UniProtKB - P17247 (TGFB2_XENLA)
Protein
Transforming growth factor beta-2 proprotein
Gene
tgfb2
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.By similarity
Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as ltbp1 and lrrc32/garp, that control activation of TGF-beta-2.By similarity
Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as ltbp1 and lrrc32/garp, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (tgfbr1 and tgfbr2), which transduce signal (By similarity).By similarity
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- transforming growth factor beta receptor binding Source: InterPro
GO - Biological processi
- positive regulation of cell division Source: UniProtKB-KW
Keywordsi
Molecular function | Growth factor, Mitogen |
Names & Taxonomyi
Protein namesi | Recommended name: Transforming growth factor beta-2 proproteinCleaved into the following 2 chains: |
Gene namesi | Name:tgfb2 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-865387, tgfb2.L |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: InterPro
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000445554 | 20 – 301 | Latency-associated peptide1 PublicationAdd BLAST | 282 | |
ChainiPRO_0000033795 | 302 – 413 | Transforming growth factor beta-21 PublicationAdd BLAST | 112 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 72 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 140 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 241 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 308 ↔ 317 | By similarity | ||
Disulfide bondi | 316 ↔ 379 | By similarity | ||
Disulfide bondi | 345 ↔ 410 | By similarity | ||
Disulfide bondi | 349 ↔ 412 | By similarity | ||
Disulfide bondi | 378 | InterchainBy similarity |
Post-translational modificationi
Transforming growth factor beta-2 proprotein: The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-2 (TGF-beta-2) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-2 inactive.By similarity
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinInteractioni
Subunit structurei
Latency-associated peptide:
Interacts with Transforming growth factor beta-2 (TGF-beta-2) chain; interaction is non-covalent and maintains (TGF-beta-2) in a latent state (By similarity). Transforming growth factor beta-2: Homodimer; disulfide-linked (By similarity). Transforming growth factor beta-2:
Interacts with TGF-beta receptors (tgfbr1 and tgfbr2), leading to signal transduction (By similarity).
By similarityGO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- transforming growth factor beta receptor binding Source: InterPro
Family & Domainsi
Sequence similaritiesi
Belongs to the TGF-beta family.Curated
Keywords - Domaini
SignalPhylogenomic databases
OMAi | QPFYPEN |
OrthoDBi | 643840at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003940, TGFb2 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01425, TGFBETA2 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P17247-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHYYVLFTFL TLDLAPVALS LSTCSALDMD QFMRKRIEAI RGQILSKLKL
60 70 80 90 100
NSPPEDYPEP GEVSQDVISI YNSTRDLLQE KANERATSCE RERSEDEYYA
110 120 130 140 150
KEVYKIDMLP YYTSENVIPP SYTTPYFRIV RFDVSSMEKN ASNLVKAEFR
160 170 180 190 200
VFRLMNTKAR VSEQRIELYQ ILKSKDLASP TQRYIDSKVV KTRAEGEWLS
210 220 230 240 250
FDVTEAVNEW LHHKDRNLGF KISLHCPCCT FIPSNNYIIP NKSEELETRF
260 270 280 290 300
AGIDDAYMYA GGDSKSKTGR KKHTGRTPHL LLMLLPSYRL ESQQSSRRKK
310 320 330 340 350
RALDAAYCFR NVQDNCCLRP LYIDFKKDLG WKWIHEPKGY NANFCAGACP
360 370 380 390 400
YLWSSDTQHS RVLSLYNTIN PEASASPCCV SQDLDSLTIL YYIGNKPKIE
410
QLSNMIVKSC KCS
Sequence cautioni
The sequence CAA36117 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X51817 mRNA Translation: CAA36116.1 X51817 mRNA Translation: CAA36117.1 Different initiation. |
PIRi | S09510, WFXLB2 |
RefSeqi | NP_001079195.1, NM_001085726.1 |
Genome annotation databases
GeneIDi | 373801 |
KEGGi | xla:373801 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X51817 mRNA Translation: CAA36116.1 X51817 mRNA Translation: CAA36117.1 Different initiation. |
PIRi | S09510, WFXLB2 |
RefSeqi | NP_001079195.1, NM_001085726.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 373801 |
KEGGi | xla:373801 |
Organism-specific databases
CTDi | 373801 |
Xenbasei | XB-GENE-865387, tgfb2.L |
Phylogenomic databases
OMAi | QPFYPEN |
OrthoDBi | 643840at2759 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003940, TGFb2 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01425, TGFBETA2 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TGFB2_XENLA | |
Accessioni | P17247Primary (citable) accession number: P17247 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | August 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families