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Protein

Homeobox protein Hox-B4

Gene

HOXB4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi162 – 221HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B4
Alternative name(s):
Homeobox protein Hox-2.6
Homeobox protein Hox-2F
Gene namesi
Name:HOXB4
Synonyms:HOX2F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000182742.5
HGNCiHGNC:5115 HOXB4
MIMi142965 gene
neXtProtiNX_P17483

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3214
OpenTargetsiENSG00000182742
PharmGKBiPA29391

Polymorphism and mutation databases

BioMutaiHOXB4
DMDMi547692

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001221 – 251Homeobox protein Hox-B4Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP17483
MaxQBiP17483
PaxDbiP17483
PeptideAtlasiP17483
PRIDEiP17483
ProteomicsDBi53477

PTM databases

iPTMnetiP17483
PhosphoSitePlusiP17483

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

BgeeiENSG00000182742 Expressed in 74 organ(s), highest expression level in right uterine tube
CleanExiHS_HOXB4
GenevisibleiP17483 HS

Organism-specific databases

HPAiHPA057432

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109454, 6 interactors
ELMiP17483
STRINGi9606.ENSP00000328928

Structurei

3D structure databases

ProteinModelPortaliP17483
SMRiP17483
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi141 – 146Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 139Pro-rich (part of the transcriptional activation domain)Add BLAST125
Compositional biasi71 – 87Poly-ProAdd BLAST17

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231179
HOVERGENiHBG016849
InParanoidiP17483
KOiK09304
OMAiPSHSSCK
OrthoDBiEOG091G09XD
PhylomeDBiP17483
TreeFamiTF352857

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P17483-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMSSFLINS NYVDPKFPPC EEYSQSDYLP SDHSPGYYAG GQRRESSFQP
60 70 80 90 100
EAGFGRRAAC TVQRYAACRD PGPPPPPPPP PPPPPPPGLS PRAPAPPPAG
110 120 130 140 150
ALLPEPGQRC EAVSSSPPPP PCAQNPLHPS PSHSACKEPV VYPWMRKVHV
160 170 180 190 200
STVNPNYAGG EPKRSRTAYT RQQVLELEKE FHYNRYLTRR RRVEIAHALC
210 220 230 240 250
LSERQIKIWF QNRRMKWKKD HKLPNTKIRS GGAAGSAGGP PGRPNGGPRA

L
Length:251
Mass (Da):27,604
Last modified:June 1, 1994 - v2
Checksum:i23EE1D0DDCCE2DB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16174 Genomic DNA Translation: CAA34296.1
AF287967 Genomic DNA Translation: AAG31554.1
AF307160 Genomic DNA Translation: AAG45052.1
BC049204 mRNA Translation: AAH49204.1
AL137449 mRNA Translation: CAB70742.1
CCDSiCCDS11529.1
PIRiB60492
T46446
RefSeqiNP_076920.1, NM_024015.4
UniGeneiHs.664706

Genome annotation databases

EnsembliENST00000332503; ENSP00000328928; ENSG00000182742
GeneIDi3214
KEGGihsa:3214
UCSCiuc002inp.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16174 Genomic DNA Translation: CAA34296.1
AF287967 Genomic DNA Translation: AAG31554.1
AF307160 Genomic DNA Translation: AAG45052.1
BC049204 mRNA Translation: AAH49204.1
AL137449 mRNA Translation: CAB70742.1
CCDSiCCDS11529.1
PIRiB60492
T46446
RefSeqiNP_076920.1, NM_024015.4
UniGeneiHs.664706

3D structure databases

ProteinModelPortaliP17483
SMRiP17483
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109454, 6 interactors
ELMiP17483
STRINGi9606.ENSP00000328928

PTM databases

iPTMnetiP17483
PhosphoSitePlusiP17483

Polymorphism and mutation databases

BioMutaiHOXB4
DMDMi547692

Proteomic databases

EPDiP17483
MaxQBiP17483
PaxDbiP17483
PeptideAtlasiP17483
PRIDEiP17483
ProteomicsDBi53477

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332503; ENSP00000328928; ENSG00000182742
GeneIDi3214
KEGGihsa:3214
UCSCiuc002inp.4 human

Organism-specific databases

CTDi3214
DisGeNETi3214
EuPathDBiHostDB:ENSG00000182742.5
GeneCardsiHOXB4
HGNCiHGNC:5115 HOXB4
HPAiHPA057432
MIMi142965 gene
neXtProtiNX_P17483
OpenTargetsiENSG00000182742
PharmGKBiPA29391
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231179
HOVERGENiHBG016849
InParanoidiP17483
KOiK09304
OMAiPSHSSCK
OrthoDBiEOG091G09XD
PhylomeDBiP17483
TreeFamiTF352857

Enzyme and pathway databases

ReactomeiR-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis

Miscellaneous databases

GeneWikiiHOXB4
GenomeRNAii3214
PROiPR:P17483
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182742 Expressed in 74 organ(s), highest expression level in right uterine tube
CleanExiHS_HOXB4
GenevisibleiP17483 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXB4_HUMAN
AccessioniPrimary (citable) accession number: P17483
Secondary accession number(s): Q9NTA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 179 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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