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UniProtKB - P17439 (GLCM_MOUSE)

Entry version 174 (29 Sep 2021)
Sequence version 1 (01 Aug 1990)
Previous versions | rss
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Protein

Lysosomal acid glucosylceramidase

Gene

Gba

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose (PubMed:24211208).

Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes (PubMed:27378698).

Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation (By similarity).

Also plays a role in cholesterol metabolism (PubMed:24211208).

May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol (PubMed:24211208).

The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction (By similarity).

Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide (By similarity).

Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol (By similarity).

By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by conduritol B epoxide/CBE.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: cholesterol metabolism

This protein is involved in the pathway cholesterol metabolism, which is part of Steroid metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway cholesterol metabolism and in Steroid metabolism.

Pathwayi: Sphingolipid metabolism

This protein is involved in Sphingolipid metabolism.1 Publication
View all proteins of this organism that are known to be involved in Sphingolipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei254Proton donorBy similarity1
Active sitei358NucleophileBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Glycosyltransferase, Hydrolase, Transferase
Biological processCholesterol metabolism, Lipid metabolism, Sphingolipid metabolism, Steroid metabolism, Sterol metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.2.1.45, 3474

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-1660662, Glycosphingolipid metabolism

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00296

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GH30, Glycoside Hydrolase Family 30

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001930

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysosomal acid glucosylceramidaseCurated (EC:3.2.1.452 Publications)
Short name:
Lysosomal acid GCase1 Publication
Alternative name(s):
Acid beta-glucosidase
Beta-glucocerebrosidase
Cholesterol glucosyltransferase1 Publication (EC:2.4.1.-1 Publication)
Short name:
SGTase1 Publication
Cholesteryl-beta-glucosidaseBy similarity (EC:3.2.1.-By similarity)
D-glucosyl-N-acylsphingosine glucohydrolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GbaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:95665, Gba

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000028048

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Homozygous knockout mice die within 24 hours of birth (PubMed:1594045). They are under weight, respire abnormally and show rapidly progressing cyanosis (PubMed:1594045). Feeding and movement are also decreased in these mice (PubMed:1594045). Macrophages accumulating glucosylceramides in tubular lysosomal deposits are found in liver (in Kupffer cells), bone marrow, spleen and brain (PubMed:1594045). Hematopoietic stem cells conditional knockout of GBA, leads to widespread and organ-specific dysfunction of immune cells. Thymus shows the earliest alteration with features of impaired T-cell maturation, aberrant B-cell recruitment, enhanced antigen presentation, and impaired egress of mature thymocytes (PubMed:22665763).2 Publications

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2278

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19By similarityAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001217820 – 515Lysosomal acid glucosylceramidaseAdd BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi23 ↔ 35By similarity
Disulfide bondi37 ↔ 42By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) (high mannose) asparagine1 Publication1
Glycosylationi289N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi480N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P17439

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P17439

MaxQB - The MaxQuant DataBase

More...MaxQBi		P17439

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P17439

PeptideAtlas

More...PeptideAtlasi		P17439

PRoteomics IDEntifications database

More...PRIDEi		P17439

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		268831

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2339, 3 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P17439, 5 sites, 3 N-linked glycans (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P17439

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P17439

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P17439

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000028048, Expressed in adult mammalian kidney and 336 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P17439, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with saposin-C.

Interacts with SCARB2.

Interacts with TCP1.

Interacts with GRN; this interaction prevents aggregation of GBA-SCARB2 complex via interaction with HSPA1A upon stress (PubMed:27789271).

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		199844, 11 interactors

Protein interaction database and analysis system

More...IntActi		P17439, 3 interactors

Molecular INTeraction database

More...MINTi		P17439

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000130660

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P17439

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P17439, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P17439

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 30 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2566, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000009464

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014379_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P17439

Identification of Orthologs from Complete Genome Data

More...OMAi		FGGIAWH

Database of Orthologous Groups

More...OrthoDBi		644299at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P17439

TreeFam database of animal gene trees

More...TreeFami		TF314254

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033452, GH30_C
IPR001139, Glyco_hydro_30
IPR033453, Glyco_hydro_30_TIM-barrel
IPR017853, Glycoside_hydrolase_SF

The PANTHER Classification System

More...PANTHERi		PTHR11069, PTHR11069, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02055, Glyco_hydro_30, 1 hit
PF17189, Glyco_hydro_30C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00843, GLHYDRLASE30

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51445, SSF51445, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P17439-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAARLIGFFL FQAVSWAYGA QPCIPKSFGY SSVVCVCNAS YCDSLDPVTL 
        60         70         80         90        100
PALGTFSRYE STRRGRRMEL SVGAIQANRT GTGLLLTLQP EKKFQKVKGF 
       110        120        130        140        150
GGAMTDATAL NILALSPPTQ KLLLRSYFST NGIEYNIIRV PMASCDFSIR 
       160        170        180        190        200
VYTYADTPND FQLSNFSLPE EDTKLKIPLI HQALKMSSRP ISLFASPWTS 
       210        220        230        240        250
PTWLKTNGRV NGKGSLKGQP GDIFHQTWAN YFVKFLDAYA KYGLRFWAVT 
       260        270        280        290        300
AENEPTAGLF TGYPFQCLGF TPEHQRDFIS RDLGPALANS SHDVKLLMLD 
       310        320        330        340        350
DQRLLLPRWA EVVLSDPEAA KYVHGIAVHW YMDFLAPAKA TLGETHRLFP 
       360        370        380        390        400
NTMLFASEAC VGSKFWEQSV RLGSWDRGMQ YSHSIITNLL YHVTGWTDWN 
       410        420        430        440        450
LALNPEGGPN WVRNFVDSPI IVDIPKDAFY KQPMFYHLGH FSKFIPEGSQ 
       460        470        480        490        500
RVALVASEST DLETVALLRP DGSAVVVVLN RSSEDVPLTI SDPDLGFLET 
       510 
VSPGYSIHTY LWRRQ
Length:515
Mass (Da):57,622
Last modified:August 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7CCD9176085FE2CB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JDK2A0A0G2JDK2_MOUSE
Glucosylceramidase
Gba
388Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M24119 mRNA Translation: AAA37671.1
AY115108 Genomic DNA Translation: AAM66757.1
AK082767 mRNA Translation: BAC38609.1
BC006663 mRNA Translation: AAH06663.1
M89949 Genomic DNA Translation: AAA37665.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS17493.1

Protein sequence database of the Protein Information Resource

More...PIRi		A32931

NCBI Reference Sequences

More...RefSeqi		NP_001070879.1, NM_001077411.2
NP_032120.1, NM_008094.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000077367; ENSMUSP00000076589; ENSMUSG00000028048
ENSMUST00000167998; ENSMUSP00000130660; ENSMUSG00000028048

Database of genes from NCBI RefSeq genomes

More...GeneIDi		14466

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:14466

UCSC genome browser

More...UCSCi		uc008pyb.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24119 mRNA Translation: AAA37671.1
AY115108 Genomic DNA Translation: AAM66757.1
AK082767 mRNA Translation: BAC38609.1
BC006663 mRNA Translation: AAH06663.1
M89949 Genomic DNA Translation: AAA37665.1
CCDSiCCDS17493.1
PIRiA32931
RefSeqiNP_001070879.1, NM_001077411.2
NP_032120.1, NM_008094.5

3D structure databases

SMRiP17439
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi199844, 11 interactors
IntActiP17439, 3 interactors
MINTiP17439
STRINGi10090.ENSMUSP00000130660

Chemistry databases

BindingDBiP17439
ChEMBLiCHEMBL2278
SwissLipidsiSLP:000001930

Protein family/group databases

CAZyiGH30, Glycoside Hydrolase Family 30

PTM databases

GlyConnecti2339, 3 N-Linked glycans (3 sites)
GlyGeniP17439, 5 sites, 3 N-linked glycans (3 sites)
iPTMnetiP17439
PhosphoSitePlusiP17439
SwissPalmiP17439

Proteomic databases

EPDiP17439
jPOSTiP17439
MaxQBiP17439
PaxDbiP17439
PeptideAtlasiP17439
PRIDEiP17439
ProteomicsDBi268831

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1678, 467 antibodies

The DNASU plasmid repository

More...DNASUi		14466

Genome annotation databases

EnsembliENSMUST00000077367; ENSMUSP00000076589; ENSMUSG00000028048
ENSMUST00000167998; ENSMUSP00000130660; ENSMUSG00000028048
GeneIDi14466
KEGGimmu:14466
UCSCiuc008pyb.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2629
MGIiMGI:95665, Gba
VEuPathDBiHostDB:ENSMUSG00000028048

Phylogenomic databases

eggNOGiKOG2566, Eukaryota
GeneTreeiENSGT00390000009464
HOGENOMiCLU_014379_1_2_1
InParanoidiP17439
OMAiFGGIAWH
OrthoDBi644299at2759
PhylomeDBiP17439
TreeFamiTF314254

Enzyme and pathway databases

UniPathwayiUPA00296
BRENDAi3.2.1.45, 3474
ReactomeiR-MMU-1660662, Glycosphingolipid metabolism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		14466, 2 hits in 64 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Gba, mouse

Protein Ontology

More...PROi		PR:P17439
RNActiP17439, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000028048, Expressed in adult mammalian kidney and 336 other tissues
GenevisibleiP17439, MM

Family and domain databases

InterProiView protein in InterPro
IPR033452, GH30_C
IPR001139, Glyco_hydro_30
IPR033453, Glyco_hydro_30_TIM-barrel
IPR017853, Glycoside_hydrolase_SF
PANTHERiPTHR11069, PTHR11069, 1 hit
PfamiView protein in Pfam
PF02055, Glyco_hydro_30, 1 hit
PF17189, Glyco_hydro_30C, 1 hit
PRINTSiPR00843, GLHYDRLASE30
SUPFAMiSSF51445, SSF51445, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLCM_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17439
Secondary accession number(s): Q78NR7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: September 29, 2021
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families
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