UniProtKB - P17452 (TOXA_PASMD)
Protein
Dermonecrotic toxin
Gene
toxA
Organism
Pasteurella multocida
Status
Functioni
This is a dermonecrotic toxin. This osteolytic toxin, induces bone resorption. Potent mitogen. This toxin is associated with the severe progressive form of the atrophic rhinitis, a major respiratory disease in pigs.
Miscellaneous
Closely spaced cysteine and histidine residues may provide the toxin with an affinity for metal.
The sequence shown is that of strain NCTC 12178.
GO - Molecular functioni
- phospholipase activity Source: AgBase
- phospholipid binding Source: AgBase
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- killing by symbiont of host cells Source: CACAO
- pathogenesis Source: UniProtKB-KW
- positive regulation by symbiont of host transcription Source: AgBase
Keywordsi
Molecular function | Toxin |
Biological process | Virulence |
Protein family/group databases
TCDBi | 1.C.57.3.1, the clostridial cytotoxin (cct) family |
Names & Taxonomyi
Protein namesi | Recommended name: Dermonecrotic toxinShort name: DNT Alternative name(s): Mitogenic toxin PMT |
Gene namesi | Name:toxA |
Organismi | Pasteurella multocida |
Taxonomic identifieri | 747 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella |
Subcellular locationi
- Cytoplasm Curated
- Secreted Curated
- Host membrane Curated; Single-pass membrane protein Curated
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 402 – 422 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
- extracellular region Source: UniProtKB-SubCell
- host cell plasma membrane Source: AgBase
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, Host membrane, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000072635 | 1 – 1285 | Dermonecrotic toxinAdd BLAST | 1285 |
Interactioni
Binary interactionsi
P17452
With | #Exp. | IntAct |
---|---|---|
Vim [P20152] from Mus musculus. | 4 | EBI-9541048,EBI-299269 |
Protein-protein interaction databases
IntActi | P17452, 2 interactors |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P17452 |
SMRi | P17452 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P17452 |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
InterProi | View protein in InterPro IPR020972, Dermonecrotic/RTX_toxin_MLD IPR038765, Papain-like_cys_pep_sf |
Pfami | View protein in Pfam PF11647, MLD, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
i Sequence
Sequence statusi: Complete.
P17452-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKTKHFFNSD FTVKGKSADE IFRRLCTDHP DKQLNNVKWK EVFINRFGQM
60 70 80 90 100
MLDTPNPRKI VEKIINEGLE KQGLKNIDPE TTYFNIFSSS DSSDGNVFHY
110 120 130 140 150
NSLSESYRVT DACLMNIFVE RYFDDWDLLN SLASNGIYSV GKEGAYYPDH
160 170 180 190 200
DYGPEYNPVW GPNEQIYHSR VIADILYARS VWDEFKKYFM EYWQKYAQLY
210 220 230 240 250
TEMLSDTFLA MAIQQYTRQT LTDEGFLMVC NTYYGNKEEV QITLLDIYGY
260 270 280 290 300
PSTDIICIEQ KGLPTPKVIL YIPGGTQPFV EFLNTDDLKQ WIAWHLKDNK
310 320 330 340 350
HMVAFRKHFS LKQRQEGETF TGIDKALQYI AEESPEWPAN KYILYNPTHL
360 370 380 390 400
ETENLFNIMM KRTEQRMLED SDVQIRSNSE ATRDYALSLL ETFISQLSAI
410 420 430 440 450
DMLVPAVGIP INFALSATAL GLSSDIVVNG DSYEKRKYGI GSLVQSALFT
460 470 480 490 500
GINLIPVISE TAEILSSFSR TEEDIPAFFT EEQALAQRFE IVEEELHSIS
510 520 530 540 550
PDDPPREITD ENLHKIRLVR LNNENQPLVV LRRLGGNKFI RIEPITFQEI
560 570 580 590 600
KGSLVSEVIN PVTNKTYYVS NAKLLGGSPY SPFRIGLEGV WTPEVLKARA
610 620 630 640 650
SVIGKPIGES YKRILAKLQR IHNSNILDER QGLMHELMEL IDLYEESQPS
660 670 680 690 700
SERLNAFREL RTQLEKALYL PEMEALKKQI LQIPNKGSGA ARFLLRTAMN
710 720 730 740 750
EMAGKTSEST ADLIRFALQD TVISAPFRGY AGAIPEAIDF PVKYVIEDIS
760 770 780 790 800
VFDKIQTNYW ELPAYESWNE GSNSALLPGL LRESQSKGML SKCRIIENSL
810 820 830 840 850
YIGHSYEEMF YSISPYSNQV GGPYELYPFT FFSMLQEVQG DLGFEQAFAT
860 870 880 890 900
RNFFNTLVSD RLSLMENTML LTESFDYTPW DAIYGDINYD EQFAAMSINE
910 920 930 940 950
RIEKCMNTYR GVAFQNSSKS IDFFLNNLTT FIDNGLTEIA ISDLPYDIVQ
960 970 980 990 1000
QEISQFLQGS NEWKTLDAML FNLDKGDING AFRKLLQSAK DNNIKFRAIG
1010 1020 1030 1040 1050
HSDNSVPPFN NPYKSLYYKG NIIAEAIEKL DREGQKFVVF ADSSLLNSTP
1060 1070 1080 1090 1100
GTGRPMPGLV QYLKIPATVV DSDGAWQFLP DVASSRVPIE VTELENWQVL
1110 1120 1130 1140 1150
TPPQGKILGL KQFKLTAGFP TEQSRLPLLE NSVSEDLREE LMQKIDAIKN
1160 1170 1180 1190 1200
DVKMNSLVCM EAGSCDSVSP KVAARLKDMG LEAGMGASIT WWRREGGMEF
1210 1220 1230 1240 1250
SHQMHTTASF KFAGKEFAVD ASHLQFVHDQ LDTTILILPV DDWALEIAQR
1260 1270 1280
NRAINPFVEY VSKTGNMLAL FMPPLFTKPR LTRAL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 304 | A → R in CAA35885 (PubMed:2201870).Curated | 1 | |
Sequence conflicti | 775 | A → R in CAA35885 (PubMed:2201870).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 853 | F → Y in strain: CVI 47459. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X51512 Genomic DNA Translation: CAA35885.1 X52478 Genomic DNA Translation: CAA36717.1 Z28388 Genomic DNA Translation: CAA82233.1 X57775 Genomic DNA Translation: CAA40921.1 AF240778 Genomic DNA Translation: AAL55665.1 |
PIRi | S12998, BTQPD |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X51512 Genomic DNA Translation: CAA35885.1 X52478 Genomic DNA Translation: CAA36717.1 Z28388 Genomic DNA Translation: CAA82233.1 X57775 Genomic DNA Translation: CAA40921.1 AF240778 Genomic DNA Translation: AAL55665.1 |
PIRi | S12998, BTQPD |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2EBF | X-ray | 1.90 | X | 569-1285 | [»] | |
2EBH | X-ray | 2.40 | X | 569-1285 | [»] | |
2EC5 | X-ray | 2.60 | A/B | 569-1285 | [»] | |
2N9V | NMR | - | A | 589-668 | [»] | |
BMRBi | P17452 | |||||
SMRi | P17452 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P17452, 2 interactors |
Protein family/group databases
TCDBi | 1.C.57.3.1, the clostridial cytotoxin (cct) family |
Miscellaneous databases
EvolutionaryTracei | P17452 |
Family and domain databases
InterProi | View protein in InterPro IPR020972, Dermonecrotic/RTX_toxin_MLD IPR038765, Papain-like_cys_pep_sf |
Pfami | View protein in Pfam PF11647, MLD, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TOXA_PASMD | |
Accessioni | P17452Primary (citable) accession number: P17452 Secondary accession number(s): Q57008 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | April 27, 2001 | |
Last modified: | December 2, 2020 | |
This is version 99 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references