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Protein

Bactericidal permeability-increasing protein

Gene

BPI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • lipopolysaccharide binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-6798695 Neutrophil degranulation
R-HSA-6803157 Antimicrobial peptides

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.C.40.1.1 the bactericidal permeability increasing protein (bpip) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bactericidal permeability-increasing protein
Short name:
BPI
Alternative name(s):
CAP 57
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BPI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000101425.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1095 BPI

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
109195 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P17213

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi49S → C: No impairment of secretion and increased propensity for dimer formation. 1 Publication1
Mutagenesisi163C → A: No impairment of secretion and/or biological activity. Loss of dimer formation. 1 Publication1
Mutagenesisi166C → S: Poorly secreted. Loss of LPS-binding and biological activity. 1 Publication1
Mutagenesisi206C → A: Not secreted. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
671

Open Targets

More...
OpenTargetsi
ENSG00000101425

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25403

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB04178 Di-Stearoyl-3-Sn-Phosphatidylcholine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BPI

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274242

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 314 PublicationsAdd BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001715432 – 487Bactericidal permeability-increasing proteinAdd BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi166 ↔ 2061 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi380N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P17213

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P17213

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P17213

PeptideAtlas

More...
PeptideAtlasi
P17213

PRoteomics IDEntifications database

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PRIDEi
P17213

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53463

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P17213

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P17213

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to cells of the myeloid series.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000101425 Expressed in 126 organ(s), highest expression level in bone marrow

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P17213 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P17213 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA061284

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Homodimer; disulfide-linked.1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262865

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1487
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P17213

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P17213

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P17213

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni32 – 42Central sheet, part 11 PublicationAdd BLAST11
Regioni41 – 224N-terminal barrel1 PublicationAdd BLAST184
Regioni226 – 290Central sheet, part 21 PublicationAdd BLAST65
Regioni240 – 245Cleavage sites for elastaseSequence analysis6
Regioni291 – 461C-terminal barrel1 PublicationAdd BLAST171
Regioni468 – 487Central sheet, part 31 PublicationAdd BLAST20

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.1 Publication
The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4160 Eukaryota
ENOG410Z88E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000110583

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG002797

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P17213

Identification of Orthologs from Complete Genome Data

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OMAi
DHDRMVY

Database of Orthologous Groups

More...
OrthoDBi
EOG091G08NV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P17213

TreeFam database of animal gene trees

More...
TreeFami
TF315617

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR030181 BPI
IPR030675 BPI/LBP
IPR032942 BPI/LBP/Plunc
IPR001124 Lipid-bd_serum_glycop_C
IPR017954 Lipid-bd_serum_glycop_CS
IPR017942 Lipid-bd_serum_glycop_N

The PANTHER Classification System

More...
PANTHERi
PTHR10504 PTHR10504, 1 hit
PTHR10504:SF84 PTHR10504:SF84, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002417 Lipid_binding_protein, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00328 BPI1, 1 hit
SM00329 BPI2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55394 SSF55394, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00400 LBP_BPI_CETP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P17213-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRENMARGPC NAPRWASLMV LVAIGTAVTA AVNPGVVVRI SQKGLDYASQ
60 70 80 90 100
QGTAALQKEL KRIKIPDYSD SFKIKHLGKG HYSFYSMDIR EFQLPSSQIS
110 120 130 140 150
MVPNVGLKFS ISNANIKISG KWKAQKRFLK MSGNFDLSIE GMSISADLKL
160 170 180 190 200
GSNPTSGKPT ITCSSCSSHI NSVHVHISKS KVGWLIQLFH KKIESALRNK
210 220 230 240 250
MNSQVCEKVT NSVSSELQPY FQTLPVMTKI DSVAGINYGL VAPPATTAET
260 270 280 290 300
LDVQMKGEFY SENHHNPPPF APPVMEFPAA HDRMVYLGLS DYFFNTAGLV
310 320 330 340 350
YQEAGVLKMT LRDDMIPKES KFRLTTKFFG TFLPEVAKKF PNMKIQIHVS
360 370 380 390 400
ASTPPHLSVQ PTGLTFYPAV DVQAFAVLPN SSLASLFLIG MHTTGSMEVS
410 420 430 440 450
AESNRLVGEL KLDRLLLELK HSNIGPFPVE LLQDIMNYIV PILVLPRVNE
460 470 480
KLQKGFPLPT PARVQLYNVV LQPHQNFLLF GADVVYK
Length:487
Mass (Da):53,900
Last modified:November 25, 2008 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i30BC73B1B465B62D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y738H0Y738_HUMAN
Bactericidal permeability-increasin...
BPI
286Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SFX6A0A0D9SFX6_HUMAN
Bactericidal permeability-increasin...
BPI
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDF1A0A2R8YDF1_HUMAN
Bactericidal permeability-increasin...
BPI
261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5M → L in AAH40955 (PubMed:15489334).Curated1
Sequence conflicti53T → R AA sequence (PubMed:1937776).Curated1
Sequence conflicti355P → S in AAG42844 (Ref. 7) Curated1
Sequence conflicti375F → L (PubMed:7517398).Curated1
Sequence conflicti411K → R in AAG42844 (Ref. 7) Curated1
Sequence conflicti433Q → L in BAG37729 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04972812A → T. Corresponds to variant dbSNP:rs5743497Ensembl.1
Natural variantiVAR_04972912A → V. Corresponds to variant dbSNP:rs5743498Ensembl.1
Natural variantiVAR_01840116A → V2 PublicationsCorresponds to variant dbSNP:rs1341023EnsemblClinVar.1
Natural variantiVAR_04973090R → C. Corresponds to variant dbSNP:rs5743500Ensembl.1
Natural variantiVAR_049732140E → Q. Corresponds to variant dbSNP:rs5743506Ensembl.1
Natural variantiVAR_018402196A → V. Corresponds to variant dbSNP:rs5743509EnsemblClinVar.1
Natural variantiVAR_018403216E → K3 PublicationsCorresponds to variant dbSNP:rs4358188EnsemblClinVar.1
Natural variantiVAR_049733280A → V. Corresponds to variant dbSNP:rs5741804Ensembl.1
Natural variantiVAR_049734377V → I. Corresponds to variant dbSNP:rs5743524Ensembl.1
Natural variantiVAR_049735404N → D2 PublicationsCorresponds to variant dbSNP:rs5741809Ensembl.1
Natural variantiVAR_049736451K → E. Corresponds to variant dbSNP:rs5743542Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J04739 mRNA Translation: AAA51841.1
DQ414688 mRNA Translation: ABD66755.1
AK315328 mRNA Translation: BAG37729.1
AL359555 Genomic DNA No translation available.
AL391095 Genomic DNA No translation available.
AL499625 Genomic DNA No translation available.
AL583962 Genomic DNA No translation available.
BC040955 mRNA Translation: AAH40955.1
AF322588 mRNA Translation: AAG42844.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13303.1

Protein sequence database of the Protein Information Resource

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PIRi
A33850 A30909

NCBI Reference Sequences

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RefSeqi
NP_001716.2, NM_001725.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.529019

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262865; ENSP00000262865; ENSG00000101425

Database of genes from NCBI RefSeq genomes

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GeneIDi
671

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:671

UCSC genome browser

More...
UCSCi
uc002xib.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04739 mRNA Translation: AAA51841.1
DQ414688 mRNA Translation: ABD66755.1
AK315328 mRNA Translation: BAG37729.1
AL359555 Genomic DNA No translation available.
AL391095 Genomic DNA No translation available.
AL499625 Genomic DNA No translation available.
AL583962 Genomic DNA No translation available.
BC040955 mRNA Translation: AAH40955.1
AF322588 mRNA Translation: AAG42844.1
CCDSiCCDS13303.1
PIRiA33850 A30909
RefSeqiNP_001716.2, NM_001725.2
UniGeneiHs.529019

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BP1X-ray2.40A32-487[»]
1EWFX-ray1.70A32-487[»]
ProteinModelPortaliP17213
SMRiP17213
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000262865

Chemistry databases

DrugBankiDB04178 Di-Stearoyl-3-Sn-Phosphatidylcholine

Protein family/group databases

TCDBi1.C.40.1.1 the bactericidal permeability increasing protein (bpip) family

PTM databases

iPTMnetiP17213
PhosphoSitePlusiP17213

Polymorphism and mutation databases

BioMutaiBPI
DMDMi215274242

Proteomic databases

EPDiP17213
MaxQBiP17213
PaxDbiP17213
PeptideAtlasiP17213
PRIDEiP17213
ProteomicsDBi53463

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262865; ENSP00000262865; ENSG00000101425
GeneIDi671
KEGGihsa:671
UCSCiuc002xib.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
671
DisGeNETi671
EuPathDBiHostDB:ENSG00000101425.12

GeneCards: human genes, protein and diseases

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GeneCardsi
BPI

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0027669
HGNCiHGNC:1095 BPI
HPAiHPA061284
MIMi109195 gene
neXtProtiNX_P17213
OpenTargetsiENSG00000101425
PharmGKBiPA25403

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4160 Eukaryota
ENOG410Z88E LUCA
GeneTreeiENSGT00730000110583
HOVERGENiHBG002797
InParanoidiP17213
OMAiDHDRMVY
OrthoDBiEOG091G08NV
PhylomeDBiP17213
TreeFamiTF315617

Enzyme and pathway databases

ReactomeiR-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-6798695 Neutrophil degranulation
R-HSA-6803157 Antimicrobial peptides

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BPI human
EvolutionaryTraceiP17213

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
671

Protein Ontology

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PROi
PR:P17213

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000101425 Expressed in 126 organ(s), highest expression level in bone marrow
ExpressionAtlasiP17213 baseline and differential
GenevisibleiP17213 HS

Family and domain databases

InterProiView protein in InterPro
IPR017943 Bactericidal_perm-incr_a/b_dom
IPR030181 BPI
IPR030675 BPI/LBP
IPR032942 BPI/LBP/Plunc
IPR001124 Lipid-bd_serum_glycop_C
IPR017954 Lipid-bd_serum_glycop_CS
IPR017942 Lipid-bd_serum_glycop_N
PANTHERiPTHR10504 PTHR10504, 1 hit
PTHR10504:SF84 PTHR10504:SF84, 1 hit
PfamiView protein in Pfam
PF01273 LBP_BPI_CETP, 1 hit
PF02886 LBP_BPI_CETP_C, 1 hit
PIRSFiPIRSF002417 Lipid_binding_protein, 1 hit
SMARTiView protein in SMART
SM00328 BPI1, 1 hit
SM00329 BPI2, 1 hit
SUPFAMiSSF55394 SSF55394, 2 hits
PROSITEiView protein in PROSITE
PS00400 LBP_BPI_CETP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBPI_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17213
Secondary accession number(s): B2RCY2
, Q1ZZU8, Q5JRW0, Q8IW58, Q9BYZ9, Q9H1L2, Q9H1M8, Q9H203, Q9UCT4, Q9UD65
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 179 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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