UniProtKB - P17181 (INAR1_HUMAN)
Interferon alpha/beta receptor 1
IFNAR1
Functioni
GO - Molecular functioni
- cytokine receptor activity Source: GO_Central
- type I interferon binding Source: UniProtKB
- type I interferon receptor activity Source: UniProtKB
GO - Biological processi
- cellular response to interferon-alpha Source: UniProtKB
- cytokine-mediated signaling pathway Source: GO_Central
- receptor signaling pathway via JAK-STAT Source: ProtInc
- response to lipopolysaccharide Source: UniProtKB
- response to virus Source: ProtInc
- type I interferon signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | P17181 |
Reactomei | R-HSA-909733, Interferon alpha/beta signaling R-HSA-912694, Regulation of IFNA signaling |
SignaLinki | P17181 |
SIGNORi | P17181 |
Protein family/group databases
TCDBi | 8.A.132.1.1, the interferon/interleukin receptor (iir) family |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon alpha/beta receptor 1Short name: IFN-R-1 Short name: IFN-alpha/beta receptor 1 Alternative name(s): Cytokine receptor class-II member 1 Cytokine receptor family 2 member 1 Short name: CRF2-1 Type I interferon receptor 1 |
Gene namesi | Name:IFNAR1 Synonyms:IFNAR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000142166.12 |
HGNCi | HGNC:5432, IFNAR1 |
MIMi | 107450, gene |
neXtProti | NX_P17181 |
Subcellular locationi
Lysosome
- Lysosome 1 Publication1 Publication
Plasma membrane
- Cell membrane 1 Publication3 Publications; Single-pass type I membrane protein Curated
Endosome
- Late endosome 1 Publication1 Publication
Note: Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes.2 Publications
Endosome
- late endosome Source: UniProtKB-SubCell
Lysosome
- lysosome Source: UniProtKB-SubCell
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 28 – 436 | ExtracellularSequence analysisAdd BLAST | 409 | |
Transmembranei | 437 – 457 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 458 – 557 | CytoplasmicSequence analysisAdd BLAST | 100 |
Keywords - Cellular componenti
Cell membrane, Endosome, Lysosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 466 | Y → F: Impairs internalization in response to interferon. 1 Publication | 1 | |
Mutagenesisi | 491 – 492 | LL → AA: Impairs interaction with TYK2. 1 Publication | 2 | |
Mutagenesisi | 496 – 497 | EE → AA: Impairs interaction with TYK2. 1 Publication | 2 | |
Mutagenesisi | 500 | E → A: Impairs interaction with TYK2. 1 Publication | 1 | |
Mutagenesisi | 501 | K → R: Mildly reduces ubiquitination. Nearly abolishes ubiquitination and subsequent degradation; when associated with 525-R-R-526. 1 Publication | 1 | |
Mutagenesisi | 525 – 526 | KK → RR: Reduces ubiquitination. Nearly abolishes ubiquitination and subsequent degradation; when associated with R-501. 1 Publication | 2 | |
Mutagenesisi | 535 | S → A: Abolishes interaction with FBXW11 and decreases ubiquitination. 2 Publications | 1 | |
Mutagenesisi | 535 | S → A: Abolishes phosphorylation at this site and interaction with SHMT2. 1 Publication | 1 | |
Mutagenesisi | 539 | S → A: Abolishes interaction with FBXW11 and decreases ubiquitination. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3454 |
OpenTargetsi | ENSG00000142166 |
PharmGKBi | PA29670 |
Miscellaneous databases
Pharosi | P17181, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1887 |
DrugBanki | DB14999, Human interferon beta DB05258, Interferon alfa DB00034, Interferon alfa-2a, Recombinant DB00105, Interferon alfa-2b DB00011, Interferon alfa-n1 DB00018, Interferon alfa-n3 DB00069, Interferon alfacon-1 DB00060, Interferon beta-1a DB00068, Interferon beta-1b DB05472, omega interferon DB00008, Peginterferon alfa-2a DB00022, Peginterferon alfa-2b |
DrugCentrali | P17181 |
GuidetoPHARMACOLOGYi | 1723 |
Polymorphism and mutation databases
BioMutai | IFNAR1 |
DMDMi | 90110827 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000011001 | 28 – 557 | Interferon alpha/beta receptor 1Add BLAST | 530 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 50 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 58 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 79 ↔ 87 | Combined sources1 Publication | ||
Glycosylationi | 81 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 88 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 110 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 172 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Disulfide bondi | 199 ↔ 220 | Combined sources1 Publication | ||
Glycosylationi | 254 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 283 ↔ 291 | Combined sources1 Publication | ||
Glycosylationi | 313 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 314 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 376 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 403 ↔ 426 | By similarity | ||
Glycosylationi | 416 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 433 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 463 | S-palmitoyl cysteine1 Publication | 1 | |
Modified residuei | 466 | Phosphotyrosine; by TYK21 Publication | 1 | |
Modified residuei | 481 | Phosphotyrosine; by TYK21 Publication | 1 | |
Modified residuei | 495 | PhosphoserineCombined sources | 1 | |
Cross-linki | 501 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Cross-linki | 525 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Cross-linki | 526 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Modified residuei | 535 | Phosphoserine4 Publications | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P17181 |
MassIVEi | P17181 |
MaxQBi | P17181 |
PaxDbi | P17181 |
PeptideAtlasi | P17181 |
PRIDEi | P17181 |
ProteomicsDBi | 4722 53460 [P17181-1] 53461 [P17181-2] 53462 [P17181-3] |
PTM databases
GlyConnecti | 1946, 8 N-Linked glycans (6 sites) |
GlyGeni | P17181, 12 sites |
iPTMneti | P17181 |
PhosphoSitePlusi | P17181 |
SwissPalmi | P17181 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000142166, Expressed in monocyte and 215 other tissues |
ExpressionAtlasi | P17181, baseline and differential |
Genevisiblei | P17181, HS |
Organism-specific databases
HPAi | ENSG00000142166, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986).
Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466 (PubMed:9121453).
Interacts with TYK2 (PubMed:7526154, PubMed:15337770, PubMed:24704786).
Interacts (serine-phosphorylated form) with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:14532120, PubMed:15337770, PubMed:18056411).
Interacts with SHMT2; this promotes interaction with ABRAXAS2 and the BRISC complex (PubMed:24075985).
10 PublicationsBinary interactionsi
Hide detailsP17181
With | #Exp. | IntAct |
---|---|---|
FBXW11 [Q9UKB1] | 8 | EBI-1547250,EBI-355189 |
LAPTM4B [Q86VI4] | 3 | EBI-1547250,EBI-3267258 |
STAT1 [P42224] | 2 | EBI-1547250,EBI-1057697 |
STAT2 [P52630] | 5 | EBI-1547250,EBI-1546963 |
Isoform 1 [P17181-1]
With | #Exp. | IntAct |
---|---|---|
TYK2 [P29597] | 3 | EBI-16099379,EBI-1383454 |
GO - Molecular functioni
- type I interferon binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109676, 30 interactors |
CORUMi | P17181 |
DIPi | DIP-57N |
ELMi | P17181 |
IntActi | P17181, 13 interactors |
MINTi | P17181 |
STRINGi | 9606.ENSP00000270139 |
Chemistry databases
BindingDBi | P17181 |
Miscellaneous databases
RNActi | P17181, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P17181 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P17181 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 126 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 127 – 227 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 101 | |
Domaini | 231 – 329 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 99 | |
Domaini | 331 – 432 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 102 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 491 – 500 | Important for interaction with TYK21 Publication | 10 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RISU, Eukaryota |
GeneTreei | ENSGT00940000158406 |
HOGENOMi | CLU_035134_0_0_1 |
InParanoidi | P17181 |
OMAi | KLPGCQH |
OrthoDBi | 941128at2759 |
PhylomeDBi | P17181 |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR015373, Interferon/interleukin_rcp_dom IPR016669, Interferon_alpha/beta_rcpt-1 |
Pfami | View protein in Pfam PF09294, Interfer-bind, 2 hits PF01108, Tissue_fac, 1 hit |
PIRSFi | PIRSF016567, IFN_alpha/beta_recept-1, 1 hit |
SUPFAMi | SSF49265, SSF49265, 4 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMVVLLGATT LVLVAVAPWV LSAAAGGKNL KSPQKVEVDI IDDNFILRWN
60 70 80 90 100
RSDESVGNVT FSFDYQKTGM DNWIKLSGCQ NITSTKCNFS SLKLNVYEEI
110 120 130 140 150
KLRIRAEKEN TSSWYEVDSF TPFRKAQIGP PEVHLEAEDK AIVIHISPGT
160 170 180 190 200
KDSVMWALDG LSFTYSLVIW KNSSGVEERI ENIYSRHKIY KLSPETTYCL
210 220 230 240 250
KVKAALLTSW KIGVYSPVHC IKTTVENELP PPENIEVSVQ NQNYVLKWDY
260 270 280 290 300
TYANMTFQVQ WLHAFLKRNP GNHLYKWKQI PDCENVKTTQ CVFPQNVFQK
310 320 330 340 350
GIYLLRVQAS DGNNTSFWSE EIKFDTEIQA FLLPPVFNIR SLSDSFHIYI
360 370 380 390 400
GAPKQSGNTP VIQDYPLIYE IIFWENTSNA ERKIIEKKTD VTVPNLKPLT
410 420 430 440 450
VYCVKARAHT MDEKLNKSSV FSDAVCEKTK PGNTSKIWLI VGICIALFAL
460 470 480 490 500
PFVIYAAKVF LRCINYVFFP SLKPSSSIDE YFSEQPLKNL LLSTSEEQIE
510 520 530 540 550
KCFIIENIST IATVEETNQT DEDHKKYSSQ TSQDSGNYSN EDESESKTSE
ELQQDFV
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J114 | C9J114_HUMAN | Interferon alpha/beta receptor 1 | IFNAR1 | 189 | Annotation score: | ||
A0A494C0E2 | A0A494C0E2_HUMAN | Interferon alpha/beta receptor 1 | IFNAR1 | 270 | Annotation score: | ||
A0A494BZU5 | A0A494BZU5_HUMAN | Interferon alpha/beta receptor 1 | IFNAR1 | 236 | Annotation score: | ||
A0A494C0P2 | A0A494C0P2_HUMAN | Interferon alpha/beta receptor 1 | IFNAR1 | 128 | Annotation score: | ||
A0A494C0K3 | A0A494C0K3_HUMAN | Interferon alpha/beta receptor 1 | IFNAR1 | 67 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 17 | A → G in AAA52730 (PubMed:2153461).Curated | 1 | |
Sequence conflicti | 59 | V → M in BAD96532 (Ref. 4) Curated | 1 | |
Sequence conflicti | 279 | Q → R in BAD96532 (Ref. 4) Curated | 1 | |
Sequence conflicti | 344 | D → G in BAG35516 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 479 | D → N in BAD96532 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_002717 | 168 | V → L3 PublicationsCorresponds to variant dbSNP:rs2257167Ensembl. | 1 | |
Natural variantiVAR_020502 | 307 | V → I1 PublicationCorresponds to variant dbSNP:rs17875833Ensembl. | 1 | |
Natural variantiVAR_020503 | 359 | T → M1 PublicationCorresponds to variant dbSNP:rs17875834Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055322 | 1 – 69 | Missing in isoform 4. 1 PublicationAdd BLAST | 69 | |
Alternative sequenceiVSP_029928 | 414 – 421 | Missing in isoform 3. 1 Publication | 8 | |
Alternative sequenceiVSP_029929 | 428 – 480 | Missing in isoform 3. 1 PublicationAdd BLAST | 53 | |
Alternative sequenceiVSP_029930 | 428 – 434 | KTKPGNT → NISLNSH in isoform 2. 1 Publication | 7 | |
Alternative sequenceiVSP_029931 | 435 – 557 | Missing in isoform 2. 1 PublicationAdd BLAST | 123 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03171 mRNA Translation: AAA52730.1 X60459 Genomic DNA Translation: CAA42992.1 AK298051 mRNA Translation: BAG60345.1 AK312631 mRNA Translation: BAG35516.1 AK222770 mRNA Translation: BAD96490.1 AK222812 mRNA Translation: BAD96532.1 AY654286 Genomic DNA Translation: AAT49100.1 AF039907 Genomic DNA No translation available. AP000296 Genomic DNA No translation available. AP000297 Genomic DNA No translation available. AP000298 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09837.1 CH471079 Genomic DNA Translation: EAX09839.1 BC002590 mRNA Translation: AAH02590.1 Sequence problems. BC021825 mRNA Translation: AAH21825.1 |
CCDSi | CCDS13624.1 [P17181-1] |
PIRi | A32694 S41602 |
RefSeqi | NP_000620.2, NM_000629.2 [P17181-1] XP_005261021.1, XM_005260964.2 |
Genome annotation databases
Ensembli | ENST00000270139; ENSP00000270139; ENSG00000142166 [P17181-1] ENST00000652450; ENSP00000498654; ENSG00000142166 [P17181-4] |
GeneIDi | 3454 |
KEGGi | hsa:3454 |
UCSCi | uc002yrn.4, human [P17181-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03171 mRNA Translation: AAA52730.1 X60459 Genomic DNA Translation: CAA42992.1 AK298051 mRNA Translation: BAG60345.1 AK312631 mRNA Translation: BAG35516.1 AK222770 mRNA Translation: BAD96490.1 AK222812 mRNA Translation: BAD96532.1 AY654286 Genomic DNA Translation: AAT49100.1 AF039907 Genomic DNA No translation available. AP000296 Genomic DNA No translation available. AP000297 Genomic DNA No translation available. AP000298 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09837.1 CH471079 Genomic DNA Translation: EAX09839.1 BC002590 mRNA Translation: AAH02590.1 Sequence problems. BC021825 mRNA Translation: AAH21825.1 |
CCDSi | CCDS13624.1 [P17181-1] |
PIRi | A32694 S41602 |
RefSeqi | NP_000620.2, NM_000629.2 [P17181-1] XP_005261021.1, XM_005260964.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3S98 | X-ray | 1.90 | A | 30-332 | [»] | |
3SE3 | X-ray | 4.00 | A | 28-436 | [»] | |
3SE4 | X-ray | 3.50 | A | 28-436 | [»] | |
4PO6 | X-ray | 1.99 | B | 478-507 | [»] | |
SMRi | P17181 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109676, 30 interactors |
CORUMi | P17181 |
DIPi | DIP-57N |
ELMi | P17181 |
IntActi | P17181, 13 interactors |
MINTi | P17181 |
STRINGi | 9606.ENSP00000270139 |
Chemistry databases
BindingDBi | P17181 |
ChEMBLi | CHEMBL1887 |
DrugBanki | DB14999, Human interferon beta DB05258, Interferon alfa DB00034, Interferon alfa-2a, Recombinant DB00105, Interferon alfa-2b DB00011, Interferon alfa-n1 DB00018, Interferon alfa-n3 DB00069, Interferon alfacon-1 DB00060, Interferon beta-1a DB00068, Interferon beta-1b DB05472, omega interferon DB00008, Peginterferon alfa-2a DB00022, Peginterferon alfa-2b |
DrugCentrali | P17181 |
GuidetoPHARMACOLOGYi | 1723 |
Protein family/group databases
TCDBi | 8.A.132.1.1, the interferon/interleukin receptor (iir) family |
PTM databases
GlyConnecti | 1946, 8 N-Linked glycans (6 sites) |
GlyGeni | P17181, 12 sites |
iPTMneti | P17181 |
PhosphoSitePlusi | P17181 |
SwissPalmi | P17181 |
Polymorphism and mutation databases
BioMutai | IFNAR1 |
DMDMi | 90110827 |
Proteomic databases
jPOSTi | P17181 |
MassIVEi | P17181 |
MaxQBi | P17181 |
PaxDbi | P17181 |
PeptideAtlasi | P17181 |
PRIDEi | P17181 |
ProteomicsDBi | 4722 53460 [P17181-1] 53461 [P17181-2] 53462 [P17181-3] |
Protocols and materials databases
ABCDi | P17181, 19 sequenced antibodies |
Antibodypediai | 3016, 785 antibodies |
DNASUi | 3454 |
Genome annotation databases
Ensembli | ENST00000270139; ENSP00000270139; ENSG00000142166 [P17181-1] ENST00000652450; ENSP00000498654; ENSG00000142166 [P17181-4] |
GeneIDi | 3454 |
KEGGi | hsa:3454 |
UCSCi | uc002yrn.4, human [P17181-1] |
Organism-specific databases
CTDi | 3454 |
DisGeNETi | 3454 |
EuPathDBi | HostDB:ENSG00000142166.12 |
GeneCardsi | IFNAR1 |
HGNCi | HGNC:5432, IFNAR1 |
HPAi | ENSG00000142166, Low tissue specificity |
MIMi | 107450, gene |
neXtProti | NX_P17181 |
OpenTargetsi | ENSG00000142166 |
PharmGKBi | PA29670 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RISU, Eukaryota |
GeneTreei | ENSGT00940000158406 |
HOGENOMi | CLU_035134_0_0_1 |
InParanoidi | P17181 |
OMAi | KLPGCQH |
OrthoDBi | 941128at2759 |
PhylomeDBi | P17181 |
Enzyme and pathway databases
PathwayCommonsi | P17181 |
Reactomei | R-HSA-909733, Interferon alpha/beta signaling R-HSA-912694, Regulation of IFNA signaling |
SignaLinki | P17181 |
SIGNORi | P17181 |
Miscellaneous databases
BioGRID-ORCSi | 3454, 6 hits in 845 CRISPR screens |
ChiTaRSi | IFNAR1, human |
EvolutionaryTracei | P17181 |
GeneWikii | IFNAR1 |
GenomeRNAii | 3454 |
Pharosi | P17181, Tclin |
PROi | PR:P17181 |
RNActi | P17181, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000142166, Expressed in monocyte and 215 other tissues |
ExpressionAtlasi | P17181, baseline and differential |
Genevisiblei | P17181, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR015373, Interferon/interleukin_rcp_dom IPR016669, Interferon_alpha/beta_rcpt-1 |
Pfami | View protein in Pfam PF09294, Interfer-bind, 2 hits PF01108, Tissue_fac, 1 hit |
PIRSFi | PIRSF016567, IFN_alpha/beta_recept-1, 1 hit |
SUPFAMi | SSF49265, SSF49265, 4 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | INAR1_HUMAN | |
Accessioni | P17181Primary (citable) accession number: P17181 Secondary accession number(s): B2R6L9 Q8WTZ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | March 7, 2006 | |
Last modified: | December 2, 2020 | |
This is version 196 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations