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UniProtKB - P17497 (VM2_BITAR)
Protein
Disintegrin bitistatin
Gene
N/A
Organism
Bitis arietans (African puff adder)
Status
Functioni
Inhibits fibrinogen interaction with platelets. Acts by binding to alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP, thrombin, platelet-activating factor and collagen.
1 PublicationMiscellaneous
The disintegrin belongs to the long disintegrin subfamily.
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Cell adhesion impairing toxin, Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Disintegrin bitistatin3 PublicationsAlternative name(s): Arietin2 Publications Bitan-alpha1 Publication Bitistatin D11 Publication Platelet aggregation activation inhibitor Venom protein CM-21 Publication |
Organismi | Bitis arietans (African puff adder) |
Taxonomic identifieri | 8692 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Viperinae › Bitis |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000101784 | 1 – 83 | Disintegrin bitistatin2 PublicationsAdd BLAST | 83 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 5 ↔ 34 | In form B1 PublicationImported | ||
Disulfide bondi | 5 ↔ 24 | In form A2 PublicationsImported | ||
Disulfide bondi | 16 ↔ 34 | In form A2 PublicationsImported | ||
Disulfide bondi | 16 ↔ 29 | In form B1 PublicationImported | ||
Disulfide bondi | 18 ↔ 29 | In form A2 PublicationsImported | ||
Disulfide bondi | 18 ↔ 24 | In form B1 PublicationImported | ||
Disulfide bondi | 28 ↔ 51 | In forms A and B2 PublicationsImported | ||
Disulfide bondi | 42 ↔ 48 | In form A and B2 PublicationsImported | ||
Disulfide bondi | 47 ↔ 72 | In form A and B2 PublicationsImported | ||
Disulfide bondi | 60 ↔ 79 | In form A and B2 PublicationsImported |
Post-translational modificationi
Exists in 3 forms in the venom. The forms A, B, and C are present at 53%, 32% and 15%. The forms A and B differ by their disulfide bond pattern in the N-terminal part. No information is known about form C.1 Publication
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Interactioni
Subunit structurei
Monomer.
1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P17497 |
BMRBi | P17497 |
SMRi | P17497 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 83 | DisintegrinPROSITE-ProRule annotationAdd BLAST | 82 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 64 – 66 | Cell attachment site | 3 |
Sequence similaritiesi
Family and domain databases
Gene3Di | 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf |
Pfami | View protein in Pfam PF00200, Disintegrin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P17497-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
SPPVCGNKIL EQGEDCDCGS PANCQDRCCN AATCKLTPGS QCNYGECCDQ
60 70 80
CRFKKAGTVC RIARGDWNDD YCTGKSSDCP WNH
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 57 | G → L AA sequence (PubMed:2043663).Curated | 1 | |
Sequence conflicti | 67 | W → S AA sequence (PubMed:2043663).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY924402 mRNA Translation: AAY43681.1 |
PIRi | A34156 F35982 S15982 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY924402 mRNA Translation: AAY43681.1 |
PIRi | A34156 F35982 S15982 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2MOP | NMR | - | 1 | 1-83 | [»] | |
2MP5 | NMR | - | 1 | 1-83 | [»] | |
AlphaFoldDBi | P17497 | |||||
BMRBi | P17497 | |||||
SMRi | P17497 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Family and domain databases
Gene3Di | 4.10.70.10, 1 hit |
InterProi | View protein in InterPro IPR018358, Disintegrin_CS IPR001762, Disintegrin_dom IPR036436, Disintegrin_dom_sf |
Pfami | View protein in Pfam PF00200, Disintegrin, 1 hit |
PRINTSi | PR00289, DISINTEGRIN |
SMARTi | View protein in SMART SM00050, DISIN, 1 hit |
SUPFAMi | SSF57552, SSF57552, 1 hit |
PROSITEi | View protein in PROSITE PS00427, DISINTEGRIN_1, 1 hit PS50214, DISINTEGRIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VM2_BITAR | |
Accessioni | P17497Primary (citable) accession number: P17497 Secondary accession number(s): Q4JCS2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | August 1, 1990 | |
Last modified: | May 25, 2022 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families