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Entry version 150 (29 Sep 2021)
Sequence version 2 (01 Feb 1996)
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Protein

Nitrogen regulatory protein areA

Gene

areA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription activator that binds the consensus DNA element 5'-CGATAG-3' and mediates nitrogen metabolite repression. Activates the transcription of uapA.

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri673 – 697GATA-typePROSITE-ProRule annotationAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi721 – 742H-T-H motifSequence analysisAdd BLAST22

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processNitrate assimilation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nitrogen regulatory protein areA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:areA
ORF Names:AN8667
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri227321 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Nidulantes
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000560 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III
  • UP000005890 Componenti: Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:AN8667

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000834651 – 876Nitrogen regulatory protein areAAdd BLAST876

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P17429

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated in nitrogen-sufficient conditions and up-regulated in nitrogen-limiting conditions.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with nmrA.

4 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
162425.CADANIAP00006378

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1876
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
P17429

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P17429

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P17429

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 65DisorderedSequence analysisAdd BLAST65
Regioni137 – 159DisorderedSequence analysisAdd BLAST23
Regioni192 – 248DisorderedSequence analysisAdd BLAST57
Regioni393 – 413DisorderedSequence analysisAdd BLAST21
Regioni451 – 498DisorderedSequence analysisAdd BLAST48
Regioni573 – 672DisorderedSequence analysisAdd BLAST100
Regioni724 – 856DisorderedSequence analysisAdd BLAST133

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi197 – 211Polar residuesSequence analysisAdd BLAST15
Compositional biasi393 – 410Polar residuesSequence analysisAdd BLAST18
Compositional biasi577 – 597Polar residuesSequence analysisAdd BLAST21
Compositional biasi598 – 613Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi614 – 672Polar residuesSequence analysisAdd BLAST59
Compositional biasi724 – 771Polar residuesSequence analysisAdd BLAST48
Compositional biasi789 – 804Polar residuesSequence analysisAdd BLAST16

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri673 – 697GATA-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1601, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009509_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P17429

Identification of Orthologs from Complete Genome Data

More...
OMAi
WRMMAMS

Database of Orthologous Groups

More...
OrthoDBi
124231at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00202, ZnF_GATA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013860, AreA_GATA
IPR011420, AreA_N
IPR039355, Transcription_factor_GATA
IPR000679, Znf_GATA
IPR013088, Znf_NHR/GATA

The PANTHER Classification System

More...
PANTHERi
PTHR10071, PTHR10071, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07573, AreA_N, 1 hit
PF08550, DUF1752, 1 hit
PF00320, GATA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00619, GATAZNFINGER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00401, ZnF_GATA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00344, GATA_ZN_FINGER_1, 1 hit
PS50114, GATA_ZN_FINGER_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P17429-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGLTLGGGS GRVRPTQAAA AFPTSHDFAD PDRSSVARNA NRPSRRFAAP
60 70 80 90 100
PQLSDDFSLE SPTDSAQVHD NLLQDALFPE WKANSPRGVD SPDEMQKKDP
110 120 130 140 150
LATQIWKLYS RTKAQLPNQE RMENLTWRMM ALSLRRQERE RAQQQARASS
160 170 180 190 200
QKSPVPGMSG IAQLRLSDRV SNTPTTTADT VSDAMNLDDF IIPFSPSDHP
210 220 230 240 250
SPSTTKASEA TTGAIPIKAR RDQSASEATP VPASFPHPAQ DQRRESEFGY
260 270 280 290 300
VPRRVRKTSI DERQFFNLQI PSRKRPAESS PHVPPVSTSM LAHDPDFSHA
310 320 330 340 350
VPEYTLDTSH GLSLQNQMNA QQLANAQNHT SPNMAFALDT FNLGDDPILP
360 370 380 390 400
SAGPYQQQFT FSPSESPMTS GNPFANLYAQ TPIASSLNST DFFSPPPSGY
410 420 430 440 450
QSTASTPQPA YDGEHSKYFD MPVDARSQRR VVPAYITQRS SNLSASLQPR
460 470 480 490 500
YMYNQGGSSQ DITQQNAHMG AQSSSMQSPG FSIPQHVDPT QVLNPNEFNG
510 520 530 540 550
NHAAMFSFGA DSDVEDDDGN QFSAGGLAMP AEFGDDSISD MNSNMAWETS
560 570 580 590 600
YPNSFQSLPA FAAQHRKHVT IGSADMMDTP SEWNQGGSLG RTHESAASVS
610 620 630 640 650
EVRNRDQDPR RQKIARTSST PNTAQLLRQS MQNQSSHTSP NTPPESGLNS
660 670 680 690 700
AAPSRPASPG GTKNGEQNGP TTCTNCFTQT TPLWRRNPEG QPLCNACGLF
710 720 730 740 750
LKLHGVVRPL SLKTDVIKKR NRNSANSLAV GSSRVSKKSA RKNSVQQVTP
760 770 780 790 800
TAPTSSRAQS NTTSESPPAM PGSSGRGSGV VPIAAAPPKS SSAATTSPGT
810 820 830 840 850
NNGCGAVQVA PKRQRRLEKA SDVDMAESPS STSSGGRSKV VPLAPAMPPA
860 870
AVNPANHSIA AGQGASQEWE WLTMSL
Length:876
Mass (Da):94,196
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9ADC2273EE536F98
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X52491 Genomic DNA Translation: CAA36731.1
AACD01000158 Genomic DNA Translation: EAA60701.1
BN001303 Genomic DNA Translation: CBF78221.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A57988

NCBI Reference Sequences

More...
RefSeqi
XP_681936.1, XM_676844.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CBF78221; CBF78221; ANIA_08667
EAA60701; EAA60701; AN8667.2

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2868505

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ani:AN8667.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52491 Genomic DNA Translation: CAA36731.1
AACD01000158 Genomic DNA Translation: EAA60701.1
BN001303 Genomic DNA Translation: CBF78221.1
PIRiA57988
RefSeqiXP_681936.1, XM_676844.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VUSX-ray2.60I/J/K/L/M/N/O/P670-712[»]
2VUTX-ray2.30I/J/K/L/M/N/O/P670-712[»]
2VUUX-ray2.80I/J/K/L/M/N/O/P670-712[»]
4GATNMR-A663-727[»]
5GATNMR-A663-727[»]
6GATNMR-A663-727[»]
7GATNMR-A663-727[»]
BMRBiP17429
SMRiP17429
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi162425.CADANIAP00006378

Proteomic databases

PRIDEiP17429

Genome annotation databases

EnsemblFungiiCBF78221; CBF78221; ANIA_08667
EAA60701; EAA60701; AN8667.2
GeneIDi2868505
KEGGiani:AN8667.2

Organism-specific databases

VEuPathDBiFungiDB:AN8667

Phylogenomic databases

eggNOGiKOG1601, Eukaryota
HOGENOMiCLU_009509_0_0_1
InParanoidiP17429
OMAiWRMMAMS
OrthoDBi124231at2759

Miscellaneous databases

EvolutionaryTraceiP17429

Family and domain databases

CDDicd00202, ZnF_GATA, 1 hit
Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR013860, AreA_GATA
IPR011420, AreA_N
IPR039355, Transcription_factor_GATA
IPR000679, Znf_GATA
IPR013088, Znf_NHR/GATA
PANTHERiPTHR10071, PTHR10071, 1 hit
PfamiView protein in Pfam
PF07573, AreA_N, 1 hit
PF08550, DUF1752, 1 hit
PF00320, GATA, 1 hit
PRINTSiPR00619, GATAZNFINGER
SMARTiView protein in SMART
SM00401, ZnF_GATA, 1 hit
PROSITEiView protein in PROSITE
PS00344, GATA_ZN_FINGER_1, 1 hit
PS50114, GATA_ZN_FINGER_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAREA_EMENI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17429
Secondary accession number(s): C8VA54, Q5ASR3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: February 1, 1996
Last modified: September 29, 2021
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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