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UniProtKB - P17509 (HXB6_HUMAN)

Entry version 193 (10 Apr 2019)
Sequence version 4 (17 Oct 2006)
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Protein

Homeobox protein Hox-B6

Gene

HOXB6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi146 – 205HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...SIGNORi		P17509

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein Hox-B6
Alternative name(s):
Homeobox protein Hox-2.2
Homeobox protein Hox-2B
Homeobox protein Hu-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HOXB6
Synonyms:HOX2B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000108511.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:5117 HOXB6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		142961 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P17509

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3216

Open Targets

More...OpenTargetsi		ENSG00000108511

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29393

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HOXB6

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242515

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002001351 – 224Homeobox protein Hox-B6Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei214PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P17509

MaxQB - The MaxQuant DataBase

More...MaxQBi		P17509

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P17509

PeptideAtlas

More...PeptideAtlasi		P17509

PRoteomics IDEntifications database

More...PRIDEi		P17509

ProteomicsDB human proteome resource

More...ProteomicsDBi		53478
53479 [P17509-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P17509

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P17509

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000108511 Expressed in 126 organ(s), highest expression level in caput epididymis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P17509 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA042063

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CLK3P497615EBI-741308,EBI-745579

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		109456, 32 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P17509

Protein interaction database and analysis system

More...IntActi		P17509, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000420009

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P17509

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P17509

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi127 – 132Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi216 – 220Poly-Glu5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0489 Eukaryota
ENOG410ZTBY LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161108

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231181

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG016849

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P17509

KEGG Orthology (KO)

More...KOi		K09306

Identification of Orthologs from Complete Genome Data

More...OMAi		PLRHYSA

Database of Orthologous Groups

More...OrthoDBi		1186205at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P17509

TreeFam database of animal gene trees

More...TreeFami		TF316310

Family and domain databases

Conserved Domains Database

More...CDDi		cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00046 Homeodomain, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00025 ANTENNAPEDIA
PR00024 HOMEOBOX

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00389 HOX, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P17509-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD 
        60         70         80         90        100
KGFATSSYYP PAGGGYGRAA PCDYGPAPAF YREKESACAL SGADEQPPFH 
       110        120        130        140        150
PEPRKSDCAQ DKSVFGETEE QKCSTPVYPW MQRMNSCNSS SFGPSGRRGR 
       160        170        180        190        200
QTYTRYQTLE LEKEFHYNRY LTRRRRIEIA HALCLTERQI KIWFQNRRMK 
       210        220 
WKKESKLLSA SQLSAEEEEE KQAE
Length:224
Mass (Da):25,432
Last modified:October 17, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF60292D4D664099C
GO
Isoform 2 (identifier: P17509-2) [UniParc]FASTAAdd to basket
Also known as: Homeobox-less

The sequence of this isoform differs from the canonical sequence as follows:
     140-140: S → E
     141-224: Missing.

Show »
Length:140
Mass (Da):15,172
Checksum:i6B18215988D4750F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24 – 25QL → HV in CAA41335 (PubMed:1672751).Curated2
Sequence conflicti24 – 25QL → HV in CAB65909 (Ref. 2) Curated2
Sequence conflicti33A → R in CAA41335 (PubMed:1672751).Curated1
Sequence conflicti60P → R in CAA41335 (PubMed:1672751).Curated1
Sequence conflicti73D → A in CAA41335 (PubMed:1672751).Curated1
Sequence conflicti149 – 150GR → A in AAA36004 (PubMed:2573064).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_002388140S → E in isoform 2. Curated1
Alternative sequenceiVSP_002389141 – 224Missing in isoform 2. CuratedAdd BLAST84

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X58431 Genomic DNA Translation: CAA41335.1
X58431 Genomic DNA Translation: CAA41336.1
AJ270993 mRNA Translation: CAB65909.1
AF287967 Genomic DNA Translation: AAG31552.1
AK292200 mRNA Translation: BAF84889.1
CH471109 Genomic DNA Translation: EAW94728.1
CH471109 Genomic DNA Translation: EAW94729.1
CH471109 Genomic DNA Translation: EAW94730.1
CH471109 Genomic DNA Translation: EAW94731.1
BC014651 mRNA Translation: AAH14651.1
M30597 mRNA Translation: AAA36004.1
K02571 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11531.1 [P17509-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A05266
S26400

NCBI Reference Sequences

More...RefSeqi		NP_061825.2, NM_018952.4 [P17509-1]
XP_005257340.1, XM_005257283.3
XP_005257341.1, XM_005257284.3 [P17509-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.98428

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000225648; ENSP00000225648; ENSG00000108511 [P17509-1]
ENST00000484302; ENSP00000420009; ENSG00000108511 [P17509-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3216

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3216

UCSC genome browser

More...UCSCi		uc002ins.2 human [P17509-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58431 Genomic DNA Translation: CAA41335.1
X58431 Genomic DNA Translation: CAA41336.1
AJ270993 mRNA Translation: CAB65909.1
AF287967 Genomic DNA Translation: AAG31552.1
AK292200 mRNA Translation: BAF84889.1
CH471109 Genomic DNA Translation: EAW94728.1
CH471109 Genomic DNA Translation: EAW94729.1
CH471109 Genomic DNA Translation: EAW94730.1
CH471109 Genomic DNA Translation: EAW94731.1
BC014651 mRNA Translation: AAH14651.1
M30597 mRNA Translation: AAA36004.1
K02571 Genomic DNA No translation available.
CCDSiCCDS11531.1 [P17509-1]
PIRiA05266
S26400
RefSeqiNP_061825.2, NM_018952.4 [P17509-1]
XP_005257340.1, XM_005257283.3
XP_005257341.1, XM_005257284.3 [P17509-1]
UniGeneiHs.98428

3D structure databases

ProteinModelPortaliP17509
SMRiP17509
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109456, 32 interactors
ELMiP17509
IntActiP17509, 9 interactors
STRINGi9606.ENSP00000420009

PTM databases

iPTMnetiP17509
PhosphoSitePlusiP17509

Polymorphism and mutation databases

BioMutaiHOXB6
DMDMi116242515

Proteomic databases

jPOSTiP17509
MaxQBiP17509
PaxDbiP17509
PeptideAtlasiP17509
PRIDEiP17509
ProteomicsDBi53478
53479 [P17509-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		3216
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225648; ENSP00000225648; ENSG00000108511 [P17509-1]
ENST00000484302; ENSP00000420009; ENSG00000108511 [P17509-1]
GeneIDi3216
KEGGihsa:3216
UCSCiuc002ins.2 human [P17509-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3216
DisGeNETi3216
EuPathDBiHostDB:ENSG00000108511.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		HOXB6
HGNCiHGNC:5117 HOXB6
HPAiHPA042063
MIMi142961 gene
neXtProtiNX_P17509
OpenTargetsiENSG00000108511
PharmGKBiPA29393

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00940000161108
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP17509
KOiK09306
OMAiPLRHYSA
OrthoDBi1186205at2759
PhylomeDBiP17509
TreeFamiTF316310

Enzyme and pathway databases

SIGNORiP17509

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HOXB6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3216

Protein Ontology

More...PROi		PR:P17509

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000108511 Expressed in 126 organ(s), highest expression level in caput epididymis
GenevisibleiP17509 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeodomain, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHXB6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17509
Secondary accession number(s): A8K835
, D3DTV5, P09068, Q9HB11, Q9UGH2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 17, 2006
Last modified: April 10, 2019
This is version 193 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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