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Protein

Fumarate reductase cytochrome b subunit

Gene

frdC

Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Iron (heme axial ligand)1
Metal bindingi93Iron (heme axial ligand)1
Metal bindingi143Iron (heme axial ligand)1
Metal bindingi182Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport, Tricarboxylic acid cycle
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciWSUC273121:G1GTD-800-MONOMER

Protein family/group databases

TCDBi3.D.10.1.3 the prokaryotic succinate dehydrogenase (sdh) family

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate reductase cytochrome b subunit
Gene namesi
Name:frdC
Ordered Locus Names:WS0832
OrganismiWolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) (Vibrio succinogenes)
Taxonomic identifieri273121 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeWolinella
Proteomesi
  • UP000000422 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30CytoplasmicAdd BLAST30
Transmembranei31 – 52HelicalAdd BLAST22
Topological domaini53 – 76PeriplasmicAdd BLAST24
Transmembranei77 – 98HelicalAdd BLAST22
Topological domaini99 – 124CytoplasmicAdd BLAST26
Transmembranei125 – 149HelicalAdd BLAST25
Topological domaini150 – 165PeriplasmicAdd BLAST16
Transmembranei166 – 188HelicalAdd BLAST23
Topological domaini189 – 206CytoplasmicAdd BLAST18
Transmembranei207 – 230HelicalAdd BLAST24
Topological domaini231 – 256PeriplasmicAdd BLAST26

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi44H → A: Loss of fumarate reductase activity. 1 Publication1
Mutagenesisi93H → A: Loss of fumarate reductase activity. 1 Publication1
Mutagenesisi114H → A: Slight reduction in fumarate reductase activity. 1 Publication1
Mutagenesisi120H → A: Reduction in fumarate reductase activity. 1 Publication1
Mutagenesisi143H → A, M or K: Loss of fumarate reductase activity. 1 Publication1
Mutagenesisi182H → A: Loss of fumarate reductase activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001586851 – 256Fumarate reductase cytochrome b subunitAdd BLAST256

Interactioni

Subunit structurei

Part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur protein, and cytochrome b-556.

Protein-protein interaction databases

STRINGi273121.WS0832

Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP17413
SMRiP17413
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17413

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108S24 Bacteria
COG2009 LUCA
HOGENOMiHOG000286335
KOiK00246
OMAiLLAHLHF
OrthoDBiPOG091H2D6G

Family and domain databases

CDDicd00581 QFR_TypeB_TM, 1 hit
Gene3Di1.20.1300.10, 1 hit
InterProiView protein in InterPro
IPR004224 Fum_red_B_TM
IPR034804 SQR/QFR_C/D
IPR000701 SuccDH_FuR_B_TM-su
PfamiView protein in Pfam
PF01127 Sdh_cyt, 1 hit
PIRSFiPIRSF000177 Fumar_rd_cyt_b, 1 hit
SUPFAMiSSF81343 SSF81343, 1 hit

Sequencei

Sequence statusi: Complete.

P17413-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNESILESY SGVTPERKKS RMPAKLDWWQ SATGLFLGLF MIGHMFFVST
60 70 80 90 100
ILLGDNVMLW VTKKFELDFI FEGGKPIVVS FLAAFVFAVF IAHAFLAMRK
110 120 130 140 150
FPINYRQYLT FKTHKDLMRH GDTTLWWIQA MTGFAMFFLG SVHLYIMMTQ
160 170 180 190 200
PQTIGPVSSS FRMVSEWMWP LYLVLLFAVE LHGSVGLYRL AVKWGWFDGE
210 220 230 240 250
TPDKTRANLK KLKTLMSAFL IVLGLLTFGA YVKKGLEQTD PNIDYKYFDY

KRTHHR
Length:256
Mass (Da):29,723
Last modified:August 1, 1990 - v1
Checksum:iE8459B884BA9E20B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000662 Genomic DNA Translation: CAA04213.1
BX571659 Genomic DNA Translation: CAE09943.1
PIRiS10164
RefSeqiWP_011138740.1, NC_005090.1

Genome annotation databases

EnsemblBacteriaiCAE09943; CAE09943; WS0832
KEGGiwsu:WS0832

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000662 Genomic DNA Translation: CAA04213.1
BX571659 Genomic DNA Translation: CAE09943.1
PIRiS10164
RefSeqiWP_011138740.1, NC_005090.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E7PX-ray3.10C/F/I/L1-256[»]
1QLBX-ray2.33C/F1-256[»]
2BS2X-ray1.78C/F1-254[»]
2BS3X-ray2.19C/F1-256[»]
2BS4X-ray2.76C/F1-256[»]
ProteinModelPortaliP17413
SMRiP17413
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273121.WS0832

Protein family/group databases

TCDBi3.D.10.1.3 the prokaryotic succinate dehydrogenase (sdh) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE09943; CAE09943; WS0832
KEGGiwsu:WS0832

Phylogenomic databases

eggNOGiENOG4108S24 Bacteria
COG2009 LUCA
HOGENOMiHOG000286335
KOiK00246
OMAiLLAHLHF
OrthoDBiPOG091H2D6G

Enzyme and pathway databases

BioCyciWSUC273121:G1GTD-800-MONOMER

Miscellaneous databases

EvolutionaryTraceiP17413

Family and domain databases

CDDicd00581 QFR_TypeB_TM, 1 hit
Gene3Di1.20.1300.10, 1 hit
InterProiView protein in InterPro
IPR004224 Fum_red_B_TM
IPR034804 SQR/QFR_C/D
IPR000701 SuccDH_FuR_B_TM-su
PfamiView protein in Pfam
PF01127 Sdh_cyt, 1 hit
PIRSFiPIRSF000177 Fumar_rd_cyt_b, 1 hit
SUPFAMiSSF81343 SSF81343, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFRDC_WOLSU
AccessioniPrimary (citable) accession number: P17413
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: February 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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