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Protein

Metallothionein-1

Gene

mtl-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein binds cations of several transition elements.

GO - Molecular functioni

GO - Biological processi

  • response to lead ion Source: WormBase
  • response to mercury ion Source: WormBase

Keywordsi

LigandCadmium, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-1
Short name:
MT-1
Alternative name(s):
Metallothionein-I
Short name:
MT-I
Gene namesi
Name:mtl-1
Synonyms:met-1
ORF Names:K11G9.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiK11G9.6 ; CE07379 ; WBGene00003473 ; mtl-1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001973582 – 75Metallothionein-1Add BLAST74

Proteomic databases

PaxDbiP17511
PeptideAtlasiP17511
PRIDEiP17511

Expressioni

Inductioni

By cadmium.

Gene expression databases

BgeeiWBGene00003473

Interactioni

Protein-protein interaction databases

IntActiP17511, 2 interactors
STRINGi6239.K11G9.6

Structurei

3D structure databases

ProteinModelPortaliP17511
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

All cysteine residues are arranged in C-X-C groups. These are thought to be the metal-binding sites in other metallothioneins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4738 Eukaryota
ENOG410Z9YK LUCA
GeneTreeiENSGT00390000017933
HOGENOMiHOG000021508
InParanoidiP17511
KOiK14739
OMAiCCEEASE
OrthoDBiEOG093718IZ

Family and domain databases

InterProiView protein in InterPro
IPR000853 Metalthion_nemt
PRINTSiPR00876 MTNEMATODE

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17511-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACKCDCKNK QCKCGDKCEC SGDKCCEKYC CEEASEKKCC PAGCKGDCKC
60 70
ANCHCAEQKQ CGDKTHQHQG TAAAH
Length:75
Mass (Da):8,090
Last modified:January 23, 2007 - v2
Checksum:iDA0D5FAFC43D26FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23D → G AA sequence (PubMed:2344361).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53244 mRNA Translation: CAA37334.1
M92909 Genomic DNA Translation: AAA28110.1
D17364 Genomic DNA Translation: BAA04180.1
FO081629 Genomic DNA Translation: CCD72928.1
PIRiB45206
RefSeqiNP_504696.1, NM_072295.5
UniGeneiCel.19722

Genome annotation databases

EnsemblMetazoaiK11G9.6; K11G9.6; WBGene00003473
GeneIDi179060
KEGGicel:CELE_K11G9.6
UCSCiC43E11.3a c. elegans

Similar proteinsi

Entry informationi

Entry nameiMT1_CAEEL
AccessioniPrimary (citable) accession number: P17511
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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