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Protein

Zinc finger protein 37A

Gene

ZNF37A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri146 – 168C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 37A
Alternative name(s):
Zinc finger protein KOX21
Gene namesi
Name:ZNF37A
Synonyms:KOX21, ZNF37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000075407.17
HGNCiHGNC:13102 ZNF37A
MIMi616085 gene
neXtProtiNX_P17032

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000075407
PharmGKBiPA37677

Polymorphism and mutation databases

BioMutaiZNF37A
DMDMi85681861

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473671 – 561Zinc finger protein 37AAdd BLAST561

Proteomic databases

EPDiP17032
MaxQBiP17032
PaxDbiP17032
PeptideAtlasiP17032
PRIDEiP17032
ProteomicsDBi53435

PTM databases

iPTMnetiP17032
PhosphoSitePlusiP17032

Expressioni

Inductioni

Down-regulated in cells with DM1 (Myotonic dystrophy type 1) mutation, via a mechanism that involves abnormal control of its mRNA stability by CUGBP1.1 Publication

Gene expression databases

BgeeiENSG00000075407 Expressed in 203 organ(s), highest expression level in visceral pleura
CleanExiHS_ZNF37A
ExpressionAtlasiP17032 baseline and differential
GenevisibleiP17032 HS

Organism-specific databases

HPAiHPA003172

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329141

Structurei

3D structure databases

ProteinModelPortaliP17032
SMRiP17032
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri146 – 168C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149024
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP17032
KOiK09228
OMAiIEYNECG
OrthoDBiEOG091G02KC
PhylomeDBiP17032
TreeFamiTF337898

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P17032-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MITSQGSVSF RDVTVGFTQE EWQHLDPAQR TLYRDVMLEN YSHLVSVGYC
60 70 80 90 100
IPKPEVILKL EKGEEPWILE EKFPSQSHLE LINTSRNYSI MKFNEFNKGG
110 120 130 140 150
KCFCDEKHEI IHSEEEPSEY NKNGNSFWLN EDLIWHQKIK NWEQSFEYNE
160 170 180 190 200
CGKAFPENSL FLVHKRGYTG QKTCKYTEHG KTCDMSFFIT HQQTHPRENH
210 220 230 240 250
YGNECGENIF EESILLEHQS VYPFSQKLNL TPIQRTHSIN NIIEYNECGT
260 270 280 290 300
FFSEKLVLHL QQRTHTGEKP YECHECGKTF TQKSAHTRHQ RTHTGGKPYE
310 320 330 340 350
CHECGKTFYK NSDLIKHQRI HTGERPYGCH ECGKSFSEKS TLTQHQRTHT
360 370 380 390 400
GEKPYECHEC GKTFSFKSVL TVHQKTHTGE KPYECYACGK AFLRKSDLIK
410 420 430 440 450
HQRIHTGEKP YECNECGKSF SEKSTLTKHL RTHTGEKPYE CIQCGKFFCY
460 470 480 490 500
YSGFTEHLRR HTGEKPFGCN ECGKTFRQKS ALIVHQRTHI RQKPYGCNQC
510 520 530 540 550
GKSFCVKSKL IAHHRTHTGE KPYECNVCGK SFYVKSKLTV HQRIHLGRNP
560
INVVNEGNYS G
Length:561
Mass (Da):65,418
Last modified:January 10, 2006 - v3
Checksum:i068789DC7DA04BC3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GVV4A0A1B0GVV4_HUMAN
Zinc finger protein 37A
ZNF37A
108Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052753105D → N. Corresponds to variant dbSNP:rs2021319Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ492195 mRNA Translation: CAD37331.1
AK092012 mRNA Translation: BAG52465.1
AL117339 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW85885.1
CH471072 Genomic DNA Translation: EAW85886.1
BC015858 mRNA Translation: AAH15858.1
X69115 mRNA Translation: CAA48868.1
X52352 mRNA Translation: CAA36578.1
CCDSiCCDS31183.1
PIRiS30238
RefSeqiNP_001007095.1, NM_001007094.2
NP_001171572.1, NM_001178101.1
NP_001311174.1, NM_001324245.1
NP_001311175.1, NM_001324246.1
NP_001311176.1, NM_001324247.1
NP_001311177.1, NM_001324248.1
NP_001311178.1, NM_001324249.1
NP_001311179.1, NM_001324250.1
NP_001311180.1, NM_001324251.1
NP_003412.1, NM_003421.2
XP_011517958.1, XM_011519656.2
XP_011517959.1, XM_011519657.2
XP_011517960.1, XM_011519658.2
UniGeneiHs.292575

Genome annotation databases

EnsembliENST00000351773; ENSP00000329141; ENSG00000075407
ENST00000361085; ENSP00000354377; ENSG00000075407
GeneIDi7587
KEGGihsa:7587
UCSCiuc001izk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ492195 mRNA Translation: CAD37331.1
AK092012 mRNA Translation: BAG52465.1
AL117339 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW85885.1
CH471072 Genomic DNA Translation: EAW85886.1
BC015858 mRNA Translation: AAH15858.1
X69115 mRNA Translation: CAA48868.1
X52352 mRNA Translation: CAA36578.1
CCDSiCCDS31183.1
PIRiS30238
RefSeqiNP_001007095.1, NM_001007094.2
NP_001171572.1, NM_001178101.1
NP_001311174.1, NM_001324245.1
NP_001311175.1, NM_001324246.1
NP_001311176.1, NM_001324247.1
NP_001311177.1, NM_001324248.1
NP_001311178.1, NM_001324249.1
NP_001311179.1, NM_001324250.1
NP_001311180.1, NM_001324251.1
NP_003412.1, NM_003421.2
XP_011517958.1, XM_011519656.2
XP_011517959.1, XM_011519657.2
XP_011517960.1, XM_011519658.2
UniGeneiHs.292575

3D structure databases

ProteinModelPortaliP17032
SMRiP17032
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000329141

PTM databases

iPTMnetiP17032
PhosphoSitePlusiP17032

Polymorphism and mutation databases

BioMutaiZNF37A
DMDMi85681861

Proteomic databases

EPDiP17032
MaxQBiP17032
PaxDbiP17032
PeptideAtlasiP17032
PRIDEiP17032
ProteomicsDBi53435

Protocols and materials databases

DNASUi7587
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000351773; ENSP00000329141; ENSG00000075407
ENST00000361085; ENSP00000354377; ENSG00000075407
GeneIDi7587
KEGGihsa:7587
UCSCiuc001izk.4 human

Organism-specific databases

CTDi7587
EuPathDBiHostDB:ENSG00000075407.17
GeneCardsiZNF37A
HGNCiHGNC:13102 ZNF37A
HPAiHPA003172
MIMi616085 gene
neXtProtiNX_P17032
OpenTargetsiENSG00000075407
PharmGKBiPA37677
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149024
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP17032
KOiK09228
OMAiIEYNECG
OrthoDBiEOG091G02KC
PhylomeDBiP17032
TreeFamiTF337898

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF37A human
GeneWikiiZNF37A
GenomeRNAii7587
PROiPR:P17032
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000075407 Expressed in 203 organ(s), highest expression level in visceral pleura
CleanExiHS_ZNF37A
ExpressionAtlasiP17032 baseline and differential
GenevisibleiP17032 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN37A_HUMAN
AccessioniPrimary (citable) accession number: P17032
Secondary accession number(s): B3KRQ3, D3DRZ3, Q96B88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 10, 2006
Last modified: September 12, 2018
This is version 173 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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