UniProtKB - P17125 (TGFB3_MOUSE)
Transforming growth factor beta-3 proprotein
Tgfb3
Functioni
GO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- identical protein binding Source: AgBase
- protein-containing complex binding Source: MGI
- transforming growth factor beta binding Source: AgBase
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: AgBase
- type I transforming growth factor beta receptor binding Source: AgBase
GO - Biological processi
- activation of MAPK activity Source: MGI
- animal organ morphogenesis Source: MGI
- BMP signaling pathway Source: GO_Central
- cell-cell junction organization Source: AgBase
- cellular response to growth factor stimulus Source: MGI
- detection of hypoxia Source: AgBase
- embryonic neurocranium morphogenesis Source: MGI
- face morphogenesis Source: UniProtKB
- gene expression Source: MGI
- in utero embryonic development Source: MGI
- lung alveolus development Source: BHF-UCL
- mammary gland development Source: MGI
- negative regulation of cell population proliferation Source: MGI
- negative regulation of macrophage cytokine production Source: AgBase
- negative regulation of neuron apoptotic process Source: MGI
- negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
- negative regulation of vascular associated smooth muscle cell proliferation Source: MGI
- ossification involved in bone remodeling Source: AgBase
- positive regulation of apoptotic process Source: MGI
- positive regulation of bone mineralization Source: AgBase
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of collagen biosynthetic process Source: AgBase
- positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
- positive regulation of filopodium assembly Source: MGI
- positive regulation of gene expression Source: UniProtKB
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
- positive regulation of protein secretion Source: MGI
- positive regulation of SMAD protein signal transduction Source: BHF-UCL
- positive regulation of stress fiber assembly Source: MGI
- positive regulation of tight junction disassembly Source: MGI
- positive regulation of transcription, DNA-templated Source: BHF-UCL
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of cell population proliferation Source: GO_Central
- response to estrogen Source: MGI
- response to hypoxia Source: AgBase
- response to progesterone Source: AgBase
- roof of mouth development Source: MGI
- salivary gland morphogenesis Source: AgBase
- secondary palate development Source: UniProtKB
- SMAD protein signal transduction Source: GO_Central
- transforming growth factor beta receptor signaling pathway Source: AgBase
Keywordsi
Molecular function | Growth factor, Mitogen |
Enzyme and pathway databases
Reactomei | R-MMU-114608, Platelet degranulation R-MMU-2129379, Molecules associated with elastic fibres |
Names & Taxonomyi
Protein namesi | Recommended name: Transforming growth factor beta-3 proproteinCleaved into the following 2 chains: |
Gene namesi | Name:Tgfb3Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98727, Tgfb3 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- collagen-containing extracellular matrix Source: MGI
- extracellular matrix Source: MGI
- extracellular space Source: MGI
Nucleus
- nucleus Source: MGI
Plasma Membrane
- T-tubule Source: MGI
Other locations
- cell surface Source: MGI
- cytoplasm Source: MGI
- intracellular membrane-bounded organelle Source: MGI
- neuronal cell body Source: MGI
- secretory granule Source: MGI
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000033798 | 24 – 298 | Latency-associated peptideBy similarityAdd BLAST | 275 | |
ChainiPRO_0000033799 | 299 – 410 | Transforming growth factor beta-3By similarityAdd BLAST | 112 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 72 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 133 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 140 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 291 | N5-methylglutamineBy similarity | 1 | |
Disulfide bondi | 305 ↔ 314 | By similarity | ||
Disulfide bondi | 313 ↔ 376 | By similarity | ||
Disulfide bondi | 342 ↔ 407 | By similarity | ||
Disulfide bondi | 346 ↔ 409 | By similarity | ||
Disulfide bondi | 375 | InterchainBy similarity |
Post-translational modificationi
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, MethylationProteomic databases
MaxQBi | P17125 |
PaxDbi | P17125 |
PeptideAtlasi | P17125 |
PRIDEi | P17125 |
PTM databases
GlyGeni | P17125, 3 sites |
iPTMneti | P17125 |
PhosphoSitePlusi | P17125 |
Interactioni
Subunit structurei
Interacts with ASPN (By similarity). Latency-associated peptide: Homodimer; disulfide-linked (By similarity). Latency-associated peptide:
Interacts with Transforming growth factor beta-3 (TGF-beta-3) chain; interaction is non-covalent and maintains (TGF-beta-3) in a latent state (By similarity). Latency-associated peptide:
Interacts with LRRC32/GARP; leading to regulate activation of TGF-beta-3 and promote epithelial fusion during palate development (PubMed:28912269). Latency-associated peptide:
Interacts (via cell attachment site) with integrins, leading to release of the active TGF-beta-3 (By similarity). Transforming growth factor beta-3: Homodimer; disulfide-linked (By similarity). Transforming growth factor beta-3:
Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity).
By similarity1 PublicationGO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- identical protein binding Source: AgBase
- transforming growth factor beta binding Source: AgBase
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: AgBase
- type I transforming growth factor beta receptor binding Source: AgBase
Protein-protein interaction databases
ComplexPortali | CPX-825, TGF-beta-3 complex CPX-826, TGF-beta-3-TGFR complex |
STRINGi | 10090.ENSMUSP00000003687 |
Miscellaneous databases
RNActi | P17125, protein |
Structurei
3D structure databases
BMRBi | P17125 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 259 – 261 | Cell attachment siteBy similarity | 3 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
InParanoidi | P17125 |
PhylomeDBi | P17125 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR015618, TGFB3 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01426, TGFBETA3 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MHLQRALVVL ALLNLATISL SLSTCTTLDF GHIKKKRVEA IRGQILSKLR
60 70 80 90 100
LTSPPEPSVM THVPYQVLAL YNSTRELLEE MHGEREEGCT QETSESEYYA
110 120 130 140 150
KEIHKFDMIQ GLAEHNELAV CPKGITSKVF RFNVSSVEKN GTNLFRAEFR
160 170 180 190 200
VLRVPNPSSK RTEQRIELFQ ILRPDEHIAK QRYIGGKNLP TRGTAEWLSF
210 220 230 240 250
DVTDTVREWL LRRESNLGLE ISIHCPCHTF QPNGDILENV HEVMEIKFKG
260 270 280 290 300
VDNEDDHGRG DLGRLKKQKD HHNPHLILMM IPPHRLDSPG QGSQRKKRAL
310 320 330 340 350
DTNYCFRNLE ENCCVRPLYI DFRQDLGWKW VHEPKGYYAN FCSGPCPYLR
360 370 380 390 400
SADTTHSTVL GLYNTLNPEA SASPCCVPQD LEPLTILYYV GRTPKVEQLS
410
NMVVKSCKCS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ91YU7 | Q91YU7_MOUSE | Transforming growth factor beta | Tgfb3 | 412 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M32745 mRNA Translation: AAA40422.1 |
PIRi | A41397 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M32745 mRNA Translation: AAA40422.1 |
PIRi | A41397 |
3D structure databases
BMRBi | P17125 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
ComplexPortali | CPX-825, TGF-beta-3 complex CPX-826, TGF-beta-3-TGFR complex |
STRINGi | 10090.ENSMUSP00000003687 |
PTM databases
GlyGeni | P17125, 3 sites |
iPTMneti | P17125 |
PhosphoSitePlusi | P17125 |
Proteomic databases
MaxQBi | P17125 |
PaxDbi | P17125 |
PeptideAtlasi | P17125 |
PRIDEi | P17125 |
Organism-specific databases
MGIi | MGI:98727, Tgfb3 |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
InParanoidi | P17125 |
PhylomeDBi | P17125 |
Enzyme and pathway databases
Reactomei | R-MMU-114608, Platelet degranulation R-MMU-2129379, Molecules associated with elastic fibres |
Miscellaneous databases
ChiTaRSi | Tgfb3, mouse |
PROi | PR:P17125 |
RNActi | P17125, protein |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR015618, TGFB3 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01426, TGFBETA3 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TGFB3_MOUSE | |
Accessioni | P17125Primary (citable) accession number: P17125 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | August 1, 1990 | |
Last modified: | October 7, 2020 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families