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Entry version 199 (11 Dec 2019)
Sequence version 4 (24 Mar 2009)
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Protein

Zinc finger protein 43

Gene

ZNF43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri174 – 196C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 252C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri594 – 616C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 672C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri678 – 700C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri706 – 728C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri734 – 756C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri762 – 784C2H2-type 22PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 43
Alternative name(s):
Zinc finger protein 39
Zinc finger protein HTF6
Zinc finger protein KOX27
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF43
Synonyms:KOX27, ZNF39, ZNF39L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198521.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13109 ZNF43

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603972 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P17038

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7594

Open Targets

More...
OpenTargetsi
ENSG00000198521

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37684

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P17038 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF43

Domain mapping of disease mutations (DMDM)

More...
DMDMi
229485311

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473761 – 809Zinc finger protein 43Add BLAST809

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P17038

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P17038

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P17038

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P17038

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P17038

PeptideAtlas

More...
PeptideAtlasi
P17038

PRoteomics IDEntifications database

More...
PRIDEi
P17038

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
53440 [P17038-1]
53441 [P17038-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P17038

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P17038

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

T- and B-cell lines.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198521 Expressed in 226 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P17038 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P17038 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050271

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000350085

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P17038 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P17038

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 75KRABPROSITE-ProRule annotationAdd BLAST69

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri174 – 196C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 252C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri594 – 616C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 672C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri678 – 700C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri706 – 728C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri734 – 756C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri762 – 784C2H2-type 22PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163744

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P17038

KEGG Orthology (KO)

More...
KOi
K09228

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P17038

TreeFam database of animal gene trees

More...
TreeFami
TF343410

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 18 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 22 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 22 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P17038-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPLTFMDVA IEFCLEEWQC LDIAQQNLYR NVMLENYRNL VFLGIAVSKP
60 70 80 90 100
DLITCLEQEK EPWEPMRRHE MVAKPPVMCS HFTQDFWPEQ HIKDPFQKAT
110 120 130 140 150
LRRYKNCEHK NVHLKKDHKS VDECKVHRGG YNGFNQCLPA TQSKIFLFDK
160 170 180 190 200
CVKAFHKFSN SNRHKISHTE KKLFKCKECG KSFCMLPHLA QHKIIHTRVN
210 220 230 240 250
FCKCEKCGKA FNCPSIITKH KRINTGEKPY TCEECGKVFN WSSRLTTHKK
260 270 280 290 300
NYTRYKLYKC EECGKAFNKS SILTTHKIIR TGEKFYKCKE CAKAFNQSSN
310 320 330 340 350
LTEHKKIHPG EKPYKCEECG KAFNWPSTLT KHKRIHTGEK PYTCEECGKA
360 370 380 390 400
FNQFSNLTTH KRIHTAEKFY KCTECGEAFS RSSNLTKHKK IHTEKKPYKC
410 420 430 440 450
EECGKAFKWS SKLTEHKLTH TGEKPYKCEE CGKAFNWPST LTKHNRIHTG
460 470 480 490 500
EKPYKCEVCG KAFNQFSNLT THKRIHTAEK PYKCEECGKA FSRSSNLTKH
510 520 530 540 550
KKIHIEKKPY KCEECGKAFK WSSKLTEHKI THTGEKPYKC EECGKAFNHF
560 570 580 590 600
SILTKHKRIH TGEKPYKCEE CGKAFTQSSN LTTHKKIHTG EKFYKCEECG
610 620 630 640 650
KAFTQSSNLT THKKIHTGGK PYKCEECGKA FNQFSTLTKH KIIHTEEKPY
660 670 680 690 700
KCEECGKAFK WSSTLTKHKI IHTGEKPYKC EECGKAFKLS STLSTHKIIH
710 720 730 740 750
TGEKPYKCEK CGKAFNRSSN LIEHKKIHTG EQPYKCEECG KAFNYSSHLN
760 770 780 790 800
THKRIHTKEQ PYKCKECGKA FNQYSNLTTH NKIHTGEKLY KPEDVTVILT

TPQTFSNIK
Length:809
Mass (Da):94,124
Last modified:March 24, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03386F299D6794C4
GO
Isoform 2 (identifier: P17038-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MGPLTFM → M

Show »
Length:803
Mass (Da):93,478
Checksum:i8A3BCB47ECDD1500
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WSW2A0A087WSW2_HUMAN
Zinc finger protein 43
ZNF43
818Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXI2M0QXI2_HUMAN
Zinc finger protein 43
ZNF43
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R3D5M0R3D5_HUMAN
Zinc finger protein 43
ZNF43
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JQ90A0A0G2JQ90_HUMAN
Zinc finger protein 43
ZNF43
475Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYJ6M0QYJ6_HUMAN
Zinc finger protein 43
ZNF43
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0T7M0R0T7_HUMAN
Zinc finger protein 43
ZNF43
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43L → M in AAA58674 (PubMed:2023909).Curated1
Sequence conflicti187P → S in AAA58674 (PubMed:2023909).Curated1
Sequence conflicti573K → R in BAF84042 (PubMed:14702039).Curated1
Sequence conflicti622Y → H in CAI45941 (PubMed:17974005).Curated1
Sequence conflicti738E → G in CAI45941 (PubMed:17974005).Curated1
Sequence conflicti797V → M in BAF84042 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035569244R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs200399581Ensembl.1
Natural variantiVAR_054794718S → P1 PublicationCorresponds to variant dbSNP:rs1063327Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0367341 – 7MGPLTFM → M in isoform 2. 4 Publications7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X59244 mRNA Translation: CAA41932.1
BT009756 mRNA Translation: AAP88758.1
AK291353 mRNA Translation: BAF84042.1
CR933640 mRNA Translation: CAI45941.1
AC010617 Genomic DNA No translation available.
AC092364 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84908.1
BC006528 mRNA Translation: AAH06528.2
M61869 mRNA Translation: AAA58674.1
X52358 mRNA Translation: CAA36584.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12413.2 [P17038-1]
CCDS59367.1 [P17038-2]

Protein sequence database of the Protein Information Resource

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PIRi
D39384
S26823

NCBI Reference Sequences

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RefSeqi
NP_001243577.1, NM_001256648.1 [P17038-2]
NP_001243578.1, NM_001256649.1 [P17038-2]
NP_001243579.1, NM_001256650.1 [P17038-2]
NP_003414.2, NM_003423.3 [P17038-1]
XP_011526559.1, XM_011528257.2 [P17038-2]
XP_011526561.1, XM_011528259.2 [P17038-2]
XP_016882696.1, XM_017027207.1 [P17038-2]
XP_016882697.1, XM_017027208.1 [P17038-2]
XP_016882698.1, XM_017027209.1 [P17038-2]
XP_016882699.1, XM_017027210.1 [P17038-2]
XP_016882700.1, XM_017027211.1 [P17038-2]
XP_016882701.1, XM_017027212.1 [P17038-2]
XP_016882702.1, XM_017027213.1 [P17038-2]
XP_016882703.1, XM_017027214.1 [P17038-2]
XP_016882704.1, XM_017027215.1 [P17038-2]
XP_016882705.1, XM_017027216.1 [P17038-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000354959; ENSP00000347045; ENSG00000198521 [P17038-1]
ENST00000594012; ENSP00000469578; ENSG00000198521 [P17038-2]
ENST00000595461; ENSP00000469645; ENSG00000198521 [P17038-2]
ENST00000598381; ENSP00000470275; ENSG00000198521 [P17038-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
7594

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7594

UCSC genome browser

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UCSCi
uc002nqj.5 human [P17038-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59244 mRNA Translation: CAA41932.1
BT009756 mRNA Translation: AAP88758.1
AK291353 mRNA Translation: BAF84042.1
CR933640 mRNA Translation: CAI45941.1
AC010617 Genomic DNA No translation available.
AC092364 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84908.1
BC006528 mRNA Translation: AAH06528.2
M61869 mRNA Translation: AAA58674.1
X52358 mRNA Translation: CAA36584.1
CCDSiCCDS12413.2 [P17038-1]
CCDS59367.1 [P17038-2]
PIRiD39384
S26823
RefSeqiNP_001243577.1, NM_001256648.1 [P17038-2]
NP_001243578.1, NM_001256649.1 [P17038-2]
NP_001243579.1, NM_001256650.1 [P17038-2]
NP_003414.2, NM_003423.3 [P17038-1]
XP_011526559.1, XM_011528257.2 [P17038-2]
XP_011526561.1, XM_011528259.2 [P17038-2]
XP_016882696.1, XM_017027207.1 [P17038-2]
XP_016882697.1, XM_017027208.1 [P17038-2]
XP_016882698.1, XM_017027209.1 [P17038-2]
XP_016882699.1, XM_017027210.1 [P17038-2]
XP_016882700.1, XM_017027211.1 [P17038-2]
XP_016882701.1, XM_017027212.1 [P17038-2]
XP_016882702.1, XM_017027213.1 [P17038-2]
XP_016882703.1, XM_017027214.1 [P17038-2]
XP_016882704.1, XM_017027215.1 [P17038-2]
XP_016882705.1, XM_017027216.1 [P17038-2]

3D structure databases

SMRiP17038
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000350085

PTM databases

iPTMnetiP17038
PhosphoSitePlusiP17038

Polymorphism and mutation databases

BioMutaiZNF43
DMDMi229485311

Proteomic databases

EPDiP17038
jPOSTiP17038
MassIVEiP17038
MaxQBiP17038
PaxDbiP17038
PeptideAtlasiP17038
PRIDEiP17038
ProteomicsDBi53440 [P17038-1]
53441 [P17038-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7594

Genome annotation databases

EnsembliENST00000354959; ENSP00000347045; ENSG00000198521 [P17038-1]
ENST00000594012; ENSP00000469578; ENSG00000198521 [P17038-2]
ENST00000595461; ENSP00000469645; ENSG00000198521 [P17038-2]
ENST00000598381; ENSP00000470275; ENSG00000198521 [P17038-2]
GeneIDi7594
KEGGihsa:7594
UCSCiuc002nqj.5 human [P17038-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7594
DisGeNETi7594
EuPathDBiHostDB:ENSG00000198521.11

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF43
HGNCiHGNC:13109 ZNF43
HPAiHPA050271
MIMi603972 gene
neXtProtiNX_P17038
OpenTargetsiENSG00000198521
PharmGKBiPA37684

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000163744
HOGENOMiHOG000234617
InParanoidiP17038
KOiK09228
OrthoDBi1318335at2759
PhylomeDBiP17038
TreeFamiTF343410

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF43 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZNF43

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7594
PharosiP17038 Tdark

Protein Ontology

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PROi
PR:P17038
RNActiP17038 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198521 Expressed in 226 organ(s), highest expression level in lung
ExpressionAtlasiP17038 baseline and differential
GenevisibleiP17038 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 18 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 22 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 22 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZNF43_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17038
Secondary accession number(s): A8K5N8
, P28160, Q53XQ2, Q5H9T3, Q96DG1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: March 24, 2009
Last modified: December 11, 2019
This is version 199 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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