UniProtKB - P17342 (ANPRC_HUMAN)
Atrial natriuretic peptide receptor 3
NPR3
Functioni
Miscellaneous
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 106 | Chloride | 1 | |
Binding sitei | 135 | Chloride; via amide nitrogen | 1 | |
Binding sitei | 136 | Chloride; via amide nitrogen | 1 |
GO - Molecular functioni
- chloride ion binding Source: CAFA
- G protein-coupled peptide receptor activity Source: BHF-UCL
- hormone binding Source: CAFA
- natriuretic peptide receptor activity Source: UniProtKB
- peptide binding Source: CAFA
- peptide hormone binding Source: UniProtKB
- protein homodimerization activity Source: CAFA
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: Ensembl
- negative regulation of adenylate cyclase activity Source: Ensembl
- negative regulation of cold-induced thermogenesis Source: YuBioLab
- negative regulation of smooth muscle cell proliferation Source: Ensembl
- osteoclast proliferation Source: UniProtKB
- pancreatic juice secretion Source: Ensembl
- phosphatidylinositol-mediated signaling Source: Ensembl
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
- positive regulation of nitric-oxide synthase activity Source: BHF-UCL
- positive regulation of urine volume Source: UniProtKB
- regulation of blood pressure Source: UniProtKB
- regulation of osteoblast proliferation Source: UniProtKB
- skeletal system development Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Ligand | Chloride |
Enzyme and pathway databases
PathwayCommonsi | P17342 |
Names & Taxonomyi
Protein namesi | Recommended name: Atrial natriuretic peptide receptor 3Alternative name(s): Atrial natriuretic peptide clearance receptor Atrial natriuretic peptide receptor type C Short name: ANP-C Short name: ANPR-C Short name: NPR-C |
Gene namesi | Name:NPR3 Synonyms:ANPRC, C5orf23, NPRC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7945, NPR3 |
MIMi | 108962, gene |
neXtProti | NX_P17342 |
VEuPathDBi | HostDB:ENSG00000113389.15 |
Subcellular locationi
Other locations
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: BHF-UCL
Other locations
- protein-containing complex Source: CAFA
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 481 | ExtracellularSequence analysisAdd BLAST | 455 | |
Transmembranei | 482 – 504 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 505 – 541 | CytoplasmicSequence analysisAdd BLAST | 37 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 4883 |
OpenTargetsi | ENSG00000113389 |
PharmGKBi | PA31737 |
Miscellaneous databases
Pharosi | P17342, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2247 |
DrugBanki | DB04899, Nesiritide |
GuidetoPHARMACOLOGYi | 1749 |
Genetic variation databases
BioMutai | NPR3 |
DMDMi | 27735161 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000012370 | 27 – 541 | Atrial natriuretic peptide receptor 3Add BLAST | 515 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 86 | N-linked (GlcNAc...) (complex) asparagine2 Publications | 1 | |
Disulfide bondi | 108 ↔ 136 | 3 Publications | ||
Disulfide bondi | 213 ↔ 261 | 3 Publications | ||
Glycosylationi | 293 | N-linked (GlcNAc...) (high mannose) asparagine3 Publications | 1 | |
Glycosylationi | 394 | N-linked (GlcNAc...) (complex) asparagine3 Publications | 1 | |
Disulfide bondi | 473 | Interchain3 Publications |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | P17342 |
MassIVEi | P17342 |
MaxQBi | P17342 |
PaxDbi | P17342 |
PeptideAtlasi | P17342 |
PRIDEi | P17342 |
ProteomicsDBi | 17357 53468 [P17342-1] 53469 [P17342-2] |
PTM databases
GlyGeni | P17342, 4 sites |
iPTMneti | P17342 |
PhosphoSitePlusi | P17342 |
Expressioni
Gene expression databases
Bgeei | ENSG00000113389, Expressed in metanephric glomerulus and 198 other tissues |
ExpressionAtlasi | P17342, baseline and differential |
Genevisiblei | P17342, HS |
Organism-specific databases
HPAi | ENSG00000113389, Tissue enhanced (kidney) |
Interactioni
Subunit structurei
Homodimer; disulfide-linked (PubMed:11533490). Dimers can also be formed through the C-terminal cysteine of isoform 2 (PubMed:11533490).
Interacts with OSTN (By similarity).
By similarity1 PublicationGO - Molecular functioni
- protein homodimerization activity Source: CAFA
Protein-protein interaction databases
BioGRIDi | 110943, 5 interactors |
IntActi | P17342, 1 interactor |
STRINGi | 9606.ENSP00000265074 |
Chemistry databases
BindingDBi | P17342 |
Miscellaneous databases
RNActi | P17342, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P17342 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P17342 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1023, Eukaryota |
GeneTreei | ENSGT00440000033872 |
HOGENOMi | CLU_013995_1_0_1 |
InParanoidi | P17342 |
OMAi | TSAYSFD |
PhylomeDBi | P17342 |
TreeFami | TF106339 |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR001170, ANPR/GUC IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit |
PRINTSi | PR00255, NATPEPTIDER |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00458, ANF_RECEPTORS, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPSLLVLTFS PCVLLGWALL AGGTGGGGVG GGGGGAGIGG GRQEREALPP
60 70 80 90 100
QKIEVLVLLP QDDSYLFSLT RVRPAIEYAL RSVEGNGTGR RLLPPGTRFQ
110 120 130 140 150
VAYEDSDCGN RALFSLVDRV AAARGAKPDL ILGPVCEYAA APVARLASHW
160 170 180 190 200
DLPMLSAGAL AAGFQHKDSE YSHLTRVAPA YAKMGEMMLA LFRHHHWSRA
210 220 230 240 250
ALVYSDDKLE RNCYFTLEGV HEVFQEEGLH TSIYSFDETK DLDLEDIVRN
260 270 280 290 300
IQASERVVIM CASSDTIRSI MLVAHRHGMT SGDYAFFNIE LFNSSSYGDG
310 320 330 340 350
SWKRGDKHDF EAKQAYSSLQ TVTLLRTVKP EFEKFSMEVK SSVEKQGLNM
360 370 380 390 400
EDYVNMFVEG FHDAILLYVL ALHEVLRAGY SKKDGGKIIQ QTWNRTFEGI
410 420 430 440 450
AGQVSIDANG DRYGDFSVIA MTDVEAGTQE VIGDYFGKEG RFEMRPNVKY
460 470 480 490 500
PWGPLKLRID ENRIVEHTNS SPCKSSGGLE ESAVTGIVVG ALLGAGLLMA
510 520 530 540
FYFFRKKYRI TIERRTQQEE SNLGKHRELR EDSIRSHFSV A
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JK69 | C9JK69_HUMAN | Atrial natriuretic peptide receptor... | NPR3 | 325 | Annotation score: | ||
D6RDL8 | D6RDL8_HUMAN | Atrial natriuretic peptide receptor... | NPR3 | 252 | Annotation score: | ||
H0Y9B9 | H0Y9B9_HUMAN | Atrial natriuretic peptide receptor... | NPR3 | 88 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 522 | N → D in BAG61896 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045901 | 1 – 40 | MPSLL…AGIGG → MEPSALGPWSLFPDLAPRDQ EGQVLAPRRCFRRECGQNEK in isoform 3. 1 PublicationAdd BLAST | 40 | |
Alternative sequenceiVSP_045902 | 41 – 256 | Missing in isoform 3. 1 PublicationAdd BLAST | 216 | |
Alternative sequenceiVSP_001812 | 476 – 477 | SG → C in isoform 2 and isoform 3. 3 Publications | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52282 mRNA Translation: CAA36523.1 M59305 mRNA Translation: AAA51734.1 AF025998 mRNA Translation: AAB88801.1 AK300094 mRNA Translation: BAG61896.1 AC008766 Genomic DNA No translation available. AC026703 Genomic DNA No translation available. CH471118 Genomic DNA Translation: EAX10799.1 BC131540 mRNA Translation: AAI31541.1 |
CCDSi | CCDS47196.1 [P17342-2] CCDS56356.1 [P17342-3] CCDS56357.1 [P17342-1] |
PIRi | S10150, OYHUCR |
RefSeqi | NP_000899.1, NM_000908.3 [P17342-2] NP_001191304.1, NM_001204375.1 [P17342-1] NP_001191305.1, NM_001204376.1 [P17342-3] |
Genome annotation databases
Ensembli | ENST00000265074; ENSP00000265074; ENSG00000113389 [P17342-1] ENST00000326958; ENSP00000318340; ENSG00000113389 [P17342-3] ENST00000415167; ENSP00000398028; ENSG00000113389 [P17342-2] |
GeneIDi | 4883 |
KEGGi | hsa:4883 |
UCSCi | uc003jhv.4, human [P17342-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X52282 mRNA Translation: CAA36523.1 M59305 mRNA Translation: AAA51734.1 AF025998 mRNA Translation: AAB88801.1 AK300094 mRNA Translation: BAG61896.1 AC008766 Genomic DNA No translation available. AC026703 Genomic DNA No translation available. CH471118 Genomic DNA Translation: EAX10799.1 BC131540 mRNA Translation: AAI31541.1 |
CCDSi | CCDS47196.1 [P17342-2] CCDS56356.1 [P17342-3] CCDS56357.1 [P17342-1] |
PIRi | S10150, OYHUCR |
RefSeqi | NP_000899.1, NM_000908.3 [P17342-2] NP_001191304.1, NM_001204375.1 [P17342-1] NP_001191305.1, NM_001204376.1 [P17342-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1JDN | X-ray | 2.90 | A | 44-485 | [»] | |
1JDP | X-ray | 2.00 | A/B | 44-485 | [»] | |
1YK0 | X-ray | 2.40 | A/B | 1-480 | [»] | |
1YK1 | X-ray | 2.90 | A/B | 2-480 | [»] | |
SMRi | P17342 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110943, 5 interactors |
IntActi | P17342, 1 interactor |
STRINGi | 9606.ENSP00000265074 |
Chemistry databases
BindingDBi | P17342 |
ChEMBLi | CHEMBL2247 |
DrugBanki | DB04899, Nesiritide |
GuidetoPHARMACOLOGYi | 1749 |
PTM databases
GlyGeni | P17342, 4 sites |
iPTMneti | P17342 |
PhosphoSitePlusi | P17342 |
Genetic variation databases
BioMutai | NPR3 |
DMDMi | 27735161 |
Proteomic databases
jPOSTi | P17342 |
MassIVEi | P17342 |
MaxQBi | P17342 |
PaxDbi | P17342 |
PeptideAtlasi | P17342 |
PRIDEi | P17342 |
ProteomicsDBi | 17357 53468 [P17342-1] 53469 [P17342-2] |
Protocols and materials databases
Antibodypediai | 5387, 436 antibodies |
Genome annotation databases
Ensembli | ENST00000265074; ENSP00000265074; ENSG00000113389 [P17342-1] ENST00000326958; ENSP00000318340; ENSG00000113389 [P17342-3] ENST00000415167; ENSP00000398028; ENSG00000113389 [P17342-2] |
GeneIDi | 4883 |
KEGGi | hsa:4883 |
UCSCi | uc003jhv.4, human [P17342-1] |
Organism-specific databases
CTDi | 4883 |
DisGeNETi | 4883 |
GeneCardsi | NPR3 |
HGNCi | HGNC:7945, NPR3 |
HPAi | ENSG00000113389, Tissue enhanced (kidney) |
MIMi | 108962, gene |
neXtProti | NX_P17342 |
OpenTargetsi | ENSG00000113389 |
PharmGKBi | PA31737 |
VEuPathDBi | HostDB:ENSG00000113389.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1023, Eukaryota |
GeneTreei | ENSGT00440000033872 |
HOGENOMi | CLU_013995_1_0_1 |
InParanoidi | P17342 |
OMAi | TSAYSFD |
PhylomeDBi | P17342 |
TreeFami | TF106339 |
Enzyme and pathway databases
PathwayCommonsi | P17342 |
Miscellaneous databases
BioGRID-ORCSi | 4883, 1 hit in 872 CRISPR screens |
EvolutionaryTracei | P17342 |
GeneWikii | NPR3 |
GenomeRNAii | 4883 |
Pharosi | P17342, Tchem |
PROi | PR:P17342 |
RNActi | P17342, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000113389, Expressed in metanephric glomerulus and 198 other tissues |
ExpressionAtlasi | P17342, baseline and differential |
Genevisiblei | P17342, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR001170, ANPR/GUC IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit |
PRINTSi | PR00255, NATPEPTIDER |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00458, ANF_RECEPTORS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANPRC_HUMAN | |
Accessioni | P17342Primary (citable) accession number: P17342 Secondary accession number(s): A2RRD1, B4DT84, E7EPG9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | January 10, 2003 | |
Last modified: | February 10, 2021 | |
This is version 195 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM