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Protein

High mobility group protein HMG-I/HMG-Y

Gene

HMGA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi21 – 31A.T hook 1Add BLAST11
DNA bindingi53 – 63A.T hook 2Add BLAST11
DNA bindingi78 – 89A.T hook 3Add BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-162592 Integration of provirus
R-HSA-164843 2-LTR circle formation
R-HSA-175567 Integration of viral DNA into host genomic DNA
R-HSA-177539 Autointegration results in viral DNA circles
R-HSA-180689 APOBEC3G mediated resistance to HIV-1 infection
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P17096

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P17096

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
High mobility group protein HMG-I/HMG-Y
Short name:
HMG-I(Y)
Alternative name(s):
High mobility group AT-hook protein 1
Short name:
High mobility group protein A1
High mobility group protein R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HMGA1
Synonyms:HMGIY
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137309.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5010 HMGA1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600701 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P17096

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi26R → A: Does not affect methylation by PRMT6. 1 Publication1
Mutagenesisi58R → A: Decreases methylation by PRMT6. Abolishes methylation by PRMT6; when associated with A-60. 1 Publication1
Mutagenesisi60R → A: Decreases methylation by PRMT6. Abolishes methylation by PRMT6; when associated with A-58. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3159

MalaCards human disease database

More...
MalaCardsi
HMGA1

Open Targets

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OpenTargetsi
ENSG00000137309

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA35094

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HMGA1

Domain mapping of disease mutations (DMDM)

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DMDMi
123377

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002067082 – 107High mobility group protein HMG-I/HMG-YAdd BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineBy similarity1
Modified residuei7N6-acetyllysineBy similarity1
Modified residuei8ADP-ribosylserine1 Publication1
Modified residuei9ADP-ribosylserine; alternate1 Publication1
Modified residuei9Phosphoserine; alternateCombined sources1
Modified residuei15N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei26Asymmetric dimethylarginine; alternate2 Publications1
Modified residuei26Omega-N-methylarginine; alternate2 Publications1
Modified residuei26Symmetric dimethylarginine; alternate2 Publications1
Modified residuei36Phosphoserine; by HIPK2 and CDC2Combined sources1
Modified residuei39PhosphothreonineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei49PhosphoserineCombined sources1
Modified residuei53Phosphothreonine; by HIPK2 and CDC2Combined sources1
Modified residuei58Asymmetric dimethylarginine; by PRMT6; alternate1 Publication1
Modified residuei58Omega-N-methylarginine; by PRMT6; alternate1 Publication1
Modified residuei60Asymmetric dimethylarginine; by PRMT6; alternate1 Publication1
Modified residuei60Omega-N-methylarginine; by PRMT6; alternate1 Publication1
Modified residuei78Phosphothreonine; by HIPK2 and CDC21 Publication1
Modified residuei99PhosphoserineCombined sources1 Publication1
Modified residuei102Phosphoserine; by CKCombined sources1 Publication1
Modified residuei103Phosphoserine; by CKCombined sources1 Publication1
Isoform HMG-Y (identifier: P17096-2)
Modified residuei42Phosphothreonine1
Modified residuei67Phosphothreonine1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Constitutively phosphorylated on two or three sites. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation of HMG-I at Ser-36, Thr-53 and Thr-78 and of HMG-Y at Thr-42 and Thr-67 by HIPK2 modulates DNA-binding affinity.2 Publications
HMG-Y is not methylated.
Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.1 Publication

Keywords - PTMi

Acetylation, ADP-ribosylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P17096

MaxQB - The MaxQuant DataBase

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MaxQBi
P17096

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P17096

PeptideAtlas

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PeptideAtlasi
P17096

PRoteomics IDEntifications database

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PRIDEi
P17096

ProteomicsDB human proteome resource

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ProteomicsDBi
53453
53454 [P17096-2]
53455 [P17096-3]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P17096-1 [P17096-1]
P17096-2 [P17096-2]
P17096-3 [P17096-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P17096

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P17096

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137309 Expressed in 224 organ(s), highest expression level in ectocervix

CleanEx database of gene expression profiles

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CleanExi
HS_HMGA1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P17096 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P17096 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB032200

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HIPK2 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109402, 108 interactors

Database of interacting proteins

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DIPi
DIP-29687N

Protein interaction database and analysis system

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IntActi
P17096, 55 interactors

Molecular INTeraction database

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MINTi
P17096

STRING: functional protein association networks

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STRINGi
9606.ENSP00000308227

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1107
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Database of protein disorder

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DisProti
DP00040

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P17096

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P17096

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni53 – 77Interaction with HIPK2By similarityAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi91 – 106Glu-rich (acidic)Add BLAST16

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HMGA family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J4ZT Eukaryota
ENOG410Z566 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00730000111329

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000076308

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG063451

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P17096

KEGG Orthology (KO)

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KOi
K09282

Identification of Orthologs from Complete Genome Data

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OMAi
NMSDKGT

TreeFam database of animal gene trees

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TreeFami
TF351623

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR017956 AT_hook_DNA-bd_motif
IPR000116 HMGA
IPR031079 HMGA1_mammal
IPR000637 HMGI/Y_DNA-bd_CS

The PANTHER Classification System

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PANTHERi
PTHR23341:SF1 PTHR23341:SF1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00929 ATHOOK
PR00930 HIGHMOBLTYIY

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00384 AT_hook, 3 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00354 HMGI_Y, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform HMG-I (identifier: P17096-1) [UniParc]FASTAAdd to basket
Also known as: HMGA1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE
60 70 80 90 100
VPTPKRPRGR PKGSKNKGAA KTRKTTTTPG RKPRGRPKKL EKEEEEGISQ

ESSEEEQ
Length:107
Mass (Da):11,676
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE9C4E3F2200914B8
GO
Isoform HMG-Y (identifier: P17096-2) [UniParc]FASTAAdd to basket
Also known as: HMGA1b

The sequence of this isoform differs from the canonical sequence as follows:
     35-45: Missing.

Show »
Length:96
Mass (Da):10,679
Checksum:iB82DCAA29E6D18FD
GO
Isoform HMG-R (identifier: P17096-3) [UniParc]FASTAAdd to basket
Also known as: HMGA1c

The sequence of this isoform differs from the canonical sequence as follows:
     66-107: NKGAAKTRKT...ISQESSEEEQ → KNWRRRKRRA...RIHTCPPGQG

Show »
Length:179
Mass (Da):19,694
Checksum:i91E56E235C504AAA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti107Q → QQQ AA sequence (PubMed:2920035).Curated1

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Isoform HMG-I : Molecular mass is 11750±12 Da from positions 2 - 107. Determined by MALDI. With 1 acetyl and 2 phosphate groups.1 Publication
Isoform HMG-I : Molecular mass is 11828±12 Da from positions 2 - 107. Determined by MALDI. With 1 acetyl and 3 phosphate groups.1 Publication
Isoform HMG-I : Molecular mass is 11765±12 Da from positions 2 - 107. Determined by MALDI. With 1 acetyl, 1 methyl and 2 phosphate groups.1 Publication
Isoform HMG-I : Molecular mass is 11844±12 Da from positions 2 - 107. Determined by MALDI. With 1 acetyl, 1 methyl and 3 phosphate groups.1 Publication
Isoform HMG-I : Molecular mass is 11780±12 Da from positions 2 - 107. Determined by MALDI. With 1 acetyl, 2 methyl and 2 phosphate groups.1 Publication
Isoform HMG-I : Molecular mass is 11858±12 Da from positions 2 - 107. Determined by MALDI. With 1 acetyl, 2 methyl and 3 phosphate groups.1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00218235 – 45Missing in isoform HMG-Y. 3 PublicationsAdd BLAST11
Alternative sequenceiVSP_01808466 – 107NKGAA…SEEEQ → KNWRRRKRRASRRSPRRRSS DPCVPPAPHWRSSFLLGLDS FAPLPPPPPLPQAHHHHRLW PPPPSSTCALTTTLHSTPAA AGLPWAEWGAVFPWPQFPAP PAHPRIHTCPPGQG in isoform HMG-R. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X14957 mRNA Translation: CAA33080.1
X14958 mRNA Translation: CAA33081.1
M23614 mRNA Translation: AAA88072.1
M23615 mRNA Translation: AAA88073.1
M23616 mRNA Translation: AAA88074.1
M23617 mRNA Translation: AAA88075.1
M23618 mRNA Translation: AAA88076.1
M23619 mRNA Translation: AAA35998.1
L17131 Genomic DNA Translation: AAB00145.1
AF176039 mRNA Translation: AAD53889.1
AL354740 Genomic DNA No translation available.
BC004924 mRNA Translation: AAH04924.1
BC008832 mRNA Translation: AAH08832.1
BC063434 mRNA Translation: AAH63434.1
BC067083 mRNA Translation: AAH67083.1
BC071864 mRNA Translation: AAH71864.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4788.1 [P17096-2]
CCDS4789.1 [P17096-1]

Protein sequence database of the Protein Information Resource

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PIRi
A32794

NCBI Reference Sequences

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RefSeqi
NP_001306006.1, NM_001319077.1 [P17096-2]
NP_001306007.1, NM_001319078.1 [P17096-1]
NP_001306008.1, NM_001319079.1 [P17096-1]
NP_001306009.1, NM_001319080.1
NP_001306010.1, NM_001319081.1 [P17096-1]
NP_001306011.1, NM_001319082.1 [P17096-1]
NP_002122.1, NM_002131.3 [P17096-2]
NP_665906.1, NM_145899.2 [P17096-1]
NP_665908.1, NM_145901.2 [P17096-1]
NP_665909.1, NM_145902.2 [P17096-2]
NP_665910.1, NM_145903.2 [P17096-2]
NP_665912.1, NM_145905.2 [P17096-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.518805
Hs.696527
Hs.703764

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000311487; ENSP00000308227; ENSG00000137309 [P17096-1]
ENST00000347617; ENSP00000288245; ENSG00000137309 [P17096-2]
ENST00000374116; ENSP00000363230; ENSG00000137309 [P17096-2]
ENST00000401473; ENSP00000385693; ENSG00000137309 [P17096-2]
ENST00000447654; ENSP00000399888; ENSG00000137309 [P17096-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3159

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3159

UCSC genome browser

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UCSCi
uc003oit.4 human [P17096-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14957 mRNA Translation: CAA33080.1
X14958 mRNA Translation: CAA33081.1
M23614 mRNA Translation: AAA88072.1
M23615 mRNA Translation: AAA88073.1
M23616 mRNA Translation: AAA88074.1
M23617 mRNA Translation: AAA88075.1
M23618 mRNA Translation: AAA88076.1
M23619 mRNA Translation: AAA35998.1
L17131 Genomic DNA Translation: AAB00145.1
AF176039 mRNA Translation: AAD53889.1
AL354740 Genomic DNA No translation available.
BC004924 mRNA Translation: AAH04924.1
BC008832 mRNA Translation: AAH08832.1
BC063434 mRNA Translation: AAH63434.1
BC067083 mRNA Translation: AAH67083.1
BC071864 mRNA Translation: AAH71864.1
CCDSiCCDS4788.1 [P17096-2]
CCDS4789.1 [P17096-1]
PIRiA32794
RefSeqiNP_001306006.1, NM_001319077.1 [P17096-2]
NP_001306007.1, NM_001319078.1 [P17096-1]
NP_001306008.1, NM_001319079.1 [P17096-1]
NP_001306009.1, NM_001319080.1
NP_001306010.1, NM_001319081.1 [P17096-1]
NP_001306011.1, NM_001319082.1 [P17096-1]
NP_002122.1, NM_002131.3 [P17096-2]
NP_665906.1, NM_145899.2 [P17096-1]
NP_665908.1, NM_145901.2 [P17096-1]
NP_665909.1, NM_145902.2 [P17096-2]
NP_665910.1, NM_145903.2 [P17096-2]
NP_665912.1, NM_145905.2 [P17096-2]
UniGeneiHs.518805
Hs.696527
Hs.703764

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EZDNMR-A51-71[»]
2EZENMR-A51-75[»]
2EZFNMR-A80-89[»]
2EZGNMR-A80-89[»]
DisProtiDP00040
ProteinModelPortaliP17096
SMRiP17096
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109402, 108 interactors
DIPiDIP-29687N
IntActiP17096, 55 interactors
MINTiP17096
STRINGi9606.ENSP00000308227

PTM databases

iPTMnetiP17096
PhosphoSitePlusiP17096

Polymorphism and mutation databases

BioMutaiHMGA1
DMDMi123377

Proteomic databases

EPDiP17096
MaxQBiP17096
PaxDbiP17096
PeptideAtlasiP17096
PRIDEiP17096
ProteomicsDBi53453
53454 [P17096-2]
53455 [P17096-3]
TopDownProteomicsiP17096-1 [P17096-1]
P17096-2 [P17096-2]
P17096-3 [P17096-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3159
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311487; ENSP00000308227; ENSG00000137309 [P17096-1]
ENST00000347617; ENSP00000288245; ENSG00000137309 [P17096-2]
ENST00000374116; ENSP00000363230; ENSG00000137309 [P17096-2]
ENST00000401473; ENSP00000385693; ENSG00000137309 [P17096-2]
ENST00000447654; ENSP00000399888; ENSG00000137309 [P17096-1]
GeneIDi3159
KEGGihsa:3159
UCSCiuc003oit.4 human [P17096-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3159
DisGeNETi3159
EuPathDBiHostDB:ENSG00000137309.19

GeneCards: human genes, protein and diseases

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GeneCardsi
HMGA1
HGNCiHGNC:5010 HMGA1
HPAiCAB032200
MalaCardsiHMGA1
MIMi600701 gene
neXtProtiNX_P17096
OpenTargetsiENSG00000137309
PharmGKBiPA35094

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J4ZT Eukaryota
ENOG410Z566 LUCA
GeneTreeiENSGT00730000111329
HOGENOMiHOG000076308
HOVERGENiHBG063451
InParanoidiP17096
KOiK09282
OMAiNMSDKGT
TreeFamiTF351623

Enzyme and pathway databases

ReactomeiR-HSA-162592 Integration of provirus
R-HSA-164843 2-LTR circle formation
R-HSA-175567 Integration of viral DNA into host genomic DNA
R-HSA-177539 Autointegration results in viral DNA circles
R-HSA-180689 APOBEC3G mediated resistance to HIV-1 infection
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)
SignaLinkiP17096
SIGNORiP17096

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HMGA1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HMGA1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3159

Protein Ontology

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PROi
PR:P17096

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137309 Expressed in 224 organ(s), highest expression level in ectocervix
CleanExiHS_HMGA1
ExpressionAtlasiP17096 baseline and differential
GenevisibleiP17096 HS

Family and domain databases

InterProiView protein in InterPro
IPR017956 AT_hook_DNA-bd_motif
IPR000116 HMGA
IPR031079 HMGA1_mammal
IPR000637 HMGI/Y_DNA-bd_CS
PANTHERiPTHR23341:SF1 PTHR23341:SF1, 1 hit
PRINTSiPR00929 ATHOOK
PR00930 HIGHMOBLTYIY
SMARTiView protein in SMART
SM00384 AT_hook, 3 hits
PROSITEiView protein in PROSITE
PS00354 HMGI_Y, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMGA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17096
Secondary accession number(s): P10910, Q5T6U9, Q9UKB0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 212 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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