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Protein

Zinc finger protein 3

Gene

ZNF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cell differentiation and/or proliferation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri200 – 222C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
  • identical protein binding Source: IntAct
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 3
Alternative name(s):
Zinc finger protein HF.12
Zinc finger protein HZF3.1
Zinc finger protein KOX25
Gene namesi
Name:ZNF3
Synonyms:KOX25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000166526.16
HGNCiHGNC:13089 ZNF3
MIMi194510 gene
601261 gene
neXtProtiNX_P17036

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166526
PharmGKBiPA37664

Polymorphism and mutation databases

DMDMi46577682

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473681 – 446Zinc finger protein 3Add BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei143PhosphoserineCombined sources1
Cross-linki151Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki163Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki173Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei419PhosphothreonineCombined sources1
Cross-linki422Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki431Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP17036
MaxQBiP17036
PaxDbiP17036
PeptideAtlasiP17036
PRIDEiP17036
ProteomicsDBi53438
53439 [P17036-2]

PTM databases

iPTMnetiP17036
PhosphoSitePlusiP17036

Expressioni

Gene expression databases

BgeeiENSG00000166526 Expressed in 201 organ(s), highest expression level in kidney
CleanExiHS_ZNF3
ExpressionAtlasiP17036 baseline and differential
GenevisibleiP17036 HS

Organism-specific databases

HPAiHPA003719

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113383, 16 interactors
IntActiP17036, 18 interactors
STRINGi9606.ENSP00000299667

Structurei

3D structure databases

ProteinModelPortaliP17036
SMRiP17036
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 123KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri200 – 222C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150877
HOVERGENiHBG077984
InParanoidiP17036
KOiK09228
OMAiPLNVMGM
OrthoDBiEOG091G02KC
PhylomeDBiP17036
TreeFamiTF337732

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P17036-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METQADLVSQ EPQALLDSAL PSKVPAFSDK DSLGDEMLAA ALLKAKSQEL
60 70 80 90 100
VTFEDVAVYF IRKEWKRLEP AQRDLYRDVM LENYGNVFSL DRETRTENDQ
110 120 130 140 150
EISEDTRSHG VLLGRFQKDI SQGLKFKEAY EREVSLKRPL GNSPGERLNR
160 170 180 190 200
KMPDFGQVTV EEKLTPRGER SEKYNDFGNS FTVNSNLISH QRLPVGDRPH
210 220 230 240 250
KCDECSKSFN RTSDLIQHQR IHTGEKPYEC NECGKAFSQS SHLIQHQRIH
260 270 280 290 300
TGEKPYECSD CGKTFSCSSA LILHRRIHTG EKPYECNECG KTFSWSSTLT
310 320 330 340 350
HHQRIHTGEK PYACNECGKA FSRSSTLIHH QRIHTGEKPY ECNECGKAFS
360 370 380 390 400
QSSHLYQHQR IHTGEKPYEC MECGGKFTYS SGLIQHQRIH TGENPYECSE
410 420 430 440
CGKAFRYSSA LVRHQRIHTG EKPLNGIGMS KSSLRVTTEL NIREST
Length:446
Mass (Da):50,916
Last modified:April 26, 2004 - v3
Checksum:iEEF50906695779A6
GO
Isoform 2 (identifier: P17036-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-446: RETRTENDQE...TTELNIREST → WIHVCLTTQK...LASVEPPDTF

Show »
Length:131
Mass (Da):14,627
Checksum:iEB7B1403D9614BAB
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JE35C9JE35_HUMAN
Zinc finger protein 3
ZNF3
104Annotation score:
C9JK31C9JK31_HUMAN
Zinc finger protein 3
ZNF3
98Annotation score:
C9JIW8C9JIW8_HUMAN
Zinc finger protein 3
ZNF3
148Annotation score:
C9J5S8C9J5S8_HUMAN
Zinc finger protein 3
ZNF3
184Annotation score:
F8WA60F8WA60_HUMAN
Zinc finger protein 3
ZNF3
20Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21P → L in BAA91019 (PubMed:14702039).Curated1
Sequence conflicti252 – 256GEKPY → IRDSG in CAA30269 (PubMed:3380682).Curated5
Sequence conflicti336 – 387GEKPY…LIQHQ → EALPTFVTLIRLLPSVDPIV TNEAAFPAESLATIFALIWR LFCVHSLMFKKV in BAA91019 (PubMed:14702039).CuratedAdd BLAST52

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052743102I → T. Corresponds to variant dbSNP:rs11550034Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04115692 – 446RETRT…IREST → WIHVCLTTQKVMLAWLTGTL SVAKGLCSSELASVEPPDTF in isoform 2. 2 PublicationsAdd BLAST355

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217988 mRNA Translation: AAG17231.1
AF193057 mRNA Translation: AAG22485.1
AK000223 mRNA Translation: BAA91019.1
AK297625 mRNA Translation: BAH12633.1
CH471091 Genomic DNA Translation: EAW76605.1
CH471091 Genomic DNA Translation: EAW76606.1
CH471091 Genomic DNA Translation: EAW76608.1
BC011887 mRNA Translation: AAH11887.2
BC013603 mRNA Translation: AAH13603.2
X60153 mRNA Translation: CAB94195.1
X52356 mRNA Translation: CAA36582.1
X07290 mRNA Translation: CAA30269.1
CCDSiCCDS43618.1 [P17036-2]
CCDS43619.1 [P17036-1]
PIRiS00754
RefSeqiNP_001265213.1, NM_001278284.1 [P17036-1]
NP_001265216.1, NM_001278287.1 [P17036-1]
NP_001265219.1, NM_001278290.1 [P17036-1]
NP_001305064.1, NM_001318135.1 [P17036-1]
NP_001305065.1, NM_001318136.1
NP_001305066.1, NM_001318137.1
NP_060185.2, NM_017715.3 [P17036-2]
NP_116313.3, NM_032924.4 [P17036-1]
UniGeneiHs.435302

Genome annotation databases

EnsembliENST00000299667; ENSP00000299667; ENSG00000166526 [P17036-1]
ENST00000303915; ENSP00000306372; ENSG00000166526 [P17036-1]
ENST00000413658; ENSP00000399951; ENSG00000166526 [P17036-2]
ENST00000424697; ENSP00000415358; ENSG00000166526 [P17036-1]
GeneIDi7551
KEGGihsa:7551
UCSCiuc003usp.5 human [P17036-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217988 mRNA Translation: AAG17231.1
AF193057 mRNA Translation: AAG22485.1
AK000223 mRNA Translation: BAA91019.1
AK297625 mRNA Translation: BAH12633.1
CH471091 Genomic DNA Translation: EAW76605.1
CH471091 Genomic DNA Translation: EAW76606.1
CH471091 Genomic DNA Translation: EAW76608.1
BC011887 mRNA Translation: AAH11887.2
BC013603 mRNA Translation: AAH13603.2
X60153 mRNA Translation: CAB94195.1
X52356 mRNA Translation: CAA36582.1
X07290 mRNA Translation: CAA30269.1
CCDSiCCDS43618.1 [P17036-2]
CCDS43619.1 [P17036-1]
PIRiS00754
RefSeqiNP_001265213.1, NM_001278284.1 [P17036-1]
NP_001265216.1, NM_001278287.1 [P17036-1]
NP_001265219.1, NM_001278290.1 [P17036-1]
NP_001305064.1, NM_001318135.1 [P17036-1]
NP_001305065.1, NM_001318136.1
NP_001305066.1, NM_001318137.1
NP_060185.2, NM_017715.3 [P17036-2]
NP_116313.3, NM_032924.4 [P17036-1]
UniGeneiHs.435302

3D structure databases

ProteinModelPortaliP17036
SMRiP17036
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113383, 16 interactors
IntActiP17036, 18 interactors
STRINGi9606.ENSP00000299667

PTM databases

iPTMnetiP17036
PhosphoSitePlusiP17036

Polymorphism and mutation databases

DMDMi46577682

Proteomic databases

EPDiP17036
MaxQBiP17036
PaxDbiP17036
PeptideAtlasiP17036
PRIDEiP17036
ProteomicsDBi53438
53439 [P17036-2]

Protocols and materials databases

DNASUi7551
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299667; ENSP00000299667; ENSG00000166526 [P17036-1]
ENST00000303915; ENSP00000306372; ENSG00000166526 [P17036-1]
ENST00000413658; ENSP00000399951; ENSG00000166526 [P17036-2]
ENST00000424697; ENSP00000415358; ENSG00000166526 [P17036-1]
GeneIDi7551
KEGGihsa:7551
UCSCiuc003usp.5 human [P17036-1]

Organism-specific databases

CTDi7551
EuPathDBiHostDB:ENSG00000166526.16
GeneCardsiZNF3
HGNCiHGNC:13089 ZNF3
HPAiHPA003719
MIMi194510 gene
601261 gene
neXtProtiNX_P17036
OpenTargetsiENSG00000166526
PharmGKBiPA37664
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150877
HOVERGENiHBG077984
InParanoidiP17036
KOiK09228
OMAiPLNVMGM
OrthoDBiEOG091G02KC
PhylomeDBiP17036
TreeFamiTF337732

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF3 human
GeneWikiiZNF3
GenomeRNAii7551
PROiPR:P17036
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166526 Expressed in 201 organ(s), highest expression level in kidney
CleanExiHS_ZNF3
ExpressionAtlasiP17036 baseline and differential
GenevisibleiP17036 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZNF3_HUMAN
AccessioniPrimary (citable) accession number: P17036
Secondary accession number(s): D6W5U0
, P13683, Q9HBR4, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: April 26, 2004
Last modified: November 7, 2018
This is version 199 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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