UniProtKB - P17481 (HXB8_HUMAN)

BLAST

>sp|P17481|HXB8_HUMAN Homeobox protein Hox-B8 OS=Homo sapiens OX=9606 GN=HOXB8 PE=2 SV=2
MSSYFVNSLFSKYKTGESLRPNYYDCGFAQDLGGRPTVVYGPSSGGSFQHPSQIQEFYHG
PSSLSTAPYQQNPCAVACHGDPGNFYGYDPLQRQSLFGAQDPDLVQYADCKLAAASGLGE
EAEGSEQSPSPTQLFPWMRPQAAAGRRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVS
HALGLTERQVKIWFQNRRMKWKKENNKDKFPSSKCEQEELEKQKLERAPEAADEGDAQKG
DKK

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History
Entry version 168 (07 Nov 2018)
Sequence version 2 (23 Jan 2002)
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Protein

Homeobox protein Hox-B8

Gene

HOXB8

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	146 – 205	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adult locomotory behavior Source: Ensembl
anterior/posterior pattern specification Source: Ensembl
dorsal spinal cord development Source: Ensembl
embryonic skeletal system morphogenesis Source: Ensembl
grooming behavior Source: Ensembl
negative regulation of myeloid cell differentiation Source: UniProtKB
negative regulation of transcription by RNA polymerase II Source: Ensembl
sensory perception of pain Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	P17481

SIGNORⁱ

P17481

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein Hox-B8 Alternative name(s): Homeobox protein Hox-2.4 Homeobox protein Hox-2D
Gene namesⁱ	Name:HOXB8 Synonyms:HOX2D
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000120068.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5119 HOXB8
MIMⁱ	142963 gene
neXtProtⁱ	NX_P17481

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3218
Open Targets More...OpenTargetsⁱ	ENSG00000120068
PharmGKBⁱ	PA29395

Polymorphism and mutation databases

BioMutaⁱ	HOXB8
DMDMⁱ	20141506

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000200148	1 – 243	Homeobox protein Hox-B8Add BLAST		243

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P17481
PaxDbⁱ	P17481
PeptideAtlas More...PeptideAtlasⁱ	P17481
PRIDEⁱ	P17481
ProteomicsDBⁱ	53475

PTM databases

iPTMnetⁱ	P17481
PhosphoSitePlusⁱ	P17481

Expressionⁱ

Developmental stageⁱ

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

Bgeeⁱ	ENSG00000120068 Expressed in 80 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_HOXB8
ExpressionAtlasⁱ	P17481 baseline and differential
Genevisibleⁱ	P17481 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA075905

HPAⁱ

HPA075905

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	109458, 3 interactors
ELMⁱ	P17481
STRINGⁱ	9606.ENSP00000239144

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P17481
SMRⁱ	P17481
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	134 – 139	Antp-type hexapeptide		6

Sequence similaritiesⁱ

Belongs to the Antp homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143983
HOGENOMⁱ	HOG000231181
HOVERGENⁱ	HBG016849
InParanoidⁱ	P17481
KEGG Orthology (KO) More...KOⁱ	K09308
OMAⁱ	AGGTFQH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09XD
PhylomeDBⁱ	P17481
TreeFamⁱ	TF316310

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR001827 Homeobox_Antennapedia_CS IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa IPR000047 HTH_motif
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX PR00031 HTHREPRESSR
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00032 ANTENNAPEDIA, 1 hit PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P17481-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MSSYFVNSLF SKYKTGESLR PNYYDCGFAQ DLGGRPTVVY GPSSGGSFQH 
        60         70         80         90        100
PSQIQEFYHG PSSLSTAPYQ QNPCAVACHG DPGNFYGYDP LQRQSLFGAQ 
       110        120        130        140        150
DPDLVQYADC KLAAASGLGE EAEGSEQSPS PTQLFPWMRP QAAAGRRRGR 
       160        170        180        190        200
QTYSRYQTLE LEKEFLFNPY LTRKRRIEVS HALGLTERQV KIWFQNRRMK 
       210        220        230        240 
WKKENNKDKF PSSKCEQEEL EKQKLERAPE AADEGDAQKG DKK

Length:243

Mass (Da):27,574

Last modified:January 23, 2002 - v2

Checksum:ⁱ36982182725F121F

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

I3L3R1	I3L3R1_HUMAN	Homeobox B8, isoform CRA_a Homeobox B8, isoform CRA_a (Homeobox protein Hox-B8)	HOXB8 hCG_1639847	242	Annotation score:
I3L383	I3L383_HUMAN	Homeobox protein Hox-B8 Homeobox protein Hox-B8	HOXB8	128	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY014294, AY014293 Genomic DNA Translation: AAG42143.1 X16173 Genomic DNA Translation: CAA34295.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11533.1
PIRⁱ	B37042
NCBI Reference Sequences More...RefSeqⁱ	NP_076921.1, NM_024016.3 XP_016880053.1, XM_017024564.1
UniGeneⁱ	Hs.514292

Genome annotation databases

Ensemblⁱ	ENST00000239144; ENSP00000239144; ENSG00000120068
GeneIDⁱ	3218
KEGGⁱ	hsa:3218
UCSC genome browser More...UCSCⁱ	uc002inw.3 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P17481	Uncharacterized protein (Fragment)		MACFA		141	UniRef100_P17481
Homeobox B8 (Fragment)		NEOPH		82
Homeobox B8 (Fragment)		BALPH		68
Homeobox protein Hox-B8 (Fragment)		ESCRO		141
HOXB8 isoform 1		PANTR		243
+25

Protein	Similar proteins		Species	Score	Length	Source
P17481	Homeobox protein Hox-B8		MOUSE		243	UniRef90_P09632
Homeo box B8 (Mapped)		RAT		243
homeobox protein Hox-B8 isoform X1		MESAU		243
Homeobox B8		GORGO		257
Homeobox B8		OTOGA		249
+158

Protein	Similar proteins		Species	Score	Length	Source
P17481	Homeobox protein Hox-B8		MOUSE		243	UniRef50_P09632
Homeobox protein Hox-B8a		TAKRU		282
Homeo box B8 (Mapped)		RAT		243
homeobox protein Hox-B8 isoform X1		MESAU		243
Homeobox B8		GORGO		257
+239

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY014294, AY014293 Genomic DNA Translation: AAG42143.1 X16173 Genomic DNA Translation: CAA34295.1
CCDSⁱ	CCDS11533.1
PIRⁱ	B37042
RefSeqⁱ	NP_076921.1, NM_024016.3 XP_016880053.1, XM_017024564.1
UniGeneⁱ	Hs.514292

3D structure databases

ProteinModelPortalⁱ	P17481
SMRⁱ	P17481
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109458, 3 interactors
ELMⁱ	P17481
STRINGⁱ	9606.ENSP00000239144

PTM databases

iPTMnetⁱ	P17481
PhosphoSitePlusⁱ	P17481

Polymorphism and mutation databases

BioMutaⁱ	HOXB8
DMDMⁱ	20141506

Proteomic databases

MaxQBⁱ	P17481
PaxDbⁱ	P17481
PeptideAtlasⁱ	P17481
PRIDEⁱ	P17481
ProteomicsDBⁱ	53475

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3218
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000239144; ENSP00000239144; ENSG00000120068
GeneIDⁱ	3218
KEGGⁱ	hsa:3218
UCSCⁱ	uc002inw.3 human

Organism-specific databases

CTDⁱ	3218
DisGeNETⁱ	3218
EuPathDBⁱ	HostDB:ENSG00000120068.6
GeneCardsⁱ	HOXB8
HGNCⁱ	HGNC:5119 HOXB8
HPAⁱ	HPA075905
MIMⁱ	142963 gene
neXtProtⁱ	NX_P17481
OpenTargetsⁱ	ENSG00000120068
PharmGKBⁱ	PA29395
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
GeneTreeⁱ	ENSGT00910000143983
HOGENOMⁱ	HOG000231181
HOVERGENⁱ	HBG016849
InParanoidⁱ	P17481
KOⁱ	K09308
OMAⁱ	AGGTFQH
OrthoDBⁱ	EOG091G09XD
PhylomeDBⁱ	P17481
TreeFamⁱ	TF316310

Enzyme and pathway databases

SIGNORⁱ	P17481

SIGNORⁱ

P17481

Miscellaneous databases

ChiTaRSⁱ	HOXB8 human
GeneWikiⁱ	HOXB8
GenomeRNAiⁱ	3218
Protein Ontology More...PROⁱ	PR:P17481
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000120068 Expressed in 80 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_HOXB8
ExpressionAtlasⁱ	P17481 baseline and differential
Genevisibleⁱ	P17481 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR001827 Homeobox_Antennapedia_CS IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa IPR000047 HTH_motif
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX PR00031 HTHREPRESSR
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00032 ANTENNAPEDIA, 1 hit PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HXB8_HUMAN
Accessionⁱ	P17481Primary (citable) accession number: P17481 Secondary accession number(s): Q9H1I2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	January 23, 2002
	Last modified:	November 7, 2018
	This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

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UniProtKB - P17481 (HXB8_HUMAN)

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Homeobox protein Hox-B8

HOXB8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ