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Protein

Metallothionein-2

Gene

mtl-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein binds cations of several transition elements.

GO - Molecular functioni

Keywordsi

LigandCadmium, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-2
Short name:
MT-2
Alternative name(s):
MT-Ce
Metallothionein-II
Short name:
MT-II
Metallothionein-like protein
Gene namesi
Name:mtl-2
Synonyms:met-2
ORF Names:T08G5.10
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiT08G5.10 ; CE25109 ; WBGene00003474 ; mtl-2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001973592 – 63Metallothionein-2Add BLAST62

Proteomic databases

PaxDbiP17512
PeptideAtlasiP17512
PRIDEiP17512

Expressioni

Inductioni

By cadmium.

Gene expression databases

BgeeiWBGene00003474 Expressed in 5 organ(s), highest expression level in material anatomical entity

Interactioni

Protein-protein interaction databases

STRINGi6239.T08G5.10

Structurei

3D structure databases

ProteinModelPortaliP17512
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4738 Eukaryota
ENOG410Z9YK LUCA
GeneTreeiENSGT00390000017933
HOGENOMiHOG000021508
InParanoidiP17512
OMAiCANCECA
OrthoDBiEOG09371CPZ

Family and domain databases

InterProiView protein in InterPro
IPR000853 Metalthion_nemt
PRINTSiPR00876 MTNEMATODE

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17512-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVCKCDCKNQ NCSCNTGTKD CDCSDAKCCE QYCCPTASEK KCCKSGCAGG
60
CKCANCECAQ AAH
Length:63
Mass (Da):6,594
Last modified:January 23, 2007 - v2
Checksum:i5D55EF8A1CBDFADA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32386 mRNA Translation: AAA28117.1
M32387 mRNA Translation: AAA28118.1
X53245 mRNA Translation: CAA37335.1
M92910 Genomic DNA Translation: AAA28111.1
D17365 Genomic DNA Translation: BAA04181.1
Z81589 Genomic DNA Translation: CAB61028.1
PIRiA45206 A34905
RefSeqiNP_506482.1, NM_074081.5
UniGeneiCel.19721
Cel.33662

Genome annotation databases

EnsemblMetazoaiT08G5.10; T08G5.10; WBGene00003474
GeneIDi179899
KEGGicel:CELE_T08G5.10
UCSCiR05D3.11 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32386 mRNA Translation: AAA28117.1
M32387 mRNA Translation: AAA28118.1
X53245 mRNA Translation: CAA37335.1
M92910 Genomic DNA Translation: AAA28111.1
D17365 Genomic DNA Translation: BAA04181.1
Z81589 Genomic DNA Translation: CAB61028.1
PIRiA45206 A34905
RefSeqiNP_506482.1, NM_074081.5
UniGeneiCel.19721
Cel.33662

3D structure databases

ProteinModelPortaliP17512
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T08G5.10

Proteomic databases

PaxDbiP17512
PeptideAtlasiP17512
PRIDEiP17512

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT08G5.10; T08G5.10; WBGene00003474
GeneIDi179899
KEGGicel:CELE_T08G5.10
UCSCiR05D3.11 c. elegans

Organism-specific databases

CTDi179899
WormBaseiT08G5.10 ; CE25109 ; WBGene00003474 ; mtl-2

Phylogenomic databases

eggNOGiKOG4738 Eukaryota
ENOG410Z9YK LUCA
GeneTreeiENSGT00390000017933
HOGENOMiHOG000021508
InParanoidiP17512
OMAiCANCECA
OrthoDBiEOG09371CPZ

Miscellaneous databases

PROiPR:P17512

Gene expression databases

BgeeiWBGene00003474 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

InterProiView protein in InterPro
IPR000853 Metalthion_nemt
PRINTSiPR00876 MTNEMATODE
ProtoNetiSearch...

Entry informationi

Entry nameiMT2_CAEEL
AccessioniPrimary (citable) accession number: P17512
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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Main funding by: National Institutes of Health

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