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Protein

Homeobox protein Hox-B6

Gene

HOXB6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi146 – 205HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP17509

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B6
Alternative name(s):
Homeobox protein Hox-2.2
Homeobox protein Hox-2B
Homeobox protein Hu-2
Gene namesi
Name:HOXB6
Synonyms:HOX2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108511.9
HGNCiHGNC:5117 HOXB6
MIMi142961 gene
neXtProtiNX_P17509

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3216
OpenTargetsiENSG00000108511
PharmGKBiPA29393

Polymorphism and mutation databases

BioMutaiHOXB6
DMDMi116242515

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001351 – 224Homeobox protein Hox-B6Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei214PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP17509
PaxDbiP17509
PeptideAtlasiP17509
PRIDEiP17509
ProteomicsDBi53478
53479 [P17509-2]

PTM databases

iPTMnetiP17509
PhosphoSitePlusiP17509

Expressioni

Gene expression databases

BgeeiENSG00000108511 Expressed in 126 organ(s), highest expression level in caput epididymis
CleanExiHS_HOXB6
GenevisibleiP17509 HS

Organism-specific databases

HPAiHPA042063

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CLK3P497615EBI-741308,EBI-745579

Protein-protein interaction databases

BioGridi109456, 32 interactors
ELMiP17509
IntActiP17509, 9 interactors
STRINGi9606.ENSP00000225648

Structurei

3D structure databases

ProteinModelPortaliP17509
SMRiP17509
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 132Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi216 – 220Poly-Glu5

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP17509
KOiK09306
OMAiPLRHYSA
OrthoDBiEOG091G09XD
PhylomeDBiP17509
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P17509-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD
60 70 80 90 100
KGFATSSYYP PAGGGYGRAA PCDYGPAPAF YREKESACAL SGADEQPPFH
110 120 130 140 150
PEPRKSDCAQ DKSVFGETEE QKCSTPVYPW MQRMNSCNSS SFGPSGRRGR
160 170 180 190 200
QTYTRYQTLE LEKEFHYNRY LTRRRRIEIA HALCLTERQI KIWFQNRRMK
210 220
WKKESKLLSA SQLSAEEEEE KQAE
Length:224
Mass (Da):25,432
Last modified:October 17, 2006 - v4
Checksum:iF60292D4D664099C
GO
Isoform 2 (identifier: P17509-2) [UniParc]FASTAAdd to basket
Also known as: Homeobox-less

The sequence of this isoform differs from the canonical sequence as follows:
     140-140: S → E
     141-224: Missing.

Show »
Length:140
Mass (Da):15,172
Checksum:i6B18215988D4750F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24 – 25QL → HV in CAA41335 (PubMed:1672751).Curated2
Sequence conflicti24 – 25QL → HV in CAB65909 (Ref. 2) Curated2
Sequence conflicti33A → R in CAA41335 (PubMed:1672751).Curated1
Sequence conflicti60P → R in CAA41335 (PubMed:1672751).Curated1
Sequence conflicti73D → A in CAA41335 (PubMed:1672751).Curated1
Sequence conflicti149 – 150GR → A in AAA36004 (PubMed:2573064).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002388140S → E in isoform 2. Curated1
Alternative sequenceiVSP_002389141 – 224Missing in isoform 2. CuratedAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58431 Genomic DNA Translation: CAA41335.1
X58431 Genomic DNA Translation: CAA41336.1
AJ270993 mRNA Translation: CAB65909.1
AF287967 Genomic DNA Translation: AAG31552.1
AK292200 mRNA Translation: BAF84889.1
CH471109 Genomic DNA Translation: EAW94728.1
CH471109 Genomic DNA Translation: EAW94729.1
CH471109 Genomic DNA Translation: EAW94730.1
CH471109 Genomic DNA Translation: EAW94731.1
BC014651 mRNA Translation: AAH14651.1
M30597 mRNA Translation: AAA36004.1
K02571 Genomic DNA No translation available.
CCDSiCCDS11531.1 [P17509-1]
PIRiA05266
S26400
RefSeqiNP_061825.2, NM_018952.4 [P17509-1]
XP_005257340.1, XM_005257283.3
XP_005257341.1, XM_005257284.3 [P17509-1]
UniGeneiHs.98428

Genome annotation databases

EnsembliENST00000225648; ENSP00000225648; ENSG00000108511 [P17509-1]
ENST00000484302; ENSP00000420009; ENSG00000108511 [P17509-1]
GeneIDi3216
KEGGihsa:3216
UCSCiuc002ins.2 human [P17509-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58431 Genomic DNA Translation: CAA41335.1
X58431 Genomic DNA Translation: CAA41336.1
AJ270993 mRNA Translation: CAB65909.1
AF287967 Genomic DNA Translation: AAG31552.1
AK292200 mRNA Translation: BAF84889.1
CH471109 Genomic DNA Translation: EAW94728.1
CH471109 Genomic DNA Translation: EAW94729.1
CH471109 Genomic DNA Translation: EAW94730.1
CH471109 Genomic DNA Translation: EAW94731.1
BC014651 mRNA Translation: AAH14651.1
M30597 mRNA Translation: AAA36004.1
K02571 Genomic DNA No translation available.
CCDSiCCDS11531.1 [P17509-1]
PIRiA05266
S26400
RefSeqiNP_061825.2, NM_018952.4 [P17509-1]
XP_005257340.1, XM_005257283.3
XP_005257341.1, XM_005257284.3 [P17509-1]
UniGeneiHs.98428

3D structure databases

ProteinModelPortaliP17509
SMRiP17509
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109456, 32 interactors
ELMiP17509
IntActiP17509, 9 interactors
STRINGi9606.ENSP00000225648

PTM databases

iPTMnetiP17509
PhosphoSitePlusiP17509

Polymorphism and mutation databases

BioMutaiHOXB6
DMDMi116242515

Proteomic databases

MaxQBiP17509
PaxDbiP17509
PeptideAtlasiP17509
PRIDEiP17509
ProteomicsDBi53478
53479 [P17509-2]

Protocols and materials databases

DNASUi3216
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225648; ENSP00000225648; ENSG00000108511 [P17509-1]
ENST00000484302; ENSP00000420009; ENSG00000108511 [P17509-1]
GeneIDi3216
KEGGihsa:3216
UCSCiuc002ins.2 human [P17509-1]

Organism-specific databases

CTDi3216
DisGeNETi3216
EuPathDBiHostDB:ENSG00000108511.9
GeneCardsiHOXB6
HGNCiHGNC:5117 HOXB6
HPAiHPA042063
MIMi142961 gene
neXtProtiNX_P17509
OpenTargetsiENSG00000108511
PharmGKBiPA29393
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP17509
KOiK09306
OMAiPLRHYSA
OrthoDBiEOG091G09XD
PhylomeDBiP17509
TreeFamiTF316310

Enzyme and pathway databases

SIGNORiP17509

Miscellaneous databases

GeneWikiiHOXB6
GenomeRNAii3216
PROiPR:P17509
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108511 Expressed in 126 organ(s), highest expression level in caput epididymis
CleanExiHS_HOXB6
GenevisibleiP17509 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXB6_HUMAN
AccessioniPrimary (citable) accession number: P17509
Secondary accession number(s): A8K835
, D3DTV5, P09068, Q9HB11, Q9UGH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 17, 2006
Last modified: November 7, 2018
This is version 189 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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