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Protein

Cystine transporter

Gene

ERS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transport cystine out of vacuoles/endodomes.1 Publication

GO - Molecular functioni

  • L-cystine transmembrane transporter activity Source: SGD

GO - Biological processi

  • L-cystine transport Source: SGD
  • transmembrane transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-29374-MONOMER
ReactomeiR-SCE-425393 Transport of inorganic cations/anions and amino acids/oligopeptides
R-SCE-5223345 Miscellaneous transport and binding events

Protein family/group databases

TCDBi2.A.43.1.3 the lysosomal cystine transporter (lct) family

Names & Taxonomyi

Protein namesi
Recommended name:
Cystine transporter
Alternative name(s):
ERD suppressor
Transmembrane protein ERS1
Gene namesi
Name:ERS1
Ordered Locus Names:YCR075C
ORF Names:YCR75C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

SGDiS000000671 ERS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 28HelicalSequence analysisAdd BLAST22
Transmembranei40 – 62HelicalSequence analysisAdd BLAST23
Transmembranei81 – 102HelicalSequence analysisAdd BLAST22
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Transmembranei151 – 175HelicalSequence analysisAdd BLAST25
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endosome, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002055191 – 260Cystine transporterAdd BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP17261
PRIDEiP17261

Interactioni

Protein-protein interaction databases

BioGridi31050, 139 interactors
DIPiDIP-8250N
IntActiP17261, 4 interactors
MINTiP17261
STRINGi4932.YCR075C

Structurei

3D structure databases

ProteinModelPortaliP17261
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 67PQ-loop 1Add BLAST67
Domaini162 – 212PQ-loop 2Add BLAST51

Sequence similaritiesi

Belongs to the cystinosin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000005338
HOGENOMiHOG000000908
InParanoidiP17261
KOiK12386
OMAiHSNQTGP
OrthoDBiEOG092C4BRM

Family and domain databases

InterProiView protein in InterPro
IPR005282 LC_transporter
IPR006603 PQ-loop_rpt
PANTHERiPTHR13131 PTHR13131, 1 hit
PfamiView protein in Pfam
PF04193 PQ-loop, 2 hits
SMARTiView protein in SMART
SM00679 CTNS, 2 hits
TIGRFAMsiTIGR00951 2A43, 1 hit

Sequencei

Sequence statusi: Complete.

P17261-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSLDDILGI VYVTSWSISM YPPIITNWRH KSASAISMDF VMLNTAGYSY
60 70 80 90 100
LVISIFLQLY CWKMTGDESD LGRPKLTQFD FWYCLHGCLM NVVLLTQVVA
110 120 130 140 150
GARIWRFPGK GHRKMNPWYL RILLASLAIF SLLTVQFMYS NYWYDWHNSR
160 170 180 190 200
TLAYCNNLFL LKISMSLIKY IPQVTHNSTR KSMDCFPIQG VFLDVTGGIA
210 220 230 240 250
SLLQLIWQLS NDQGFSLDTF VTNFGKVGLS MVTLIFNFIF IMQWFVYRSR
260
GHDLASEYPL
Length:260
Mass (Da):30,116
Last modified:August 1, 1990 - v1
Checksum:iBF9E129E44D20655
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52468 Genomic DNA Translation: CAA36706.1
X59720 Genomic DNA Translation: CAA42264.1
BK006937 Genomic DNA Translation: DAA07546.1
PIRiS22850
RefSeqiNP_010000.1, NM_001178784.1

Genome annotation databases

EnsemblFungiiCAA42264; CAA42264; CAA42264
YCR075C; YCR075C; YCR075C
GeneIDi850438
KEGGisce:YCR075C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52468 Genomic DNA Translation: CAA36706.1
X59720 Genomic DNA Translation: CAA42264.1
BK006937 Genomic DNA Translation: DAA07546.1
PIRiS22850
RefSeqiNP_010000.1, NM_001178784.1

3D structure databases

ProteinModelPortaliP17261
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31050, 139 interactors
DIPiDIP-8250N
IntActiP17261, 4 interactors
MINTiP17261
STRINGi4932.YCR075C

Protein family/group databases

TCDBi2.A.43.1.3 the lysosomal cystine transporter (lct) family

Proteomic databases

PaxDbiP17261
PRIDEiP17261

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42264; CAA42264; CAA42264
YCR075C; YCR075C; YCR075C
GeneIDi850438
KEGGisce:YCR075C

Organism-specific databases

SGDiS000000671 ERS1

Phylogenomic databases

GeneTreeiENSGT00390000005338
HOGENOMiHOG000000908
InParanoidiP17261
KOiK12386
OMAiHSNQTGP
OrthoDBiEOG092C4BRM

Enzyme and pathway databases

BioCyciYEAST:G3O-29374-MONOMER
ReactomeiR-SCE-425393 Transport of inorganic cations/anions and amino acids/oligopeptides
R-SCE-5223345 Miscellaneous transport and binding events

Miscellaneous databases

PROiPR:P17261

Family and domain databases

InterProiView protein in InterPro
IPR005282 LC_transporter
IPR006603 PQ-loop_rpt
PANTHERiPTHR13131 PTHR13131, 1 hit
PfamiView protein in Pfam
PF04193 PQ-loop, 2 hits
SMARTiView protein in SMART
SM00679 CTNS, 2 hits
TIGRFAMsiTIGR00951 2A43, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERS1_YEAST
AccessioniPrimary (citable) accession number: P17261
Secondary accession number(s): D6VR77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names
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