UniProtKB - P17029 (ZKSC1_HUMAN)
Protein
Zinc finger protein with KRAB and SCAN domains 1
Gene
ZKSCAN1
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 377 – 399 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 405 – 427 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 433 – 455 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 461 – 483 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 489 – 511 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 517 – 539 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P17029 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein with KRAB and SCAN domains 1Alternative name(s): Zinc finger protein 139 Zinc finger protein 36 Zinc finger protein KOX18 |
Gene namesi | Name:ZKSCAN1 Synonyms:KOX18, ZNF139, ZNF36 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000106261.16 |
HGNCi | HGNC:13101, ZKSCAN1 |
MIMi | 601260, gene |
neXtProti | NX_P17029 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7586 |
NIAGADSi | ENSG00000106261 |
OpenTargetsi | ENSG00000106261 |
PharmGKBi | PA37676 |
Miscellaneous databases
Pharosi | P17029, Tbio |
Polymorphism and mutation databases
BioMutai | ZKSCAN1 |
DMDMi | 85681856 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047753 | 1 – 563 | Zinc finger protein with KRAB and SCAN domains 1Add BLAST | 563 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 13 | PhosphoserineCombined sources | 1 | |
Cross-linki | 27 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 181 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 208 | PhosphoserineCombined sources | 1 | |
Cross-linki | 228 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 280 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 299 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 304 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 339 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 375 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 412 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 440 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 478 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 560 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P17029 |
jPOSTi | P17029 |
MassIVEi | P17029 |
MaxQBi | P17029 |
PaxDbi | P17029 |
PeptideAtlasi | P17029 |
PRIDEi | P17029 |
ProteomicsDBi | 53431 |
PTM databases
iPTMneti | P17029 |
PhosphoSitePlusi | P17029 |
Expressioni
Gene expression databases
Bgeei | ENSG00000106261, Expressed in stomach and 241 other tissues |
ExpressionAtlasi | P17029, baseline and differential |
Genevisiblei | P17029, HS |
Organism-specific databases
HPAi | ENSG00000106261, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsP17029
With | #Exp. | IntAct |
---|---|---|
MAPK7 [Q13164] | 3 | EBI-10199654,EBI-1213983 |
ZSCAN32 [Q9NX65] | 5 | EBI-10199654,EBI-739949 |
Protein-protein interaction databases
BioGRIDi | 113414, 37 interactors |
IntActi | P17029, 22 interactors |
STRINGi | 9606.ENSP00000323148 |
Miscellaneous databases
RNActi | P17029, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 56 – 138 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 227 – 300 | KRABPROSITE-ProRule annotationAdd BLAST | 74 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 377 – 399 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 405 – 427 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 433 – 455 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 461 – 483 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 489 – 511 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 517 – 539 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161592 |
InParanoidi | P17029 |
OMAi | WGQDASL |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P17029 |
TreeFami | TF350830 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P17029-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMTAESREAT GLSPQAAQEK DGIVIVKVEE EDEEDHMWGQ DSTLQDTPPP
60 70 80 90 100
DPEIFRQRFR RFCYQNTFGP REALSRLKEL CHQWLRPEIN TKEQILELLV
110 120 130 140 150
LEQFLSILPK ELQVWLQEYR PDSGEEAVTL LEDLELDLSG QQVPGQVHGP
160 170 180 190 200
EMLARGMVPL DPVQESSSFD LHHEATQSHF KHSSRKPRLL QSRALPAAHI
210 220 230 240 250
PAPPHEGSPR DQAMASALFT ADSQAMVKIE DMAVSLILEE WGCQNLARRN
260 270 280 290 300
LSRDNRQENY GSAFPQGGEN RNENEESTSK AETSEDSASR GETTGRSQKE
310 320 330 340 350
FGEKRDQEGK TGERQQKNPE EKTRKEKRDS GPAIGKDKKT ITGERGPREK
360 370 380 390 400
GKGLGRSFSL SSNFTTPEEV PTGTKSHRCD ECGKCFTRSS SLIRHKIIHT
410 420 430 440 450
GEKPYECSEC GKAFSLNSNL VLHQRIHTGE KPHECNECGK AFSHSSNLIL
460 470 480 490 500
HQRIHSGEKP YECNECGKAF SQSSDLTKHQ RIHTGEKPYE CSECGKAFNR
510 520 530 540 550
NSYLILHRRI HTREKPYKCT KCGKAFTRSS TLTLHHRIHA RERASEYSPA
560
SLDAFGAFLK SCV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PC66 | E9PC66_HUMAN | Zinc finger protein with KRAB and S... | ZKSCAN1 | 527 | Annotation score: | ||
B3KRF7 | B3KRF7_HUMAN | Zinc finger protein with KRAB and S... | ZKSCAN1 | 350 | Annotation score: | ||
C9JRM9 | C9JRM9_HUMAN | Zinc finger protein with KRAB and S... | ZKSCAN1 | 125 | Annotation score: |
Sequence cautioni
The sequence AAC50264 differs from that shown. Reason: Frameshift.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024839 | 26 | V → A1 PublicationCorresponds to variant dbSNP:rs17851996Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074116 mRNA Translation: BAB84942.1 BX640646 mRNA Translation: CAE45792.1 CH236956 Genomic DNA Translation: EAL23861.1 CH471091 Genomic DNA Translation: EAW76613.1 BC022378 mRNA Translation: AAH22378.1 BC112224 mRNA Translation: AAI12225.1 BC113697 mRNA Translation: AAI13698.1 U09848 mRNA Translation: AAC50264.1 Frameshift. X52349 mRNA Translation: CAA36575.1 |
CCDSi | CCDS34698.1 |
PIRi | I38616 |
RefSeqi | NP_001333510.1, NM_001346581.1 NP_003430.1, NM_003439.3 XP_011514861.1, XM_011516559.2 |
Genome annotation databases
Ensembli | ENST00000324306; ENSP00000323148; ENSG00000106261 |
GeneIDi | 7586 |
KEGGi | hsa:7586 |
UCSCi | uc003usk.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074116 mRNA Translation: BAB84942.1 BX640646 mRNA Translation: CAE45792.1 CH236956 Genomic DNA Translation: EAL23861.1 CH471091 Genomic DNA Translation: EAW76613.1 BC022378 mRNA Translation: AAH22378.1 BC112224 mRNA Translation: AAI12225.1 BC113697 mRNA Translation: AAI13698.1 U09848 mRNA Translation: AAC50264.1 Frameshift. X52349 mRNA Translation: CAA36575.1 |
CCDSi | CCDS34698.1 |
PIRi | I38616 |
RefSeqi | NP_001333510.1, NM_001346581.1 NP_003430.1, NM_003439.3 XP_011514861.1, XM_011516559.2 |
3D structure databases
SMRi | P17029 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113414, 37 interactors |
IntActi | P17029, 22 interactors |
STRINGi | 9606.ENSP00000323148 |
PTM databases
iPTMneti | P17029 |
PhosphoSitePlusi | P17029 |
Polymorphism and mutation databases
BioMutai | ZKSCAN1 |
DMDMi | 85681856 |
Proteomic databases
EPDi | P17029 |
jPOSTi | P17029 |
MassIVEi | P17029 |
MaxQBi | P17029 |
PaxDbi | P17029 |
PeptideAtlasi | P17029 |
PRIDEi | P17029 |
ProteomicsDBi | 53431 |
Protocols and materials databases
ABCDi | P17029, 1 sequenced antibody |
Antibodypediai | 1764, 160 antibodies |
DNASUi | 7586 |
Genome annotation databases
Ensembli | ENST00000324306; ENSP00000323148; ENSG00000106261 |
GeneIDi | 7586 |
KEGGi | hsa:7586 |
UCSCi | uc003usk.3, human |
Organism-specific databases
CTDi | 7586 |
DisGeNETi | 7586 |
EuPathDBi | HostDB:ENSG00000106261.16 |
GeneCardsi | ZKSCAN1 |
HGNCi | HGNC:13101, ZKSCAN1 |
HPAi | ENSG00000106261, Low tissue specificity |
MIMi | 601260, gene |
neXtProti | NX_P17029 |
NIAGADSi | ENSG00000106261 |
OpenTargetsi | ENSG00000106261 |
PharmGKBi | PA37676 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161592 |
InParanoidi | P17029 |
OMAi | WGQDASL |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P17029 |
TreeFami | TF350830 |
Enzyme and pathway databases
PathwayCommonsi | P17029 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 7586, 8 hits in 868 CRISPR screens |
ChiTaRSi | ZKSCAN1, human |
GeneWikii | ZKSCAN1 |
GenomeRNAii | 7586 |
Pharosi | P17029, Tbio |
PROi | PR:P17029 |
RNActi | P17029, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000106261, Expressed in stomach and 241 other tissues |
ExpressionAtlasi | P17029, baseline and differential |
Genevisiblei | P17029, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF02023, SCAN, 1 hit PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 6 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZKSC1_HUMAN | |
Accessioni | P17029Primary (citable) accession number: P17029 Secondary accession number(s): A4D294 Q8TEK7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | January 10, 2006 | |
Last modified: | December 2, 2020 | |
This is version 199 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations