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Entry version 162 (16 Oct 2019)
Sequence version 1 (01 Aug 1990)
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Protein

Transmembrane protein 11, mitochondrial

Gene

TMEM11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in mitochondrial morphogenesis.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8949613 Cristae formation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 11, mitochondrial
Alternative name(s):
Protein PM1
Protein PMI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM11
Synonyms:C17orf35, PM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16823 TMEM11

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P17152

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei84 – 100HelicalSequence analysisAdd BLAST17
Transmembranei107 – 124HelicalSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8834

Open Targets

More...
OpenTargetsi
ENSG00000178307

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134893886

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P17152

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM11

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000725621 – 192Transmembrane protein 11, mitochondrialAdd BLAST192

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P17152

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P17152

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P17152

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P17152

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P17152

PeptideAtlas

More...
PeptideAtlasi
P17152

PRoteomics IDEntifications database

More...
PRIDEi
P17152

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
53458

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P17152

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P17152

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P17152

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P17152

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000178307 Expressed in 223 organ(s), highest expression level in muscle of leg

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P17152 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA051795
HPA062854

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9.

Interacts with IMMT/MIC60.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
114361, 40 interactors

Protein interaction database and analysis system

More...
IntActi
P17152, 74 interactors

Molecular INTeraction database

More...
MINTi
P17152

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000319992

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM11 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGFW Eukaryota
ENOG410Z9AV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006617

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007261

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P17152

Identification of Orthologs from Complete Genome Data

More...
OMAi
LYTVSWQ

Database of Orthologous Groups

More...
OrthoDBi
1222072at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P17152

TreeFam database of animal gene trees

More...
TreeFami
TF324685

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026120 TMEM11

The PANTHER Classification System

More...
PANTHERi
PTHR15099 PTHR15099, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14972 Mito_morph_reg, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P17152-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAWGRRRLG PGSSGGSARE RVSLSATDCY IVHEIYNGEN AQDQFEYELE
60 70 80 90 100
QALEAQYKYI VIEPTRIGDE TARWITVGNC LHKTAVLAGT ACLFTPLALP
110 120 130 140 150
LDYSHYISLP AGVLSLACCT LYGISWQFDP CCKYQVEYDA YKLSRLPLHT
160 170 180 190
LTSSTPVVLV RKDDLHRKRL HNTIALAALV YCVKKIYELY AV
Length:192
Mass (Da):21,541
Last modified:August 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE46BACEBF5ACD1D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X51804 mRNA Translation: CAA36102.1
AK311965 mRNA Translation: BAG34905.1
BT006768 mRNA Translation: AAP35414.1
AC087294 Genomic DNA No translation available.
AC087393 Genomic DNA No translation available.
CH471210 Genomic DNA Translation: EAX02598.1
BC002819 mRNA Translation: AAH02819.1
BC005268 mRNA Translation: AAH05268.1
BC020815 mRNA Translation: AAH20815.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11216.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S15930

NCBI Reference Sequences

More...
RefSeqi
NP_003867.1, NM_003876.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000317635; ENSP00000319992; ENSG00000178307

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8834

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8834

UCSC genome browser

More...
UCSCi
uc002gyp.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51804 mRNA Translation: CAA36102.1
AK311965 mRNA Translation: BAG34905.1
BT006768 mRNA Translation: AAP35414.1
AC087294 Genomic DNA No translation available.
AC087393 Genomic DNA No translation available.
CH471210 Genomic DNA Translation: EAX02598.1
BC002819 mRNA Translation: AAH02819.1
BC005268 mRNA Translation: AAH05268.1
BC020815 mRNA Translation: AAH20815.1
CCDSiCCDS11216.1
PIRiS15930
RefSeqiNP_003867.1, NM_003876.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi114361, 40 interactors
IntActiP17152, 74 interactors
MINTiP17152
STRINGi9606.ENSP00000319992

PTM databases

iPTMnetiP17152
PhosphoSitePlusiP17152
SwissPalmiP17152

Polymorphism and mutation databases

BioMutaiTMEM11

Proteomic databases

EPDiP17152
jPOSTiP17152
MassIVEiP17152
MaxQBiP17152
PaxDbiP17152
PeptideAtlasiP17152
PRIDEiP17152
ProteomicsDBi53458
TopDownProteomicsiP17152

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8834

Genome annotation databases

EnsembliENST00000317635; ENSP00000319992; ENSG00000178307
GeneIDi8834
KEGGihsa:8834
UCSCiuc002gyp.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8834
DisGeNETi8834

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM11
HGNCiHGNC:16823 TMEM11
HPAiHPA051795
HPA062854
neXtProtiNX_P17152
OpenTargetsiENSG00000178307
PharmGKBiPA134893886

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGFW Eukaryota
ENOG410Z9AV LUCA
GeneTreeiENSGT00390000006617
HOGENOMiHOG000007261
InParanoidiP17152
OMAiLYTVSWQ
OrthoDBi1222072at2759
PhylomeDBiP17152
TreeFamiTF324685

Enzyme and pathway databases

ReactomeiR-HSA-8949613 Cristae formation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMEM11 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8834
PharosiP17152

Protein Ontology

More...
PROi
PR:P17152

Gene expression databases

BgeeiENSG00000178307 Expressed in 223 organ(s), highest expression level in muscle of leg
GenevisibleiP17152 HS

Family and domain databases

InterProiView protein in InterPro
IPR026120 TMEM11
PANTHERiPTHR15099 PTHR15099, 1 hit
PfamiView protein in Pfam
PF14972 Mito_morph_reg, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMM11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17152
Secondary accession number(s): Q53YB2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: October 16, 2019
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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