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Protein

Homeobox protein Hox-B8

Gene

HOXB8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi146 – 205HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP17481

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B8
Alternative name(s):
Homeobox protein Hox-2.4
Homeobox protein Hox-2D
Gene namesi
Name:HOXB8
Synonyms:HOX2D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000120068.6
HGNCiHGNC:5119 HOXB8
MIMi142963 gene
neXtProtiNX_P17481

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3218
OpenTargetsiENSG00000120068
PharmGKBiPA29395

Polymorphism and mutation databases

BioMutaiHOXB8
DMDMi20141506

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001481 – 243Homeobox protein Hox-B8Add BLAST243

Proteomic databases

MaxQBiP17481
PaxDbiP17481
PeptideAtlasiP17481
PRIDEiP17481
ProteomicsDBi53475

PTM databases

iPTMnetiP17481
PhosphoSitePlusiP17481

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

BgeeiENSG00000120068 Expressed in 80 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_HOXB8
ExpressionAtlasiP17481 baseline and differential
GenevisibleiP17481 HS

Organism-specific databases

HPAiHPA075905

Interactioni

Protein-protein interaction databases

BioGridi109458, 3 interactors
ELMiP17481
STRINGi9606.ENSP00000239144

Structurei

3D structure databases

ProteinModelPortaliP17481
SMRiP17481
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi134 – 139Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP17481
KOiK09308
OMAiAGGTFQH
OrthoDBiEOG091G09XD
PhylomeDBiP17481
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P17481-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH
60 70 80 90 100
PSQIQEFYHG PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ
110 120 130 140 150
DPDLVQYADC KLAAASGLGE EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR
160 170 180 190 200
QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS HALGLTERQV KIWFQNRRMK
210 220 230 240
WKKENNKDKF PSSKCEQEEL EKQKLERAPE AADEGDAQKG DKK
Length:243
Mass (Da):27,574
Last modified:January 23, 2002 - v2
Checksum:i36982182725F121F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L3R1I3L3R1_HUMAN
Homeobox B8, isoform CRA_a
HOXB8 hCG_1639847
242Annotation score:
I3L383I3L383_HUMAN
Homeobox protein Hox-B8
HOXB8
128Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014294, AY014293 Genomic DNA Translation: AAG42143.1
X16173 Genomic DNA Translation: CAA34295.1
CCDSiCCDS11533.1
PIRiB37042
RefSeqiNP_076921.1, NM_024016.3
XP_016880053.1, XM_017024564.1
UniGeneiHs.514292

Genome annotation databases

EnsembliENST00000239144; ENSP00000239144; ENSG00000120068
GeneIDi3218
KEGGihsa:3218
UCSCiuc002inw.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014294, AY014293 Genomic DNA Translation: AAG42143.1
X16173 Genomic DNA Translation: CAA34295.1
CCDSiCCDS11533.1
PIRiB37042
RefSeqiNP_076921.1, NM_024016.3
XP_016880053.1, XM_017024564.1
UniGeneiHs.514292

3D structure databases

ProteinModelPortaliP17481
SMRiP17481
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109458, 3 interactors
ELMiP17481
STRINGi9606.ENSP00000239144

PTM databases

iPTMnetiP17481
PhosphoSitePlusiP17481

Polymorphism and mutation databases

BioMutaiHOXB8
DMDMi20141506

Proteomic databases

MaxQBiP17481
PaxDbiP17481
PeptideAtlasiP17481
PRIDEiP17481
ProteomicsDBi53475

Protocols and materials databases

DNASUi3218
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239144; ENSP00000239144; ENSG00000120068
GeneIDi3218
KEGGihsa:3218
UCSCiuc002inw.3 human

Organism-specific databases

CTDi3218
DisGeNETi3218
EuPathDBiHostDB:ENSG00000120068.6
GeneCardsiHOXB8
HGNCiHGNC:5119 HOXB8
HPAiHPA075905
MIMi142963 gene
neXtProtiNX_P17481
OpenTargetsiENSG00000120068
PharmGKBiPA29395
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP17481
KOiK09308
OMAiAGGTFQH
OrthoDBiEOG091G09XD
PhylomeDBiP17481
TreeFamiTF316310

Enzyme and pathway databases

SIGNORiP17481

Miscellaneous databases

ChiTaRSiHOXB8 human
GeneWikiiHOXB8
GenomeRNAii3218
PROiPR:P17481
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120068 Expressed in 80 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_HOXB8
ExpressionAtlasiP17481 baseline and differential
GenevisibleiP17481 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
IPR000047 HTH_motif
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
PR00031 HTHREPRESSR
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXB8_HUMAN
AccessioniPrimary (citable) accession number: P17481
Secondary accession number(s): Q9H1I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2002
Last modified: November 7, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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