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Protein

Interleukin-2

Gene

Il2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.

GO - Molecular functioni

  • carbohydrate binding Source: RGD
  • cytokine activity Source: RGD
  • glycosphingolipid binding Source: RGD
  • growth factor activity Source: UniProtKB-KW
  • interleukin-2 receptor binding Source: RGD
  • kappa-type opioid receptor binding Source: RGD

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • G-protein coupled receptor signaling pathway Source: RGD
  • leukocyte activation involved in immune response Source: Ensembl
  • negative regulation of B cell apoptotic process Source: Ensembl
  • negative regulation of heart contraction Source: RGD
  • negative regulation of protein phosphorylation Source: RGD
  • positive regulation of activated T cell proliferation Source: Ensembl
  • positive regulation of B cell proliferation Source: Ensembl
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of dendritic spine development Source: RGD
  • positive regulation of interleukin-17 production Source: Ensembl
  • positive regulation of protein phosphorylation Source: RGD
  • positive regulation of regulatory T cell differentiation Source: RGD
  • positive regulation of T cell differentiation Source: RGD
  • positive regulation of T cell proliferation Source: RGD
  • positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
  • protein kinase C-activating G-protein coupled receptor signaling pathway Source: RGD
  • response to ethanol Source: RGD

Keywordsi

Molecular functionCytokine, Growth factor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-RNO-392451 G beta:gamma signalling through PI3Kgamma
R-RNO-5673001 RAF/MAP kinase cascade
R-RNO-9020558 Interleukin-2 signaling
R-RNO-912526 Interleukin receptor SHC signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2
Short name:
IL-2
Alternative name(s):
T-cell growth factor
Short name:
TCGF
Gene namesi
Name:Il2
Synonyms:Il-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi620047 Il2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001550021 – 155Interleukin-2Add BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi23O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi78 ↔ 126By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP17108
PRIDEiP17108

Expressioni

Gene expression databases

BgeeiENSRNOG00000017348
GenevisibleiP17108 RN

Interactioni

GO - Molecular functioni

  • cytokine activity Source: RGD
  • growth factor activity Source: UniProtKB-KW
  • interleukin-2 receptor binding Source: RGD
  • kappa-type opioid receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023327

Structurei

3D structure databases

ProteinModelPortaliP17108
SMRiP17108
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J049 Eukaryota
ENOG41119SF LUCA
GeneTreeiENSGT00390000003555
HOGENOMiHOG000048727
HOVERGENiHBG007496
InParanoidiP17108
KOiK05429
OMAiKWITFCQ
OrthoDBiEOG091G0VTZ
PhylomeDBiP17108
TreeFamiTF338200

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000779 IL-2
IPR030477 IL-2_CS
PANTHERiPTHR45426 PTHR45426, 1 hit
PfamiView protein in Pfam
PF00715 IL2, 1 hit
PRINTSiPR00265 INTERLEUKIN2
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003649 Interleukin-2, 1 hit
SMARTiView protein in SMART
SM00189 IL2, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00424 INTERLEUKIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P17108-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSMQLASCV ALTLVLLVNS APTSSPAKET QQHLEQLLLD LQVLLRGIDN
60 70 80 90 100
YKNLKLPMML TFKFYLPKQA TELKHLQCLE NELGALQRVL DLTQSKSFHL
110 120 130 140 150
EDAGNFISNI RVTVVKLKGS ENKFECQFDD EPATVVEFLR RWIAICQSII

STMTQ
Length:155
Mass (Da):17,633
Last modified:August 1, 1990 - v1
Checksum:i67A8554A73BF30A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22899 mRNA Translation: AAA41427.1
PIRiA45882 A31278
RefSeqiNP_446288.1, NM_053836.1
UniGeneiRn.9871

Genome annotation databases

EnsembliENSRNOT00000023327; ENSRNOP00000023327; ENSRNOG00000017348
GeneIDi116562
KEGGirno:116562
UCSCiRGD:620047 rat

Similar proteinsi

Entry informationi

Entry nameiIL2_RAT
AccessioniPrimary (citable) accession number: P17108
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: August 1, 1990
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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