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Protein

Rho-related GTP-binding protein RhoQ

Gene

RHOQ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.1 Publication

Activity regulationi

Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi121 – 124GTPBy similarity4

GO - Molecular functioni

  • GBD domain binding Source: BHF-UCL
  • GTPase activity Source: BHF-UCL
  • GTP binding Source: GO_Central
  • profilin binding Source: BHF-UCL
  • protein kinase binding Source: GO_Central

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-194840 Rho GTPase cycle
R-HSA-5627083 RHO GTPases regulate CFTR trafficking
SignaLinkiP17081
SIGNORiP17081

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoQ
Alternative name(s):
Ras-like protein TC10
Ras-like protein family member 7A
Gene namesi
Name:RHOQ
Synonyms:ARHQ, RASL7A, TC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000119729.10
HGNCiHGNC:17736 RHOQ
MIMi605857 gene
neXtProtiNX_P17081

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi23T → N: Loss of interaction with GOPC. 1 Publication1
Mutagenesisi44D → A: Loss of interaction with GOPC. 1 Publication1
Mutagenesisi67Q → L: Constitutively active. Interacts with PARD6 proteins and GOPC. 1 Publication1

Organism-specific databases

DisGeNETi23433
OpenTargetsiENSG00000119729
PharmGKBiPA134904280

Polymorphism and mutation databases

BioMutaiRHOQ
DMDMi62906861

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988711 – 202Rho-related GTP-binding protein RhoQAdd BLAST202
PropeptideiPRO_0000281222203 – 205Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei202Cysteine methyl esterBy similarity1
Lipidationi202S-farnesyl cysteineBy similarity1

Post-translational modificationi

May be post-translationally modified by both palmitoylation and polyisoprenylation.

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP17081
PaxDbiP17081
PeptideAtlasiP17081
PRIDEiP17081
ProteomicsDBi53452

PTM databases

iPTMnetiP17081
PhosphoSitePlusiP17081
SwissPalmiP17081

Expressioni

Gene expression databases

BgeeiENSG00000119729 Expressed in 237 organ(s), highest expression level in heart
CleanExiHS_RHOQ
ExpressionAtlasiP17081 baseline and differential
GenevisibleiP17081 HS

Organism-specific databases

HPAiHPA044938

Interactioni

Subunit structurei

Interacts with CDC42EP4 in a GTP-dependent manner. Interacts with ARHGAP33/TCGAP (By similarity). Interacts with CDC42EP1, CDC42EP2, CDC42EP3, PARD6A, PARD6G (and probably PARD6B) in a GTP-dependent manner. Part of a quaternary complex containing PARD3, some PARD6 protein (PARD6A, PARD6B or PARD6G) and some atypical PKC protein (PRKCI or PRKCZ). Interacts with EXO70 in a GTP-dependent manner. Interacts with GOPC.By similarity4 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117001, 13 interactors
IntActiP17081, 6 interactors
STRINGi9606.ENSP00000238738

Structurei

Secondary structure

1205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP17081
SMRiP17081
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP17081

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 46Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118978
HOVERGENiHBG009351
InParanoidiP17081
KOiK07194
OMAiIMANGTG
PhylomeDBiP17081
TreeFamiTF101109

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P17081-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHGPGALML KCVVVGDGAV GKTCLLMSYA NDAFPEEYVP TVFDHYAVSV
60 70 80 90 100
TVGGKQYLLG LYDTAGQEDY DRLRPLSYPM TDVFLICFSV VNPASFQNVK
110 120 130 140 150
EEWVPELKEY APNVPFLLIG TQIDLRDDPK TLARLNDMKE KPICVEQGQK
160 170 180 190 200
LAKEIGACCY VECSALTQKG LKTVFDEAII AILTPKKHTV KKRIGSRCIN

CCLIT
Length:205
Mass (Da):22,659
Last modified:April 26, 2005 - v2
Checksum:i82695B4F8FBF0B75
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WET9F8WET9_HUMAN
Rho-related GTP-binding protein Rho...
RHOQ
50Annotation score:
E5RFZ3E5RFZ3_HUMAN
Rho-related GTP-binding protein Rho...
RHOQ
75Annotation score:
H0YB40H0YB40_HUMAN
Rho-related GTP-binding protein Rho...
RHOQ
91Annotation score:
H0YB93H0YB93_HUMAN
Rho-related GTP-binding protein Rho...
RHOQ
34Annotation score:

Sequence cautioni

The sequence AAA36547 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAM21123 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31470 mRNA Translation: AAA36547.1 Different initiation.
AF498976 mRNA Translation: AAM21123.1 Different initiation.
AC018682 Genomic DNA Translation: AAY14834.1
CH471053 Genomic DNA Translation: EAX00251.1
BC056154 mRNA Translation: AAH56154.3
BC065291 mRNA Translation: AAH65291.2
BC070485 mRNA Translation: AAH70485.2
BC093805 mRNA Translation: AAH93805.2
BC101806 mRNA Translation: AAI01807.1
CCDSiCCDS33191.1
PIRiD34788 TVHUC4
RefSeqiNP_036381.2, NM_012249.3
UniGeneiHs.709193

Genome annotation databases

EnsembliENST00000238738; ENSP00000238738; ENSG00000119729
GeneIDi23433
KEGGihsa:23433
UCSCiuc061ivt.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31470 mRNA Translation: AAA36547.1 Different initiation.
AF498976 mRNA Translation: AAM21123.1 Different initiation.
AC018682 Genomic DNA Translation: AAY14834.1
CH471053 Genomic DNA Translation: EAX00251.1
BC056154 mRNA Translation: AAH56154.3
BC065291 mRNA Translation: AAH65291.2
BC070485 mRNA Translation: AAH70485.2
BC093805 mRNA Translation: AAH93805.2
BC101806 mRNA Translation: AAI01807.1
CCDSiCCDS33191.1
PIRiD34788 TVHUC4
RefSeqiNP_036381.2, NM_012249.3
UniGeneiHs.709193

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ATXX-ray2.65A/B1-185[»]
ProteinModelPortaliP17081
SMRiP17081
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117001, 13 interactors
IntActiP17081, 6 interactors
STRINGi9606.ENSP00000238738

PTM databases

iPTMnetiP17081
PhosphoSitePlusiP17081
SwissPalmiP17081

Polymorphism and mutation databases

BioMutaiRHOQ
DMDMi62906861

Proteomic databases

EPDiP17081
PaxDbiP17081
PeptideAtlasiP17081
PRIDEiP17081
ProteomicsDBi53452

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238738; ENSP00000238738; ENSG00000119729
GeneIDi23433
KEGGihsa:23433
UCSCiuc061ivt.1 human

Organism-specific databases

CTDi23433
DisGeNETi23433
EuPathDBiHostDB:ENSG00000119729.10
GeneCardsiRHOQ
HGNCiHGNC:17736 RHOQ
HPAiHPA044938
MIMi605857 gene
neXtProtiNX_P17081
OpenTargetsiENSG00000119729
PharmGKBiPA134904280
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118978
HOVERGENiHBG009351
InParanoidiP17081
KOiK07194
OMAiIMANGTG
PhylomeDBiP17081
TreeFamiTF101109

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-194840 Rho GTPase cycle
R-HSA-5627083 RHO GTPases regulate CFTR trafficking
SignaLinkiP17081
SIGNORiP17081

Miscellaneous databases

ChiTaRSiRHOQ human
EvolutionaryTraceiP17081
GeneWikiiRHOQ
GenomeRNAii23433
PROiPR:P17081
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119729 Expressed in 237 organ(s), highest expression level in heart
CleanExiHS_RHOQ
ExpressionAtlasiP17081 baseline and differential
GenevisibleiP17081 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHOQ_HUMAN
AccessioniPrimary (citable) accession number: P17081
Secondary accession number(s): D6W5A6
, Q0VGN1, Q52LS8, Q53SJ1, Q6NS39, Q6P146, Q7Z480
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: April 26, 2005
Last modified: November 7, 2018
This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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