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Protein

Homeobox protein Hox-B9

Gene

HOXB9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi185 – 244HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP17482

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B9
Alternative name(s):
Homeobox protein Hox-2.5
Homeobox protein Hox-2E
Gene namesi
Name:HOXB9
Synonyms:HOX2E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000170689.9
HGNCiHGNC:5120 HOXB9
MIMi142964 gene
neXtProtiNX_P17482

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3219
OpenTargetsiENSG00000170689
PharmGKBiPA29396

Polymorphism and mutation databases

BioMutaiHOXB9
DMDMi20141507

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001551 – 250Homeobox protein Hox-B9Add BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei133PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP17482
PeptideAtlasiP17482
PRIDEiP17482
ProteomicsDBi53476

PTM databases

iPTMnetiP17482
PhosphoSitePlusiP17482

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

BgeeiENSG00000170689 Expressed in 76 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_HOXB9
GenevisibleiP17482 HS

Organism-specific databases

HPAiHPA031463

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi109459, 52 interactors
IntActiP17482, 61 interactors
MINTiP17482
STRINGi9606.ENSP00000309439

Structurei

3D structure databases

ProteinModelPortaliP17482
SMRiP17482
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231180
HOVERGENiHBG016849
InParanoidiP17482
KOiK09294
OMAiRSWLDCA
OrthoDBiEOG091G0H4X
PhylomeDBiP17482
TreeFamiTF317819

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR006711 Hox9_activation_N
IPR017112 HXA9/HXB9/HXC9
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF04617 Hox9_act, 1 hit
PIRSFiPIRSF037109 Homeobox_Hox9, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P17482-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYASSRQPG HAEHLEFPSC
60 70 80 90 100
SFQPKAPVFG ASWAPLSPHA SGSLPSVYHP YIQPQGVPPA ESRYLRTWLE
110 120 130 140 150
PAPRGEAAPG QGQAAVKAEP LLGAPGELLK QGTPEYSLET SAGREAVLSN
160 170 180 190 200
QRPGYGDNKI CEGSEDKERP DQTNPSANWL HARSSRKKRC PYTKYQTLEL
210 220 230 240 250
EKEFLFNMYL TRDRRHEVAR LLNLSERQVK IWFQNRRMKM KKMNKEQGKE
Length:250
Mass (Da):28,059
Last modified:January 23, 2002 - v2
Checksum:iF06ECBC08FBBED2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173T → A in CAA34294 (PubMed:2570724).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014296, AY014295 Genomic DNA Translation: AAG42144.1
AK315480 mRNA Translation: BAG37864.1
CH471109 Genomic DNA Translation: EAW94721.1
BC015565 mRNA Translation: AAH15565.1
X16172 Genomic DNA Translation: CAA34294.1
CCDSiCCDS11534.1
PIRiA37042
RefSeqiNP_076922.1, NM_024017.4
UniGeneiHs.463350

Genome annotation databases

EnsembliENST00000311177; ENSP00000309439; ENSG00000170689
GeneIDi3219
KEGGihsa:3219
UCSCiuc002inx.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014296, AY014295 Genomic DNA Translation: AAG42144.1
AK315480 mRNA Translation: BAG37864.1
CH471109 Genomic DNA Translation: EAW94721.1
BC015565 mRNA Translation: AAH15565.1
X16172 Genomic DNA Translation: CAA34294.1
CCDSiCCDS11534.1
PIRiA37042
RefSeqiNP_076922.1, NM_024017.4
UniGeneiHs.463350

3D structure databases

ProteinModelPortaliP17482
SMRiP17482
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109459, 52 interactors
IntActiP17482, 61 interactors
MINTiP17482
STRINGi9606.ENSP00000309439

PTM databases

iPTMnetiP17482
PhosphoSitePlusiP17482

Polymorphism and mutation databases

BioMutaiHOXB9
DMDMi20141507

Proteomic databases

PaxDbiP17482
PeptideAtlasiP17482
PRIDEiP17482
ProteomicsDBi53476

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311177; ENSP00000309439; ENSG00000170689
GeneIDi3219
KEGGihsa:3219
UCSCiuc002inx.4 human

Organism-specific databases

CTDi3219
DisGeNETi3219
EuPathDBiHostDB:ENSG00000170689.9
GeneCardsiHOXB9
HGNCiHGNC:5120 HOXB9
HPAiHPA031463
MIMi142964 gene
neXtProtiNX_P17482
OpenTargetsiENSG00000170689
PharmGKBiPA29396
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231180
HOVERGENiHBG016849
InParanoidiP17482
KOiK09294
OMAiRSWLDCA
OrthoDBiEOG091G0H4X
PhylomeDBiP17482
TreeFamiTF317819

Enzyme and pathway databases

SIGNORiP17482

Miscellaneous databases

ChiTaRSiHOXB9 human
GeneWikiiHOXB9
GenomeRNAii3219
PROiPR:P17482
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170689 Expressed in 76 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_HOXB9
GenevisibleiP17482 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR006711 Hox9_activation_N
IPR017112 HXA9/HXB9/HXC9
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF04617 Hox9_act, 1 hit
PIRSFiPIRSF037109 Homeobox_Hox9, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXB9_HUMAN
AccessioniPrimary (citable) accession number: P17482
Secondary accession number(s): B2RDB7, Q9H1I1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2002
Last modified: November 7, 2018
This is version 179 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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