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Protein

Zinc finger protein 8

Gene

ZNF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 8
Alternative name(s):
Zinc finger protein HF.18
Gene namesi
Name:ZNF8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000278129.1
HGNCiHGNC:13154 ZNF8
MIMi194532 gene
neXtProtiNX_P17098

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000278129
PharmGKBiPA37728

Polymorphism and mutation databases

BioMutaiZNF8
DMDMi55977777

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473311 – 575Zinc finger protein 8Add BLAST575

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki174Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki249Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki441Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki545Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP17098
MaxQBiP17098
PaxDbiP17098
PeptideAtlasiP17098
PRIDEiP17098
ProteomicsDBi53457

PTM databases

iPTMnetiP17098
PhosphoSitePlusiP17098

Expressioni

Tissue specificityi

Ubiquitously present in many human cell lines of different embryological derivation.1 Publication

Gene expression databases

BgeeiENSG00000278129
CleanExiHS_ZNF8
GenevisibleiP17098 HS

Organism-specific databases

HPAiHPA034797
HPA034798

Interactioni

Subunit structurei

Interacts with SMAD1 (via MH1 and MH2 domains) (By similarity). Interacts with SMAD5 (PubMed:12370310). Interacts weakly with SMAD2 (By similarity). Interacts weakly with SMAD3 and SMAD4 (PubMed:12370310).By similarity1 Publication

Protein-protein interaction databases

BioGridi113386, 14 interactors
IntActiP17098, 6 interactors
STRINGi9606.ENSP00000196548

Structurei

3D structure databases

ProteinModelPortaliP17098
SMRiP17098
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 96KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri257 – 279C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00740000115096
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP17098
KOiK09228
OMAiGENCVLS
OrthoDBiEOG091G02KC
PhylomeDBiP17098
TreeFamiTF337055

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequencei

Sequence statusi: Complete.

P17098-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPEDEGVAG VMSVGPPAAR LQEPVTFRDV AVDFTQEEWG QLDPTQRILY
60 70 80 90 100
RDVMLETFGH LLSIGPELPK PEVISQLEQG TELWVAERGT TQGCHPAWEP
110 120 130 140 150
RSESQASRKE EGLPEEEPSH VTGREGFPTD APYPTTLGKD RECQSQSLAL
160 170 180 190 200
KEQNNLKQLE FGLKEAPVQD QGYKTLRLRE NCVLSSSPNP FPEISRGEYL
210 220 230 240 250
YTYDSQITDS EHNSSLVSQQ TGSPGKQPGE NSDCHRDSSQ AIPITELTKS
260 270 280 290 300
QVQDKPYKCT DCGKSFNHNA HLTVHKRIHT GERPYMCKEC GKAFSQNSSL
310 320 330 340 350
VQHERIHTGD KPYKCAECGK SFCHSTHLTV HRRIHTGEKP YECQDCGRAF
360 370 380 390 400
NQNSSLGRHK RTHTGEKPYT CSVCGKSFSR TTCLFLHLRT HTEERPYECN
410 420 430 440 450
HCGKGFRHSS SLAQHQRKHA GEKPFECRQR LIFEQTPALT KHEWTEALGC
460 470 480 490 500
DPPLSQDERT HRSDRPFKCN QCGKCFIQSS HLIRHQITHT REEQPHGRSR
510 520 530 540 550
RREQSSSRNS HLVQHQHPNS RKSSAGGAKA GQPESRALAL FDIQKIMQEK
560 570
NPVHVIGVEE PSVGASMLFD IREST
Length:575
Mass (Da):64,970
Last modified:November 23, 2004 - v2
Checksum:iE8F5B9C2FBED92C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60H → Y in AAA61314 (PubMed:2106481).Curated1
Sequence conflicti172G → A in AAA61314 (PubMed:2106481).Curated1
Sequence conflicti528A → R in AAA61314 (PubMed:2106481).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC039323 mRNA Translation: AAH39323.1
M29581 mRNA Translation: AAA61314.1
CCDSiCCDS12974.1
PIRiB34612
RefSeqiNP_066575.2, NM_021089.2
UniGeneiHs.590941
Hs.713519

Genome annotation databases

EnsembliENST00000621650; ENSP00000477716; ENSG00000278129
GeneIDi7554
KEGGihsa:7554
UCSCiuc002qry.2 human

Similar proteinsi

Entry informationi

Entry nameiZNF8_HUMAN
AccessioniPrimary (citable) accession number: P17098
Secondary accession number(s): Q6PI99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: November 23, 2004
Last modified: July 18, 2018
This is version 184 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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