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UniProtKB - P17105 (IP3KA_RAT)
Protein
Inositol-trisphosphate 3-kinase A
Gene
Itpka
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalytic activityi
- 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H+1 PublicationEC:2.7.1.1271 Publication
Activity regulationi
IP3K is activated by calmodulin.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 195 | ATPBy similarity | 1 | |
Binding sitei | 207 | ATP | 1 | |
Binding sitei | 260 | ATP | 1 | |
Binding sitei | 262 | SubstrateBy similarity | 1 | |
Binding sitei | 283 | SubstrateBy similarity | 1 | |
Binding sitei | 334 | ATPBy similarity | 1 | |
Binding sitei | 414 | ATP | 1 | |
Binding sitei | 417 | SubstrateBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 247 – 249 | ATP | 3 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
- calmodulin-dependent protein kinase activity Source: RGD
- inositol-1,4,5-trisphosphate 3-kinase activity Source: RGD
- inositol hexakisphosphate kinase activity Source: GO_Central
- kinase activity Source: GO_Central
- small GTPase binding Source: MGI
GO - Biological processi
- actin cytoskeleton organization Source: MGI
- dendritic spine maintenance Source: MGI
- inositol metabolic process Source: RGD
- inositol phosphate biosynthetic process Source: GO_Central
- phosphatidylinositol phosphate biosynthetic process Source: GO_Central
- positive regulation of dendritic spine morphogenesis Source: MGI
- regulation of synaptic plasticity Source: RGD
Keywordsi
Molecular function | Calmodulin-binding, Kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.1.127, 5301 |
Reactomei | R-RNO-1855204, Synthesis of IP3 and IP4 in the cytosol |
SABIO-RKi | P17105 |
Names & Taxonomyi
Protein namesi | Recommended name: Inositol-trisphosphate 3-kinase A (EC:2.7.1.127)Alternative name(s): Inositol 1,4,5-trisphosphate 3-kinase A Short name: IP3 3-kinase A Short name: IP3K A Short name: InsP 3-kinase A |
Gene namesi | Name:Itpka |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 619950, Itpka |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- dendritic spine Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066867 | 1 – 459 | Inositol-trisphosphate 3-kinase AAdd BLAST | 459 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 35 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 55 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 62 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 135 | PhosphoserineCombined sources | 1 | |
Modified residuei | 195 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
PaxDbi | P17105 |
PRIDEi | P17105 |
PTM databases
iPTMneti | P17105 |
PhosphoSitePlusi | P17105 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000005284, Expressed in brain and 21 other tissues |
Genevisiblei | P17105, RN |
Interactioni
GO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
- small GTPase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 249574, 3 interactors |
STRINGi | 10116.ENSRNOP00000007247 |
Chemistry databases
BindingDBi | P17105 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P17105 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P17105 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 26 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 49 – 164 | DisorderedSequence analysisAdd BLAST | 116 | |
Regioni | 285 – 293 | Calmodulin-binding | 9 | |
Regioni | 310 – 317 | Substrate bindingBy similarity | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 113 – 134 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 145 – 159 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the inositol phosphokinase (IPK) family.Curated
Phylogenomic databases
eggNOGi | KOG1621, Eukaryota |
GeneTreei | ENSGT00940000161350 |
HOGENOMi | CLU_017767_1_1_1 |
InParanoidi | P17105 |
OMAi | TGNAQVW |
OrthoDBi | 966687at2759 |
PhylomeDBi | P17105 |
TreeFami | TF318394 |
Family and domain databases
DisProti | DP02461 |
Gene3Di | 3.30.470.160, 1 hit |
InterProi | View protein in InterPro IPR005522, IPK IPR038286, IPK_sf |
PANTHERi | PTHR12400, PTHR12400, 1 hit |
Pfami | View protein in Pfam PF03770, IPK, 1 hit |
i Sequence
Sequence statusi: Complete.
P17105-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTLPGHPTGM ARPRGAGPCS PGLERAPRRS VGELRLLFEA RCAAVAAAAA
60 70 80 90 100
AGEPRARGAK RRGGQVPNGL PRAAPAPVIP QLTVTSEEDV APASPGPPDR
110 120 130 140 150
EGNWLPAAGS HLQQPRRLST SSLSSTGSSS LLEDSEDDLL SDSESRSRGN
160 170 180 190 200
VQLETSEDVG QKSHWQKIRT MVNLPVMSPF KKRYSWVQLA GHTGSFKAAG
210 220 230 240 250
TSGLILKRSS EPEHYCLVRL MADVLRGCVP AFHGVVERDG ESYLQLQDLL
260 270 280 290 300
DGFDGPCVLD CKMGVRTYLE EELTKARERP KLRKDMYKKM LAVDPEAPTE
310 320 330 340 350
EEHAQRAVTK PRYMQWREGI SSSTTLGFRI EGIKKADGSC STDFKTTRSR
360 370 380 390 400
EQVTRVFEEF MQGDAEVLKR YLNRLQQIRD TLEISDFFRR HEVIGSSLLF
410 420 430 440 450
VHDHCHRAGV WLIDFGKTTP LPDGQILDHR RPWEEGNRED GYLLGLDNLI
GILANLAER
Sequence cautioni
The sequence AAA41457 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56917 mRNA Translation: CAA40248.1 M29787 mRNA Translation: AAA41457.1 Different initiation. |
PIRi | S13064 |
RefSeqi | NP_112307.2, NM_031045.2 |
Genome annotation databases
Ensembli | ENSRNOT00000007247; ENSRNOP00000007247; ENSRNOG00000005284 |
GeneIDi | 81677 |
KEGGi | rno:81677 |
UCSCi | RGD:619950, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56917 mRNA Translation: CAA40248.1 M29787 mRNA Translation: AAA41457.1 Different initiation. |
PIRi | S13064 |
RefSeqi | NP_112307.2, NM_031045.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1TZD | X-ray | 2.20 | A/B | 185-459 | [»] | |
SMRi | P17105 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 249574, 3 interactors |
STRINGi | 10116.ENSRNOP00000007247 |
Chemistry databases
BindingDBi | P17105 |
ChEMBLi | CHEMBL3261 |
PTM databases
iPTMneti | P17105 |
PhosphoSitePlusi | P17105 |
Proteomic databases
PaxDbi | P17105 |
PRIDEi | P17105 |
Genome annotation databases
Ensembli | ENSRNOT00000007247; ENSRNOP00000007247; ENSRNOG00000005284 |
GeneIDi | 81677 |
KEGGi | rno:81677 |
UCSCi | RGD:619950, rat |
Organism-specific databases
CTDi | 3706 |
RGDi | 619950, Itpka |
Phylogenomic databases
eggNOGi | KOG1621, Eukaryota |
GeneTreei | ENSGT00940000161350 |
HOGENOMi | CLU_017767_1_1_1 |
InParanoidi | P17105 |
OMAi | TGNAQVW |
OrthoDBi | 966687at2759 |
PhylomeDBi | P17105 |
TreeFami | TF318394 |
Enzyme and pathway databases
BRENDAi | 2.7.1.127, 5301 |
Reactomei | R-RNO-1855204, Synthesis of IP3 and IP4 in the cytosol |
SABIO-RKi | P17105 |
Miscellaneous databases
EvolutionaryTracei | P17105 |
PROi | PR:P17105 |
Gene expression databases
Bgeei | ENSRNOG00000005284, Expressed in brain and 21 other tissues |
Genevisiblei | P17105, RN |
Family and domain databases
DisProti | DP02461 |
Gene3Di | 3.30.470.160, 1 hit |
InterProi | View protein in InterPro IPR005522, IPK IPR038286, IPK_sf |
PANTHERi | PTHR12400, PTHR12400, 1 hit |
Pfami | View protein in Pfam PF03770, IPK, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IP3KA_RAT | |
Accessioni | P17105Primary (citable) accession number: P17105 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | November 1, 1991 | |
Last modified: | February 23, 2022 | |
This is version 149 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families