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Entry version 153 (13 Nov 2019)
Sequence version 2 (01 Nov 1997)
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Protein

PTS system N,N'-diacetylchitobiose-specific EIIC component

Gene

chbC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ChbABC PTS system is involved in the transport of the chitin disaccharide N,N'-diacetylchitobiose (GlcNAc2) (PubMed:10913117). Also able to use N,N',N''-triacetyl chitotriose (GlcNAc3) (PubMed:10913117).1 Publication1 Publication

Caution

Was originally (PubMed:2179047) characterized as part of a cryptic cel operon for a cellobiose degradation system. The Cel+ phenotype is due to mutations making expression chitobiose-independent and altering the substrate specificity.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:CELB-MONOMER
ECOL316407:JW1726-MONOMER
MetaCyc:CELB-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
4.A.3.2.1 the pts lactose-n,n'-diacetylchitobiose-Beta-glucoside (lac) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PTS system N,N'-diacetylchitobiose-specific EIIC component1 Publication
Alternative name(s):
EIIC-Chb1 Publication
IIcel1 Publication
N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIC component1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:chbC1 Publication
Synonyms:celB1 Publication
Ordered Locus Names:b1737, JW1726
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 34CytoplasmicSequence analysisAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei35 – 55HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini56 – 85PeriplasmicSequence analysisAdd BLAST30
Transmembranei86 – 106HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini107 – 113CytoplasmicSequence analysis7
Transmembranei114 – 134HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini135 – 146PeriplasmicSequence analysisAdd BLAST12
Transmembranei147 – 167HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini168 – 186CytoplasmicSequence analysisAdd BLAST19
Transmembranei187 – 207HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini208 – 228PeriplasmicSequence analysisAdd BLAST21
Transmembranei229 – 249HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini250 – 299CytoplasmicSequence analysisAdd BLAST50
Transmembranei300 – 320HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini321 – 343PeriplasmicSequence analysisAdd BLAST23
Transmembranei344 – 364HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini365 – 366CytoplasmicSequence analysis2
Transmembranei367 – 387HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini388 – 408PeriplasmicSequence analysisAdd BLAST21
Transmembranei409 – 429HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini430 – 452CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001864851 – 452PTS system N,N'-diacetylchitobiose-specific EIIC componentAdd BLAST452

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P17334

PRoteomics IDEntifications database

More...
PRIDEi
P17334

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By GlcNAc2, GlcNAc3 and beta-N,N'-diacetylchitobiose (Me-TCB).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4260315, 20 interactors

Database of interacting proteins

More...
DIPi
DIP-9264N

Protein interaction database and analysis system

More...
IntActi
P17334, 1 interactor

STRING: functional protein association networks

More...
STRINGi
511145.b1737

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 426PTS EIIC type-3PROSITE-ProRule annotationAdd BLAST419

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The EIIC type-3 domain forms the PTS system translocation channel and contains the specific substrate-binding site.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CK1 Bacteria
COG1455 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000224102

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P17334

KEGG Orthology (KO)

More...
KOi
K02761

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P17334

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003352 PTS_EIIC
IPR004501 PTS_EIIC_3
IPR004796 PTS_IIC_cello

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02378 PTS_EIIC, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006351 PTS_EIIC-Cellobiose, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00359 cello_pts_IIC, 1 hit
TIGR00410 lacE, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51105 PTS_EIIC_TYPE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P17334-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNVIASLEK VLLPFAVKIG KQPHVNAIKN GFIRLMPLTL AGAMFVLINN
60 70 80 90 100
VFLSFGEGSF FYSLGIRLDA STIETLNGLK GIGGNVYNGT LGIMSLMAPF
110 120 130 140 150
FIGMALAEER KVDALAAGLL SVAAFMTVTP YSVGEAYAVG ANWLGGANII
160 170 180 190 200
SGIIIGLVVA EMFTFIVRRN WVIKLPDSVP ASVSRSFSAL IPGFIILSVM
210 220 230 240 250
GIIAWALNTW GTNFHQIIMD TISTPLASLG SVVGWAYVIF VPLLWFFGIH
260 270 280 290 300
GALALTALDN GIMTPWALEN IATYQQYGSV EAALAAGKTF HIWAKPMLDS
310 320 330 340 350
FIFLGGSGAT LGLILAIFIA SRRADYRQVA KLALPSGIFQ INEPILFGLP
360 370 380 390 400
IIMNPVMFIP FVLVQPILAA ITLAAYYMGI IPPVTNIAPW TMPTGLGAFF
410 420 430 440 450
NTNGSVAALL VALFNLGIAT LIYLPFVVVA NKAQNAIDKE ESEEDIANAL

KF
Length:452
Mass (Da):48,332
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC3CBFEED6231068
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti190 – 205LIPGF…GIIAW → FNSRLYYSFRDGDYCL in CAA37070 (PubMed:2179047).CuratedAdd BLAST16
Sequence conflicti233 – 235VGW → WL in CAA37070 (PubMed:2179047).Curated3
Sequence conflicti240 – 265FVPLL…GIMTP → LSTALVLRIHAACADRTGQR HYDA in CAA37070 (PubMed:2179047).CuratedAdd BLAST26
Sequence conflicti361 – 366FVLVQP → LYWYNR in CAA37070 (PubMed:2179047).Curated6
Sequence conflicti405 – 452SVAAL…NALKF → TSPHCWSHSSTLASQR in CAA37070 (PubMed:2179047).CuratedAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X52890 Genomic DNA Translation: CAA37070.1
U00096 Genomic DNA Translation: AAC74807.1
AP009048 Genomic DNA Translation: BAA15518.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A64933
S10871

NCBI Reference Sequences

More...
RefSeqi
NP_416251.1, NC_000913.3
WP_000073041.1, NZ_SSZK01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74807; AAC74807; b1737
BAA15518; BAA15518; BAA15518

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
945982

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW1726
eco:b1737

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.519

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52890 Genomic DNA Translation: CAA37070.1
U00096 Genomic DNA Translation: AAC74807.1
AP009048 Genomic DNA Translation: BAA15518.1
PIRiA64933
S10871
RefSeqiNP_416251.1, NC_000913.3
WP_000073041.1, NZ_SSZK01000001.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi4260315, 20 interactors
DIPiDIP-9264N
IntActiP17334, 1 interactor
STRINGi511145.b1737

Protein family/group databases

TCDBi4.A.3.2.1 the pts lactose-n,n'-diacetylchitobiose-Beta-glucoside (lac) family

Proteomic databases

PaxDbiP17334
PRIDEiP17334

Genome annotation databases

EnsemblBacteriaiAAC74807; AAC74807; b1737
BAA15518; BAA15518; BAA15518
GeneIDi945982
KEGGiecj:JW1726
eco:b1737
PATRICifig|1411691.4.peg.519

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0139

Phylogenomic databases

eggNOGiENOG4105CK1 Bacteria
COG1455 LUCA
HOGENOMiHOG000224102
InParanoidiP17334
KOiK02761
PhylomeDBiP17334

Enzyme and pathway databases

BioCyciEcoCyc:CELB-MONOMER
ECOL316407:JW1726-MONOMER
MetaCyc:CELB-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P17334

Family and domain databases

InterProiView protein in InterPro
IPR003352 PTS_EIIC
IPR004501 PTS_EIIC_3
IPR004796 PTS_IIC_cello
PfamiView protein in Pfam
PF02378 PTS_EIIC, 1 hit
PIRSFiPIRSF006351 PTS_EIIC-Cellobiose, 1 hit
TIGRFAMsiTIGR00359 cello_pts_IIC, 1 hit
TIGR00410 lacE, 1 hit
PROSITEiView protein in PROSITE
PS51105 PTS_EIIC_TYPE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTQC_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17334
Secondary accession number(s): P76212, P76907, P77332
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1997
Last modified: November 13, 2019
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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