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Protein

Dermonecrotic toxin

Gene

toxA

Organism
Pasteurella multocida
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a dermonecrotic toxin. This osteolytic toxin, induces bone resorption. Potent mitogen. This toxin is associated with the severe progressive form of the atrophic rhinitis, a major respiratory disease in pigs.

Miscellaneous

Closely spaced cysteine and histidine residues may provide the toxin with an affinity for metal.
The sequence shown is that of strain NCTC 12178.

GO - Molecular functioni

  • phospholipase activity Source: AgBase
  • phospholipid binding Source: AgBase
  • toxin activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionToxin

Protein family/group databases

TCDBi1.C.57.3.1 the clostridial cytotoxin (cct) family

Names & Taxonomyi

Protein namesi
Recommended name:
Dermonecrotic toxin
Short name:
DNT
Alternative name(s):
Mitogenic toxin
PMT
Gene namesi
Name:toxA
OrganismiPasteurella multocida
Taxonomic identifieri747 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei402 – 422HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Host membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000726351 – 1285Dermonecrotic toxinAdd BLAST1285

Proteomic databases

PRIDEiP17452

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
VimP201524EBI-9541048,EBI-299269From Mus musculus.

Protein-protein interaction databases

IntActiP17452, 2 interactors

Structurei

Secondary structure

11285
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP17452
SMRiP17452
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17452

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR020972 Dermonecrotic/RTX_toxin_MLD
IPR038765 Papain_like_cys_pep_sf
PfamiView protein in Pfam
PF11647 MLD, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit

Sequencei

Sequence statusi: Complete.

P17452-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTKHFFNSD FTVKGKSADE IFRRLCTDHP DKQLNNVKWK EVFINRFGQM
60 70 80 90 100
MLDTPNPRKI VEKIINEGLE KQGLKNIDPE TTYFNIFSSS DSSDGNVFHY
110 120 130 140 150
NSLSESYRVT DACLMNIFVE RYFDDWDLLN SLASNGIYSV GKEGAYYPDH
160 170 180 190 200
DYGPEYNPVW GPNEQIYHSR VIADILYARS VWDEFKKYFM EYWQKYAQLY
210 220 230 240 250
TEMLSDTFLA MAIQQYTRQT LTDEGFLMVC NTYYGNKEEV QITLLDIYGY
260 270 280 290 300
PSTDIICIEQ KGLPTPKVIL YIPGGTQPFV EFLNTDDLKQ WIAWHLKDNK
310 320 330 340 350
HMVAFRKHFS LKQRQEGETF TGIDKALQYI AEESPEWPAN KYILYNPTHL
360 370 380 390 400
ETENLFNIMM KRTEQRMLED SDVQIRSNSE ATRDYALSLL ETFISQLSAI
410 420 430 440 450
DMLVPAVGIP INFALSATAL GLSSDIVVNG DSYEKRKYGI GSLVQSALFT
460 470 480 490 500
GINLIPVISE TAEILSSFSR TEEDIPAFFT EEQALAQRFE IVEEELHSIS
510 520 530 540 550
PDDPPREITD ENLHKIRLVR LNNENQPLVV LRRLGGNKFI RIEPITFQEI
560 570 580 590 600
KGSLVSEVIN PVTNKTYYVS NAKLLGGSPY SPFRIGLEGV WTPEVLKARA
610 620 630 640 650
SVIGKPIGES YKRILAKLQR IHNSNILDER QGLMHELMEL IDLYEESQPS
660 670 680 690 700
SERLNAFREL RTQLEKALYL PEMEALKKQI LQIPNKGSGA ARFLLRTAMN
710 720 730 740 750
EMAGKTSEST ADLIRFALQD TVISAPFRGY AGAIPEAIDF PVKYVIEDIS
760 770 780 790 800
VFDKIQTNYW ELPAYESWNE GSNSALLPGL LRESQSKGML SKCRIIENSL
810 820 830 840 850
YIGHSYEEMF YSISPYSNQV GGPYELYPFT FFSMLQEVQG DLGFEQAFAT
860 870 880 890 900
RNFFNTLVSD RLSLMENTML LTESFDYTPW DAIYGDINYD EQFAAMSINE
910 920 930 940 950
RIEKCMNTYR GVAFQNSSKS IDFFLNNLTT FIDNGLTEIA ISDLPYDIVQ
960 970 980 990 1000
QEISQFLQGS NEWKTLDAML FNLDKGDING AFRKLLQSAK DNNIKFRAIG
1010 1020 1030 1040 1050
HSDNSVPPFN NPYKSLYYKG NIIAEAIEKL DREGQKFVVF ADSSLLNSTP
1060 1070 1080 1090 1100
GTGRPMPGLV QYLKIPATVV DSDGAWQFLP DVASSRVPIE VTELENWQVL
1110 1120 1130 1140 1150
TPPQGKILGL KQFKLTAGFP TEQSRLPLLE NSVSEDLREE LMQKIDAIKN
1160 1170 1180 1190 1200
DVKMNSLVCM EAGSCDSVSP KVAARLKDMG LEAGMGASIT WWRREGGMEF
1210 1220 1230 1240 1250
SHQMHTTASF KFAGKEFAVD ASHLQFVHDQ LDTTILILPV DDWALEIAQR
1260 1270 1280
NRAINPFVEY VSKTGNMLAL FMPPLFTKPR LTRAL
Length:1,285
Mass (Da):146,383
Last modified:April 27, 2001 - v2
Checksum:iE67A9FCA58C107DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti304A → R in CAA35885 (PubMed:2201870).Curated1
Sequence conflicti775A → R in CAA35885 (PubMed:2201870).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti853F → Y in strain: CVI 47459. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51512 Genomic DNA Translation: CAA35885.1
X52478 Genomic DNA Translation: CAA36717.1
Z28388 Genomic DNA Translation: CAA82233.1
X57775 Genomic DNA Translation: CAA40921.1
AF240778 Genomic DNA Translation: AAL55665.1
PIRiS12998 BTQPD

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51512 Genomic DNA Translation: CAA35885.1
X52478 Genomic DNA Translation: CAA36717.1
Z28388 Genomic DNA Translation: CAA82233.1
X57775 Genomic DNA Translation: CAA40921.1
AF240778 Genomic DNA Translation: AAL55665.1
PIRiS12998 BTQPD

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EBFX-ray1.90X569-1285[»]
2EBHX-ray2.40X569-1285[»]
2EC5X-ray2.60A/B569-1285[»]
2N9VNMR-A589-668[»]
ProteinModelPortaliP17452
SMRiP17452
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP17452, 2 interactors

Protein family/group databases

TCDBi1.C.57.3.1 the clostridial cytotoxin (cct) family

Proteomic databases

PRIDEiP17452

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP17452

Family and domain databases

InterProiView protein in InterPro
IPR020972 Dermonecrotic/RTX_toxin_MLD
IPR038765 Papain_like_cys_pep_sf
PfamiView protein in Pfam
PF11647 MLD, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOXA_PASMD
AccessioniPrimary (citable) accession number: P17452
Secondary accession number(s): Q57008
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: April 27, 2001
Last modified: June 20, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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