UniProtKB - P17029 (ZKSC1_HUMAN)
Protein
Zinc finger protein with KRAB and SCAN domains 1
Gene
ZKSCAN1
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 377 – 399 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 405 – 427 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 433 – 455 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 461 – 483 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 489 – 511 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 517 – 539 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- regulation of transcription, DNA-templated Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-HSA-212436 Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein with KRAB and SCAN domains 1Alternative name(s): Zinc finger protein 139 Zinc finger protein 36 Zinc finger protein KOX18 |
Gene namesi | Name:ZKSCAN1 Synonyms:KOX18, ZNF139, ZNF36 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13101 ZKSCAN1 |
MIMi | 601260 gene |
neXtProti | NX_P17029 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7586 |
NIAGADSi | ENSG00000106261 |
OpenTargetsi | ENSG00000106261 |
PharmGKBi | PA37676 |
Miscellaneous databases
Pharosi | P17029 |
Polymorphism and mutation databases
BioMutai | ZKSCAN1 |
DMDMi | 85681856 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047753 | 1 – 563 | Zinc finger protein with KRAB and SCAN domains 1Add BLAST | 563 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 13 | PhosphoserineCombined sources | 1 | |
Cross-linki | 27 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 181 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 208 | PhosphoserineCombined sources | 1 | |
Cross-linki | 228 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 280 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 299 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 304 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 339 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 375 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 412 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 440 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 478 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 560 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P17029 |
jPOSTi | P17029 |
MassIVEi | P17029 |
MaxQBi | P17029 |
PaxDbi | P17029 |
PeptideAtlasi | P17029 |
PRIDEi | P17029 |
ProteomicsDBi | 53431 |
PTM databases
iPTMneti | P17029 |
PhosphoSitePlusi | P17029 |
Expressioni
Gene expression databases
Bgeei | ENSG00000106261 Expressed in 229 organ(s), highest expression level in brain |
ExpressionAtlasi | P17029 baseline and differential |
Genevisiblei | P17029 HS |
Organism-specific databases
HPAi | HPA006672 |
Interactioni
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
Q9NX65 | 4 | EBI-10199654,EBI-739949 |
Protein-protein interaction databases
BioGridi | 113414, 36 interactors |
IntActi | P17029, 22 interactors |
STRINGi | 9606.ENSP00000323148 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 56 – 138 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 227 – 300 | KRABPROSITE-ProRule annotationAdd BLAST | 74 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 377 – 399 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 405 – 427 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 433 – 455 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 461 – 483 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 489 – 511 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 517 – 539 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00940000161592 |
HOGENOMi | HOG000234619 |
InParanoidi | P17029 |
KOi | K09229 |
OMAi | QEEVPTG |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P17029 |
TreeFami | TF350830 |
Family and domain databases
CDDi | cd07765 KRAB_A-box, 1 hit cd07936 SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfami | View protein in Pfam PF01352 KRAB, 1 hit PF02023 SCAN, 1 hit PF00096 zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00349 KRAB, 1 hit SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 6 hits |
SUPFAMi | SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50805 KRAB, 1 hit PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 6 hits PS50157 ZINC_FINGER_C2H2_2, 6 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P17029-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMTAESREAT GLSPQAAQEK DGIVIVKVEE EDEEDHMWGQ DSTLQDTPPP
60 70 80 90 100
DPEIFRQRFR RFCYQNTFGP REALSRLKEL CHQWLRPEIN TKEQILELLV
110 120 130 140 150
LEQFLSILPK ELQVWLQEYR PDSGEEAVTL LEDLELDLSG QQVPGQVHGP
160 170 180 190 200
EMLARGMVPL DPVQESSSFD LHHEATQSHF KHSSRKPRLL QSRALPAAHI
210 220 230 240 250
PAPPHEGSPR DQAMASALFT ADSQAMVKIE DMAVSLILEE WGCQNLARRN
260 270 280 290 300
LSRDNRQENY GSAFPQGGEN RNENEESTSK AETSEDSASR GETTGRSQKE
310 320 330 340 350
FGEKRDQEGK TGERQQKNPE EKTRKEKRDS GPAIGKDKKT ITGERGPREK
360 370 380 390 400
GKGLGRSFSL SSNFTTPEEV PTGTKSHRCD ECGKCFTRSS SLIRHKIIHT
410 420 430 440 450
GEKPYECSEC GKAFSLNSNL VLHQRIHTGE KPHECNECGK AFSHSSNLIL
460 470 480 490 500
HQRIHSGEKP YECNECGKAF SQSSDLTKHQ RIHTGEKPYE CSECGKAFNR
510 520 530 540 550
NSYLILHRRI HTREKPYKCT KCGKAFTRSS TLTLHHRIHA RERASEYSPA
560
SLDAFGAFLK SCV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PC66 | E9PC66_HUMAN | Zinc finger protein with KRAB and S... | ZKSCAN1 | 527 | Annotation score: | ||
B3KRF7 | B3KRF7_HUMAN | Zinc finger protein with KRAB and S... | ZKSCAN1 | 350 | Annotation score: | ||
C9JRM9 | C9JRM9_HUMAN | Zinc finger protein with KRAB and S... | ZKSCAN1 | 125 | Annotation score: |
Sequence cautioni
The sequence AAC50264 differs from that shown. Reason: Frameshift.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024839 | 26 | V → A1 PublicationCorresponds to variant dbSNP:rs17851996Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074116 mRNA Translation: BAB84942.1 BX640646 mRNA Translation: CAE45792.1 CH236956 Genomic DNA Translation: EAL23861.1 CH471091 Genomic DNA Translation: EAW76613.1 BC022378 mRNA Translation: AAH22378.1 BC112224 mRNA Translation: AAI12225.1 BC113697 mRNA Translation: AAI13698.1 U09848 mRNA Translation: AAC50264.1 Frameshift. X52349 mRNA Translation: CAA36575.1 |
CCDSi | CCDS34698.1 |
PIRi | I38616 |
RefSeqi | NP_001333510.1, NM_001346581.1 NP_003430.1, NM_003439.3 XP_011514861.1, XM_011516559.2 |
Genome annotation databases
Ensembli | ENST00000324306; ENSP00000323148; ENSG00000106261 |
GeneIDi | 7586 |
KEGGi | hsa:7586 |
UCSCi | uc003usk.3 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074116 mRNA Translation: BAB84942.1 BX640646 mRNA Translation: CAE45792.1 CH236956 Genomic DNA Translation: EAL23861.1 CH471091 Genomic DNA Translation: EAW76613.1 BC022378 mRNA Translation: AAH22378.1 BC112224 mRNA Translation: AAI12225.1 BC113697 mRNA Translation: AAI13698.1 U09848 mRNA Translation: AAC50264.1 Frameshift. X52349 mRNA Translation: CAA36575.1 |
CCDSi | CCDS34698.1 |
PIRi | I38616 |
RefSeqi | NP_001333510.1, NM_001346581.1 NP_003430.1, NM_003439.3 XP_011514861.1, XM_011516559.2 |
3D structure databases
SMRi | P17029 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 113414, 36 interactors |
IntActi | P17029, 22 interactors |
STRINGi | 9606.ENSP00000323148 |
PTM databases
iPTMneti | P17029 |
PhosphoSitePlusi | P17029 |
Polymorphism and mutation databases
BioMutai | ZKSCAN1 |
DMDMi | 85681856 |
Proteomic databases
EPDi | P17029 |
jPOSTi | P17029 |
MassIVEi | P17029 |
MaxQBi | P17029 |
PaxDbi | P17029 |
PeptideAtlasi | P17029 |
PRIDEi | P17029 |
ProteomicsDBi | 53431 |
Protocols and materials databases
ABCDi | P17029 |
DNASUi | 7586 |
Genome annotation databases
Ensembli | ENST00000324306; ENSP00000323148; ENSG00000106261 |
GeneIDi | 7586 |
KEGGi | hsa:7586 |
UCSCi | uc003usk.3 human |
Organism-specific databases
CTDi | 7586 |
DisGeNETi | 7586 |
GeneCardsi | ZKSCAN1 |
HGNCi | HGNC:13101 ZKSCAN1 |
HPAi | HPA006672 |
MIMi | 601260 gene |
neXtProti | NX_P17029 |
NIAGADSi | ENSG00000106261 |
OpenTargetsi | ENSG00000106261 |
PharmGKBi | PA37676 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721 Eukaryota COG5048 LUCA |
GeneTreei | ENSGT00940000161592 |
HOGENOMi | HOG000234619 |
InParanoidi | P17029 |
KOi | K09229 |
OMAi | QEEVPTG |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P17029 |
TreeFami | TF350830 |
Enzyme and pathway databases
Reactomei | R-HSA-212436 Generic Transcription Pathway |
Miscellaneous databases
ChiTaRSi | ZKSCAN1 human |
GeneWikii | ZKSCAN1 |
GenomeRNAii | 7586 |
Pharosi | P17029 |
PROi | PR:P17029 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000106261 Expressed in 229 organ(s), highest expression level in brain |
ExpressionAtlasi | P17029 baseline and differential |
Genevisiblei | P17029 HS |
Family and domain databases
CDDi | cd07765 KRAB_A-box, 1 hit cd07936 SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909 KRAB IPR036051 KRAB_dom_sf IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type |
Pfami | View protein in Pfam PF01352 KRAB, 1 hit PF02023 SCAN, 1 hit PF00096 zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00349 KRAB, 1 hit SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 6 hits |
SUPFAMi | SSF109640 SSF109640, 1 hit SSF57667 SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50805 KRAB, 1 hit PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 6 hits PS50157 ZINC_FINGER_C2H2_2, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZKSC1_HUMAN | |
Accessioni | P17029Primary (citable) accession number: P17029 Secondary accession number(s): A4D294 Q8TEK7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | January 10, 2006 | |
Last modified: | October 16, 2019 | |
This is version 192 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot