IFNAR1

Functionⁱ

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).By similarity1 Publication6 Publications

GO - Molecular functionⁱ

type I interferon binding Source: UniProtKB
type I interferon receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 7665574

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to interferon-alpha Source: UniProtKB
cytokine-mediated signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
JAK-STAT cascade
Source: ProtInc
Traceable author statementⁱ
- 7665574
response to lipopolysaccharide Source: UniProtKB
response to virus
Source: ProtInc
Traceable author statementⁱ
- 2153461
type I interferon signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 7665574

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor

Molecular function

Receptor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-909733 Interferon alpha/beta signaling R-HSA-912694 Regulation of IFNA signaling
SignaLinkⁱ	P17181
SIGNORⁱ	P17181

Protein family/group databases

TCDBⁱ	8.A.47.2.1 the neuropilin and tolloid-like (neto) family

TCDBⁱ

8.A.47.2.1 the neuropilin and tolloid-like (neto) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interferon alpha/beta receptor 1 Short name: IFN-R-1 Short name: IFN-alpha/beta receptor 1 Alternative name(s): Cytokine receptor class-II member 1 Cytokine receptor family 2 member 1 Short name: CRF2-1 Type I interferon receptor 1
Gene namesⁱ	Name:IFNAR1 Synonyms:IFNAR
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 21

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000142166.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5432 IFNAR1
MIMⁱ	107450 gene
neXtProtⁱ	NX_P17181

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	28 – 436	ExtracellularSequence analysisAdd BLAST	409
Transmembraneⁱ	437 – 457	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	458 – 557	CytoplasmicSequence analysisAdd BLAST	100

Keywords - Cellular componentⁱ

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	466	Y → F: Impairs internalization in response to interferon. 1 Publication	1
Mutagenesisⁱ	491 – 492	LL → AA: Impairs interaction with TYK2. 1 Publication	2
Mutagenesisⁱ	496 – 497	EE → AA: Impairs interaction with TYK2. 1 Publication	2
Mutagenesisⁱ	500	E → A: Impairs interaction with TYK2. 1 Publication	1
Mutagenesisⁱ	501	K → R: Mildly reduces ubiquitination. Nearly abolishes ubiquitination and subsequent degradation; when associated with 525-R-R-526. 1 Publication	1
Mutagenesisⁱ	525 – 526	KK → RR: Reduces ubiquitination. Nearly abolishes ubiquitination and subsequent degradation; when associated with R-501. 1 Publication	2
Mutagenesisⁱ	535	S → A: Abolishes interaction with FBXW11 and decreases ubiquitination. 2 Publications	1
Mutagenesisⁱ	535	S → A: Abolishes phosphorylation at this site and interaction with SHMT2. 1 Publication	1
Mutagenesisⁱ	539	S → A: Abolishes interaction with FBXW11 and decreases ubiquitination. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3454
Open Targets More...OpenTargetsⁱ	ENSG00000142166
PharmGKBⁱ	PA29670

Chemistry databases

ChEMBLⁱ	CHEMBL1887
Drug and drug target database More...DrugBankⁱ	DB00011 Interferon alfa-n1 DB00018 Interferon alfa-n3 DB00069 Interferon alfacon-1 DB00060 Interferon beta-1a DB00068 Interferon beta-1b DB05258 Natural alpha interferon DB05472 omega interferon DB00008 Peginterferon alfa-2a DB00022 Peginterferon alfa-2b
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1723

Polymorphism and mutation databases

BioMutaⁱ	IFNAR1
DMDMⁱ	90110827

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 27	Sequence analysisAdd BLAST		27
ChainⁱPRO_0000011001	28 – 557	Interferon alpha/beta receptor 1Add BLAST		530

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	50	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	58	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	79 ↔ 87	Combined sources1 Publication
Glycosylationⁱ	81	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	88	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	110	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	172	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1
Disulfide bondⁱ	199 ↔ 220	Combined sources1 Publication
Glycosylationⁱ	254	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	283 ↔ 291	Combined sources1 Publication
Glycosylationⁱ	313	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	314	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	376	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	403 ↔ 426	By similarity
Glycosylationⁱ	416	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	433	N-linked (GlcNAc...) asparagineSequence analysis	1
Lipidationⁱ	463	S-palmitoyl cysteine1 Publication	1
Modified residueⁱ	466	Phosphotyrosine; by TYK21 Publication	1
Modified residueⁱ	481	Phosphotyrosine; by TYK21 Publication	1
Modified residueⁱ	495	PhosphoserineCombined sources	1
Cross-linkⁱ	501	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linkⁱ	525	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linkⁱ	526	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residueⁱ	535	Phosphoserine4 Publications	1

Post-translational modificationⁱ

Ubiquitinated, leading to its internalization and degradation (PubMed:14532120, PubMed:15337770). Polyubiquitinated via 'Lys-48'-linked and 'Lys-63'-linked ubiquitin chains, leading to receptor internalization and lysosomal degradation (PubMed:18056411). The 'Lys-63'-linked ubiquitin chains are cleaved off by the BRISC complex (PubMed:24075985).4 Publications

Phosphorylated on serine residues in response to interferon binding; this promotes interaction with FBXW11 and ubiquitination (PubMed:14532120, PubMed:15337770, PubMed:24075985). Phosphorylated on tyrosine residues by TYK2 tyrosine kinase (PubMed:7526154). Phosphorylated on tyrosine residues in response to interferon (PubMed:10049744).4 Publications

Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P17181
PaxDbⁱ	P17181
PeptideAtlas More...PeptideAtlasⁱ	P17181
PRIDEⁱ	P17181
ProteomicsDBⁱ	53460 53461 [P17181-2] 53462 [P17181-3]

PTM databases

iPTMnetⁱ	P17181
PhosphoSitePlusⁱ	P17181
SwissPalmⁱ	P17181

Expressionⁱ

Tissue specificityⁱ

IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000142166 Expressed in 195 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_IFNAR1
ExpressionAtlasⁱ	P17181 baseline and differential
Genevisibleⁱ	P17181 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA018015 HPA029226

HPAⁱ

HPA018015
HPA029226

Interactionⁱ

Subunit structureⁱ

Heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466 (PubMed:9121453). Interacts with TYK2 (PubMed:7526154, PubMed:15337770, PubMed:24704786). Interacts (serine-phosphorylated form) with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:14532120, PubMed:15337770, PubMed:18056411). Interacts with SHMT2; this promotes interaction with ABRAXAS2 and the BRISC complex (PubMed:24075985).10 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
FBXW11	Q9UKB1	8	EBI-1547250,EBI-355189
STAT1	P42224	2	EBI-1547250,EBI-1057697
STAT2	P52630	5	EBI-1547250,EBI-1546963
TYK2	P29597	3	EBI-16099379,EBI-1383454

GO - Molecular functionⁱ

type I interferon binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109676, 29 interactors
CORUMⁱ	P17181
Database of interacting proteins More...DIPⁱ	DIP-57N
ELMⁱ	P17181
IntActⁱ	P17181, 9 interactors
Molecular INTeraction database More...MINTⁱ	P17181
STRINGⁱ	9606.ENSP00000270139

Chemistry databases

BindingDBⁱ

P17181

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	37 – 41	Combined sources	5
Beta strandⁱ	44 – 48	Combined sources	5
Beta strandⁱ	60 – 69	Combined sources	10
Beta strandⁱ	80 – 88	Combined sources	9
Beta strandⁱ	100 – 107	Combined sources	8
Beta strandⁱ	112 – 116	Combined sources	5
Helixⁱ	122 – 125	Combined sources	4
Beta strandⁱ	132 – 137	Combined sources	6
Beta strandⁱ	142 – 147	Combined sources	6
Beta strandⁱ	164 – 171	Combined sources	8
Turnⁱ	172 – 174	Combined sources	3
Beta strandⁱ	178 – 183	Combined sources	6
Beta strandⁱ	186 – 189	Combined sources	4
Beta strandⁱ	197 – 206	Combined sources	10
Helixⁱ	207 – 209	Combined sources	3
Beta strandⁱ	219 – 222	Combined sources	4
Beta strandⁱ	233 – 240	Combined sources	8
Beta strandⁱ	243 – 249	Combined sources	7
Beta strandⁱ	251 – 254	Combined sources	4
Beta strandⁱ	256 – 263	Combined sources	8
Helixⁱ	264 – 267	Combined sources	4
Helixⁱ	281 – 283	Combined sources	3
Beta strandⁱ	286 – 294	Combined sources	9
Helixⁱ	295 – 297	Combined sources	3
Beta strandⁱ	300 – 310	Combined sources	11
Beta strandⁱ	322 – 325	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P17181
SMRⁱ	P17181
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P17181

EvolutionaryTraceⁱ

P17181

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	32 – 126	Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST	95
Domainⁱ	127 – 227	Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST	101
Domainⁱ	231 – 329	Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST	99
Domainⁱ	331 – 432	Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST	102

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	491 – 500	Important for interaction with TYK21 Publication		10

Sequence similaritiesⁱ

Belongs to the type II cytokine receptor family.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IKIP Eukaryota ENOG4111QEU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063449
HOVERGENⁱ	HBG052126
InParanoidⁱ	P17181
KEGG Orthology (KO) More...KOⁱ	K05130
OMAⁱ	WIKLPGC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04H5
PhylomeDBⁱ	P17181

Family and domain databases

Gene3Dⁱ	2.60.40.10, 5 hits
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR013783 Ig-like_fold IPR015373 Interferon/interleukin_rcp_dom IPR016669 Interferon_alpha/beta_rcpt-1
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09294 Interfer-bind, 2 hits PF01108 Tissue_fac, 1 hit
PIRSFⁱ	PIRSF016567 IFN_alpha/beta_recept-1, 1 hit
SUPFAMⁱ	SSF49265 SSF49265, 4 hits
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 4 hits

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P17181-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMVVLLGATT LVLVAVAPWV LSAAAGGKNL KSPQKVEVDI IDDNFILRWN 
        60         70         80         90        100
RSDESVGNVT FSFDYQKTGM DNWIKLSGCQ NITSTKCNFS SLKLNVYEEI 
       110        120        130        140        150
KLRIRAEKEN TSSWYEVDSF TPFRKAQIGP PEVHLEAEDK AIVIHISPGT 
       160        170        180        190        200
KDSVMWALDG LSFTYSLVIW KNSSGVEERI ENIYSRHKIY KLSPETTYCL 
       210        220        230        240        250
KVKAALLTSW KIGVYSPVHC IKTTVENELP PPENIEVSVQ NQNYVLKWDY 
       260        270        280        290        300
TYANMTFQVQ WLHAFLKRNP GNHLYKWKQI PDCENVKTTQ CVFPQNVFQK 
       310        320        330        340        350
GIYLLRVQAS DGNNTSFWSE EIKFDTEIQA FLLPPVFNIR SLSDSFHIYI 
       360        370        380        390        400
GAPKQSGNTP VIQDYPLIYE IIFWENTSNA ERKIIEKKTD VTVPNLKPLT 
       410        420        430        440        450
VYCVKARAHT MDEKLNKSSV FSDAVCEKTK PGNTSKIWLI VGICIALFAL 
       460        470        480        490        500
PFVIYAAKVF LRCINYVFFP SLKPSSSIDE YFSEQPLKNL LLSTSEEQIE 
       510        520        530        540        550
KCFIIENIST IATVEETNQT DEDHKKYSSQ TSQDSGNYSN EDESESKTSE 

ELQQDFV

Length:557

Mass (Da):63,525

Last modified:March 7, 2006 - v3

Checksum:ⁱ24A01779DB7F356F

GO

Isoform 2 (identifier: P17181-2) [UniParc]FASTA Add to basket

Also known as: Sol-1, Soluble form 1

The sequence of this isoform differs from the canonical sequence as follows:
428-434: KTKPGNT → NISLNSH
435-557: Missing.

« Hide

        10         20         30         40         50
MMVVLLGATT LVLVAVAPWV LSAAAGGKNL KSPQKVEVDI IDDNFILRWN 
        60         70         80         90        100
RSDESVGNVT FSFDYQKTGM DNWIKLSGCQ NITSTKCNFS SLKLNVYEEI 
       110        120        130        140        150
KLRIRAEKEN TSSWYEVDSF TPFRKAQIGP PEVHLEAEDK AIVIHISPGT 
       160        170        180        190        200
KDSVMWALDG LSFTYSLVIW KNSSGVEERI ENIYSRHKIY KLSPETTYCL 
       210        220        230        240        250
KVKAALLTSW KIGVYSPVHC IKTTVENELP PPENIEVSVQ NQNYVLKWDY 
       260        270        280        290        300
TYANMTFQVQ WLHAFLKRNP GNHLYKWKQI PDCENVKTTQ CVFPQNVFQK 
       310        320        330        340        350
GIYLLRVQAS DGNNTSFWSE EIKFDTEIQA FLLPPVFNIR SLSDSFHIYI 
       360        370        380        390        400
GAPKQSGNTP VIQDYPLIYE IIFWENTSNA ERKIIEKKTD VTVPNLKPLT 
       410        420        430 
VYCVKARAHT MDEKLNKSSV FSDAVCENIS LNSH

Note: Incomplete sequence.

Show »

Length:434

Mass (Da):49,547

Checksum:ⁱ4744EF06968FD2EA

GO

Isoform 3 (identifier: P17181-3) [UniParc]FASTA Add to basket

Also known as: Sol-2, Soluble form 2

The sequence of this isoform differs from the canonical sequence as follows:
414-421: Missing.
428-480: Missing.

« Hide

        10         20         30         40         50
MMVVLLGATT LVLVAVAPWV LSAAAGGKNL KSPQKVEVDI IDDNFILRWN 
        60         70         80         90        100
RSDESVGNVT FSFDYQKTGM DNWIKLSGCQ NITSTKCNFS SLKLNVYEEI 
       110        120        130        140        150
KLRIRAEKEN TSSWYEVDSF TPFRKAQIGP PEVHLEAEDK AIVIHISPGT 
       160        170        180        190        200
KDSVMWALDG LSFTYSLVIW KNSSGVEERI ENIYSRHKIY KLSPETTYCL 
       210        220        230        240        250
KVKAALLTSW KIGVYSPVHC IKTTVENELP PPENIEVSVQ NQNYVLKWDY 
       260        270        280        290        300
TYANMTFQVQ WLHAFLKRNP GNHLYKWKQI PDCENVKTTQ CVFPQNVFQK 
       310        320        330        340        350
GIYLLRVQAS DGNNTSFWSE EIKFDTEIQA FLLPPVFNIR SLSDSFHIYI 
       360        370        380        390        400
GAPKQSGNTP VIQDYPLIYE IIFWENTSNA ERKIIEKKTD VTVPNLKPLT 
       410        420        430        440        450
VYCVKARAHT MDESDAVCEY FSEQPLKNLL LSTSEEQIEK CFIIENISTI 
       460        470        480        490 
ATVEETNQTD EDHKKYSSQT SQDSGNYSNE DESESKTSEE LQQDFV

Note: Incomplete sequence.

Show »

Length:496

Mass (Da):56,718

Checksum:ⁱ16984A61FE2BF41C

GO

Isoform 4 (identifier: P17181-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-69: Missing.

« Hide

        10         20         30         40         50
MDNWIKLSGC QNITSTKCNF SSLKLNVYEE IKLRIRAEKE NTSSWYEVDS 
        60         70         80         90        100
FTPFRKAQIG PPEVHLEAED KAIVIHISPG TKDSVMWALD GLSFTYSLVI 
       110        120        130        140        150
WKNSSGVEER IENIYSRHKI YKLSPETTYC LKVKAALLTS WKIGVYSPVH 
       160        170        180        190        200
CIKTTVENEL PPPENIEVSV QNQNYVLKWD YTYANMTFQV QWLHAFLKRN 
       210        220        230        240        250
PGNHLYKWKQ IPDCENVKTT QCVFPQNVFQ KGIYLLRVQA SDGNNTSFWS 
       260        270        280        290        300
EEIKFDTEIQ AFLLPPVFNI RSLSDSFHIY IGAPKQSGNT PVIQDYPLIY 
       310        320        330        340        350
EIIFWENTSN AERKIIEKKT DVTVPNLKPL TVYCVKARAH TMDEKLNKSS 
       360        370        380        390        400
VFSDAVCEKT KPGNTSKIWL IVGICIALFA LPFVIYAAKV FLRCINYVFF 
       410        420        430        440        450
PSLKPSSSID EYFSEQPLKN LLLSTSEEQI EKCFIIENIS TIATVEETNQ 
       460        470        480 
TDEDHKKYSS QTSQDSGNYS NEDESESKTS EELQQDFV

Note: No experimental confirmation available.

Show »

Length:488

Mass (Da):56,046

Checksum:ⁱ29AF6E22379E2E7C

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C9J114	C9J114_HUMAN		Interferon alpha/beta receptor 1 Interferon alpha/beta receptor 1	IFNAR1	136	Annotation score:

Sequence cautionⁱ

The sequence AAH02590 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	17	A → G in AAA52730 (PubMed:2153461).Curated	1
Sequence conflictⁱ	59	V → M in BAD96532 (Ref. 4) Curated	1
Sequence conflictⁱ	279	Q → R in BAD96532 (Ref. 4) Curated	1
Sequence conflictⁱ	344	D → G in BAG35516 (PubMed:14702039).Curated	1
Sequence conflictⁱ	479	D → N in BAD96532 (Ref. 4) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_002717	168	V → L3 PublicationsCorresponds to variant dbSNP:rs2257167Ensembl.	1
Natural variantⁱVAR_020502	307	V → I1 PublicationCorresponds to variant dbSNP:rs17875833Ensembl.	1
Natural variantⁱVAR_020503	359	T → M1 PublicationCorresponds to variant dbSNP:rs17875834Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_055322	1 – 69	Missing in isoform 4. 1 PublicationAdd BLAST	69
Alternative sequenceⁱVSP_029928	414 – 421	Missing in isoform 3. 1 Publication	8
Alternative sequenceⁱVSP_029929	428 – 480	Missing in isoform 3. 1 PublicationAdd BLAST	53
Alternative sequenceⁱVSP_029930	428 – 434	KTKPGNT → NISLNSH in isoform 2. 1 Publication	7
Alternative sequenceⁱVSP_029931	435 – 557	Missing in isoform 2. 1 PublicationAdd BLAST	123

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03171 mRNA Translation: AAA52730.1 X60459 Genomic DNA Translation: CAA42992.1 AK298051 mRNA Translation: BAG60345.1 AK312631 mRNA Translation: BAG35516.1 AK222770 mRNA Translation: BAD96490.1 AK222812 mRNA Translation: BAD96532.1 AY654286 Genomic DNA Translation: AAT49100.1 AF039907 Genomic DNA No translation available. AP000296 Genomic DNA No translation available. AP000297 Genomic DNA No translation available. AP000298 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09837.1 CH471079 Genomic DNA Translation: EAX09839.1 BC002590 mRNA Translation: AAH02590.1 Sequence problems. BC021825 mRNA Translation: AAH21825.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13624.1 [P17181-1]
PIRⁱ	A32694 S41602
NCBI Reference Sequences More...RefSeqⁱ	NP_000620.2, NM_000629.2 [P17181-1] XP_005261021.1, XM_005260964.2 [P17181-4]
UniGeneⁱ	Hs.529400

Genome annotation databases

Ensemblⁱ	ENST00000270139; ENSP00000270139; ENSG00000142166 [P17181-1]
GeneIDⁱ	3454
KEGGⁱ	hsa:3454
UCSC genome browser More...UCSCⁱ	uc002yrn.4 human [P17181-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P17181	Isoform 4 of Interferon alpha/beta receptor 1		HUMAN		488	UniRef90_P17181
Uncharacterized protein		CHLSB		571
Uncharacterized protein		MACMU		559
Uncharacterized protein		MACFA		559
IFNAR1 isoform 2		PANTR		558
+35
P17181-2	IFNAR1 isoform 4		PONAB		435	UniRef90_P17181-2
UPI0005F3CFD8		CERAT		524

Protein	Similar proteins		Species	Score	Length	Source
P17181	Interferon alpha/beta receptor 1		SHEEP		560	UniRef50_P17181
Interferon alpha/beta receptor 1		BOVIN		560
Interferon alpha/beta receptor 1		PIG		560
Isoform 4 of Interferon alpha/beta receptor 1		HUMAN		488
Uncharacterized protein		CHLSB		571
+152

Cross-referencesⁱ

Web resourcesⁱ

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03171 mRNA Translation: AAA52730.1 X60459 Genomic DNA Translation: CAA42992.1 AK298051 mRNA Translation: BAG60345.1 AK312631 mRNA Translation: BAG35516.1 AK222770 mRNA Translation: BAD96490.1 AK222812 mRNA Translation: BAD96532.1 AY654286 Genomic DNA Translation: AAT49100.1 AF039907 Genomic DNA No translation available. AP000296 Genomic DNA No translation available. AP000297 Genomic DNA No translation available. AP000298 Genomic DNA No translation available. CH471079 Genomic DNA Translation: EAX09837.1 CH471079 Genomic DNA Translation: EAX09839.1 BC002590 mRNA Translation: AAH02590.1 Sequence problems. BC021825 mRNA Translation: AAH21825.1
CCDSⁱ	CCDS13624.1 [P17181-1]
PIRⁱ	A32694 S41602
RefSeqⁱ	NP_000620.2, NM_000629.2 [P17181-1] XP_005261021.1, XM_005260964.2 [P17181-4]
UniGeneⁱ	Hs.529400

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3S98	X-ray	1.90	A	30-332	[»]
	3SE3	X-ray	4.00	A	28-436	[»]
	3SE4	X-ray	3.50	A	28-436	[»]
	4PO6	X-ray	1.99	B	478-507	[»]
ProteinModelPortalⁱ	P17181
SMRⁱ	P17181
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109676, 29 interactors
CORUMⁱ	P17181
DIPⁱ	DIP-57N
ELMⁱ	P17181
IntActⁱ	P17181, 9 interactors
MINTⁱ	P17181
STRINGⁱ	9606.ENSP00000270139

Chemistry databases

BindingDBⁱ	P17181
ChEMBLⁱ	CHEMBL1887
DrugBankⁱ	DB00011 Interferon alfa-n1 DB00018 Interferon alfa-n3 DB00069 Interferon alfacon-1 DB00060 Interferon beta-1a DB00068 Interferon beta-1b DB05258 Natural alpha interferon DB05472 omega interferon DB00008 Peginterferon alfa-2a DB00022 Peginterferon alfa-2b
GuidetoPHARMACOLOGYⁱ	1723

Protein family/group databases

TCDBⁱ	8.A.47.2.1 the neuropilin and tolloid-like (neto) family

TCDBⁱ

8.A.47.2.1 the neuropilin and tolloid-like (neto) family

PTM databases

iPTMnetⁱ	P17181
PhosphoSitePlusⁱ	P17181
SwissPalmⁱ	P17181

Polymorphism and mutation databases

BioMutaⁱ	IFNAR1
DMDMⁱ	90110827

Proteomic databases

MaxQBⁱ	P17181
PaxDbⁱ	P17181
PeptideAtlasⁱ	P17181
PRIDEⁱ	P17181
ProteomicsDBⁱ	53460 53461 [P17181-2] 53462 [P17181-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3454
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000270139; ENSP00000270139; ENSG00000142166 [P17181-1]
GeneIDⁱ	3454
KEGGⁱ	hsa:3454
UCSCⁱ	uc002yrn.4 human [P17181-1]

Organism-specific databases

CTDⁱ	3454
DisGeNETⁱ	3454
EuPathDBⁱ	HostDB:ENSG00000142166.12
GeneCardsⁱ	IFNAR1
HGNCⁱ	HGNC:5432 IFNAR1
HPAⁱ	HPA018015 HPA029226
MIMⁱ	107450 gene
neXtProtⁱ	NX_P17181
OpenTargetsⁱ	ENSG00000142166
PharmGKBⁱ	PA29670
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IKIP Eukaryota ENOG4111QEU LUCA
GeneTreeⁱ	ENSGT00530000063449
HOVERGENⁱ	HBG052126
InParanoidⁱ	P17181
KOⁱ	K05130
OMAⁱ	WIKLPGC
OrthoDBⁱ	EOG091G04H5
PhylomeDBⁱ	P17181

Enzyme and pathway databases

Reactomeⁱ	R-HSA-909733 Interferon alpha/beta signaling R-HSA-912694 Regulation of IFNA signaling
SignaLinkⁱ	P17181
SIGNORⁱ	P17181

Miscellaneous databases

ChiTaRSⁱ	IFNAR1 human
EvolutionaryTraceⁱ	P17181
GeneWikiⁱ	IFNAR1
GenomeRNAiⁱ	3454
Protein Ontology More...PROⁱ	PR:P17181
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000142166 Expressed in 195 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_IFNAR1
ExpressionAtlasⁱ	P17181 baseline and differential
Genevisibleⁱ	P17181 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 5 hits
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR013783 Ig-like_fold IPR015373 Interferon/interleukin_rcp_dom IPR016669 Interferon_alpha/beta_rcpt-1
Pfamⁱ	View protein in Pfam PF09294 Interfer-bind, 2 hits PF01108 Tissue_fac, 1 hit
PIRSFⁱ	PIRSF016567 IFN_alpha/beta_recept-1, 1 hit
SUPFAMⁱ	SSF49265 SSF49265, 4 hits
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	INAR1_HUMAN
Accessionⁱ	P17181Primary (citable) accession number: P17181 Secondary accession number(s): B2R6L9 Q8WTZ2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	March 7, 2006
	Last modified:	November 7, 2018
	This is version 180 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P17181 (INAR1_HUMAN)

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Interferon alpha/beta receptor 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endosome

Lysosome

Endosome

Lysosome

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ