HOXB6

Functionⁱ

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	146 – 205	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889
RNA polymerase II distal enhancer sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterior/posterior pattern specification
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
embryonic skeletal system morphogenesis Source: Ensembl
erythrocyte homeostasis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	P17509

SIGNORⁱ

P17509

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein Hox-B6 Alternative name(s): Homeobox protein Hox-2.2 Homeobox protein Hox-2B Homeobox protein Hu-2
Gene namesⁱ	Name:HOXB6 Synonyms:HOX2B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000108511.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5117 HOXB6
MIMⁱ	142961 gene
neXtProtⁱ	NX_P17509

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3216
Open Targets More...OpenTargetsⁱ	ENSG00000108511
PharmGKBⁱ	PA29393

Polymorphism and mutation databases

BioMutaⁱ	HOXB6
DMDMⁱ	116242515

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000200135	1 – 224	Homeobox protein Hox-B6Add BLAST		224

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	214	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P17509
PaxDbⁱ	P17509
PeptideAtlas More...PeptideAtlasⁱ	P17509
PRIDEⁱ	P17509
ProteomicsDBⁱ	53478 53479 [P17509-2]

PTM databases

iPTMnetⁱ	P17509
PhosphoSitePlusⁱ	P17509

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000108511 Expressed in 126 organ(s), highest expression level in caput epididymis
CleanExⁱ	HS_HOXB6
Genevisibleⁱ	P17509 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA042063

HPAⁱ

HPA042063

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CLK3	P49761	5	EBI-741308,EBI-745579

With

Entry

#Exp.

IntAct

Notes

CLK3

P49761

5

EBI-741308,EBI-745579

Protein-protein interaction databases

BioGridⁱ	109456, 32 interactors
ELMⁱ	P17509
IntActⁱ	P17509, 9 interactors
STRINGⁱ	9606.ENSP00000225648

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P17509
SMRⁱ	P17509
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	127 – 132	Antp-type hexapeptide		6

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	216 – 220	Poly-Glu		5

Sequence similaritiesⁱ

Belongs to the Antp homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143983
HOGENOMⁱ	HOG000231181
HOVERGENⁱ	HBG016849
InParanoidⁱ	P17509
KEGG Orthology (KO) More...KOⁱ	K09306
OMAⁱ	PLRHYSA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09XD
PhylomeDBⁱ	P17509
TreeFamⁱ	TF316310

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017995 Homeobox_antennapedia IPR001827 Homeobox_Antennapedia_CS IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00025 ANTENNAPEDIA PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00032 ANTENNAPEDIA, 1 hit PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P17509-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD 
        60         70         80         90        100
KGFATSSYYP PAGGGYGRAA PCDYGPAPAF YREKESACAL SGADEQPPFH 
       110        120        130        140        150
PEPRKSDCAQ DKSVFGETEE QKCSTPVYPW MQRMNSCNSS SFGPSGRRGR 
       160        170        180        190        200
QTYTRYQTLE LEKEFHYNRY LTRRRRIEIA HALCLTERQI KIWFQNRRMK 
       210        220 
WKKESKLLSA SQLSAEEEEE KQAE

Length:224

Mass (Da):25,432

Last modified:October 17, 2006 - v4

Checksum:ⁱF60292D4D664099C

GO

Isoform 2 (identifier: P17509-2) [UniParc]FASTA Add to basket

Also known as: Homeobox-less

The sequence of this isoform differs from the canonical sequence as follows:
140-140: S → E
141-224: Missing.

« Hide

        10         20         30         40         50
MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD 
        60         70         80         90        100
KGFATSSYYP PAGGGYGRAA PCDYGPAPAF YREKESACAL SGADEQPPFH 
       110        120        130        140
PEPRKSDCAQ DKSVFGETEE QKCSTPVYPW MQRMNSCNSE

Show »

Length:140

Mass (Da):15,172

Checksum:ⁱ6B18215988D4750F

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	24 – 25	QL → HV in CAA41335 (PubMed:1672751).Curated	2
Sequence conflictⁱ	24 – 25	QL → HV in CAB65909 (Ref. 2) Curated	2
Sequence conflictⁱ	33	A → R in CAA41335 (PubMed:1672751).Curated	1
Sequence conflictⁱ	60	P → R in CAA41335 (PubMed:1672751).Curated	1
Sequence conflictⁱ	73	D → A in CAA41335 (PubMed:1672751).Curated	1
Sequence conflictⁱ	149 – 150	GR → A in AAA36004 (PubMed:2573064).Curated	2

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_002388	140	S → E in isoform 2. Curated		1
Alternative sequenceⁱVSP_002389	141 – 224	Missing in isoform 2. CuratedAdd BLAST		84

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X58431 Genomic DNA Translation: CAA41335.1 X58431 Genomic DNA Translation: CAA41336.1 AJ270993 mRNA Translation: CAB65909.1 AF287967 Genomic DNA Translation: AAG31552.1 AK292200 mRNA Translation: BAF84889.1 CH471109 Genomic DNA Translation: EAW94728.1 CH471109 Genomic DNA Translation: EAW94729.1 CH471109 Genomic DNA Translation: EAW94730.1 CH471109 Genomic DNA Translation: EAW94731.1 BC014651 mRNA Translation: AAH14651.1 M30597 mRNA Translation: AAA36004.1 K02571 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11531.1 [P17509-1]
PIRⁱ	A05266 S26400
NCBI Reference Sequences More...RefSeqⁱ	NP_061825.2, NM_018952.4 [P17509-1] XP_005257340.1, XM_005257283.3 XP_005257341.1, XM_005257284.3 [P17509-1]
UniGeneⁱ	Hs.98428

Genome annotation databases

Ensemblⁱ	ENST00000225648; ENSP00000225648; ENSG00000108511 [P17509-1] ENST00000484302; ENSP00000420009; ENSG00000108511 [P17509-1]
GeneIDⁱ	3216
KEGGⁱ	hsa:3216
UCSC genome browser More...UCSCⁱ	uc002ins.2 human [P17509-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P17509	HOXB6 isoform 1		PANTR		224	UniRef100_P17509
Uncharacterized protein		PANPA		224
UPI0004F0C071		PANPA		304

Protein	Similar proteins		Species	Score	Length	Source
P17509	HOXB6 isoform 1		PANTR		224	UniRef90_P17509
Uncharacterized protein		PANPA		224
Uncharacterized protein		MACMU		224
Uncharacterized protein		COLAP		224
Uncharacterized protein		CERAT		224
+9
P17509-2	homeobox protein Hox-B6-like		LEPWE		140	UniRef90_P17509-2
Homeobox B6 (Fragment)		wrinkle-lipped free-tailed bat		139

Protein	Similar proteins		Species	Score	Length	Source
P17509	Homeobox protein Hox-B6		MOUSE		224	UniRef50_P09023
Homeobox protein Hox-B6b		TAKRU		233
Homeo box B6		RAT		224
homeobox protein Hox-B6		MESAU		224
Uncharacterized protein		NEOLE		224
+160
P17509-2	homeobox protein Hox-B6-like		LEPWE		140	UniRef50_P17509-2
Homeobox B6 (Fragment)		wrinkle-lipped free-tailed bat		139
Homeodomain protein (Fragment)		MEGAM		143
Homeo box B6b (Fragment)		NOTKU		174
Homeo box B6b (Fragment)		Nothobranchius pienaari		174
+2

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X58431 Genomic DNA Translation: CAA41335.1 X58431 Genomic DNA Translation: CAA41336.1 AJ270993 mRNA Translation: CAB65909.1 AF287967 Genomic DNA Translation: AAG31552.1 AK292200 mRNA Translation: BAF84889.1 CH471109 Genomic DNA Translation: EAW94728.1 CH471109 Genomic DNA Translation: EAW94729.1 CH471109 Genomic DNA Translation: EAW94730.1 CH471109 Genomic DNA Translation: EAW94731.1 BC014651 mRNA Translation: AAH14651.1 M30597 mRNA Translation: AAA36004.1 K02571 Genomic DNA No translation available.
CCDSⁱ	CCDS11531.1 [P17509-1]
PIRⁱ	A05266 S26400
RefSeqⁱ	NP_061825.2, NM_018952.4 [P17509-1] XP_005257340.1, XM_005257283.3 XP_005257341.1, XM_005257284.3 [P17509-1]
UniGeneⁱ	Hs.98428

3D structure databases

ProteinModelPortalⁱ	P17509
SMRⁱ	P17509
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109456, 32 interactors
ELMⁱ	P17509
IntActⁱ	P17509, 9 interactors
STRINGⁱ	9606.ENSP00000225648

PTM databases

iPTMnetⁱ	P17509
PhosphoSitePlusⁱ	P17509

Polymorphism and mutation databases

BioMutaⁱ	HOXB6
DMDMⁱ	116242515

Proteomic databases

MaxQBⁱ	P17509
PaxDbⁱ	P17509
PeptideAtlasⁱ	P17509
PRIDEⁱ	P17509
ProteomicsDBⁱ	53478 53479 [P17509-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3216
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000225648; ENSP00000225648; ENSG00000108511 [P17509-1] ENST00000484302; ENSP00000420009; ENSG00000108511 [P17509-1]
GeneIDⁱ	3216
KEGGⁱ	hsa:3216
UCSCⁱ	uc002ins.2 human [P17509-1]

Organism-specific databases

CTDⁱ	3216
DisGeNETⁱ	3216
EuPathDBⁱ	HostDB:ENSG00000108511.9
GeneCardsⁱ	HOXB6
HGNCⁱ	HGNC:5117 HOXB6
HPAⁱ	HPA042063
MIMⁱ	142961 gene
neXtProtⁱ	NX_P17509
OpenTargetsⁱ	ENSG00000108511
PharmGKBⁱ	PA29393
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
GeneTreeⁱ	ENSGT00910000143983
HOGENOMⁱ	HOG000231181
HOVERGENⁱ	HBG016849
InParanoidⁱ	P17509
KOⁱ	K09306
OMAⁱ	PLRHYSA
OrthoDBⁱ	EOG091G09XD
PhylomeDBⁱ	P17509
TreeFamⁱ	TF316310

Enzyme and pathway databases

SIGNORⁱ	P17509

SIGNORⁱ

P17509

Miscellaneous databases

GeneWikiⁱ	HOXB6
GenomeRNAiⁱ	3216
Protein Ontology More...PROⁱ	PR:P17509
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000108511 Expressed in 126 organ(s), highest expression level in caput epididymis
CleanExⁱ	HS_HOXB6
Genevisibleⁱ	P17509 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017995 Homeobox_antennapedia IPR001827 Homeobox_Antennapedia_CS IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00025 ANTENNAPEDIA PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00032 ANTENNAPEDIA, 1 hit PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HXB6_HUMAN
Accessionⁱ	P17509Primary (citable) accession number: P17509 Secondary accession number(s): A8K835 , D3DTV5, P09068, Q9HB11, Q9UGH2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	October 17, 2006
	Last modified:	November 7, 2018
	This is version 189 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P17509 (HXB6_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Homeobox protein Hox-B6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ