UniProtKB - P17108 (IL2_RAT)
Protein
Interleukin-2
Gene
Il2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
GO - Molecular functioni
- carbohydrate binding Source: RGD
- cytokine activity Source: RGD
- glycosphingolipid binding Source: RGD
- growth factor activity Source: UniProtKB-KW
- interleukin-2 receptor binding Source: RGD
- kappa-type opioid receptor binding Source: RGD
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- extrinsic apoptotic signaling pathway in absence of ligand Source: RGD
- G protein-coupled receptor signaling pathway Source: RGD
- leukocyte activation involved in immune response Source: RGD
- negative regulation of B cell apoptotic process Source: RGD
- negative regulation of heart contraction Source: RGD
- negative regulation of inflammatory response Source: RGD
- negative regulation of lymphocyte proliferation Source: RGD
- negative regulation of protein phosphorylation Source: RGD
- negative regulation of T-helper 17 cell differentiation Source: RGD
- positive regulation of activated T cell proliferation Source: RGD
- positive regulation of B cell proliferation Source: RGD
- positive regulation of cytosolic calcium ion concentration Source: RGD
- positive regulation of dendritic spine development Source: RGD
- positive regulation of immunoglobulin secretion Source: RGD
- positive regulation of interferon-gamma production Source: RGD
- positive regulation of interleukin-17 production Source: RGD
- positive regulation of isotype switching to IgG isotypes Source: RGD
- positive regulation of plasma cell differentiation Source: Ensembl
- positive regulation of protein phosphorylation Source: RGD
- positive regulation of regulatory T cell differentiation Source: RGD
- positive regulation of T cell differentiation Source: RGD
- positive regulation of T cell proliferation Source: RGD
- positive regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of tyrosine phosphorylation of STAT protein Source: RGD
- protein kinase C-activating G protein-coupled receptor signaling pathway Source: RGD
- regulation of T cell homeostatic proliferation Source: RGD
- response to ethanol Source: RGD
Keywordsi
Molecular function | Cytokine, Growth factor |
Biological process | Adaptive immunity, Immunity |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-2Short name: IL-2 Alternative name(s): T-cell growth factor Short name: TCGF |
Gene namesi | Name:Il2 Synonyms:Il-2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620047, Il2 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | By similarityAdd BLAST | 20 | |
ChainiPRO_0000015500 | 21 – 155 | Interleukin-2Add BLAST | 135 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 23 | O-linked (GalNAc...) threonineBy similarity | 1 | |
Disulfide bondi | 78 ↔ 126 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P17108 |
PTM databases
GlyGeni | P17108, 1 site |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000017348, Expressed in kidney and 15 other tissues |
Genevisiblei | P17108, RN |
Interactioni
GO - Molecular functioni
- cytokine activity Source: RGD
- growth factor activity Source: UniProtKB-KW
- interleukin-2 receptor binding Source: RGD
- kappa-type opioid receptor binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000023327 |
Family & Domainsi
Sequence similaritiesi
Belongs to the IL-2 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RVR5, Eukaryota |
GeneTreei | ENSGT00390000003555 |
HOGENOMi | CLU_124210_0_0_1 |
InParanoidi | P17108 |
OMAi | FCQSIFS |
OrthoDBi | 1491449at2759 |
PhylomeDBi | P17108 |
TreeFami | TF338200 |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000779, IL-2 IPR030477, IL-2_CS |
Pfami | View protein in Pfam PF00715, IL2, 1 hit |
PRINTSi | PR00265, INTERLEUKIN2 |
SMARTi | View protein in SMART SM00189, IL2, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00424, INTERLEUKIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P17108-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYSMQLASCV ALTLVLLVNS APTSSPAKET QQHLEQLLLD LQVLLRGIDN
60 70 80 90 100
YKNLKLPMML TFKFYLPKQA TELKHLQCLE NELGALQRVL DLTQSKSFHL
110 120 130 140 150
EDAGNFISNI RVTVVKLKGS ENKFECQFDD EPATVVEFLR RWIAICQSII
STMTQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22899 mRNA Translation: AAA41427.1 |
PIRi | A45882, A31278 |
RefSeqi | NP_446288.1, NM_053836.1 |
Genome annotation databases
Ensembli | ENSRNOT00000023327; ENSRNOP00000023327; ENSRNOG00000017348 |
GeneIDi | 116562 |
KEGGi | rno:116562 |
UCSCi | RGD:620047, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22899 mRNA Translation: AAA41427.1 |
PIRi | A45882, A31278 |
RefSeqi | NP_446288.1, NM_053836.1 |
3D structure databases
SMRi | P17108 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000023327 |
PTM databases
GlyGeni | P17108, 1 site |
Proteomic databases
PaxDbi | P17108 |
Genome annotation databases
Ensembli | ENSRNOT00000023327; ENSRNOP00000023327; ENSRNOG00000017348 |
GeneIDi | 116562 |
KEGGi | rno:116562 |
UCSCi | RGD:620047, rat |
Organism-specific databases
CTDi | 3558 |
RGDi | 620047, Il2 |
Phylogenomic databases
eggNOGi | ENOG502RVR5, Eukaryota |
GeneTreei | ENSGT00390000003555 |
HOGENOMi | CLU_124210_0_0_1 |
InParanoidi | P17108 |
OMAi | FCQSIFS |
OrthoDBi | 1491449at2759 |
PhylomeDBi | P17108 |
TreeFami | TF338200 |
Miscellaneous databases
PROi | PR:P17108 |
Gene expression databases
Bgeei | ENSRNOG00000017348, Expressed in kidney and 15 other tissues |
Genevisiblei | P17108, RN |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000779, IL-2 IPR030477, IL-2_CS |
Pfami | View protein in Pfam PF00715, IL2, 1 hit |
PRINTSi | PR00265, INTERLEUKIN2 |
SMARTi | View protein in SMART SM00189, IL2, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00424, INTERLEUKIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IL2_RAT | |
Accessioni | P17108Primary (citable) accession number: P17108 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | August 1, 1990 | |
Last modified: | February 10, 2021 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families