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Entry version 57 (05 Jun 2019)
Sequence version 2 (30 May 2000)
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Protein

Early phosphoprotein p84

Gene

UL112/UL113

Organism
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes efficient viral DNA replication. Recruits the DNA polymerase processivity factor to pre-replication foci.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • bidirectional double-stranded viral DNA replication Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Early phosphoprotein p84
Cleaved into the following 3 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UL112/UL113
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10360 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008992 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000008991 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

p20 :
p26 :
p28 :

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Host nucleus, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001163281 – 684Early phosphoprotein p84Add BLAST684
ChainiPRO_00004381611 – 243p281 PublicationAdd BLAST243
ChainiPRO_00004381621 – 231p261 PublicationAdd BLAST231
ChainiPRO_00004381631 – 200p201 PublicationAdd BLAST200

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The isoforms p34, p43, p50 and p84 are cleaved by host calpain-1/CAPN1 and calpain-2/CAPN2 to generate p20, p26 and p28.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P17151

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Keywords - Developmental stagei

Early protein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoforms p34, p43, p50 and p84 self-interact and interact with each other via a shared N-terminal region; these interactions play an important role in their intranuclear targeting and in the recruitment of UL44 to subnuclear sites for viral replication.

1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P17151

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi261 – 264Nuclear localization signalSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi148 – 153Poly-Gly6
Compositional biasi197 – 200Poly-Ser4
Compositional biasi202 – 220Poly-GlyAdd BLAST19
Compositional biasi271 – 276Poly-Gly6
Compositional biasi285 – 296Poly-GlyAdd BLAST12
Compositional biasi314 – 318Poly-Ser5
Compositional biasi321 – 324Poly-Ser4
Compositional biasi327 – 334Poly-His8
Compositional biasi390 – 397Poly-Ala8
Compositional biasi563 – 568Poly-Ala6
Compositional biasi569 – 576Poly-Ser8
Compositional biasi578 – 585Poly-Pro8
Compositional biasi599 – 606Poly-Gly8
Compositional biasi615 – 621Poly-Ser7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the herpesviridae U79/UL112 family.Curated

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004138 U79_P34

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03064 U79_P34, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Isoforms 1, 2, 3 and 4 share a common N-terminus.
Isoform p84 (identifier: P17151-1) [UniParc]FASTAAdd to basket
Also known as: 84 kDa phosphoprotein

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLPTTVVRK YWTFANPNRI LHQSVNQTFD VRQFVFDTAR LVNCVDGDGK
60 70 80 90 100
VLHLNKGWLC ATIMQHGEAS AGAKTQQGFM SIDITGDGEL QEHLFVRGGI
110 120 130 140 150
VFNKSVSSVV GSSGPNESAL LTMISENGNL QVTYVRHYLK NHGESSSGGG
160 170 180 190 200
GCGAASTASA VCVSSLGGSG GTRDGPSAEE QQRRRQEQRH EERRKKSSSS
210 220 230 240 250
AGGGGGGGAG GGGGGGGSGG QHSSDSANGL LRDPRLMNRQ KERRPPPSSE
260 270 280 290 300
NDGSPPLREA KRQKTTAQHE GHGGGGKNET EQQSGGAGGG GGGGSGRMSL
310 320 330 340 350
PLDTSEAVAF LNYSSSSSAV SSSSNNHHHH HHHHNAVTDV AAGTDGALLL
360 370 380 390 400
PIERGAVVSS PSSTSPSSLL SLPRPSSAHS AGETVQESEA AATAAAAGLM
410 420 430 440 450
MMRRMRRAPA EAAEAPPQSE EENDSTTPVS NCRVPPNSQE SAAPQPPRSP
460 470 480 490 500
RFDDIIQSLT KMLNDCKEKR LCDLPLVSSR LLPETSGGTV VVNHSSVART
510 520 530 540 550
AAAVSAAGVG PPAAACPPLV TTGVVPSGSV AGVAPVAAAI ETPAAPPRPV
560 570 580 590 600
CEIKPYVVNP VVATAAAASN SSSSSSAPLP PPPPPSGGRR GRARNNTRGG
610 620 630 640 650
GGGGGGRNSR RQAASSSSSS SRRSRRRNNR HEDEEDNDPL LRLSQVAGNG
660 670 680
RRRGPSFLED GLEIIDPSEE AAIAAASIAA FFDD
Length:684
Mass (Da):70,272
Last modified:May 30, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF3325CE2E29EF449
GO
Isoform p50 (identifier: P17151-2) [UniParc]FASTAAdd to basket
Also known as: 50 kDa phosphoprotein

The sequence of this isoform differs from the canonical sequence as follows:
     346-423: GALLLPIERG...EAPPQSEEEN → DSCQRRRAGL...GPCVKSSPTW
     424-684: Missing.

Show »
Length:423
Mass (Da):44,045
Checksum:iE3D7635CE917B284
GO
Isoform p43 (identifier: P17151-3) [UniParc]FASTAAdd to basket
Also known as: 43 kDa phosphoprotein

The sequence of this isoform differs from the canonical sequence as follows:
     347-358: ALLLPIERGAVV → IRGASASSQSAF
     359-684: Missing.

Note: Most abundant product which level of expression remains constant throughout infection.
Show »
Length:358
Mass (Da):36,951
Checksum:i269BE524C6E85CE9
GO
Isoform p34 (identifier: P17151-4) [UniParc]FASTAAdd to basket
Also known as: 34 kDa phosphoprotein

The sequence of this isoform differs from the canonical sequence as follows:
     254-268: SPPLREAKRQKTTAQ → ESRPSSRHGAFRVDS
     269-684: Missing.

Show »
Length:268
Mass (Da):28,142
Checksum:iBD5906F4EAB28FC9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034767254 – 268SPPLR…KTTAQ → ESRPSSRHGAFRVDS in isoform p34. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_034768269 – 684Missing in isoform p34. 1 PublicationAdd BLAST416
Alternative sequenceiVSP_034769346 – 423GALLL…SEEEN → DSCQRRRAGLSSSTTAASRG PPQLSPQPALAPQQPHVRHS SPPVLYPQVPSPVSRPLPPQ SKHQLLLPGPCVKSSPTW in isoform p50. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_034770347 – 358ALLLP…RGAVV → IRGASASSQSAF in isoform p43. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_034771359 – 684Missing in isoform p43. 1 PublicationAdd BLAST326
Alternative sequenceiVSP_034772424 – 684Missing in isoform p50. 1 PublicationAdd BLAST261

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X17403 Genomic DNA Translation: CAA35315.1
U57431 mRNA Translation: AAB53250.1
U57432 mRNA Translation: AAB53251.1
U57433 mRNA Translation: AAB53252.1
U57434 mRNA Translation: AAB53253.1
BK000394 Genomic DNA Translation: DAA00103.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S09860
S09880

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17403 Genomic DNA Translation: CAA35315.1
U57431 mRNA Translation: AAB53250.1
U57432 mRNA Translation: AAB53251.1
U57433 mRNA Translation: AAB53252.1
U57434 mRNA Translation: AAB53253.1
BK000394 Genomic DNA Translation: DAA00103.1
PIRiS09860
S09880

3D structure databases

SMRiP17151
ModBaseiSearch...

Proteomic databases

PRIDEiP17151

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR004138 U79_P34
PfamiView protein in Pfam
PF03064 U79_P34, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEP84_HCMVA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17151
Secondary accession number(s): O10417
, O10418, O12567, P16768, P87888, Q7M6T1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: May 30, 2000
Last modified: June 5, 2019
This is version 57 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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