UniProtKB - P17481 (HXB8_HUMAN)
Protein
Homeobox protein Hox-B8
Gene
HOXB8
Organism
Homo sapiens (Human)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 146 – 205 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: Ensembl
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- adult locomotory behavior Source: Ensembl
- anterior/posterior pattern specification Source: Ensembl
- dorsal spinal cord development Source: Ensembl
- embryonic skeletal system morphogenesis Source: Ensembl
- grooming behavior Source: Ensembl
- negative regulation of myeloid cell differentiation Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- sensory perception of pain Source: Ensembl
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P17481 |
SIGNORi | P17481 |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-B8Alternative name(s): Homeobox protein Hox-2.4 Homeobox protein Hox-2D |
Gene namesi | Name:HOXB8 Synonyms:HOX2D |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5119, HOXB8 |
MIMi | 142963, gene |
neXtProti | NX_P17481 |
VEuPathDBi | HostDB:ENSG00000120068.6 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3218 |
OpenTargetsi | ENSG00000120068 |
PharmGKBi | PA29395 |
Miscellaneous databases
Pharosi | P17481, Tbio |
Genetic variation databases
BioMutai | HOXB8 |
DMDMi | 20141506 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200148 | 1 – 243 | Homeobox protein Hox-B8Add BLAST | 243 |
Proteomic databases
jPOSTi | P17481 |
MassIVEi | P17481 |
MaxQBi | P17481 |
PaxDbi | P17481 |
PeptideAtlasi | P17481 |
PRIDEi | P17481 |
ProteomicsDBi | 53475 |
PTM databases
iPTMneti | P17481 |
PhosphoSitePlusi | P17481 |
Expressioni
Developmental stagei
Expressed in whole embryos and fetuses at 5-9 weeks from conception.
Gene expression databases
Bgeei | ENSG00000120068, Expressed in C1 segment of cervical spinal cord and 97 other tissues |
ExpressionAtlasi | P17481, baseline and differential |
Genevisiblei | P17481, HS |
Organism-specific databases
HPAi | ENSG00000120068, Group enriched (brain, ductus deferens, epididymis, kidney, seminal vesicle) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 109458, 3 interactors |
ELMi | P17481 |
STRINGi | 9606.ENSP00000239144 |
Miscellaneous databases
RNActi | P17481, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 134 – 139 | Antp-type hexapeptide | 6 |
Sequence similaritiesi
Belongs to the Antp homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000161529 |
HOGENOMi | CLU_061398_1_0_1 |
InParanoidi | P17481 |
OMAi | CCEKTHK |
OrthoDBi | 976319at2759 |
PhylomeDBi | P17481 |
TreeFami | TF316310 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001827, Homeobox_Antennapedia_CS IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR000047, HTH_motif |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00032, ANTENNAPEDIA, 1 hit PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P17481-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH
60 70 80 90 100
PSQIQEFYHG PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ
110 120 130 140 150
DPDLVQYADC KLAAASGLGE EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR
160 170 180 190 200
QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS HALGLTERQV KIWFQNRRMK
210 220 230 240
WKKENNKDKF PSSKCEQEEL EKQKLERAPE AADEGDAQKG DKK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketI3L383 | I3L383_HUMAN | Homeobox protein Hox-B8 | HOXB8 | 128 | Annotation score: | ||
I3L3R1 | I3L3R1_HUMAN | Homeobox B8, isoform CRA_a | HOXB8 hCG_1639847 | 242 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY014294, AY014293 Genomic DNA Translation: AAG42143.1 X16173 Genomic DNA Translation: CAA34295.1 |
CCDSi | CCDS11533.1 |
PIRi | B37042 |
RefSeqi | NP_076921.1, NM_024016.3 XP_016880053.1, XM_017024564.1 |
Genome annotation databases
Ensembli | ENST00000239144; ENSP00000239144; ENSG00000120068 |
GeneIDi | 3218 |
KEGGi | hsa:3218 |
UCSCi | uc002inw.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY014294, AY014293 Genomic DNA Translation: AAG42143.1 X16173 Genomic DNA Translation: CAA34295.1 |
CCDSi | CCDS11533.1 |
PIRi | B37042 |
RefSeqi | NP_076921.1, NM_024016.3 XP_016880053.1, XM_017024564.1 |
3D structure databases
SMRi | P17481 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109458, 3 interactors |
ELMi | P17481 |
STRINGi | 9606.ENSP00000239144 |
PTM databases
iPTMneti | P17481 |
PhosphoSitePlusi | P17481 |
Genetic variation databases
BioMutai | HOXB8 |
DMDMi | 20141506 |
Proteomic databases
jPOSTi | P17481 |
MassIVEi | P17481 |
MaxQBi | P17481 |
PaxDbi | P17481 |
PeptideAtlasi | P17481 |
PRIDEi | P17481 |
ProteomicsDBi | 53475 |
Protocols and materials databases
Antibodypediai | 30298, 211 antibodies |
DNASUi | 3218 |
Genome annotation databases
Ensembli | ENST00000239144; ENSP00000239144; ENSG00000120068 |
GeneIDi | 3218 |
KEGGi | hsa:3218 |
UCSCi | uc002inw.3, human |
Organism-specific databases
CTDi | 3218 |
DisGeNETi | 3218 |
GeneCardsi | HOXB8 |
HGNCi | HGNC:5119, HOXB8 |
HPAi | ENSG00000120068, Group enriched (brain, ductus deferens, epididymis, kidney, seminal vesicle) |
MIMi | 142963, gene |
neXtProti | NX_P17481 |
OpenTargetsi | ENSG00000120068 |
PharmGKBi | PA29395 |
VEuPathDBi | HostDB:ENSG00000120068.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000161529 |
HOGENOMi | CLU_061398_1_0_1 |
InParanoidi | P17481 |
OMAi | CCEKTHK |
OrthoDBi | 976319at2759 |
PhylomeDBi | P17481 |
TreeFami | TF316310 |
Enzyme and pathway databases
PathwayCommonsi | P17481 |
SIGNORi | P17481 |
Miscellaneous databases
BioGRID-ORCSi | 3218, 5 hits in 1016 CRISPR screens |
ChiTaRSi | HOXB8, human |
GeneWikii | HOXB8 |
GenomeRNAii | 3218 |
Pharosi | P17481, Tbio |
PROi | PR:P17481 |
RNActi | P17481, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000120068, Expressed in C1 segment of cervical spinal cord and 97 other tissues |
ExpressionAtlasi | P17481, baseline and differential |
Genevisiblei | P17481, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001827, Homeobox_Antennapedia_CS IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa IPR000047, HTH_motif |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX PR00031, HTHREPRESSR |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00032, ANTENNAPEDIA, 1 hit PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HXB8_HUMAN | |
Accessioni | P17481Primary (citable) accession number: P17481 Secondary accession number(s): Q9H1I2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | January 23, 2002 | |
Last modified: | April 7, 2021 | |
This is version 183 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families