UniProtKB - P17220 (PSA2_RAT)

BLAST

>sp|P17220|PSA2_RAT Proteasome subunit alpha type-2 OS=Rattus norvegicus OX=10116 GN=Psma2 PE=1 SV=3
MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDER
SVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQE
YTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNE
DLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVRDYLAAIA

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History
Entry version 160 (12 Sep 2018)
Sequence version 3 (23 Jan 2007)
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Protein

Proteasome subunit alpha type-2

Gene

Psma2

Organism

Rattus norvegicus (Rat)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).By similarity

Catalytic activityⁱ

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functionⁱ

threonine-type endopeptidase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ubiquitin-dependent protein catabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Threonine protease

Molecular function

Hydrolase, Protease, Threonine protease

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	T01.972

MEROPSⁱ

T01.972

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Proteasome subunit alpha type-2 (EC:3.4.25.1By similarity) Alternative name(s): Macropain subunit C3 Multicatalytic endopeptidase complex subunit C3 Proteasome component C3
Gene namesⁱ	Name:Psma2
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 17

Organism-specific databases

Rat genome database More...RGDⁱ	61842 Psma2

RGDⁱ

61842 Psma2

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus, Proteasome

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	121	Y → F: Abolishes nuclear localization and phosphorylation. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000124079	2 – 234	Proteasome subunit alpha type-2Add BLAST		233

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanine1 Publication	1
Modified residueⁱ	6	PhosphotyrosineBy similarity	1
Modified residueⁱ	7	PhosphoserineBy similarity	1
Modified residueⁱ	14	PhosphoserineBy similarity	1
Modified residueⁱ	16	PhosphoserineBy similarity	1
Modified residueⁱ	24	PhosphotyrosineBy similarity	1
Modified residueⁱ	70	N6-acetyllysineBy similarity	1
Modified residueⁱ	76	PhosphotyrosineBy similarity	1
Modified residueⁱ	121	Phosphotyrosine1 Publication	1
Modified residueⁱ	171	N6-acetyllysineBy similarity	1

Post-translational modificationⁱ

Phosphorylated on tyrosine residues; which may be important for nuclear import.1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	P17220
PRIDEⁱ	P17220

2D gel databases

The World-2DPAGE database More...World-2DPAGEⁱ	0004:P17220

World-2DPAGEⁱ

0004:P17220

PTM databases

iPTMnetⁱ	P17220
PhosphoSitePlusⁱ	P17220

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSRNOG00000049920 Expressed in 10 organ(s), highest expression level in colon
Genevisibleⁱ	P17220 RN

Interactionⁱ

Subunit structureⁱ

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.By similarity

Protein-protein interaction databases

BioGridⁱ	248290, 5 interactors
IntActⁱ	P17220, 1 interactor
STRINGⁱ	10116.ENSRNOP00000066950

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P17220
SMRⁱ	P17220
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0181 Eukaryota ENOG410XPQ8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074870
HOVERGENⁱ	HBG003005
InParanoidⁱ	P17220
KEGG Orthology (KO) More...KOⁱ	K02726
OMAⁱ	FAWKASA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GX6
PhylomeDBⁱ	P17220

Family and domain databases

Gene3Dⁱ	3.60.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR029055 Ntn_hydrolases_N IPR023332 Proteasome_alpha-type IPR000426 Proteasome_asu_N IPR001353 Proteasome_sua/b IPR034644 Proteasome_subunit_alpha2
PANTHERⁱ	PTHR11599:SF16 PTHR11599:SF16, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00227 Proteasome, 1 hit PF10584 Proteasome_A_N, 1 hit
SMARTⁱ	View protein in SMART SM00948 Proteasome_A_N, 1 hit
SUPFAMⁱ	SSF56235 SSF56235, 1 hit
PROSITEⁱ	View protein in PROSITE PS00388 PROTEASOME_ALPHA_1, 1 hit PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P17220-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAERGYSFSL TTFSPSGKLV QIEYALAAVA GGAPSVGIKA ANGVVLATEK 
        60         70         80         90        100
KQKSILYDER SVHKVEPITK HIGLVYSGMG PDYRVLVHRA RKLAQQYYLV 
       110        120        130        140        150
YQEPIPTAQL VQRVASVMQE YTQSGGVRPF GVSLLICGWN EGRPYLFQSD 
       160        170        180        190        200
PSGAYFAWKA TAMGKNYVNG KTFLEKRYNE DLELEDAIHT AILTLKESFE 
       210        220        230 
GQMTEDNIEV GICNEAGFRR LTPTEVRDYL AAIA

Length:234

Mass (Da):25,927

Last modified:January 23, 2007 - v3

Checksum:ⁱ4ECB56A233583821

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J02897 mRNA Translation: AAA40838.1
PIRⁱ	A34535 SNRTC3
NCBI Reference Sequences More...RefSeqⁱ	NP_058975.1, NM_017279.1
UniGeneⁱ	Rn.1617

Genome annotation databases

Ensemblⁱ	ENSRNOT00000073834; ENSRNOP00000066950; ENSRNOG00000049920
GeneIDⁱ	29669
KEGGⁱ	rno:29669
UCSC genome browser More...UCSCⁱ	RGD:61842 rat

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P17220	Proteasome subunit alpha type-2	)	MOUSE		234	UniRef100_P49722
Proteasome subunit alpha type		Daphnia magna		234
Proteasome endopeptidase complex (Fragment)		MOUSE		183

Protein	Similar proteins		Species	Score	Length	Source
P17220	Proteasome subunit alpha type-2	)	MOUSE		234	UniRef90_P49722
Proteasome subunit alpha type-2		XENLA		234
Proteasome subunit alpha type		Daphnia magna		234
Proteasome subunit alpha type		DANRE		234
Proteasome subunit alpha type		LOXAF		234
+92

Protein	Similar proteins		Species	Score	Length	Source
P17220	Proteasome subunit alpha type-2	)	HUMAN		234	UniRef50_P25787
Proteasome subunit alpha type-2	)	BOVIN		234
Proteasome subunit alpha type-2	)	MOUSE		234
Proteasome subunit alpha type-2		XENLA		234
Proteasome subunit alpha type		ODORO		295
+293

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J02897 mRNA Translation: AAA40838.1
PIRⁱ	A34535 SNRTC3
RefSeqⁱ	NP_058975.1, NM_017279.1
UniGeneⁱ	Rn.1617

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6EPC	electron microscopy	12.30	B	1-234	[»]
	6EPD	electron microscopy	15.40	B	1-234	[»]
	6EPE	electron microscopy	12.80	B	1-234	[»]
	6EPF	electron microscopy	11.80	B	1-234	[»]
ProteinModelPortalⁱ	P17220
SMRⁱ	P17220
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	248290, 5 interactors
IntActⁱ	P17220, 1 interactor
STRINGⁱ	10116.ENSRNOP00000066950

Protein family/group databases

MEROPSⁱ	T01.972

MEROPSⁱ

T01.972

PTM databases

iPTMnetⁱ	P17220
PhosphoSitePlusⁱ	P17220

2D gel databases

World-2DPAGEⁱ	0004:P17220

World-2DPAGEⁱ

0004:P17220

Proteomic databases

PaxDbⁱ	P17220
PRIDEⁱ	P17220

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000073834; ENSRNOP00000066950; ENSRNOG00000049920
GeneIDⁱ	29669
KEGGⁱ	rno:29669
UCSCⁱ	RGD:61842 rat

Organism-specific databases

CTDⁱ	5683
RGDⁱ	61842 Psma2

Phylogenomic databases

eggNOGⁱ	KOG0181 Eukaryota ENOG410XPQ8 LUCA
GeneTreeⁱ	ENSGT00550000074870
HOVERGENⁱ	HBG003005
InParanoidⁱ	P17220
KOⁱ	K02726
OMAⁱ	FAWKASA
OrthoDBⁱ	EOG091G0GX6
PhylomeDBⁱ	P17220

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P17220

PROⁱ

PR:P17220

Gene expression databases

Bgeeⁱ	ENSRNOG00000049920 Expressed in 10 organ(s), highest expression level in colon
Genevisibleⁱ	P17220 RN

Family and domain databases

Gene3Dⁱ	3.60.20.10, 1 hit
InterProⁱ	View protein in InterPro IPR029055 Ntn_hydrolases_N IPR023332 Proteasome_alpha-type IPR000426 Proteasome_asu_N IPR001353 Proteasome_sua/b IPR034644 Proteasome_subunit_alpha2
PANTHERⁱ	PTHR11599:SF16 PTHR11599:SF16, 1 hit
Pfamⁱ	View protein in Pfam PF00227 Proteasome, 1 hit PF10584 Proteasome_A_N, 1 hit
SMARTⁱ	View protein in SMART SM00948 Proteasome_A_N, 1 hit
SUPFAMⁱ	SSF56235 SSF56235, 1 hit
PROSITEⁱ	View protein in PROSITE PS00388 PROTEASOME_ALPHA_1, 1 hit PS51475 PROTEASOME_ALPHA_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PSA2_RAT
Accessionⁱ	P17220Primary (citable) accession number: P17220
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniProtKB - P17220 (PSA2_RAT)

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Proteasome subunit alpha type-2

Psma2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ