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Protein

C-X-C motif chemokine 10

Gene

Cxcl10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 10
Alternative name(s):
10 kDa interferon gamma-induced protein
Short name:
Gamma-IP10
Short name:
IP-10
C7
Interferon-gamma induced protein CRG-2
Small-inducible cytokine B10
Gene namesi
Name:Cxcl10
Synonyms:Crg2, Ifi10, Inp10, Scyb10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1352450 Cxcl10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000510422 – 98C-X-C motif chemokine 10Add BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26CitrullineBy similarity1
Disulfide bondi30 ↔ 571 Publication
Disulfide bondi32 ↔ 741 Publication

Keywords - PTMi

Citrullination, Disulfide bond

Proteomic databases

PaxDbiP17515
PRIDEiP17515

PTM databases

PhosphoSitePlusiP17515

Expressioni

Tissue specificityi

Expressed in the spleen, thymus, lymph nodes and liver.1 Publication

Inductioni

By interferon gamma.

Gene expression databases

BgeeiENSMUSG00000034855 Expressed in 121 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiMM_CXCL10
ExpressionAtlasiP17515 baseline and differential
GenevisibleiP17515 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047646

Structurei

Secondary structure

198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP17515
SMRiP17515
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17515

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1VC Eukaryota
ENOG410ZTJK LUCA
GeneTreeiENSGT00530000063958
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP17515
KOiK12671
OMAiRCTCIKI
OrthoDBiEOG091G0YSL
PhylomeDBiP17515
TreeFamiTF333433

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P17515-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPSAAVIFC LILLGLSGTQ GIPLARTVRC NCIHIDDGPV RMRAIGKLEI
60 70 80 90
IPASLSCPRV EIIATMKKND EQRCLNPESK TIKNLMKAFS QKRSKRAP
Length:98
Mass (Da):10,789
Last modified:August 1, 1990 - v1
Checksum:i42B0E6A0CC56FE36
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YW23D3YW23_MOUSE
C-X-C motif chemokine
Cxcl10
93Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33266 mRNA Translation: AAA02968.1
M86829 mRNA Translation: AAA21489.1
L07417 Genomic DNA Translation: AAA75249.1
BC030067 mRNA Translation: AAH30067.1
CCDSiCCDS39153.1
PIRiA45492
RefSeqiNP_067249.1, NM_021274.2
UniGeneiMm.877

Genome annotation databases

EnsembliENSMUST00000038816; ENSMUSP00000047646; ENSMUSG00000034855
GeneIDi15945
KEGGimmu:15945
UCSCiuc008ycz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33266 mRNA Translation: AAA02968.1
M86829 mRNA Translation: AAA21489.1
L07417 Genomic DNA Translation: AAA75249.1
BC030067 mRNA Translation: AAH30067.1
CCDSiCCDS39153.1
PIRiA45492
RefSeqiNP_067249.1, NM_021274.2
UniGeneiMm.877

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R3ZX-ray2.50A/B/C/D23-89[»]
ProteinModelPortaliP17515
SMRiP17515
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047646

PTM databases

PhosphoSitePlusiP17515

Proteomic databases

PaxDbiP17515
PRIDEiP17515

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038816; ENSMUSP00000047646; ENSMUSG00000034855
GeneIDi15945
KEGGimmu:15945
UCSCiuc008ycz.2 mouse

Organism-specific databases

CTDi3627
MGIiMGI:1352450 Cxcl10

Phylogenomic databases

eggNOGiENOG410J1VC Eukaryota
ENOG410ZTJK LUCA
GeneTreeiENSGT00530000063958
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP17515
KOiK12671
OMAiRCTCIKI
OrthoDBiEOG091G0YSL
PhylomeDBiP17515
TreeFamiTF333433

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

EvolutionaryTraceiP17515
PROiPR:P17515
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034855 Expressed in 121 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiMM_CXCL10
ExpressionAtlasiP17515 baseline and differential
GenevisibleiP17515 MM

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCXL10_MOUSE
AccessioniPrimary (citable) accession number: P17515
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 7, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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