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Protein

Mevalonate kinase

Gene

Mvk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.By similarity

Miscellaneous

The authors of PubMed:14730012 identify two forms of Mvk in rat liver, one form localizes to the cytosol and the other form to the peroxisome, whereas according to the authors of PubMed:14730012 the protein is found only in the cytoplasm with no evidence for its peroxisomal localization.

Catalytic activityi

ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate.By similarity

Cofactori

Mg2+1 Publication

Pathwayi: isopentenyl diphosphate biosynthesis via mevalonate pathway

This protein is involved in step 1 of the subpathway that synthesizes isopentenyl diphosphate from (R)-mevalonate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Mevalonate kinase (Mvk), Mevalonate kinase (Mvk)
  2. Phosphomevalonate kinase (Pmvk)
  3. no protein annotated in this organism
This subpathway is part of the pathway isopentenyl diphosphate biosynthesis via mevalonate pathway, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isopentenyl diphosphate from (R)-mevalonate, the pathway isopentenyl diphosphate biosynthesis via mevalonate pathway and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei13ATPCombined sources1 Publication1
Binding sitei55ATPCombined sources1 Publication1
Binding sitei104ATP; via carbonyl oxygenCombined sources1 Publication1
Binding sitei108ATPCombined sources1 Publication1
Binding sitei135ATPCombined sources1 Publication1
Metal bindingi146MagnesiumCombined sources1 Publication1
Metal bindingi193MagnesiumCombined sources1 Publication1
Active sitei204Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi140 – 146ATPCombined sources1 Publication7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.36 5301
SABIO-RKiP17256
UniPathwayi
UPA00057;UER00098

Protein family/group databases

MoonProtiP17256

Names & Taxonomyi

Protein namesi
Recommended name:
Mevalonate kinaseCurated (EC:2.7.1.36By similarity)
Short name:
MK
Gene namesi
Name:MvkImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621295 Mvk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Peroxisome

Pathology & Biotechi

Involvement in diseasei

Mutation in the mevalonate kinase gene causes mevalonicaciduria.

Chemistry databases

ChEMBLiCHEMBL4274
GuidetoPHARMACOLOGYi640

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001566591 – 395Mevalonate kinaseAdd BLAST395

Proteomic databases

PRIDEiP17256

PTM databases

iPTMnetiP17256
PhosphoSitePlusiP17256

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249600, 5 interactors

Chemistry databases

BindingDBiP17256

Structurei

Secondary structure

1395
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP17256
SMRiP17256
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17256

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG000402
InParanoidiP17256
KOiK00869
PhylomeDBiP17256

Family and domain databases

Gene3Di3.30.230.10, 1 hit
3.30.70.890, 1 hit
InterProiView protein in InterPro
IPR013750 GHMP_kinase_C_dom
IPR036554 GHMP_kinase_C_sf
IPR006204 GHMP_kinase_N_dom
IPR006203 GHMP_knse_ATP-bd_CS
IPR006205 Mev_gal_kin
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PfamiView protein in Pfam
PF08544 GHMP_kinases_C, 1 hit
PF00288 GHMP_kinases_N, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55060 SSF55060, 1 hit
TIGRFAMsiTIGR00549 mevalon_kin, 1 hit
PROSITEiView protein in PROSITE
PS00627 GHMP_KINASES_ATP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P17256-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSEVLLVSA PGKVILHGEH AVVHGKVALA VALNLRTFLV LRPQSNGKVS
60 70 80 90 100
LNLPNVGIKQ VWDVATLQLL DTGFLEQGDV PAPTLEQLEK LKKVAGLPRD
110 120 130 140 150
CVGNEGLSLL AFLYLYLAIC RKQRTLPSLD IMVWSELPPG AGLGSSAAYS
160 170 180 190 200
VCVAAALLTA CEEVTNPLKD RGSIGSWPEE DLKSINKWAY EGERVIHGNP
210 220 230 240 250
SGVDNSVSTW GGALRYQQGK MSSLKRLPAL QILLTNTKVP RSTKALVAGV
260 270 280 290 300
RSRLIKFPEI MAPLLTSIDA ISLECERVLG EMAAAPVPEQ YLVLEELMDM
310 320 330 340 350
NQHHLNALGV GHASLDQLCQ VTAAHGLHSK LTGAGGGGCG ITLLKPGLER
360 370 380 390
AKVEAAKQAL TGCGFDCWET SIGAPGVSMH SATSIEDPVR QALGL
Length:395
Mass (Da):41,988
Last modified:August 1, 1990 - v1
Checksum:i803D1F44E3C525FC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R5W4M0R5W4_RAT
Mevalonate kinase
Mvk
395Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29472 mRNA Translation: AAA41588.1
PIRiA35629
RefSeqiNP_112325.1, NM_031063.1
UniGeneiRn.6995

Genome annotation databases

GeneIDi81727
KEGGirno:81727

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29472 mRNA Translation: AAA41588.1
PIRiA35629
RefSeqiNP_112325.1, NM_031063.1
UniGeneiRn.6995

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KVKX-ray2.40A1-395[»]
2R42X-ray2.40A1-395[»]
ProteinModelPortaliP17256
SMRiP17256
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249600, 5 interactors

Chemistry databases

BindingDBiP17256
ChEMBLiCHEMBL4274
GuidetoPHARMACOLOGYi640

Protein family/group databases

MoonProtiP17256

PTM databases

iPTMnetiP17256
PhosphoSitePlusiP17256

Proteomic databases

PRIDEiP17256

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81727
KEGGirno:81727

Organism-specific databases

CTDi4598
RGDi621295 Mvk

Phylogenomic databases

HOVERGENiHBG000402
InParanoidiP17256
KOiK00869
PhylomeDBiP17256

Enzyme and pathway databases

UniPathwayi
UPA00057;UER00098

BRENDAi2.7.1.36 5301
SABIO-RKiP17256

Miscellaneous databases

EvolutionaryTraceiP17256
PROiPR:P17256

Family and domain databases

Gene3Di3.30.230.10, 1 hit
3.30.70.890, 1 hit
InterProiView protein in InterPro
IPR013750 GHMP_kinase_C_dom
IPR036554 GHMP_kinase_C_sf
IPR006204 GHMP_kinase_N_dom
IPR006203 GHMP_knse_ATP-bd_CS
IPR006205 Mev_gal_kin
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PfamiView protein in Pfam
PF08544 GHMP_kinases_C, 1 hit
PF00288 GHMP_kinases_N, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55060 SSF55060, 1 hit
TIGRFAMsiTIGR00549 mevalon_kin, 1 hit
PROSITEiView protein in PROSITE
PS00627 GHMP_KINASES_ATP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKIME_RAT
AccessioniPrimary (citable) accession number: P17256
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: November 7, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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