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Protein

Transcription factor jun-B

Gene

JUNB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
R-HSA-6785807 Interleukin-4 and 13 signaling
SignaLinkiP17275
SIGNORiP17275

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor jun-B
Gene namesi
Name:JUNB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171223.5
HGNCiHGNC:6205 JUNB
MIMi165161 gene
neXtProtiNX_P17275

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3726
OpenTargetsiENSG00000171223
PharmGKBiPA30007

Polymorphism and mutation databases

BioMutaiJUNB
DMDMi135304

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764381 – 347Transcription factor jun-BAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki4Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki36Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki81Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei102PhosphothreonineCombined sources1
Modified residuei104PhosphothreonineCombined sources1
Modified residuei117PhosphoserineCombined sources1
Cross-linki141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei240N6-acetyllysine; alternateBy similarity1
Cross-linki240Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki240Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei251PhosphoserineCombined sources1
Modified residuei255PhosphothreonineCombined sources1
Modified residuei259PhosphoserineCombined sources1
Cross-linki343Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Ubiquitinated by ITCH, leading to its degradation.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP17275
PaxDbiP17275
PeptideAtlasiP17275
PRIDEiP17275
ProteomicsDBi53465

PTM databases

iPTMnetiP17275
PhosphoSitePlusiP17275

Expressioni

Inductioni

By growth factors.

Gene expression databases

BgeeiENSG00000171223
CleanExiHS_JUNB
ExpressionAtlasiP17275 baseline and differential
GenevisibleiP17275 HS

Organism-specific databases

HPAiCAB004464
HPA019149

Interactioni

Subunit structurei

Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains).1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109929, 70 interactors
DIPiDIP-1052N
IntActiP17275, 43 interactors
MINTiP17275
STRINGi9606.ENSP00000303315

Structurei

3D structure databases

ProteinModelPortaliP17275
SMRiP17275
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 331bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni268 – 295Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni296 – 324Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated

Phylogenomic databases

eggNOGiKOG0837 Eukaryota
ENOG410XRWH LUCA
GeneTreeiENSGT00390000009929
HOGENOMiHOG000006648
HOVERGENiHBG001722
InParanoidiP17275
KOiK09028
OMAiPTPAHYL
OrthoDBiEOG091G0N0L
PhylomeDBiP17275

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR005643 JNK
IPR029822 JunB
IPR002112 Leuzip_Jun
IPR008917 TF_DNA-bd_sf
PANTHERiPTHR11462:SF37 PTHR11462:SF37, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PF03957 Jun, 1 hit
PRINTSiPR00043 LEUZIPPRJUN
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

P17275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCTKMEQPFY HDDSYTATGY GRAPGGLSLH DYKLLKPSLA VNLADPYRSL
60 70 80 90 100
KAPGARGPGP EGGGGGSYFS GQGSDTGASL KLASSELERL IVPNSNGVIT
110 120 130 140 150
TTPTPPGQYF YPRGGGSGGG AGGAGGGVTE EQEGFADGFV KALDDLHKMN
160 170 180 190 200
HVTPPNVSLG ATGGPPAGPG GVYAGPEPPP VYTNLSSYSP ASASSGGAGA
210 220 230 240 250
AVGTGSSYPT TTISYLPHAP PFAGGHPAQL GLGRGASTFK EEPQTVPEAR
260 270 280 290 300
SRDATPPVSP INMEDQERIK VERKRLRNRL AATKCRKRKL ERIARLEDKV
310 320 330 340
KTLKAENAGL SSTAGLLREQ VAQLKQKVMT HVSNGCQLLL GVKGHAF
Length:347
Mass (Da):35,879
Last modified:August 1, 1990 - v1
Checksum:iDF8CD1CD4409C6BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124A → G in AAH09465 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021081230L → V1 PublicationCorresponds to variant dbSNP:rs17880705Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29039 Genomic DNA Translation: AAA59198.1
X51345 mRNA Translation: CAA35738.1
U20734 Genomic DNA Translation: AAA74915.1
AY751746 Genomic DNA Translation: AAU43800.1
BC004250 mRNA Translation: AAH04250.1
BC009465 mRNA Translation: AAH09465.1
BC009466 mRNA Translation: AAH09466.1
CCDSiCCDS12280.1
PIRiS10183 TVHUJB
RefSeqiNP_002220.1, NM_002229.2
UniGeneiHs.25292

Genome annotation databases

EnsembliENST00000302754; ENSP00000303315; ENSG00000171223
GeneIDi3726
KEGGihsa:3726

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiJUNB_HUMAN
AccessioniPrimary (citable) accession number: P17275
Secondary accession number(s): Q96GH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: July 18, 2018
This is version 196 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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