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Entry version 196 (23 Feb 2022)
Sequence version 5 (24 Jul 2013)
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Protein

Collagen alpha-1(IV) chain

Gene

emb-9

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons (PubMed:25080592).

May play a role in axon regeneration in embryos following injury in D-type motor neurons (PubMed:27984580).

Curated2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1442490, Collagen degradation
R-CEL-1474244, Extracellular matrix organization
R-CEL-186797, Signaling by PDGF
R-CEL-2022090, Assembly of collagen fibrils and other multimeric structures
R-CEL-216083, Integrin cell surface interactions
R-CEL-2243919, Crosslinking of collagen fibrils
R-CEL-3000157, Laminin interactions
R-CEL-419037, NCAM1 interactions

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P17139

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-1(IV) chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:emb-9Imported
Synonyms:clb-2Imported
ORF Names:K04H4.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
K04H4.1a ; CE48054 ; WBGene00001263 ; emb-9
K04H4.1b ; CE36390 ; WBGene00001263 ; emb-9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

At 20 degrees Celsius, there is reduced axon regeneration following injury in D-type motor neurons in temperature-sensitive mutant embryos.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi141P → L in ju1197; suppresses the lethal phenotypes of the pxn-2 tm3464 mutant. 1 Publication1
Mutagenesisi213G → E in b189; temperature-sensitive mutant. At the subrestrictive temperature of 22 degrees Celsius, causes the formation of ectopic presynaptic boutons on the ventral cord axons. Enhances the lethality of the pxn-2 ju436 mutant at 20 degrees Celsius. 2 Publications1
Mutagenesisi258G → E in xd51; formation of ectopic presynaptic boutons on the ventral cord axons associated with a disruption of synapse basement membrane. 1 Publication1
Mutagenesisi403G → E in allele g34; temperature-sensitive lethality during late embryogenesis. 1 Publication1
Mutagenesisi409G → E in allele g23/hc70; temperature-sensitive lethality during late embryogenesis. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000575221 – ?194N-terminal propeptide (7S domain)Add BLAST174
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000005753?195 – 1759Collagen alpha-1(IV) chainAdd BLAST1565

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1550 ↔ 1641Or C-1550 with C-1638PROSITE-ProRule annotation
Disulfide bondi1583 ↔ 1638Or C-1583 with C-1641PROSITE-ProRule annotation
Disulfide bondi1595 ↔ 1601PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1623S-Lysyl-methionine sulfilimine (Met-Lys) (interchain with K-1741)By similarity
Disulfide bondi1660 ↔ 1755Or C-1660 with C-1752PROSITE-ProRule annotation
Disulfide bondi1694 ↔ 1752Or C-1694 with C-1755PROSITE-ProRule annotation
Disulfide bondi1706 ↔ 1712PROSITE-ProRule annotation
Cross-linki1741S-Lysyl-methionine sulfilimine (Lys-Met) (interchain with M-1623)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.
The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.By similarity

Keywords - PTMi

Disulfide bond, Hydroxylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P17139

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P17139

PeptideAtlas

More...
PeptideAtlasi
P17139

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001263, Expressed in multi-cellular organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Trimers of two alpha 1(IV) and one alpha 2(IV) chain. Type IV collagen forms a mesh-like network linked through intermolecular interactions between 7S domains and between NC1 domains.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
41512, 6 interactors

Protein interaction database and analysis system

More...
IntActi
P17139, 7 interactors

STRING: functional protein association networks

More...
STRINGi
6239.K04H4.1a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P17139

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1535 – 1759Collagen IV NC1PROSITE-ProRule annotationAdd BLAST225

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni51 – 245DisorderedSequence analysisAdd BLAST195
Regioni195 – 1530Triple-helical regionAdd BLAST1336
Regioni269 – 415DisorderedSequence analysisAdd BLAST147
Regioni548 – 596DisorderedSequence analysisAdd BLAST49
Regioni618 – 650DisorderedSequence analysisAdd BLAST33
Regioni666 – 720DisorderedSequence analysisAdd BLAST55
Regioni787 – 1522DisorderedSequence analysisAdd BLAST736

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi300 – 314Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type IV collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153991

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P17139

Identification of Orthologs from Complete Genome Data

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OMAi
SCLMRFT

Database of Orthologous Groups

More...
OrthoDBi
63831at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P17139

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.170.240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160, Collagen
IPR001442, Collagen_IV_NC
IPR036954, Collagen_IV_NC_sf
IPR016187, CTDL_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01413, C4, 2 hits
PF01391, Collagen, 15 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00111, C4, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436, SSF56436, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51403, NC1_IV, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: P17139-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRLSLLGLT AAVVLLSSFC QDRIHVDAAA ACKGCAPPCV CPGTKGERGN
60 70 80 90 100
PGFGGEPGHP GAPGQDGPEG APGAPGMFGA EGDFGDMGSK GARGDRGLPG
110 120 130 140 150
SPGHPGLQGL DGLPGLKGEE GIPGCNGTDG FPGMPGLAGP PGQSGQNGNP
160 170 180 190 200
GRPGLSGPPG EGGVNSQGRK GVKGESGRSG VPGLPGNSGY PGLKGAKGDP
210 220 230 240 250
GPYGLPGFPG VSGLKGRMGV RTSGVKGEKG LPGPPGPPGQ PGSYPWASKP
260 270 280 290 300
IEMEVLQGPV GPAGVKGEKG RDGPVGPPGM LGLDGPPGYP GLKGQKGDLG
310 320 330 340 350
DAGQRGKRGK DGVPGNYGEK GSQGEQGLGG TPGYPGTKGG AGEPGYPGRP
360 370 380 390 400
GFEGDCGPEG PLGEGTGEAG PHGAQGFDGV QGGKGLPGHD GLPGPVGPRG
410 420 430 440 450
PVGAPGAPGQ PGIDGMPGYT EKGDRGEDGY PGFAGEPGLP GEPGDCGYPG
460 470 480 490 500
EDGLPGYDIQ GPPGLDGQSG RDGFPGIPGD IGDPGYSGEK GFPGTGVNKV
510 520 530 540 550
GPPGMTGLPG EPGMPGRIGV DGYPGPPGNN GERGEDCGYC PDGVPGNAGD
560 570 580 590 600
PGFPGMNGYP GPPGPNGDHG DCGMPGAPGK PGSAGSDGLS GSPGLPGIPG
610 620 630 640 650
YPGMKGEAGE IVGPMENPAG IPGLKGDHGL PGLPGRPGSD GLPGYPGGPG
660 670 680 690 700
QNGFPGLQGE PGLAGIDGKR GRQGSLGIPG LQGPPGDSFP GQPGTPGYKG
710 720 730 740 750
ERGADGLPGL PGAQGPRGIP APLRIVNQVA GQPGVDGMPG LPGDRGADGL
760 770 780 790 800
PGLPGPVGPD GYPGTPGERG MDGLPGFPGL HGEPGMRGQQ GEVGFNGIDG
810 820 830 840 850
DCGEPGLDGY PGAPGAPGAP GETGFGFPGQ VGYPGPNGDA GAAGLPGPDG
860 870 880 890 900
YPGRDGLPGT PGYPGEAGMN GQDGAPGQPG SRGESGLVGI DGKKGRDGTP
910 920 930 940 950
GTRGQDGGPG YSGEAGAPGQ NGMDGYPGAP GDQGYPGSPG QDGYPGPSGI
960 970 980 990 1000
PGEDGLVGFP GLRGEHGDNG LPGLEGECGE EGSRGLDGVP GYPGEHGTDG
1010 1020 1030 1040 1050
LPGLPGADGQ PGFVGEAGEP GTPGYRGQPG EPGNLAYPGQ PGDVGYPGPD
1060 1070 1080 1090 1100
GPPGLPGQDG LPGLNGERGD NGDSYPGNPG LSGQPGDAGY DGLDGVPGPP
1110 1120 1130 1140 1150
GYPGITGMPG LKGESGLPGL PGRQGNDGIP GQPGLEGECG EDGFPGSPGQ
1160 1170 1180 1190 1200
PGYPGQQGRE GEKGYPGIPG ENGLPGLRGQ DGQPGLKGEN GLDGQPGYPG
1210 1220 1230 1240 1250
SAGQLGTPGD VGYPGAPGEN GDNGNQGRDG QPGLRGESGQ PGQPGLPGRD
1260 1270 1280 1290 1300
GQPGPVGPPG DDGYPGAPGQ DIYGPPGQAG QDGYPGLDGL PGAPGLNGEP
1310 1320 1330 1340 1350
GSPGQYGMPG LPGGPGESGL PGYPGERGLP GLDGKRGHDG LPGAPGVPGV
1360 1370 1380 1390 1400
EGVPGLEGDC GEDGYPGAPG APGSNGYPGE RGLPGVPGQQ GRSGDNGYPG
1410 1420 1430 1440 1450
APGQPGIKGP RGDDGFPGRD GLDGLPGRPG REGLPGPMAM AVRNPPGQPG
1460 1470 1480 1490 1500
ENGYPGEKGY PGLPGDNGLS GPPGKAGYPG APGTDGYPGP PGLSGMPGHG
1510 1520 1530 1540 1550
GDQGFQGAAG RTGNPGLPGT PGYPGSPGGW APSRGFTFAK HSQTTAVPQC
1560 1570 1580 1590 1600
PPGASQLWEG YSLLYVQGNG RASGQDLGQP GSCLSKFNTM PFMFCNMNSV
1610 1620 1630 1640 1650
CHVSSRNDYS FWLSTDEPMT PMMNPVTGTA IRPYISRCAV CEVPTQIIAV
1660 1670 1680 1690 1700
HSQDTSVPQC PQGWSGMWTG YSFVMHTAAG AEGTGQSLQS PGSCLEEFRA
1710 1720 1730 1740 1750
VPFIECHGRG TCNYYATNHG FWLSIVDQDK QFRKPMSQTL KAGGLKDRVS

RCQVCLKNR
Length:1,759
Mass (Da):170,987
Last modified:July 24, 2013 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28BB24660E91BB7F
GO
Isoform b (identifier: P17139-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     502-758: Missing.

Show »
Length:1,502
Mass (Da):146,687
Checksum:i021478C18F992F52
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti302 – 305AGQR → LDN in CAA40299 (PubMed:1996137).Curated4
Sequence conflicti769R → P in CAA40299 (PubMed:1996137).Curated1
Sequence conflicti831V → D in CAA40299 (PubMed:1996137).Curated1
Sequence conflicti1515P → Q in AAB59179 (PubMed:2793871).Curated1
Sequence conflicti1723L → P in CAA40299 (PubMed:1996137).Curated1
Sequence conflicti1723L → P in AAB59179 (PubMed:2793871).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_011573502 – 758Missing in isoform b. CuratedAdd BLAST257

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X56979 Genomic DNA Translation: CAA40299.1
BX284603 Genomic DNA Translation: CAA81584.5
BX284603 Genomic DNA Translation: CAE52901.2
J05067 Genomic DNA Translation: AAB59179.1

Protein sequence database of the Protein Information Resource

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PIRi
S40991

NCBI Reference Sequences

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RefSeqi
NP_001022662.2, NM_001027491.4 [P17139-1]
NP_001022663.1, NM_001027492.4 [P17139-2]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
K04H4.1a.1; K04H4.1a.1; WBGene00001263 [P17139-1]
K04H4.1b.1; K04H4.1b.1; WBGene00001263 [P17139-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
176314

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_K04H4.1

UCSC genome browser

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UCSCi
K04H4.1b, c. elegans [P17139-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56979 Genomic DNA Translation: CAA40299.1
BX284603 Genomic DNA Translation: CAA81584.5
BX284603 Genomic DNA Translation: CAE52901.2
J05067 Genomic DNA Translation: AAB59179.1
PIRiS40991
RefSeqiNP_001022662.2, NM_001027491.4 [P17139-1]
NP_001022663.1, NM_001027492.4 [P17139-2]

3D structure databases

SMRiP17139
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi41512, 6 interactors
IntActiP17139, 7 interactors
STRINGi6239.K04H4.1a

Proteomic databases

EPDiP17139
PaxDbiP17139
PeptideAtlasiP17139

Genome annotation databases

EnsemblMetazoaiK04H4.1a.1; K04H4.1a.1; WBGene00001263 [P17139-1]
K04H4.1b.1; K04H4.1b.1; WBGene00001263 [P17139-2]
GeneIDi176314
KEGGicel:CELE_K04H4.1
UCSCiK04H4.1b, c. elegans [P17139-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
176314
WormBaseiK04H4.1a ; CE48054 ; WBGene00001263 ; emb-9
K04H4.1b ; CE36390 ; WBGene00001263 ; emb-9

Phylogenomic databases

eggNOGiKOG3544, Eukaryota
GeneTreeiENSGT00940000153991
InParanoidiP17139
OMAiSCLMRFT
OrthoDBi63831at2759
PhylomeDBiP17139

Enzyme and pathway databases

ReactomeiR-CEL-1442490, Collagen degradation
R-CEL-1474244, Extracellular matrix organization
R-CEL-186797, Signaling by PDGF
R-CEL-2022090, Assembly of collagen fibrils and other multimeric structures
R-CEL-216083, Integrin cell surface interactions
R-CEL-2243919, Crosslinking of collagen fibrils
R-CEL-3000157, Laminin interactions
R-CEL-419037, NCAM1 interactions
SignaLinkiP17139

Miscellaneous databases

Protein Ontology

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PROi
PR:P17139

Gene expression databases

BgeeiWBGene00001263, Expressed in multi-cellular organism and 5 other tissues

Family and domain databases

Gene3Di2.170.240.10, 1 hit
InterProiView protein in InterPro
IPR008160, Collagen
IPR001442, Collagen_IV_NC
IPR036954, Collagen_IV_NC_sf
IPR016187, CTDL_fold
PfamiView protein in Pfam
PF01413, C4, 2 hits
PF01391, Collagen, 15 hits
SMARTiView protein in SMART
SM00111, C4, 2 hits
SUPFAMiSSF56436, SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS51403, NC1_IV, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO4A1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17139
Secondary accession number(s): Q6LAD0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: July 24, 2013
Last modified: February 23, 2022
This is version 196 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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