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Protein

Alpha-1-antiproteinase

Gene

Serpina1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of serine proteases. The primary target is elastase, but also has a moderate affinity for plasmin and thrombin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei376 – 377Reactive bond2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processAcute phase

Protein family/group databases

MEROPSiI04.001

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1-antiproteinase
Alternative name(s):
Alpha-1-antitrypsin
Alpha-1-proteinase inhibitor
Serpin A1
Gene namesi
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3326 Serpina1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000003239825 – 411Alpha-1-antiproteinaseAdd BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineBy similarity1
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi265N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei377PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP17475
PRIDEiP17475

PTM databases

iPTMnetiP17475
PhosphoSitePlusiP17475
SwissPalmiP17475

Expressioni

Tissue specificityi

Plasma.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012577

Structurei

3D structure databases

ProteinModelPortaliP17475
SMRiP17475
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni367 – 386RCLAdd BLAST20

Domaini

The reactive center loop (RCL) extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site within the RCL, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable (By similarity).By similarity

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
HOGENOMiHOG000238521
HOVERGENiHBG005957
InParanoidiP17475
KOiK03984
PhylomeDBiP17475
TreeFamiTF343201

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

P17475-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPSISRGLL LLAALCCLAP SFLAEDAQET DTSQQDQSPT YRKISSNLAD
60 70 80 90 100
FAFSLYRELV HQSNTSNIFF SPMSITTAFA MLSLGSKGDT RKQILEGLEF
110 120 130 140 150
NLTQIPEADI HKAFHHLLQT LNRPDSELQL NTGNGLFVNK NLKLVEKFLE
160 170 180 190 200
EVKNNYHSEA FSVNFADSEE AKKVINDYVE KGTQGKIVDL MKQLDEDTVF
210 220 230 240 250
ALVNYIFFKG KWKRPFNPEH TRDADFHVDK STTVKVPMMN RLGMFDMHYC
260 270 280 290 300
STLSSWVLMM DYLGNATAIF LLPDDGKMQH LEQTLTKDLI SRFLLNRQTR
310 320 330 340 350
SAILYFPKLS ISGTYNLKTL LSSLGITRVF NNDADLSGIT EDAPLKLSQA
360 370 380 390 400
VHKAVLTLDE RGTEAAGATV VEAVPMSLPP QVKFDHPFIF MIVESETQSP
410
LFVGKVIDPT R
Length:411
Mass (Da):46,136
Last modified:February 1, 1991 - v2
Checksum:iB4245CFE21C5C761
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JZ73A0A0G2JZ73_RAT
Alpha-1-antiproteinase
Serpina1
415Annotation score:
A0A0G2JY31A0A0G2JY31_RAT
Alpha-1-antiproteinase
Serpina1 rCG_20666
411Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14A → G in BAA00579 (PubMed:2229024).Curated1
Sequence conflicti14A → G in AAH78824 (PubMed:15489334).Curated1
Sequence conflicti84L → V in BAA00579 (PubMed:2229024).Curated1
Sequence conflicti247M → I in CAA34349 (Ref. 5) Curated1
Sequence conflicti248H → Y in BAA00579 (PubMed:2229024).Curated1
Sequence conflicti318K → N in BAA00579 (PubMed:2229024).Curated1
Sequence conflicti322S → D in CAA34349 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00675 mRNA Translation: BAA00579.1
BC078824 mRNA Translation: AAH78824.1
M32247 mRNA Translation: AAA40788.1
X16273 mRNA Translation: CAA34349.1
PIRiA33892 ITRT
RefSeqiNP_071964.2, NM_022519.2
XP_006240518.1, XM_006240456.1
XP_017449521.1, XM_017594032.1
UniGeneiRn.1419

Genome annotation databases

GeneIDi24648
KEGGirno:24648
UCSCiRGD:3326 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00675 mRNA Translation: BAA00579.1
BC078824 mRNA Translation: AAH78824.1
M32247 mRNA Translation: AAA40788.1
X16273 mRNA Translation: CAA34349.1
PIRiA33892 ITRT
RefSeqiNP_071964.2, NM_022519.2
XP_006240518.1, XM_006240456.1
XP_017449521.1, XM_017594032.1
UniGeneiRn.1419

3D structure databases

ProteinModelPortaliP17475
SMRiP17475
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012577

Protein family/group databases

MEROPSiI04.001

PTM databases

iPTMnetiP17475
PhosphoSitePlusiP17475
SwissPalmiP17475

Proteomic databases

PaxDbiP17475
PRIDEiP17475

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24648
KEGGirno:24648
UCSCiRGD:3326 rat

Organism-specific databases

CTDi5265
RGDi3326 Serpina1

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
HOGENOMiHOG000238521
HOVERGENiHBG005957
InParanoidiP17475
KOiK03984
PhylomeDBiP17475
TreeFamiTF343201

Miscellaneous databases

PROiPR:P17475

Family and domain databases

InterProiView protein in InterPro
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA1AT_RAT
AccessioniPrimary (citable) accession number: P17475
Secondary accession number(s): Q6AYZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 1, 1991
Last modified: May 23, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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