UniProtKB - P17509 (HXB6_HUMAN)
Protein
Homeobox protein Hox-B6
Gene
HOXB6
Organism
Homo sapiens (Human)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 146 – 205 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- anterior/posterior pattern specification Source: GO_Central
- embryonic skeletal system morphogenesis Source: Ensembl
- erythrocyte homeostasis Source: Ensembl
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P17509 |
SIGNORi | P17509 |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-B6Alternative name(s): Homeobox protein Hox-2.2 Homeobox protein Hox-2B Homeobox protein Hu-2 |
Gene namesi | Name:HOXB6 Synonyms:HOX2B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000108511.9 |
HGNCi | HGNC:5117, HOXB6 |
MIMi | 142961, gene |
neXtProti | NX_P17509 |
Subcellular locationi
Nucleus
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3216 |
OpenTargetsi | ENSG00000108511 |
PharmGKBi | PA29393 |
Miscellaneous databases
Pharosi | P17509, Tbio |
Polymorphism and mutation databases
BioMutai | HOXB6 |
DMDMi | 116242515 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200135 | 1 – 224 | Homeobox protein Hox-B6Add BLAST | 224 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 214 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P17509 |
MassIVEi | P17509 |
MaxQBi | P17509 |
PaxDbi | P17509 |
PeptideAtlasi | P17509 |
PRIDEi | P17509 |
ProteomicsDBi | 53478 [P17509-1] 53479 [P17509-2] |
PTM databases
iPTMneti | P17509 |
PhosphoSitePlusi | P17509 |
Expressioni
Gene expression databases
Bgeei | ENSG00000108511, Expressed in caput epididymis and 141 other tissues |
Genevisiblei | P17509, HS |
Organism-specific databases
HPAi | ENSG00000108511, Tissue enhanced (ductus deferens, seminal vesicle) |
Interactioni
Binary interactionsi
Hide detailsP17509
Protein-protein interaction databases
BioGRIDi | 109456, 39 interactors |
ELMi | P17509 |
IntActi | P17509, 13 interactors |
STRINGi | 9606.ENSP00000420009 |
Miscellaneous databases
RNActi | P17509, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 127 – 132 | Antp-type hexapeptide | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 216 – 220 | Poly-Glu | 5 |
Sequence similaritiesi
Belongs to the Antp homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000161108 |
HOGENOMi | CLU_061398_1_1_1 |
InParanoidi | P17509 |
OMAi | SAPVYPW |
OrthoDBi | 1186205at2759 |
PhylomeDBi | P17509 |
TreeFami | TF316310 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017995, Homeobox_antennapedia IPR001827, Homeobox_Antennapedia_CS IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00025, ANTENNAPEDIA PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00032, ANTENNAPEDIA, 1 hit PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P17509-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSYFVNSTF PVTLASGQES FLGQLPLYSS GYADPLRHYP APYGPGPGQD
60 70 80 90 100
KGFATSSYYP PAGGGYGRAA PCDYGPAPAF YREKESACAL SGADEQPPFH
110 120 130 140 150
PEPRKSDCAQ DKSVFGETEE QKCSTPVYPW MQRMNSCNSS SFGPSGRRGR
160 170 180 190 200
QTYTRYQTLE LEKEFHYNRY LTRRRRIEIA HALCLTERQI KIWFQNRRMK
210 220
WKKESKLLSA SQLSAEEEEE KQAE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 24 – 25 | QL → HV in CAA41335 (PubMed:1672751).Curated | 2 | |
Sequence conflicti | 24 – 25 | QL → HV in CAB65909 (Ref. 2) Curated | 2 | |
Sequence conflicti | 33 | A → R in CAA41335 (PubMed:1672751).Curated | 1 | |
Sequence conflicti | 60 | P → R in CAA41335 (PubMed:1672751).Curated | 1 | |
Sequence conflicti | 73 | D → A in CAA41335 (PubMed:1672751).Curated | 1 | |
Sequence conflicti | 149 – 150 | GR → A in AAA36004 (PubMed:2573064).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002388 | 140 | S → E in isoform 2. Curated | 1 | |
Alternative sequenceiVSP_002389 | 141 – 224 | Missing in isoform 2. CuratedAdd BLAST | 84 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X58431 Genomic DNA Translation: CAA41335.1 X58431 Genomic DNA Translation: CAA41336.1 AJ270993 mRNA Translation: CAB65909.1 AF287967 Genomic DNA Translation: AAG31552.1 AK292200 mRNA Translation: BAF84889.1 CH471109 Genomic DNA Translation: EAW94728.1 CH471109 Genomic DNA Translation: EAW94729.1 CH471109 Genomic DNA Translation: EAW94730.1 CH471109 Genomic DNA Translation: EAW94731.1 BC014651 mRNA Translation: AAH14651.1 M30597 mRNA Translation: AAA36004.1 K02571 Genomic DNA No translation available. |
CCDSi | CCDS11531.1 [P17509-1] |
PIRi | A05266 S26400 |
RefSeqi | NP_061825.2, NM_018952.4 [P17509-1] XP_005257340.1, XM_005257283.3 XP_005257341.1, XM_005257284.3 |
Genome annotation databases
Ensembli | ENST00000225648; ENSP00000225648; ENSG00000108511 [P17509-1] ENST00000484302; ENSP00000420009; ENSG00000108511 [P17509-1] |
GeneIDi | 3216 |
KEGGi | hsa:3216 |
UCSCi | uc002ins.2, human [P17509-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X58431 Genomic DNA Translation: CAA41335.1 X58431 Genomic DNA Translation: CAA41336.1 AJ270993 mRNA Translation: CAB65909.1 AF287967 Genomic DNA Translation: AAG31552.1 AK292200 mRNA Translation: BAF84889.1 CH471109 Genomic DNA Translation: EAW94728.1 CH471109 Genomic DNA Translation: EAW94729.1 CH471109 Genomic DNA Translation: EAW94730.1 CH471109 Genomic DNA Translation: EAW94731.1 BC014651 mRNA Translation: AAH14651.1 M30597 mRNA Translation: AAA36004.1 K02571 Genomic DNA No translation available. |
CCDSi | CCDS11531.1 [P17509-1] |
PIRi | A05266 S26400 |
RefSeqi | NP_061825.2, NM_018952.4 [P17509-1] XP_005257340.1, XM_005257283.3 XP_005257341.1, XM_005257284.3 |
3D structure databases
SMRi | P17509 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109456, 39 interactors |
ELMi | P17509 |
IntActi | P17509, 13 interactors |
STRINGi | 9606.ENSP00000420009 |
PTM databases
iPTMneti | P17509 |
PhosphoSitePlusi | P17509 |
Polymorphism and mutation databases
BioMutai | HOXB6 |
DMDMi | 116242515 |
Proteomic databases
jPOSTi | P17509 |
MassIVEi | P17509 |
MaxQBi | P17509 |
PaxDbi | P17509 |
PeptideAtlasi | P17509 |
PRIDEi | P17509 |
ProteomicsDBi | 53478 [P17509-1] 53479 [P17509-2] |
Protocols and materials databases
Antibodypediai | 17852, 160 antibodies |
DNASUi | 3216 |
Genome annotation databases
Ensembli | ENST00000225648; ENSP00000225648; ENSG00000108511 [P17509-1] ENST00000484302; ENSP00000420009; ENSG00000108511 [P17509-1] |
GeneIDi | 3216 |
KEGGi | hsa:3216 |
UCSCi | uc002ins.2, human [P17509-1] |
Organism-specific databases
CTDi | 3216 |
DisGeNETi | 3216 |
EuPathDBi | HostDB:ENSG00000108511.9 |
GeneCardsi | HOXB6 |
HGNCi | HGNC:5117, HOXB6 |
HPAi | ENSG00000108511, Tissue enhanced (ductus deferens, seminal vesicle) |
MIMi | 142961, gene |
neXtProti | NX_P17509 |
OpenTargetsi | ENSG00000108511 |
PharmGKBi | PA29393 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000161108 |
HOGENOMi | CLU_061398_1_1_1 |
InParanoidi | P17509 |
OMAi | SAPVYPW |
OrthoDBi | 1186205at2759 |
PhylomeDBi | P17509 |
TreeFami | TF316310 |
Enzyme and pathway databases
PathwayCommonsi | P17509 |
SIGNORi | P17509 |
Miscellaneous databases
BioGRID-ORCSi | 3216, 17 hits in 869 CRISPR screens |
ChiTaRSi | HOXB6, human |
GeneWikii | HOXB6 |
GenomeRNAii | 3216 |
Pharosi | P17509, Tbio |
PROi | PR:P17509 |
RNActi | P17509, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108511, Expressed in caput epididymis and 141 other tissues |
Genevisiblei | P17509, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017995, Homeobox_antennapedia IPR001827, Homeobox_Antennapedia_CS IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00025, ANTENNAPEDIA PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00032, ANTENNAPEDIA, 1 hit PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HXB6_HUMAN | |
Accessioni | P17509Primary (citable) accession number: P17509 Secondary accession number(s): A8K835 Q9UGH2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | October 17, 2006 | |
Last modified: | December 2, 2020 | |
This is version 204 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries