UniProtKB - P17029 (ZKSC1_HUMAN)

BLAST

>sp|P17029|ZKSC1_HUMAN Zinc finger protein with KRAB and SCAN domains 1 OS=Homo sapiens OX=9606 GN=ZKSCAN1 PE=1 SV=3
MMTAESREATGLSPQAAQEKDGIVIVKVEEEDEEDHMWGQDSTLQDTPPPDPEIFRQRFR
RFCYQNTFGPREALSRLKELCHQWLRPEINTKEQILELLVLEQFLSILPKELQVWLQEYR
PDSGEEAVTLLEDLELDLSGQQVPGQVHGPEMLARGMVPLDPVQESSSFDLHHEATQSHF
KHSSRKPRLLQSRALPAAHIPAPPHEGSPRDQAMASALFTADSQAMVKIEDMAVSLILEE
WGCQNLARRNLSRDNRQENYGSAFPQGGENRNENEESTSKAETSEDSASRGETTGRSQKE
FGEKRDQEGKTGERQQKNPEEKTRKEKRDSGPAIGKDKKTITGERGPREKGKGLGRSFSL
SSNFTTPEEVPTGTKSHRCDECGKCFTRSSSLIRHKIIHTGEKPYECSECGKAFSLNSNL
VLHQRIHTGEKPHECNECGKAFSHSSNLILHQRIHSGEKPYECNECGKAFSQSSDLTKHQ
RIHTGEKPYECSECGKAFNRNSYLILHRRIHTREKPYKCTKCGKAFTRSSTLTLHHRIHA
RERASEYSPASLDAFGAFLKSCV

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History
Entry version 183 (10 Oct 2018)
Sequence version 3 (10 Jan 2006)
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Protein

Zinc finger protein with KRAB and SCAN domains 1

Gene

ZKSCAN1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	377 – 399	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	405 – 427	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	433 – 455	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	461 – 483	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	489 – 511	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	517 – 539	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity
Source: UniProtKB
Non-traceable author statementⁱ
- 7557990
metal ion binding Source: UniProtKB-KW
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated
Source: UniProtKB
Non-traceable author statementⁱ
- 7557990
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein with KRAB and SCAN domains 1 Alternative name(s): Zinc finger protein 139 Zinc finger protein 36 Zinc finger protein KOX18
Gene namesⁱ	Name:ZKSCAN1 Synonyms:KOX18, ZNF139, ZNF36
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000106261.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13101 ZKSCAN1
MIMⁱ	601260 gene
neXtProtⁱ	NX_P17029

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000106261
PharmGKBⁱ	PA37676

Polymorphism and mutation databases

DMDMⁱ	85681856

DMDMⁱ

85681856

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047753	1 – 563	Zinc finger protein with KRAB and SCAN domains 1Add BLAST		563

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	13	PhosphoserineCombined sources	1
Cross-linkⁱ	27	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	181	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	208	PhosphoserineCombined sources	1
Cross-linkⁱ	228	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	280	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	299	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	304	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	339	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	375	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	412	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	440	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	478	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	560	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P17029
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P17029
PaxDbⁱ	P17029
PeptideAtlas More...PeptideAtlasⁱ	P17029
PRIDEⁱ	P17029
ProteomicsDBⁱ	53431

PTM databases

iPTMnetⁱ	P17029
PhosphoSitePlusⁱ	P17029

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000106261 Expressed in 229 organ(s), highest expression level in brain
CleanExⁱ	HS_ZKSCAN1
ExpressionAtlasⁱ	P17029 baseline and differential
Genevisibleⁱ	P17029 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA006672

HPAⁱ

HPA006672

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ZSCAN32	I3L3J2	3	EBI-10199654,EBI-10178206

With

Entry

#Exp.

IntAct

Notes

ZSCAN32

I3L3J2

EBI-10199654,EBI-10178206

Protein-protein interaction databases

BioGridⁱ	113414, 31 interactors
IntActⁱ	P17029, 3 interactors
STRINGⁱ	9606.ENSP00000323148

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P17029
SMRⁱ	P17029
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	56 – 138	SCAN boxPROSITE-ProRule annotationAdd BLAST		83
Domainⁱ	227 – 300	KRABPROSITE-ProRule annotationAdd BLAST		74

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	377 – 399	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	405 – 427	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	433 – 455	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	461 – 483	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	489 – 511	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	517 – 539	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118881
HOGENOMⁱ	HOG000234619
HOVERGENⁱ	HBG018163
InParanoidⁱ	P17029
KEGG Orthology (KO) More...KOⁱ	K09229
OMAⁱ	QVHGPEM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G046Q
PhylomeDBⁱ	P17029
TreeFamⁱ	TF350830

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07765 KRAB_A-box, 1 hit cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF02023 SCAN, 1 hit PF00096 zf-C2H2, 6 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 6 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 6 hits PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

P17029-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMTAESREAT GLSPQAAQEK DGIVIVKVEE EDEEDHMWGQ DSTLQDTPPP 
        60         70         80         90        100
DPEIFRQRFR RFCYQNTFGP REALSRLKEL CHQWLRPEIN TKEQILELLV 
       110        120        130        140        150
LEQFLSILPK ELQVWLQEYR PDSGEEAVTL LEDLELDLSG QQVPGQVHGP 
       160        170        180        190        200
EMLARGMVPL DPVQESSSFD LHHEATQSHF KHSSRKPRLL QSRALPAAHI 
       210        220        230        240        250
PAPPHEGSPR DQAMASALFT ADSQAMVKIE DMAVSLILEE WGCQNLARRN 
       260        270        280        290        300
LSRDNRQENY GSAFPQGGEN RNENEESTSK AETSEDSASR GETTGRSQKE 
       310        320        330        340        350
FGEKRDQEGK TGERQQKNPE EKTRKEKRDS GPAIGKDKKT ITGERGPREK 
       360        370        380        390        400
GKGLGRSFSL SSNFTTPEEV PTGTKSHRCD ECGKCFTRSS SLIRHKIIHT 
       410        420        430        440        450
GEKPYECSEC GKAFSLNSNL VLHQRIHTGE KPHECNECGK AFSHSSNLIL 
       460        470        480        490        500
HQRIHSGEKP YECNECGKAF SQSSDLTKHQ RIHTGEKPYE CSECGKAFNR 
       510        520        530        540        550
NSYLILHRRI HTREKPYKCT KCGKAFTRSS TLTLHHRIHA RERASEYSPA 
       560 
SLDAFGAFLK SCV

Length:563

Mass (Da):63,630

Last modified:January 10, 2006 - v3

Checksum:ⁱ9960C9E320554352

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PC66	E9PC66_HUMAN	Zinc finger protein with KRAB and S... Zinc finger protein with KRAB and SCAN domains 1	ZKSCAN1	527	Annotation score:
B3KRF7	B3KRF7_HUMAN	Zinc finger protein with KRAB and S... Zinc finger protein with KRAB and SCAN domains 1 (cDNA FLJ34152 fis, clone FCBBF3012901, highly similar to Zinc finger with KRAB and SCAN domain-containing protein 1)	ZKSCAN1	350	Annotation score:
C9JRM9	C9JRM9_HUMAN	Zinc finger protein with KRAB and S... Zinc finger protein with KRAB and SCAN domains 1	ZKSCAN1	125	Annotation score:

Sequence cautionⁱ

The sequence AAC50264 differs from that shown. Reason: Frameshift at position 241.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_024839	26	V → A1 PublicationCorresponds to variant dbSNP:rs17851996Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK074116 mRNA Translation: BAB84942.1 BX640646 mRNA Translation: CAE45792.1 CH236956 Genomic DNA Translation: EAL23861.1 CH471091 Genomic DNA Translation: EAW76613.1 BC022378 mRNA Translation: AAH22378.1 BC112224 mRNA Translation: AAI12225.1 BC113697 mRNA Translation: AAI13698.1 U09848 mRNA Translation: AAC50264.1 Frameshift. X52349 mRNA Translation: CAA36575.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34698.1
PIRⁱ	I38616
NCBI Reference Sequences More...RefSeqⁱ	NP_001333510.1, NM_001346581.1 NP_003430.1, NM_003439.3 XP_011514861.1, XM_011516559.2
UniGeneⁱ	Hs.615360 Hs.633338 Hs.743424

Genome annotation databases

Ensemblⁱ	ENST00000324306; ENSP00000323148; ENSG00000106261
GeneIDⁱ	7586
KEGGⁱ	hsa:7586
UCSC genome browser More...UCSCⁱ	uc003usk.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P17029	Zinc finger protein with KRAB and SCAN domains 1		HUMAN		350	UniRef100_P17029
Zinc finger protein with KRAB and SCAN domains 1		HUMAN		527
Zinc finger protein with KRAB and SCAN domains 1 (Fragment)		HUMAN		125

Protein	Similar proteins		Species	Score	Length	Source
P17029	Zinc finger protein with KRAB and SCAN domains 1		PONAB		563	UniRef90_P17029
Zinc finger protein with KRAB and SCAN domains 1		HUMAN		350
Uncharacterized protein		MACMU		563
zinc finger protein with KRAB and SCAN domains 1 isoform X1		ODORO		563
Zinc finger with KRAB and SCAN domains 1		SAIBB		563
+39

Protein	Similar proteins		Species	Score	Length	Source
P17029	Zinc finger protein with KRAB and SCAN domains 1		PONAB		563	UniRef50_P17029
Zinc finger protein with KRAB and SCAN domains 1		MOUSE		561
Zinc finger protein with KRAB and SCAN domains 1		RAT		562
Zinc finger protein with KRAB and SCAN domains 1		HUMAN		350
Uncharacterized protein		CERAT		563
+114

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK074116 mRNA Translation: BAB84942.1 BX640646 mRNA Translation: CAE45792.1 CH236956 Genomic DNA Translation: EAL23861.1 CH471091 Genomic DNA Translation: EAW76613.1 BC022378 mRNA Translation: AAH22378.1 BC112224 mRNA Translation: AAI12225.1 BC113697 mRNA Translation: AAI13698.1 U09848 mRNA Translation: AAC50264.1 Frameshift. X52349 mRNA Translation: CAA36575.1
CCDSⁱ	CCDS34698.1
PIRⁱ	I38616
RefSeqⁱ	NP_001333510.1, NM_001346581.1 NP_003430.1, NM_003439.3 XP_011514861.1, XM_011516559.2
UniGeneⁱ	Hs.615360 Hs.633338 Hs.743424

3D structure databases

ProteinModelPortalⁱ	P17029
SMRⁱ	P17029
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113414, 31 interactors
IntActⁱ	P17029, 3 interactors
STRINGⁱ	9606.ENSP00000323148

PTM databases

iPTMnetⁱ	P17029
PhosphoSitePlusⁱ	P17029

Polymorphism and mutation databases

DMDMⁱ	85681856

DMDMⁱ

85681856

Proteomic databases

EPDⁱ	P17029
MaxQBⁱ	P17029
PaxDbⁱ	P17029
PeptideAtlasⁱ	P17029
PRIDEⁱ	P17029
ProteomicsDBⁱ	53431

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7586
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000324306; ENSP00000323148; ENSG00000106261
GeneIDⁱ	7586
KEGGⁱ	hsa:7586
UCSCⁱ	uc003usk.3 human

Organism-specific databases

CTDⁱ	7586
EuPathDBⁱ	HostDB:ENSG00000106261.16
GeneCardsⁱ	ZKSCAN1
HGNCⁱ	HGNC:13101 ZKSCAN1
HPAⁱ	HPA006672
MIMⁱ	601260 gene
neXtProtⁱ	NX_P17029
OpenTargetsⁱ	ENSG00000106261
PharmGKBⁱ	PA37676
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000118881
HOGENOMⁱ	HOG000234619
HOVERGENⁱ	HBG018163
InParanoidⁱ	P17029
KOⁱ	K09229
OMAⁱ	QVHGPEM
OrthoDBⁱ	EOG091G046Q
PhylomeDBⁱ	P17029
TreeFamⁱ	TF350830

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSⁱ	ZKSCAN1 human
GeneWikiⁱ	ZKSCAN1
GenomeRNAiⁱ	7586
Protein Ontology More...PROⁱ	PR:P17029
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000106261 Expressed in 229 organ(s), highest expression level in brain
CleanExⁱ	HS_ZKSCAN1
ExpressionAtlasⁱ	P17029 baseline and differential
Genevisibleⁱ	P17029 HS

Family and domain databases

CDDⁱ	cd07765 KRAB_A-box, 1 hit cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF01352 KRAB, 1 hit PF02023 SCAN, 1 hit PF00096 zf-C2H2, 6 hits
SMARTⁱ	View protein in SMART SM00349 KRAB, 1 hit SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 6 hits
SUPFAMⁱ	SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS50805 KRAB, 1 hit PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 6 hits PS50157 ZINC_FINGER_C2H2_2, 6 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZKSC1_HUMAN
Accessionⁱ	P17029Primary (citable) accession number: P17029 Secondary accession number(s): A4D294 , P52745, Q2M1U1, Q8TBW5, Q8TEK7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	January 10, 2006
	Last modified:	October 10, 2018
	This is version 183 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - P17029 (ZKSC1_HUMAN)

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Zinc finger protein with KRAB and SCAN domains 1

ZKSCAN1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ