UniProtKB - P17098 (ZNF8_HUMAN)
Protein
Zinc finger protein 8
Gene
ZNF8
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 257 – 279 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 285 – 307 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 313 – 335 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 341 – 363 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 369 – 391 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 397 – 419 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 467 – 489 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- zinc ion binding Source: UniProtKB
GO - Biological processi
- BMP signaling pathway Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P17098 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 8Alternative name(s): Zinc finger protein HF.18 |
Gene namesi | Name:ZNF8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13154, ZNF8 |
MIMi | 194532, gene |
neXtProti | NX_P17098 |
VEuPathDBi | HostDB:ENSG00000278129.1 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000278129 |
PharmGKBi | PA37728 |
Miscellaneous databases
Pharosi | P17098, Tdark |
Genetic variation databases
BioMutai | ZNF8 |
DMDMi | 55977777 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047331 | 1 – 575 | Zinc finger protein 8Add BLAST | 575 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 174 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 249 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 441 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 545 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | P17098 |
jPOSTi | P17098 |
MassIVEi | P17098 |
MaxQBi | P17098 |
PaxDbi | P17098 |
PeptideAtlasi | P17098 |
PRIDEi | P17098 |
ProteomicsDBi | 53457 |
PTM databases
iPTMneti | P17098 |
PhosphoSitePlusi | P17098 |
Expressioni
Tissue specificityi
Ubiquitously present in many human cell lines of different embryological derivation.1 Publication
Gene expression databases
Bgeei | ENSG00000278129, Expressed in cerebral cortex and 199 other tissues |
Genevisiblei | P17098, HS |
Organism-specific databases
HPAi | ENSG00000278129, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Hide detailsP17098
With | #Exp. | IntAct |
---|---|---|
AP1M1 [Q9BXS5] | 3 | EBI-2555757,EBI-541426 |
MCRS1 [Q96EZ8] | 3 | EBI-2555757,EBI-348259 |
ZNF114 [Q8NC26] | 3 | EBI-2555757,EBI-10265237 |
Protein-protein interaction databases
BioGRIDi | 113386, 19 interactors |
IntActi | P17098, 7 interactors |
STRINGi | 9606.ENSP00000477716 |
Miscellaneous databases
RNActi | P17098, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 96 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 257 – 279 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 285 – 307 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 313 – 335 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 341 – 363 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 369 – 391 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 397 – 419 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 467 – 489 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162352 |
HOGENOMi | CLU_002678_57_1_1 |
InParanoidi | P17098 |
OMAi | GVEEPSM |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P17098 |
TreeFami | TF337055 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 7 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
i Sequence
Sequence statusi: Complete.
P17098-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPEDEGVAG VMSVGPPAAR LQEPVTFRDV AVDFTQEEWG QLDPTQRILY
60 70 80 90 100
RDVMLETFGH LLSIGPELPK PEVISQLEQG TELWVAERGT TQGCHPAWEP
110 120 130 140 150
RSESQASRKE EGLPEEEPSH VTGREGFPTD APYPTTLGKD RECQSQSLAL
160 170 180 190 200
KEQNNLKQLE FGLKEAPVQD QGYKTLRLRE NCVLSSSPNP FPEISRGEYL
210 220 230 240 250
YTYDSQITDS EHNSSLVSQQ TGSPGKQPGE NSDCHRDSSQ AIPITELTKS
260 270 280 290 300
QVQDKPYKCT DCGKSFNHNA HLTVHKRIHT GERPYMCKEC GKAFSQNSSL
310 320 330 340 350
VQHERIHTGD KPYKCAECGK SFCHSTHLTV HRRIHTGEKP YECQDCGRAF
360 370 380 390 400
NQNSSLGRHK RTHTGEKPYT CSVCGKSFSR TTCLFLHLRT HTEERPYECN
410 420 430 440 450
HCGKGFRHSS SLAQHQRKHA GEKPFECRQR LIFEQTPALT KHEWTEALGC
460 470 480 490 500
DPPLSQDERT HRSDRPFKCN QCGKCFIQSS HLIRHQITHT REEQPHGRSR
510 520 530 540 550
RREQSSSRNS HLVQHQHPNS RKSSAGGAKA GQPESRALAL FDIQKIMQEK
560 570
NPVHVIGVEE PSVGASMLFD IREST
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 60 | H → Y in AAA61314 (PubMed:2106481).Curated | 1 | |
Sequence conflicti | 172 | G → A in AAA61314 (PubMed:2106481).Curated | 1 | |
Sequence conflicti | 528 | A → R in AAA61314 (PubMed:2106481).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC039323 mRNA Translation: AAH39323.1 M29581 mRNA Translation: AAA61314.1 |
CCDSi | CCDS12974.1 |
PIRi | B34612 |
RefSeqi | NP_066575.2, NM_021089.2 |
Genome annotation databases
Ensembli | ENST00000621650; ENSP00000477716; ENSG00000278129 |
GeneIDi | 7554 |
KEGGi | hsa:7554 |
UCSCi | uc002qry.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC039323 mRNA Translation: AAH39323.1 M29581 mRNA Translation: AAA61314.1 |
CCDSi | CCDS12974.1 |
PIRi | B34612 |
RefSeqi | NP_066575.2, NM_021089.2 |
3D structure databases
SMRi | P17098 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113386, 19 interactors |
IntActi | P17098, 7 interactors |
STRINGi | 9606.ENSP00000477716 |
PTM databases
iPTMneti | P17098 |
PhosphoSitePlusi | P17098 |
Genetic variation databases
BioMutai | ZNF8 |
DMDMi | 55977777 |
Proteomic databases
EPDi | P17098 |
jPOSTi | P17098 |
MassIVEi | P17098 |
MaxQBi | P17098 |
PaxDbi | P17098 |
PeptideAtlasi | P17098 |
PRIDEi | P17098 |
ProteomicsDBi | 53457 |
Protocols and materials databases
Antibodypediai | 74823, 89 antibodies |
DNASUi | 7554 |
Genome annotation databases
Ensembli | ENST00000621650; ENSP00000477716; ENSG00000278129 |
GeneIDi | 7554 |
KEGGi | hsa:7554 |
UCSCi | uc002qry.2, human |
Organism-specific databases
CTDi | 7554 |
GeneCardsi | ZNF8 |
HGNCi | HGNC:13154, ZNF8 |
HPAi | ENSG00000278129, Low tissue specificity |
MIMi | 194532, gene |
neXtProti | NX_P17098 |
OpenTargetsi | ENSG00000278129 |
PharmGKBi | PA37728 |
VEuPathDBi | HostDB:ENSG00000278129.1 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162352 |
HOGENOMi | CLU_002678_57_1_1 |
InParanoidi | P17098 |
OMAi | GVEEPSM |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P17098 |
TreeFami | TF337055 |
Enzyme and pathway databases
PathwayCommonsi | P17098 |
Miscellaneous databases
BioGRID-ORCSi | 7554, 10 hits in 1014 CRISPR screens |
GeneWikii | ZNF8 |
GenomeRNAii | 7554 |
Pharosi | P17098, Tdark |
PROi | PR:P17098 |
RNActi | P17098, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000278129, Expressed in cerebral cortex and 199 other tissues |
Genevisiblei | P17098, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 7 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 7 hits PS50157, ZINC_FINGER_C2H2_2, 7 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZNF8_HUMAN | |
Accessioni | P17098Primary (citable) accession number: P17098 Secondary accession number(s): Q6PI99 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | November 23, 2004 | |
Last modified: | April 7, 2021 | |
This is version 203 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families