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Protein

Colicin I receptor

Gene

cirA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB.

GO - Molecular functioni

  • colicin transmembrane transporter activity Source: EcoCyc
  • siderophore transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • ion transport Source: UniProtKB-KW
  • iron assimilation Source: EcoCyc

Keywordsi

Molecular functionReceptor
Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

BioCyciEcoCyc:EG10155-MONOMER
MetaCyc:EG10155-MONOMER

Protein family/group databases

TCDBi1.B.14.1.4 the outer membrane receptor (omr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Colicin I receptor
Gene namesi
Name:cirA
Synonyms:cir, feuA
Ordered Locus Names:b2155, JW2142
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10155 cirA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Chemistry databases

DrugBankiDB04147 Lauryl Dimethylamine-N-Oxide
DB02415 N-Octyl-2-Hydroxyethyl Sulfoxide

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000003474426 – 663Colicin I receptorAdd BLAST638

Proteomic databases

EPDiP17315
PaxDbiP17315
PRIDEiP17315

2D gel databases

SWISS-2DPAGEiP17315

Expressioni

Inductioni

By iron and by a cAMP/cAMP receptor protein complex.

Interactioni

Protein-protein interaction databases

BioGridi4260473, 99 interactors
DIPiDIP-9282N
IntActiP17315, 7 interactors
MINTiP17315
STRINGi316385.ECDH10B_2312

Structurei

Secondary structure

1663
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP17315
SMRiP17315
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17315

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi31 – 38TonB box8
Motifi646 – 663TonB C-terminal boxAdd BLAST18

Sequence similaritiesi

Belongs to the TonB-dependent receptor family.Curated

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105D05 Bacteria
COG4771 LUCA
HOGENOMiHOG000276828
InParanoidiP17315
KOiK16089
OMAiDIHTGTY
PhylomeDBiP17315

Family and domain databases

Gene3Di2.170.130.10, 1 hit
2.40.170.20, 1 hit
InterProiView protein in InterPro
IPR012910 Plug_dom
IPR037066 Plug_dom_sf
IPR000531 TonB-dep_rcpt_b-brl
IPR010916 TonB_box_CS
IPR036942 TonB_rcpt_b-brl_sf
IPR010917 TonB_rcpt_CS
PfamiView protein in Pfam
PF07715 Plug, 1 hit
PF00593 TonB_dep_Rec, 1 hit
PROSITEiView protein in PROSITE
PS00430 TONB_DEPENDENT_REC_1, 1 hit
PS01156 TONB_DEPENDENT_REC_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17315-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRLNPFVRV GLCLSAISCA WPVLAVDDDG ETMVVTASSV EQNLKDAPAS
60 70 80 90 100
ISVITQEDLQ RKPVQNLKDV LKEVPGVQLT NEGDNRKGVS IRGLDSSYTL
110 120 130 140 150
ILVDGKRVNS RNAVFRHNDF DLNWIPVDSI ERIEVVRGPM SSLYGSDALG
160 170 180 190 200
GVVNIITKKI GQKWSGTVTV DTTIQEHRDR GDTYNGQFFT SGPLIDGVLG
210 220 230 240 250
MKAYGSLAKR EKDDPQNSTT TDTGETPRIE GFSSRDGNVE FAWTPNQNHD
260 270 280 290 300
FTAGYGFDRQ DRDSDSLDKN RLERQNYSVS HNGRWDYGTS ELKYYGEKVE
310 320 330 340 350
NKNPGNSSPI TSESNTVDGK YTLPLTAINQ FLTVGGEWRH DKLSDAVNLT
360 370 380 390 400
GGTSSKTSAS QYALFVEDEW RIFEPLALTT GVRMDDHETY GEHWSPRAYL
410 420 430 440 450
VYNATDTVTV KGGWATAFKA PSLLQLSPDW TSNSCRGACK IVGSPDLKPE
460 470 480 490 500
TSESWELGLY YMGEEGWLEG VESSVTVFRN DVKDRISISR TSDVNAAPGY
510 520 530 540 550
QNFVGFETGA NGRRIPVFSY YNVNKARIQG VETELKIPFN DEWKLSINYT
560 570 580 590 600
YNDGRDVSNG ENKPLSDLPF HTANGTLDWK PLALEDWSFY VSGHYTGQKR
610 620 630 640 650
ADSATAKTPG GYTIWNTGAA WQVTKDVKLR AGVLNLGDKD LSRDDYSYNE
660
DGRRYFMAVD YRF
Length:663
Mass (Da):73,896
Last modified:November 1, 1997 - v2
Checksum:i2C68A45D4B5EE414
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97S → D in AAA17054 (PubMed:1315732).Curated1
Sequence conflicti528I → N in AAA75183 (PubMed:2644220).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04229 Genomic DNA Translation: AAA75183.1
U00007 Genomic DNA Translation: AAA60531.1
U00096 Genomic DNA Translation: AAC75216.1
AP009048 Genomic DNA Translation: BAE76632.1
M19295 Genomic DNA Translation: AAA23581.1
M89774 Genomic DNA Translation: AAA17054.1
PIRiB64984 QRECIC
RefSeqiNP_416660.1, NC_000913.3
WP_000489247.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75216; AAC75216; b2155
BAE76632; BAE76632; BAE76632
GeneIDi949042
KEGGiecj:JW2142
eco:b2155
PATRICifig|1411691.4.peg.85

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04229 Genomic DNA Translation: AAA75183.1
U00007 Genomic DNA Translation: AAA60531.1
U00096 Genomic DNA Translation: AAC75216.1
AP009048 Genomic DNA Translation: BAE76632.1
M19295 Genomic DNA Translation: AAA23581.1
M89774 Genomic DNA Translation: AAA17054.1
PIRiB64984 QRECIC
RefSeqiNP_416660.1, NC_000913.3
WP_000489247.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HDFX-ray2.65A26-663[»]
2HDIX-ray2.50A26-663[»]
ProteinModelPortaliP17315
SMRiP17315
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260473, 99 interactors
DIPiDIP-9282N
IntActiP17315, 7 interactors
MINTiP17315
STRINGi316385.ECDH10B_2312

Chemistry databases

DrugBankiDB04147 Lauryl Dimethylamine-N-Oxide
DB02415 N-Octyl-2-Hydroxyethyl Sulfoxide

Protein family/group databases

TCDBi1.B.14.1.4 the outer membrane receptor (omr) family

2D gel databases

SWISS-2DPAGEiP17315

Proteomic databases

EPDiP17315
PaxDbiP17315
PRIDEiP17315

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75216; AAC75216; b2155
BAE76632; BAE76632; BAE76632
GeneIDi949042
KEGGiecj:JW2142
eco:b2155
PATRICifig|1411691.4.peg.85

Organism-specific databases

EchoBASEiEB0153
EcoGeneiEG10155 cirA

Phylogenomic databases

eggNOGiENOG4105D05 Bacteria
COG4771 LUCA
HOGENOMiHOG000276828
InParanoidiP17315
KOiK16089
OMAiDIHTGTY
PhylomeDBiP17315

Enzyme and pathway databases

BioCyciEcoCyc:EG10155-MONOMER
MetaCyc:EG10155-MONOMER

Miscellaneous databases

EvolutionaryTraceiP17315
PROiPR:P17315

Family and domain databases

Gene3Di2.170.130.10, 1 hit
2.40.170.20, 1 hit
InterProiView protein in InterPro
IPR012910 Plug_dom
IPR037066 Plug_dom_sf
IPR000531 TonB-dep_rcpt_b-brl
IPR010916 TonB_box_CS
IPR036942 TonB_rcpt_b-brl_sf
IPR010917 TonB_rcpt_CS
PfamiView protein in Pfam
PF07715 Plug, 1 hit
PF00593 TonB_dep_Rec, 1 hit
PROSITEiView protein in PROSITE
PS00430 TONB_DEPENDENT_REC_1, 1 hit
PS01156 TONB_DEPENDENT_REC_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCIRA_ECOLI
AccessioniPrimary (citable) accession number: P17315
Secondary accession number(s): Q2MAS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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