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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciEcoCyc:NACGLCTRANS-MONOMER
MetaCyc:NACGLCTRANS-MONOMER
BRENDAi2.4.1.227 2026
UniPathwayi
UPA00219

Protein family/group databases

CAZyiGT28 Glycosyltransferase Family 28

Chemistry databases

SwissLipidsiSLP:000001814

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:b0090, JW0088
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10623 murG

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3596078
DrugBankiDB02196 Uridine-Diphosphate-N-Acetylgalactosamine

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001091702 – 355UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseAdd BLAST354

Proteomic databases

PaxDbiP17443
PRIDEiP17443

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
yfiFP0AGJ53EBI-554881,EBI-547368

Protein-protein interaction databases

BioGridi4261859, 572 interactors
DIPiDIP-10282N
IntActiP17443, 27 interactors
STRINGi316385.ECDH10B_0072

Structurei

Secondary structure

1355
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP17443
SMRiP17443
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17443

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVQ Bacteria
COG0707 LUCA
HOGENOMiHOG000218321
InParanoidiP17443
KOiK02563
OMAiHQTKNAM
PhylomeDBiP17443

Family and domain databases

CDDicd03785 GT1_MurG, 1 hit
HAMAPiMF_00033 MurG, 1 hit
InterProiView protein in InterPro
IPR006009 GlcNAc_MurG
IPR007235 Glyco_trans_28_C
IPR004276 GlycoTrans_28_N
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF03033 Glyco_transf_28, 1 hit
TIGRFAMsiTIGR01133 murG, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17443-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGQGKRLMV MAGGTGGHVF PGLAVAHHLM AQGWQVRWLG TADRMEADLV
60 70 80 90 100
PKHGIEIDFI RISGLRGKGI KALIAAPLRI FNAWRQARAI MKAYKPDVVL
110 120 130 140 150
GMGGYVSGPG GLAAWSLGIP VVLHEQNGIA GLTNKWLAKI ATKVMQAFPG
160 170 180 190 200
AFPNAEVVGN PVRTDVLALP LPQQRLAGRE GPVRVLVVGG SQGARILNQT
210 220 230 240 250
MPQVAAKLGD SVTIWHQSGK GSQQSVEQAY AEAGQPQHKV TEFIDDMAAA
260 270 280 290 300
YAWADVVVCR SGALTVSEIA AAGLPALFVP FQHKDRQQYW NALPLEKAGA
310 320 330 340 350
AKIIEQPQLS VDAVANTLAG WSRETLLTMA ERARAASIPD ATERVANEVS

RVARA
Length:355
Mass (Da):37,815
Last modified:January 23, 2007 - v3
Checksum:iDE347361A7B9293A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52644 Genomic DNA Translation: CAA36867.1
X52540 Genomic DNA Translation: CAA36776.1
X55034 Genomic DNA Translation: CAA38867.1
U00096 Genomic DNA Translation: AAC73201.1
AP009048 Genomic DNA Translation: BAB96658.1
PIRiJQ0544 BVECMG
RefSeqiNP_414632.1, NC_000913.3
WP_000016560.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73201; AAC73201; b0090
BAB96658; BAB96658; BAB96658
GeneIDi946321
KEGGiecj:JW0088
eco:b0090
PATRICifig|1411691.4.peg.2190

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52644 Genomic DNA Translation: CAA36867.1
X52540 Genomic DNA Translation: CAA36776.1
X55034 Genomic DNA Translation: CAA38867.1
U00096 Genomic DNA Translation: AAC73201.1
AP009048 Genomic DNA Translation: BAB96658.1
PIRiJQ0544 BVECMG
RefSeqiNP_414632.1, NC_000913.3
WP_000016560.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F0KX-ray1.90A/B1-355[»]
1NLMX-ray2.50A/B2-355[»]
ProteinModelPortaliP17443
SMRiP17443
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261859, 572 interactors
DIPiDIP-10282N
IntActiP17443, 27 interactors
STRINGi316385.ECDH10B_0072

Chemistry databases

ChEMBLiCHEMBL3596078
DrugBankiDB02196 Uridine-Diphosphate-N-Acetylgalactosamine
SwissLipidsiSLP:000001814

Protein family/group databases

CAZyiGT28 Glycosyltransferase Family 28

Proteomic databases

PaxDbiP17443
PRIDEiP17443

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73201; AAC73201; b0090
BAB96658; BAB96658; BAB96658
GeneIDi946321
KEGGiecj:JW0088
eco:b0090
PATRICifig|1411691.4.peg.2190

Organism-specific databases

EchoBASEiEB0618
EcoGeneiEG10623 murG

Phylogenomic databases

eggNOGiENOG4105DVQ Bacteria
COG0707 LUCA
HOGENOMiHOG000218321
InParanoidiP17443
KOiK02563
OMAiHQTKNAM
PhylomeDBiP17443

Enzyme and pathway databases

UniPathwayi
UPA00219

BioCyciEcoCyc:NACGLCTRANS-MONOMER
MetaCyc:NACGLCTRANS-MONOMER
BRENDAi2.4.1.227 2026

Miscellaneous databases

EvolutionaryTraceiP17443
PROiPR:P17443

Family and domain databases

CDDicd03785 GT1_MurG, 1 hit
HAMAPiMF_00033 MurG, 1 hit
InterProiView protein in InterPro
IPR006009 GlcNAc_MurG
IPR007235 Glyco_trans_28_C
IPR004276 GlycoTrans_28_N
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF03033 Glyco_transf_28, 1 hit
TIGRFAMsiTIGR01133 murG, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMURG_ECOLI
AccessioniPrimary (citable) accession number: P17443
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 176 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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