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Protein

Heat shock 70 kDa protein 6

Gene

HSPA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei73ATP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi14 – 17ATP4
Nucleotide bindingi204 – 206ATP3
Nucleotide bindingi270 – 277ATP8
Nucleotide bindingi341 – 344ATP4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATPase activity, coupled Source: UniProtKB
  • ATP binding Source: GO_Central
  • enzyme binding Source: BHF-UCL
  • heat shock protein binding Source: UniProtKB
  • misfolded protein binding Source: GO_Central
  • protein binding involved in protein folding Source: GO_Central
  • unfolded protein binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-6798695 Neutrophil degranulation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P17066

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Heat shock 70 kDa protein 6
Alternative name(s):
Heat shock 70 kDa protein B'
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HSPA6
Synonyms:HSP70B'
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000173110.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5239 HSPA6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
140555 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P17066

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi563K → R: Complete loss of in vitro methylation by METTL21A. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
3310

Open Targets

More...
OpenTargetsi
ENSG00000173110

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29505

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3232688

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HSPA6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34978357

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000782641 – 643Heat shock 70 kDa protein 6Add BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei563N6,N6,N6-trimethyllysine; by METTL21A; in vitro1 Publication1

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P17066

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P17066

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P17066

PeptideAtlas

More...
PeptideAtlasi
P17066

PRoteomics IDEntifications database

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PRIDEi
P17066

ProteomicsDB human proteome resource

More...
ProteomicsDBi
53451

2D gel databases

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P17066

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1298

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P17066

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P17066

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P17066

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Only at higher temperatures, and no basal expression.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173110 Expressed in 83 organ(s), highest expression level in hypothalamus

CleanEx database of gene expression profiles

More...
CleanExi
HS_HSPA6

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P17066 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017452
HPA028549
HPA052504

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TERF1P542742EBI-355106,EBI-710997

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109542, 92 interactors

Protein interaction database and analysis system

More...
IntActi
P17066, 50 interactors

Molecular INTeraction database

More...
MINTi
P17066

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000310219

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1643
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P17066

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P17066

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P17066

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni3 – 388Nucleotide-binding domain (NBD)By similarityAdd BLAST386
Regioni396 – 511Substrate-binding domain (SBD)By similarityAdd BLAST116

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0101 Eukaryota
COG0443 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163722

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000228135

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051845

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P17066

KEGG Orthology (KO)

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KOi
K03283

Identification of Orthologs from Complete Genome Data

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OMAi
SLEAYVF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G03SF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P17066

TreeFam database of animal gene trees

More...
TreeFami
TF105042

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.10, 1 hit
2.60.34.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam

The PANTHER Classification System

More...
PANTHERi
PTHR19375 PTHR19375, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00012 HSP70, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00301 HEATSHOCK70

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P17066-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQAPRELAVG IDLGTTYSCV GVFQQGRVEI LANDQGNRTT PSYVAFTDTE
60 70 80 90 100
RLVGDAAKSQ AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFRVVSEG
110 120 130 140 150
GKPKVRVCYR GEDKTFYPEE ISSMVLSKMK ETAEAYLGQP VKHAVITVPA
160 170 180 190 200
YFNDSQRQAT KDAGAIAGLN VLRIINEPTA AAIAYGLDRR GAGERNVLIF
210 220 230 240 250
DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV NHFMEEFRRK
260 270 280 290 300
HGKDLSGNKR ALRRLRTACE RAKRTLSSST QATLEIDSLF EGVDFYTSIT
310 320 330 340 350
RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDVVLVG GSTRIPKVQK
360 370 380 390 400
LLQDFFNGKE LNKSINPDEA VAYGAAVQAA VLMGDKCEKV QDLLLLDVAP
410 420 430 440 450
LSLGLETAGG VMTTLIQRNA TIPTKQTQTF TTYSDNQPGV FIQVYEGERA
460 470 480 490 500
MTKDNNLLGR FELSGIPPAP RGVPQIEVTF DIDANGILSV TATDRSTGKA
510 520 530 540 550
NKITITNDKG RLSKEEVERM VHEAEQYKAE DEAQRDRVAA KNSLEAHVFH
560 570 580 590 600
VKGSLQEESL RDKIPEEDRR KMQDKCREVL AWLEHNQLAE KEEYEHQKRE
610 620 630 640
LEQICRPIFS RLYGGPGVPG GSSCGTQARQ GDPSTGPIIE EVD
Length:643
Mass (Da):71,028
Last modified:September 19, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBCE348F0226DB70B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti106 – 108RVC → PVS in CAA36061 (PubMed:2327978).Curated3
Sequence conflicti263R → G in CAA36061 (PubMed:2327978).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06071865P → T1 PublicationCorresponds to variant dbSNP:rs41297698Ensembl.1
Natural variantiVAR_06071995R → Q1 PublicationCorresponds to variant dbSNP:rs400835Ensembl.1
Natural variantiVAR_049605150A → T1 PublicationCorresponds to variant dbSNP:rs10919224Ensembl.1
Natural variantiVAR_049606153N → S1 PublicationCorresponds to variant dbSNP:rs10919225Ensembl.1
Natural variantiVAR_049607154D → N1 PublicationCorresponds to variant dbSNP:rs10919226Ensembl.1
Natural variantiVAR_060720159A → V1 PublicationCorresponds to variant dbSNP:rs41297702Ensembl.1
Natural variantiVAR_049608170N → K1 PublicationCorresponds to variant dbSNP:rs41297704Ensembl.1
Natural variantiVAR_049609173R → P1 PublicationCorresponds to variant dbSNP:rs41297708Ensembl.1
Natural variantiVAR_049610178P → A1 PublicationCorresponds to variant dbSNP:rs41297710Ensembl.1
Natural variantiVAR_049611194E → K1 PublicationCorresponds to variant dbSNP:rs41297714Ensembl.1
Natural variantiVAR_024182198L → F1 PublicationCorresponds to variant dbSNP:rs1079109Ensembl.1
Natural variantiVAR_049612260R → H. Corresponds to variant dbSNP:rs41299256Ensembl.1
Natural variantiVAR_060721297T → K1 PublicationCorresponds to variant dbSNP:rs41297718Ensembl.1
Natural variantiVAR_059360336V → F. Corresponds to variant dbSNP:rs417707Ensembl.1
Natural variantiVAR_049613464S → I1 PublicationCorresponds to variant dbSNP:rs388218Ensembl.1
Natural variantiVAR_049614471R → H1 PublicationCorresponds to variant dbSNP:rs41299256Ensembl.1
Natural variantiVAR_049615528K → E1 PublicationCorresponds to variant dbSNP:rs570189Ensembl.1
Natural variantiVAR_059361528K → R. Corresponds to variant dbSNP:rs570167Ensembl.1
Natural variantiVAR_024183562D → E1 PublicationCorresponds to variant dbSNP:rs753856Ensembl.1
Natural variantiVAR_049616572M → V. Corresponds to variant dbSNP:rs452004Ensembl.1
Natural variantiVAR_049617577R → Q1 PublicationCorresponds to variant dbSNP:rs368844Ensembl.1
Natural variantiVAR_049618626T → A1 PublicationCorresponds to variant dbSNP:rs41299260Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X51757 Genomic DNA Translation: CAA36061.1
X51758 mRNA Translation: CAA36062.1
DQ521571 Genomic DNA Translation: ABF47108.1
AL590385 Genomic DNA No translation available.
BC004279 mRNA Translation: AAH04279.1
BC035665 mRNA Translation: AAH35665.1
S78631 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1231.1

Protein sequence database of the Protein Information Resource

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PIRi
S09036

NCBI Reference Sequences

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RefSeqi
NP_002146.2, NM_002155.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.654614

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000309758; ENSP00000310219; ENSG00000173110

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3310

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3310

UCSC genome browser

More...
UCSCi
uc001gaq.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51757 Genomic DNA Translation: CAA36061.1
X51758 mRNA Translation: CAA36062.1
DQ521571 Genomic DNA Translation: ABF47108.1
AL590385 Genomic DNA No translation available.
BC004279 mRNA Translation: AAH04279.1
BC035665 mRNA Translation: AAH35665.1
S78631 Genomic DNA No translation available.
CCDSiCCDS1231.1
PIRiS09036
RefSeqiNP_002146.2, NM_002155.4
UniGeneiHs.654614

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FE1X-ray2.20A/B/C6-385[»]
ProteinModelPortaliP17066
SMRiP17066
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109542, 92 interactors
IntActiP17066, 50 interactors
MINTiP17066
STRINGi9606.ENSP00000310219

Chemistry databases

ChEMBLiCHEMBL3232688

PTM databases

GlyConnecti1298
iPTMnetiP17066
PhosphoSitePlusiP17066
SwissPalmiP17066

Polymorphism and mutation databases

BioMutaiHSPA6
DMDMi34978357

2D gel databases

UCD-2DPAGEiP17066

Proteomic databases

EPDiP17066
MaxQBiP17066
PaxDbiP17066
PeptideAtlasiP17066
PRIDEiP17066
ProteomicsDBi53451

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3310
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309758; ENSP00000310219; ENSG00000173110
GeneIDi3310
KEGGihsa:3310
UCSCiuc001gaq.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3310
DisGeNETi3310
EuPathDBiHostDB:ENSG00000173110.7

GeneCards: human genes, protein and diseases

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GeneCardsi
HSPA6
HGNCiHGNC:5239 HSPA6
HPAiCAB017452
HPA028549
HPA052504
MIMi140555 gene
neXtProtiNX_P17066
OpenTargetsiENSG00000173110
PharmGKBiPA29505

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0101 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00940000163722
HOGENOMiHOG000228135
HOVERGENiHBG051845
InParanoidiP17066
KOiK03283
OMAiSLEAYVF
OrthoDBiEOG091G03SF
PhylomeDBiP17066
TreeFamiTF105042

Enzyme and pathway databases

ReactomeiR-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-6798695 Neutrophil degranulation
SIGNORiP17066

Miscellaneous databases

EvolutionaryTraceiP17066

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HSPA6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3310

Protein Ontology

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PROi
PR:P17066

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000173110 Expressed in 83 organ(s), highest expression level in hypothalamus
CleanExiHS_HSPA6
GenevisibleiP17066 HS

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHSP76_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17066
Secondary accession number(s): Q1HBA8, Q8IYK7, Q9BT95
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: September 19, 2003
Last modified: December 5, 2018
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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