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Entry version 182 (13 Feb 2019)
Sequence version 4 (23 Jan 2007)
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Protein

High mobility group protein HMG-I/HMG-Y

Gene

Hmga1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi21 – 31A.T hook 1Add BLAST11
DNA bindingi53 – 63A.T hook 2Add BLAST11
DNA bindingi78 – 89A.T hook 3Add BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
High mobility group protein HMG-I/HMG-Y
Short name:
HMG-I(Y)
Alternative name(s):
High mobility group AT-hook protein 1
Short name:
High mobility group protein A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hmga1
Synonyms:Hmgi, Hmgiy
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 11, Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:96160 Hmga1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002067092 – 107High mobility group protein HMG-I/HMG-YAdd BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei7N6-acetyllysineCombined sources1
Modified residuei8ADP-ribosylserineBy similarity1
Modified residuei9ADP-ribosylserine; alternateBy similarity1
Modified residuei9Phosphoserine; alternateBy similarity1
Modified residuei15N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei26Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei26Omega-N-methylarginine; alternateBy similarity1
Modified residuei26Symmetric dimethylarginine; alternateBy similarity1
Modified residuei36Phosphoserine; by HIPK2 and CDC2By similarity1
Modified residuei39PhosphothreonineBy similarity1
Modified residuei44PhosphoserineBy similarity1
Modified residuei49PhosphoserineBy similarity1
Modified residuei53Phosphothreonine; by HIPK2 and CDC2Combined sources1
Modified residuei58Asymmetric dimethylarginine; by PRMT6; alternateBy similarity1
Modified residuei58Omega-N-methylarginine; by PRMT6; alternateBy similarity1
Modified residuei60Asymmetric dimethylarginine; by PRMT6; alternateBy similarity1
Modified residuei60Omega-N-methylarginine; by PRMT6; alternateBy similarity1
Modified residuei99PhosphoserineCombined sources1 Publication1
Modified residuei102PhosphoserineCombined sources1 Publication1
Modified residuei103PhosphoserineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation may modulate DNA-binding affinity (By similarity).By similarity
Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.By similarity

Keywords - PTMi

Acetylation, ADP-ribosylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P17095

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P17095

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P17095

PeptideAtlas

More...
PeptideAtlasi
P17095

PRoteomics IDEntifications database

More...
PRIDEi
P17095

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P17095-1 [P17095-1]
P17095-2 [P17095-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P17095

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P17095

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000046711 Expressed in 60 organ(s), highest expression level in embryonic stem cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P17095 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P17095 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HIPK2.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
200340, 8 interactors

Database of interacting proteins

More...
DIPi
DIP-53N

Protein interaction database and analysis system

More...
IntActi
P17095, 4 interactors

Molecular INTeraction database

More...
MINTi
P17095

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000113011

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P17095

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni53 – 77Interaction with HIPK21 PublicationAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi91 – 106Glu-rich (acidic)Add BLAST16

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HMGA family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J4ZT Eukaryota
ENOG410Z566 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111329

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000076308

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG063451

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P17095

KEGG Orthology (KO)

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KOi
K09282

Identification of Orthologs from Complete Genome Data

More...
OMAi
NMSDKGT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P17095

TreeFam database of animal gene trees

More...
TreeFami
TF351623

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR017956 AT_hook_DNA-bd_motif
IPR000116 HMGA
IPR031079 HMGA1_mammal
IPR000637 HMGI/Y_DNA-bd_CS

The PANTHER Classification System

More...
PANTHERi
PTHR23341:SF1 PTHR23341:SF1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00929 ATHOOK
PR00930 HIGHMOBLTYIY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00384 AT_hook, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00354 HMGI_Y, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform HMG-I (identifier: P17095-2) [UniParc]FASTAAdd to basket
Also known as: HMGA1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSESGSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE
60 70 80 90 100
VPTPKRPRGR PKGSKNKGAA KTRKVTTAPG RKPRGRPKKL EKEEEEGISQ

ESSEEEQ
Length:107
Mass (Da):11,614
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4EC39386611959FC
GO
Isoform HMG-Y (identifier: P17095-1) [UniParc]FASTAAdd to basket
Also known as: HMGA1b, HMGI-E

The sequence of this isoform differs from the canonical sequence as follows:
     35-45: Missing.

Show »
Length:96
Mass (Da):10,617
Checksum:iA77A3FD7CA6C08EC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QK51J3QK51_MOUSE
High mobility group AT-hook 1B
Hmga1b
39Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3TE85Q3TE85_MOUSE
High mobility group protein HMG-I/H...
Hmga1
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P6E8A0A338P6E8_MOUSE
High mobility group protein HMG-I/H...
Hmga1
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P6F6A0A338P6F6_MOUSE
High mobility group protein HMG-I/H...
Hmga1
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P6G6A0A338P6G6_MOUSE
High mobility group protein HMG-I/H...
Hmga1
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A384DV79A0A384DV79_MOUSE
High mobility group protein HMG-I/H...
Hmga1
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P6D0A0A338P6D0_MOUSE
High mobility group protein HMG-I/H...
Hmga1
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti106E → G in AAK66158 (PubMed:11410365).Curated1
Sequence conflicti106E → G in AAK66159 (PubMed:11410365).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01240635 – 45Missing in isoform HMG-Y. 2 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J04179 mRNA Translation: AAA37820.1
AF285780 Genomic DNA Translation: AAK66158.1
AF285780 Genomic DNA Translation: AAK66159.1
AK010617 mRNA Translation: BAB27065.1
BC013455 mRNA Translation: AAH13455.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28564.1 [P17095-2]
CCDS49010.1 [P17095-2]
CCDS50044.1 [P17095-1]

Protein sequence database of the Protein Information Resource

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PIRi
A31895

NCBI Reference Sequences

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RefSeqi
NP_001020598.1, NM_001025427.3 [P17095-2]
NP_001034445.1, NM_001039356.2 [P17095-2]
NP_001159948.1, NM_001166476.1 [P17095-2]
NP_001159949.1, NM_001166477.1 [P17095-1]
NP_001160007.1, NM_001166535.1 [P17095-2]
NP_001160008.1, NM_001166536.1 [P17095-2]
NP_001160009.1, NM_001166537.1 [P17095-1]
NP_001160011.1, NM_001166539.1 [P17095-1]
NP_001160012.1, NM_001166540.1 [P17095-1]
NP_001160013.1, NM_001166541.1 [P17095-1]
NP_001160014.1, NM_001166542.1 [P17095-1]
NP_057869.2, NM_016660.3 [P17095-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.426212
Mm.440289
Mm.4438

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000105046; ENSMUSP00000100667; ENSMUSG00000078249 [P17095-2]
ENSMUST00000114888; ENSMUSP00000110538; ENSMUSG00000046711 [P17095-1]
ENSMUST00000118570; ENSMUSP00000114101; ENSMUSG00000046711 [P17095-1]
ENSMUST00000118599; ENSMUSP00000113015; ENSMUSG00000046711 [P17095-2]
ENSMUST00000119486; ENSMUSP00000113916; ENSMUSG00000046711 [P17095-2]
ENSMUST00000231358; ENSMUSP00000155876; ENSMUSG00000046711 [P17095-1]
ENSMUST00000231825; ENSMUSP00000156327; ENSMUSG00000046711 [P17095-1]
ENSMUST00000231874; ENSMUSP00000156199; ENSMUSG00000046711 [P17095-2]
ENSMUST00000232013; ENSMUSP00000155886; ENSMUSG00000046711 [P17095-2]
ENSMUST00000232265; ENSMUSP00000156173; ENSMUSG00000046711 [P17095-2]
ENSMUST00000232552; ENSMUSP00000156044; ENSMUSG00000046711 [P17095-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
111241
15361

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:111241
mmu:15361

UCSC genome browser

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UCSCi
uc008boz.2 mouse [P17095-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04179 mRNA Translation: AAA37820.1
AF285780 Genomic DNA Translation: AAK66158.1
AF285780 Genomic DNA Translation: AAK66159.1
AK010617 mRNA Translation: BAB27065.1
BC013455 mRNA Translation: AAH13455.1
CCDSiCCDS28564.1 [P17095-2]
CCDS49010.1 [P17095-2]
CCDS50044.1 [P17095-1]
PIRiA31895
RefSeqiNP_001020598.1, NM_001025427.3 [P17095-2]
NP_001034445.1, NM_001039356.2 [P17095-2]
NP_001159948.1, NM_001166476.1 [P17095-2]
NP_001159949.1, NM_001166477.1 [P17095-1]
NP_001160007.1, NM_001166535.1 [P17095-2]
NP_001160008.1, NM_001166536.1 [P17095-2]
NP_001160009.1, NM_001166537.1 [P17095-1]
NP_001160011.1, NM_001166539.1 [P17095-1]
NP_001160012.1, NM_001166540.1 [P17095-1]
NP_001160013.1, NM_001166541.1 [P17095-1]
NP_001160014.1, NM_001166542.1 [P17095-1]
NP_057869.2, NM_016660.3 [P17095-2]
UniGeneiMm.426212
Mm.440289
Mm.4438

3D structure databases

ProteinModelPortaliP17095
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200340, 8 interactors
DIPiDIP-53N
IntActiP17095, 4 interactors
MINTiP17095
STRINGi10090.ENSMUSP00000113011

PTM databases

iPTMnetiP17095
PhosphoSitePlusiP17095

Proteomic databases

EPDiP17095
jPOSTiP17095
PaxDbiP17095
PeptideAtlasiP17095
PRIDEiP17095
TopDownProteomicsiP17095-1 [P17095-1]
P17095-2 [P17095-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105046; ENSMUSP00000100667; ENSMUSG00000078249 [P17095-2]
ENSMUST00000114888; ENSMUSP00000110538; ENSMUSG00000046711 [P17095-1]
ENSMUST00000118570; ENSMUSP00000114101; ENSMUSG00000046711 [P17095-1]
ENSMUST00000118599; ENSMUSP00000113015; ENSMUSG00000046711 [P17095-2]
ENSMUST00000119486; ENSMUSP00000113916; ENSMUSG00000046711 [P17095-2]
ENSMUST00000231358; ENSMUSP00000155876; ENSMUSG00000046711 [P17095-1]
ENSMUST00000231825; ENSMUSP00000156327; ENSMUSG00000046711 [P17095-1]
ENSMUST00000231874; ENSMUSP00000156199; ENSMUSG00000046711 [P17095-2]
ENSMUST00000232013; ENSMUSP00000155886; ENSMUSG00000046711 [P17095-2]
ENSMUST00000232265; ENSMUSP00000156173; ENSMUSG00000046711 [P17095-2]
ENSMUST00000232552; ENSMUSP00000156044; ENSMUSG00000046711 [P17095-1]
GeneIDi111241
15361
KEGGimmu:111241
mmu:15361
UCSCiuc008boz.2 mouse [P17095-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
111241
3159
MGIiMGI:96160 Hmga1

Phylogenomic databases

eggNOGiENOG410J4ZT Eukaryota
ENOG410Z566 LUCA
GeneTreeiENSGT00730000111329
HOGENOMiHOG000076308
HOVERGENiHBG063451
InParanoidiP17095
KOiK09282
OMAiNMSDKGT
PhylomeDBiP17095
TreeFamiTF351623

Enzyme and pathway databases

ReactomeiR-MMU-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Miscellaneous databases

Protein Ontology

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PROi
PR:P17095

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000046711 Expressed in 60 organ(s), highest expression level in embryonic stem cell
ExpressionAtlasiP17095 baseline and differential
GenevisibleiP17095 MM

Family and domain databases

InterProiView protein in InterPro
IPR017956 AT_hook_DNA-bd_motif
IPR000116 HMGA
IPR031079 HMGA1_mammal
IPR000637 HMGI/Y_DNA-bd_CS
PANTHERiPTHR23341:SF1 PTHR23341:SF1, 1 hit
PRINTSiPR00929 ATHOOK
PR00930 HIGHMOBLTYIY
SMARTiView protein in SMART
SM00384 AT_hook, 3 hits
PROSITEiView protein in PROSITE
PS00354 HMGI_Y, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMGA1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17095
Secondary accession number(s): Q91WV2, Q924L7, Q924L8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 23, 2007
Last modified: February 13, 2019
This is version 182 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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