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Protein

Transcription factor jun-D

Gene

JUND

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor binding AP-1 sites.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-9018519 Estrogen-dependent gene expression
SignaLinkiP17535
SIGNORiP17535

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor jun-D
Gene namesi
Name:JUND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130522.5
HGNCiHGNC:6206 JUND
MIMi165162 gene
neXtProtiNX_P17535

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3727
OpenTargetsiENSG00000130522
PharmGKBiPA30008

Polymorphism and mutation databases

DMDMi229462969

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764421 – 347Transcription factor jun-DAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei251PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei259PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP17535
MaxQBiP17535
PaxDbiP17535
PeptideAtlasiP17535
PRIDEiP17535
ProteomicsDBi53481

PTM databases

iPTMnetiP17535
PhosphoSitePlusiP17535

Expressioni

Gene expression databases

BgeeiENSG00000130522
CleanExiHS_JUND
ExpressionAtlasiP17535 baseline and differential
GenevisibleiP17535 HS

Organism-specific databases

HPAiCAB005268
HPA063029

Interactioni

Subunit structurei

Binds DNA as a dimer (By similarity). Interacts with MEN1; this interaction represses transcriptional activation.By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • ligand-dependent nuclear receptor binding Source: Ensembl
  • transcription factor binding Source: GO_Central

Protein-protein interaction databases

BioGridi109930, 45 interactors
ComplexPortaliCPX-497 Menin-JUND transcription inhibition complex
CORUMiP17535
DIPiDIP-1053N
IntActiP17535, 31 interactors
MINTiP17535
STRINGi9606.ENSP00000252818

Structurei

Secondary structure

1347
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi266 – 329Combined sources64

3D structure databases

ProteinModelPortaliP17535
SMRiP17535
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 331bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni268 – 295Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni296 – 324Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi158 – 166Poly-Ala9

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated

Phylogenomic databases

eggNOGiKOG0837 Eukaryota
ENOG410XRWH LUCA
GeneTreeiENSGT00390000009929
HOGENOMiHOG000006648
HOVERGENiHBG001722
InParanoidiP17535
KOiK04449
OMAiAPVYANL
OrthoDBiEOG091G0N0L
PhylomeDBiP17535
TreeFamiTF323952

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR005643 JNK
IPR029823 JunD
IPR002112 Leuzip_Jun
IPR008917 TF_DNA-bd_sf
PANTHERiPTHR11462:SF7 PTHR11462:SF7, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PF03957 Jun, 1 hit
PRINTSiPR00043 LEUZIPPRJUN
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

P17535-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPFYGDEA LSGLGGGASG SGGSFASPGR LFPGAPPTAA AGSMMKKDAL
60 70 80 90 100
TLSLSEQVAA ALKPAAAPPP TPLRADGAPS AAPPDGLLAS PDLGLLKLAS
110 120 130 140 150
PELERLIIQS NGLVTTTPTS SQFLYPKVAA SEEQEFAEGF VKALEDLHKQ
160 170 180 190 200
NQLGAGAAAA AAAAAAGGPS GTATGSAPPG ELAPAAAAPE APVYANLSSY
210 220 230 240 250
AGGAGGAGGA ATVAFAAEPV PFPPPPPPGA LGPPRLAALK DEPQTVPDVP
260 270 280 290 300
SFGESPPLSP IDMDTQERIK AERKRLRNRI AASKCRKRKL ERISRLEEKV
310 320 330 340
KTLKSQNTEL ASTASLLREQ VAQLKQKVLS HVNSGCQLLP QHQVPAY
Length:347
Mass (Da):35,174
Last modified:May 5, 2009 - v3
Checksum:iFE85A1AA2B5B9597
GO

Sequence cautioni

The sequence CAA40010 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24S → T in CAA40010 (PubMed:1903194).Curated1
Sequence conflicti157A → R in CAA40010 (PubMed:1903194).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05524720G → V1 PublicationCorresponds to variant dbSNP:rs41478151Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56681 mRNA Translation: CAA40010.1 Frameshift.
EF044249 Genomic DNA Translation: ABJ53425.1
AK223630 mRNA Translation: BAD97350.1
CH471106 Genomic DNA Translation: EAW84684.1
X51346 mRNA Translation: CAA35739.1
CCDSiCCDS32959.1
PIRiA43815
S10184 TVHUJD
RefSeqiNP_001273897.1, NM_001286968.1
NP_005345.3, NM_005354.5
UniGeneiHs.2780

Genome annotation databases

EnsembliENST00000252818; ENSP00000252818; ENSG00000130522
GeneIDi3727
KEGGihsa:3727
UCSCiuc002nip.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiJUND_HUMAN
AccessioniPrimary (citable) accession number: P17535
Secondary accession number(s): Q53EK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: May 5, 2009
Last modified: July 18, 2018
This is version 175 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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