17538
PRIDEiP17538
ProteomicsDBi53482

PTM databases

iPTMnetiP17538
PhosphoSitePlusiP17538

Expressioni

Gene expression databases

BgeeiENSG00000168925 Expressed in 77 organ(s), highest expression level in body of pancreas
CleanExiHS_CTRB1
ExpressionAtlasiP17538 baseline and differential
GenevisibleiP17538 HS

Structurei

3D structure databases

ProteinModelPortaliP17538
SMRiP17538
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 261Peptidase S1PROSITE-ProRule annotationAdd BLAST228

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP17538
KOiK01310
OMAiIMAFLWI
OrthoDBiEOG091G0AH5
PhylomeDBiP17538
TreeFamiTF330455

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P17538-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASLWLLSCF SLVGAAFGCG VPAIHPVLSG LSRIVNGEDA VPGSWPWQVS
60 70 80 90 100
LQDKTGFHFC GGSLISEDWV VTAAHCGVRT SDVVVAGEFD QGSDEENIQV
110 120 130 140 150
LKIAKVFKNP KFSILTVNND ITLLKLATPA RFSQTVSAVC LPSADDDFPA
160 170 180 190 200
GTLCATTGWG KTKYNANKTP DKLQQAALPL LSNAECKKSW GRRITDVMIC
210 220 230 240 250
AGASGVSSCM GDSGGPLVCQ KDGAWTLVGI VSWGSDTCST SSPGVYARVT
260
KLIPWVQKIL AAN
Length:263
Mass (Da):27,713
Last modified:November 2, 2016 - v2
Checksum:iEDA816A133D42DE7
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YG87A0A2R8YG87_HUMAN
Chymotrypsinogen B
CTRB1
263Annotation score:
J3QKZ2J3QKZ2_HUMAN
Chymotrypsinogen B
CTRB1
182Annotation score:
A0A2R8Y4E9A0A2R8Y4E9_HUMAN
Chymotrypsinogen B
CTRB1
16Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3S → F in AAA52128 (PubMed:2917002).Curated1
Sequence conflicti3S → F in AAP36020 (Ref. 2) Curated1
Sequence conflicti3S → F in AAH05385 (PubMed:15489334).Curated1
Sequence conflicti10 – 16FSLVGAA → WALLGTT in AAA52128 (PubMed:2917002).Curated7
Sequence conflicti10 – 16FSLVGAA → WALLGTT in AAP36020 (Ref. 2) Curated7
Sequence conflicti10 – 16FSLVGAA → WALLGTT in AAH05385 (PubMed:15489334).Curated7

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057158222D → H. Corresponds to variant dbSNP:rs8061550Ensembl.1
Natural variantiVAR_014566250T → A. Corresponds to variant dbSNP:rs4737Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24400 mRNA Translation: AAA52128.1
BT007356 mRNA Translation: AAP36020.1
AC009078 Genomic DNA No translation available.
BC005385 mRNA Translation: AAH05385.1
CCDSiCCDS32490.1
PIRiA31299
RefSeqiNP_001316119.1, NM_001329190.1
NP_001897.4, NM_001906.5
UniGeneiHs.610926

Genome annotation databases

EnsembliENST00000361017; ENSP00000354294; ENSG00000168925
GeneIDi1504
KEGGihsa:1504
UCSCiuc002fds.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Chymotrypsin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24400 mRNA Translation: AAA52128.1
BT007356 mRNA Translation: AAP36020.1
AC009078 Genomic DNA No translation available.
BC005385 mRNA Translation: AAH05385.1
CCDSiCCDS32490.1
PIRiA31299
RefSeqiNP_001316119.1, NM_001329190.1
NP_001897.4, NM_001906.5
UniGeneiHs.610926

3D structure databases

ProteinModelPortaliP17538
SMRiP17538
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL4796
DrugBankiDB07899 (2S) N-ACETYL-L-ALANYL-ALPHAL-PHENYLALANYL-CHLOROETHYLKETONE
DB07749 2-ACETYLAMINO-4-METHYL-PENTANOIC ACID (1-FORMYL-2-PHENYL-ETHYL)-AMIDE
DB07668 3-(4-DIETHYLAMINO-2-HYDROXY-PHENYL)-2-METHYL-PROPIONIC ACID
DB06692 Aprotinin
DB08692 D-1-(4-CHLOROPHENYL)-2-(ACETAMIDO)ETHANE BORONIC ACID
DB08566 D-1-NAPHTHYL-2-ACETAMIDO-ETHANE BORONIC ACID
DB08693 L-1-(4-CHLOROPHENYL)-2-(ACETAMIDO)ETHANE BORONIC ACID
DB08565 L-1-NAPHTHYL-2-ACETAMIDO-ETHANE BORONIC ACID
DB08374 PHENYLALANYLMETHYLCHLORIDE
DB01963 Phenylethane Boronic Acid
DB03976 Phosphorylisopropane
DB01662 Trans-O-Hydroxy-Alpha-Methyl Cinnamate

PTM databases

iPTMnetiP17538
PhosphoSitePlusiP17538

Polymorphism and mutation databases

DMDMi117617

Proteomic databases

PeptideAtlasiP17538
PRIDEiP17538
ProteomicsDBi53482

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361017; ENSP00000354294; ENSG00000168925
GeneIDi1504
KEGGihsa:1504
UCSCiuc002fds.4 human

Organism-specific databases

CTDi1504
DisGeNETi1504
EuPathDBiHostDB:ENSG00000168925.10
GeneCardsiCTRB1
H-InvDBiHIX0013242
HGNCiHGNC:2521 CTRB1
MIMi118890 gene
neXtProtiNX_P17538
OpenTargetsiENSG00000168925
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP17538
KOiK01310
OMAiIMAFLWI
OrthoDBiEOG091G0AH5
PhylomeDBiP17538
TreeFamiTF330455

Enzyme and pathway databases

ReactomeiR-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism

Miscellaneous databases

PROiPR:P17538
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168925 Expressed in 77 organ(s), highest expression level in body of pancreas
CleanExiHS_CTRB1
ExpressionAtlasiP17538 baseline and differential
GenevisibleiP17538 HS

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTRB1_HUMAN
AccessioniPrimary (citable) accession number: P17538
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 2, 2016
Last modified: November 7, 2018
This is version 166 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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