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Protein

Zinc finger protein 43

Gene

ZNF43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri174 – 196C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 252C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri594 – 616C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 672C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri678 – 700C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri706 – 728C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri734 – 756C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri762 – 784C2H2-type 22PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 43
Alternative name(s):
Zinc finger protein 39
Zinc finger protein HTF6
Zinc finger protein KOX27
Gene namesi
Name:ZNF43
Synonyms:KOX27, ZNF39, ZNF39L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000198521.11
HGNCiHGNC:13109 ZNF43
MIMi603972 gene
neXtProtiNX_P17038

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198521
PharmGKBiPA37684

Polymorphism and mutation databases

BioMutaiZNF43
DMDMi229485311

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473761 – 809Zinc finger protein 43Add BLAST809

Proteomic databases

EPDiP17038
MaxQBiP17038
PaxDbiP17038
PeptideAtlasiP17038
PRIDEiP17038
ProteomicsDBi53440
53441 [P17038-2]

PTM databases

iPTMnetiP17038
PhosphoSitePlusiP17038

Expressioni

Tissue specificityi

T- and B-cell lines.

Gene expression databases

BgeeiENSG00000198521 Expressed in 226 organ(s), highest expression level in lung
CleanExiHS_ZNF43
ExpressionAtlasiP17038 baseline and differential
GenevisibleiP17038 HS

Organism-specific databases

HPAiHPA050271

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347045

Structurei

3D structure databases

ProteinModelPortaliP17038
SMRiP17038
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 75KRABPROSITE-ProRule annotationAdd BLAST69

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri174 – 196C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 252C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri594 – 616C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri622 – 644C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri650 – 672C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri678 – 700C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri706 – 728C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri734 – 756C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri762 – 784C2H2-type 22PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150816
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP17038
KOiK09228
PhylomeDBiP17038
TreeFamiTF343410

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 19 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 22 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 22 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P17038-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPLTFMDVA IEFCLEEWQC LDIAQQNLYR NVMLENYRNL VFLGIAVSKP
60 70 80 90 100
DLITCLEQEK EPWEPMRRHE MVAKPPVMCS HFTQDFWPEQ HIKDPFQKAT
110 120 130 140 150
LRRYKNCEHK NVHLKKDHKS VDECKVHRGG YNGFNQCLPA TQSKIFLFDK
160 170 180 190 200
CVKAFHKFSN SNRHKISHTE KKLFKCKECG KSFCMLPHLA QHKIIHTRVN
210 220 230 240 250
FCKCEKCGKA FNCPSIITKH KRINTGEKPY TCEECGKVFN WSSRLTTHKK
260 270 280 290 300
NYTRYKLYKC EECGKAFNKS SILTTHKIIR TGEKFYKCKE CAKAFNQSSN
310 320 330 340 350
LTEHKKIHPG EKPYKCEECG KAFNWPSTLT KHKRIHTGEK PYTCEECGKA
360 370 380 390 400
FNQFSNLTTH KRIHTAEKFY KCTECGEAFS RSSNLTKHKK IHTEKKPYKC
410 420 430 440 450
EECGKAFKWS SKLTEHKLTH TGEKPYKCEE CGKAFNWPST LTKHNRIHTG
460 470 480 490 500
EKPYKCEVCG KAFNQFSNLT THKRIHTAEK PYKCEECGKA FSRSSNLTKH
510 520 530 540 550
KKIHIEKKPY KCEECGKAFK WSSKLTEHKI THTGEKPYKC EECGKAFNHF
560 570 580 590 600
SILTKHKRIH TGEKPYKCEE CGKAFTQSSN LTTHKKIHTG EKFYKCEECG
610 620 630 640 650
KAFTQSSNLT THKKIHTGGK PYKCEECGKA FNQFSTLTKH KIIHTEEKPY
660 670 680 690 700
KCEECGKAFK WSSTLTKHKI IHTGEKPYKC EECGKAFKLS STLSTHKIIH
710 720 730 740 750
TGEKPYKCEK CGKAFNRSSN LIEHKKIHTG EQPYKCEECG KAFNYSSHLN
760 770 780 790 800
THKRIHTKEQ PYKCKECGKA FNQYSNLTTH NKIHTGEKLY KPEDVTVILT

TPQTFSNIK
Length:809
Mass (Da):94,124
Last modified:March 24, 2009 - v4
Checksum:i03386F299D6794C4
GO
Isoform 2 (identifier: P17038-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MGPLTFM → M

Show »
Length:803
Mass (Da):93,478
Checksum:i8A3BCB47ECDD1500
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WSW2A0A087WSW2_HUMAN
Zinc finger protein 43
ZNF43
818Annotation score:
M0QXI2M0QXI2_HUMAN
Zinc finger protein 43
ZNF43
60Annotation score:
M0R3D5M0R3D5_HUMAN
Zinc finger protein 43
ZNF43
84Annotation score:
A0A0G2JQ90A0A0G2JQ90_HUMAN
Zinc finger protein 43
ZNF43
475Annotation score:
M0QYJ6M0QYJ6_HUMAN
Zinc finger protein 43
ZNF43
121Annotation score:
M0R0T7M0R0T7_HUMAN
Zinc finger protein 43
ZNF43
53Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43L → M in AAA58674 (PubMed:2023909).Curated1
Sequence conflicti187P → S in AAA58674 (PubMed:2023909).Curated1
Sequence conflicti573K → R in BAF84042 (PubMed:14702039).Curated1
Sequence conflicti622Y → H in CAI45941 (PubMed:17974005).Curated1
Sequence conflicti738E → G in CAI45941 (PubMed:17974005).Curated1
Sequence conflicti797V → M in BAF84042 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035569244R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs200399581Ensembl.1
Natural variantiVAR_054794718S → P1 PublicationCorresponds to variant dbSNP:rs1063327Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0367341 – 7MGPLTFM → M in isoform 2. 4 Publications7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59244 mRNA Translation: CAA41932.1
BT009756 mRNA Translation: AAP88758.1
AK291353 mRNA Translation: BAF84042.1
CR933640 mRNA Translation: CAI45941.1
AC010617 Genomic DNA No translation available.
AC092364 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84908.1
BC006528 mRNA Translation: AAH06528.2
M61869 mRNA Translation: AAA58674.1
X52358 mRNA Translation: CAA36584.1
CCDSiCCDS12413.2 [P17038-1]
CCDS59367.1 [P17038-2]
PIRiD39384
S26823
RefSeqiNP_001243577.1, NM_001256648.1 [P17038-2]
NP_001243578.1, NM_001256649.1 [P17038-2]
NP_001243579.1, NM_001256650.1 [P17038-2]
NP_003414.2, NM_003423.3 [P17038-1]
XP_011526559.1, XM_011528257.2 [P17038-2]
XP_011526561.1, XM_011528259.2 [P17038-2]
XP_016882696.1, XM_017027207.1 [P17038-2]
XP_016882697.1, XM_017027208.1 [P17038-2]
XP_016882698.1, XM_017027209.1 [P17038-2]
XP_016882699.1, XM_017027210.1 [P17038-2]
XP_016882700.1, XM_017027211.1 [P17038-2]
XP_016882701.1, XM_017027212.1 [P17038-2]
XP_016882702.1, XM_017027213.1 [P17038-2]
XP_016882703.1, XM_017027214.1 [P17038-2]
XP_016882704.1, XM_017027215.1 [P17038-2]
XP_016882705.1, XM_017027216.1 [P17038-2]
UniGeneiHs.534365

Genome annotation databases

EnsembliENST00000354959; ENSP00000347045; ENSG00000198521 [P17038-1]
ENST00000594012; ENSP00000469578; ENSG00000198521 [P17038-2]
ENST00000595461; ENSP00000469645; ENSG00000198521 [P17038-2]
ENST00000598381; ENSP00000470275; ENSG00000198521 [P17038-2]
GeneIDi7594
KEGGihsa:7594
UCSCiuc002nqj.5 human [P17038-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59244 mRNA Translation: CAA41932.1
BT009756 mRNA Translation: AAP88758.1
AK291353 mRNA Translation: BAF84042.1
CR933640 mRNA Translation: CAI45941.1
AC010617 Genomic DNA No translation available.
AC092364 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84908.1
BC006528 mRNA Translation: AAH06528.2
M61869 mRNA Translation: AAA58674.1
X52358 mRNA Translation: CAA36584.1
CCDSiCCDS12413.2 [P17038-1]
CCDS59367.1 [P17038-2]
PIRiD39384
S26823
RefSeqiNP_001243577.1, NM_001256648.1 [P17038-2]
NP_001243578.1, NM_001256649.1 [P17038-2]
NP_001243579.1, NM_001256650.1 [P17038-2]
NP_003414.2, NM_003423.3 [P17038-1]
XP_011526559.1, XM_011528257.2 [P17038-2]
XP_011526561.1, XM_011528259.2 [P17038-2]
XP_016882696.1, XM_017027207.1 [P17038-2]
XP_016882697.1, XM_017027208.1 [P17038-2]
XP_016882698.1, XM_017027209.1 [P17038-2]
XP_016882699.1, XM_017027210.1 [P17038-2]
XP_016882700.1, XM_017027211.1 [P17038-2]
XP_016882701.1, XM_017027212.1 [P17038-2]
XP_016882702.1, XM_017027213.1 [P17038-2]
XP_016882703.1, XM_017027214.1 [P17038-2]
XP_016882704.1, XM_017027215.1 [P17038-2]
XP_016882705.1, XM_017027216.1 [P17038-2]
UniGeneiHs.534365

3D structure databases

ProteinModelPortaliP17038
SMRiP17038
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347045

PTM databases

iPTMnetiP17038
PhosphoSitePlusiP17038

Polymorphism and mutation databases

BioMutaiZNF43
DMDMi229485311

Proteomic databases

EPDiP17038
MaxQBiP17038
PaxDbiP17038
PeptideAtlasiP17038
PRIDEiP17038
ProteomicsDBi53440
53441 [P17038-2]

Protocols and materials databases

DNASUi7594
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354959; ENSP00000347045; ENSG00000198521 [P17038-1]
ENST00000594012; ENSP00000469578; ENSG00000198521 [P17038-2]
ENST00000595461; ENSP00000469645; ENSG00000198521 [P17038-2]
ENST00000598381; ENSP00000470275; ENSG00000198521 [P17038-2]
GeneIDi7594
KEGGihsa:7594
UCSCiuc002nqj.5 human [P17038-1]

Organism-specific databases

CTDi7594
EuPathDBiHostDB:ENSG00000198521.11
GeneCardsiZNF43
HGNCiHGNC:13109 ZNF43
HPAiHPA050271
MIMi603972 gene
neXtProtiNX_P17038
OpenTargetsiENSG00000198521
PharmGKBiPA37684
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150816
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP17038
KOiK09228
PhylomeDBiP17038
TreeFamiTF343410

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF43 human
GeneWikiiZNF43
GenomeRNAii7594
PROiPR:P17038
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198521 Expressed in 226 organ(s), highest expression level in lung
CleanExiHS_ZNF43
ExpressionAtlasiP17038 baseline and differential
GenevisibleiP17038 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 19 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 22 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 19 hits
PS50157 ZINC_FINGER_C2H2_2, 22 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZNF43_HUMAN
AccessioniPrimary (citable) accession number: P17038
Secondary accession number(s): A8K5N8
, P28160, Q53XQ2, Q5H9T3, Q96DG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: March 24, 2009
Last modified: November 7, 2018
This is version 190 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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