ZNF24

Functionⁱ

Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro.By similarity1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	251 – 273	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	279 – 301	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	307 – 329	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	335 – 357	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 11532988
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 11532988
zinc ion binding
Source: UniProtKB
Non-traceable author statementⁱ
- 10585455

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

myelination Source: UniProtKB
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 10585455
- 12801647
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 11532988

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 24 Alternative name(s): Retinoic acid suppression protein A Short name: RSG-A Zinc finger and SCAN domain-containing protein 3 Zinc finger protein 191 Zinc finger protein KOX17
Gene namesⁱ	Name:ZNF24 Synonyms:KOX17, ZNF191, ZSCAN3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 18

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172466.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13032 ZNF24
MIMⁱ	194534 gene
neXtProtⁱ	NX_P17028

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	286	K → A: Partial cytoplasmic accumulation. 1 Publication		1
Mutagenesisⁱ	290	R → A: Partial cytoplasmic accumulation. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7572
Open Targets More...OpenTargetsⁱ	ENSG00000172466
PharmGKBⁱ	PA37610

Polymorphism and mutation databases

BioMutaⁱ	ZNF24
DMDMⁱ	160376173

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047352	1 – 368	Zinc finger protein 24Add BLAST		368

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	22	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	27	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linkⁱ	27	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	132	PhosphoserineCombined sources	1
Modified residueⁱ	142	PhosphoserineCombined sources	1
Cross-linkⁱ	147	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	177	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	236	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	274	PhosphoserineCombined sources	1
Cross-linkⁱ	277	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	286	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	292	PhosphoserineCombined sources	1
Modified residueⁱ	335	PhosphotyrosineCombined sources	1
Cross-linkⁱ	361	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	367	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Sumoylated.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P17028
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P17028
PaxDbⁱ	P17028
PeptideAtlas More...PeptideAtlasⁱ	P17028
PRIDEⁱ	P17028
ProteomicsDBⁱ	53429 53430 [P17028-2]

PTM databases

iPTMnetⁱ	P17028
PhosphoSitePlusⁱ	P17028

Miscellaneous databases

PMAP-CutDBⁱ	P17028

PMAP-CutDBⁱ

P17028

Expressionⁱ

Tissue specificityⁱ

Expressed in many tissues except in heart.

Gene expression databases

Bgeeⁱ	ENSG00000172466 Expressed in 243 organ(s), highest expression level in globus pallidus
CleanExⁱ	HS_ZNF24
ExpressionAtlasⁱ	P17028 baseline and differential
Genevisibleⁱ	P17028 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025642 HPA024062

HPAⁱ

CAB025642
HPA024062

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
APLP1	P51693	2	EBI-707773,EBI-74648
CCDC130	P13994	3	EBI-707773,EBI-716093
DDX6	P26196	3	EBI-707773,EBI-351257
DZIP3	Q86Y13	3	EBI-707773,EBI-948630
LMO2	P25791	3	EBI-707773,EBI-739696
MID2	Q9UJV3-2	3	EBI-707773,EBI-10172526
PGBD1	Q96JS3	6	EBI-707773,EBI-10290053
PRPF31	Q8WWY3	3	EBI-707773,EBI-1567797
SCAND1	P57086	5	EBI-707773,EBI-745846
TCAF1	Q9Y4C2	3	EBI-707773,EBI-750484
ZNF446	Q9NWS9-2	10	EBI-707773,EBI-740232
ZNF483	Q6P088	3	EBI-707773,EBI-10196963
ZSCAN21	Q9Y5A6	5	EBI-707773,EBI-10281938
ZSCAN22	P10073	4	EBI-707773,EBI-10178224
ZSCAN32	I3L3J2	5	EBI-707773,EBI-10178206
ZSCAN32	Q9NX65	3	EBI-707773,EBI-739949

Protein-protein interaction databases

BioGridⁱ	113403, 75 interactors
IntActⁱ	P17028, 68 interactors
Molecular INTeraction database More...MINTⁱ	P17028
STRINGⁱ	9606.ENSP00000261332

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	47 – 57	Combined sources	11
Helixⁱ	60 – 62	Combined sources	3
Beta strandⁱ	63 – 65	Combined sources	3
Helixⁱ	66 – 81	Combined sources	16
Turnⁱ	83 – 85	Combined sources	3
Helixⁱ	88 – 102	Combined sources	15
Helixⁱ	106 – 114	Combined sources	9
Helixⁱ	120 – 134	Combined sources	15
Turnⁱ	272 – 275	Combined sources	4
Beta strandⁱ	282 – 284	Combined sources	3
Beta strandⁱ	287 – 290	Combined sources	4
Helixⁱ	291 – 299	Combined sources	9
Helixⁱ	300 – 302	Combined sources	3
Beta strandⁱ	310 – 312	Combined sources	3
Beta strandⁱ	315 – 318	Combined sources	4
Helixⁱ	319 – 330	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	P17028
SMRⁱ	P17028
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P17028

EvolutionaryTraceⁱ

P17028

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	52 – 134	SCAN boxPROSITE-ProRule annotationAdd BLAST		83

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	251 – 301	Necessary and sufficient for nuclear localizationAdd BLAST		51

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	251 – 273	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	279 – 301	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	307 – 329	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	335 – 357	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118881
HOGENOMⁱ	HOG000234619
HOVERGENⁱ	HBG066767
InParanoidⁱ	P17028
KEGG Orthology (KO) More...KOⁱ	K09230
OMAⁱ	TWNHLPD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09O3
PhylomeDBⁱ	P17028
TreeFamⁱ	TF338304

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02023 SCAN, 1 hit PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P17028-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAQSVEEDS ILIIPTPDEE EKILRVKLEE DPDGEEGSSI PWNHLPDPEI 
        60         70         80         90        100
FRQRFRQFGY QDSPGPREAV SQLRELCRLW LRPETHTKEQ ILELVVLEQF 
       110        120        130        140        150
VAILPKELQT WVRDHHPENG EEAVTVLEDL ESELDDPGQP VSLRRRKREV 
       160        170        180        190        200
LVEDMVSQEE AQGLPSSELD AVENQLKWAS WELHSLRHCD DDGRTENGAL 
       210        220        230        240        250
APKQELPSAL ESHEVPGTLN MGVPQIFKYG ETCFPKGRFE RKRNPSRKKQ 
       260        270        280        290        300
HICDECGKHF SQGSALILHQ RIHSGEKPYG CVECGKAFSR SSILVQHQRV 
       310        320        330        340        350
HTGEKPYKCL ECGKAFSQNS GLINHQRIHT GEKPYECVQC GKSYSQSSNL 
       360 
FRHQRRHNAE KLLNVVKV

Length:368

Mass (Da):42,155

Last modified:October 23, 2007 - v4

Checksum:ⁱB890EDC512493E0E

GO

Isoform 2 (identifier: P17028-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
190-193: DDDG → VIIP
194-368: Missing.

« Hide

        10         20         30         40         50
MSAQSVEEDS ILIIPTPDEE EKILRVKLEE DPDGEEGSSI PWNHLPDPEI 
        60         70         80         90        100
FRQRFRQFGY QDSPGPREAV SQLRELCRLW LRPETHTKEQ ILELVVLEQF 
       110        120        130        140        150
VAILPKELQT WVRDHHPENG EEAVTVLEDL ESELDDPGQP VSLRRRKREV 
       160        170        180        190 
LVEDMVSQEE AQGLPSSELD AVENQLKWAS WELHSLRHCV IIP

Show »

Length:193

Mass (Da):22,382

Checksum:ⁱA6A9515C74EA57E0

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7EPL1	K7EPL1_HUMAN	Zinc finger protein 24 Zinc finger protein 24	ZNF24	138	Annotation score:
K7EQP8	K7EQP8_HUMAN	Zinc finger protein 24 Zinc finger protein 24	ZNF24	96	Annotation score:
K7EPZ8	K7EPZ8_HUMAN	Zinc finger protein 24 Zinc finger protein 24	ZNF24	102	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	367	K → E in AAB37275 (Ref. 1) Curated		1
Sequence conflictⁱ	367	K → E in CAG29324 (Ref. 4) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_012017	220	N → S5 PublicationsCorresponds to variant dbSNP:rs2032729Ensembl.		1
Natural variantⁱVAR_012018	331	G → W. Corresponds to variant dbSNP:rs3568Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_039219	190 – 193	DDDG → VIIP in isoform 2. 1 Publication		4
Alternative sequenceⁱVSP_039220	194 – 368	Missing in isoform 2. 1 PublicationAdd BLAST		175

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U68536 mRNA Translation: AAB37275.1 AF016052 Genomic DNA Translation: AAB70216.1 AF542097 mRNA Translation: AAN40767.1 AF038964 mRNA Translation: AAD19827.1 AK291246 mRNA Translation: BAF83935.1 BT006658 mRNA Translation: AAP35304.1 CR450328 mRNA Translation: CAG29324.1 AC116447 Genomic DNA No translation available. CH471088 Genomic DNA Translation: EAX01348.1 CH471088 Genomic DNA Translation: EAX01349.1 BC003566 mRNA Translation: AAH03566.1 BC016801 mRNA Translation: AAH16801.1 X52348 mRNA Translation: CAA36574.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11912.1 [P17028-1] CCDS77175.1 [P17028-2]
PIRⁱ	I37956
NCBI Reference Sequences More...RefSeqⁱ	NP_001295052.1, NM_001308123.1 [P17028-2] NP_008896.2, NM_006965.3 [P17028-1] XP_005258398.1, XM_005258341.3 [P17028-1]
UniGeneⁱ	Hs.514802

Genome annotation databases

Ensemblⁱ	ENST00000261332; ENSP00000261332; ENSG00000172466 [P17028-1] ENST00000399061; ENSP00000382015; ENSG00000172466 [P17028-1] ENST00000589881; ENSP00000467655; ENSG00000172466 [P17028-2]
GeneIDⁱ	7572
KEGGⁱ	hsa:7572
UCSC genome browser More...UCSCⁱ	uc002kys.3 human [P17028-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
P17028	Zinc finger protein 24 (Fragment)		HUMAN		96	UniRef100_P17028
ZNF24 isoform 5 (Fragment)		PONAB		96
ZNF24 isoform 6 (Fragment)		PANTR		96
Zinc finger protein 24 (Fragment)		HUMAN		102
ZNF24 isoform 4 (Fragment)		PONAB		102
+3
P17028-2	ZNF24 isoform 3		PANTR		193	UniRef100_A0A2I3TG78
Uncharacterized protein		COLAP		193
ZNF24 isoform 6		PONAB		193
Uncharacterized protein		RHIRO		193
Zinc finger protein 24		GORGO		193
+1

Protein	Similar proteins		Species	Score	Length	Source
P17028	Zinc finger protein 24		MOUSE		368	UniRef90_P17028
Zinc finger protein 24		PANPA		368
Zinc finger protein 24		PANTR		368
Zinc finger protein 24		PONAB		368
Zinc finger protein 24		RAT		368
+111
P17028-2	ZNF24 isoform 3		PANTR		193	UniRef90_A0A2I3TG78
Uncharacterized protein		COLAP		193
ZNF24 isoform 6		PONAB		193
Uncharacterized protein		RHIRO		193
Zinc finger protein 24		GORGO		193
+18

Protein	Similar proteins		Species	Score	Length	Source
P17028	Zinc finger protein 24		MOUSE		368	UniRef50_P17028
Zinc finger protein 24		PONAB		368
Zinc finger protein 24		PANPA		368
Zinc finger protein 24		RAT		368
Zinc finger protein 24		PANTR		368
+113
P17028-2	Uncharacterized protein		RABIT		218	UniRef50_U3KLY8
Uncharacterized protein		SHEEP		229
zinc finger and SCAN domain-containing protein 30-like		BALAS		195
zinc finger protein 24		LEPWE		235
zinc finger protein 24 isoform X2		DELLE		198
+32

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U68536 mRNA Translation: AAB37275.1 AF016052 Genomic DNA Translation: AAB70216.1 AF542097 mRNA Translation: AAN40767.1 AF038964 mRNA Translation: AAD19827.1 AK291246 mRNA Translation: BAF83935.1 BT006658 mRNA Translation: AAP35304.1 CR450328 mRNA Translation: CAG29324.1 AC116447 Genomic DNA No translation available. CH471088 Genomic DNA Translation: EAX01348.1 CH471088 Genomic DNA Translation: EAX01349.1 BC003566 mRNA Translation: AAH03566.1 BC016801 mRNA Translation: AAH16801.1 X52348 mRNA Translation: CAA36574.1
CCDSⁱ	CCDS11912.1 [P17028-1] CCDS77175.1 [P17028-2]
PIRⁱ	I37956
RefSeqⁱ	NP_001295052.1, NM_001308123.1 [P17028-2] NP_008896.2, NM_006965.3 [P17028-1] XP_005258398.1, XM_005258341.3 [P17028-1]
UniGeneⁱ	Hs.514802

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1X6E	NMR	-	A	272-330	[»]
	3LHR	X-ray	1.90	A/B	46-136	[»]
ProteinModelPortalⁱ	P17028
SMRⁱ	P17028
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113403, 75 interactors
IntActⁱ	P17028, 68 interactors
MINTⁱ	P17028
STRINGⁱ	9606.ENSP00000261332

PTM databases

iPTMnetⁱ	P17028
PhosphoSitePlusⁱ	P17028

Polymorphism and mutation databases

BioMutaⁱ	ZNF24
DMDMⁱ	160376173

Proteomic databases

EPDⁱ	P17028
MaxQBⁱ	P17028
PaxDbⁱ	P17028
PeptideAtlasⁱ	P17028
PRIDEⁱ	P17028
ProteomicsDBⁱ	53429 53430 [P17028-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7572
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000261332; ENSP00000261332; ENSG00000172466 [P17028-1] ENST00000399061; ENSP00000382015; ENSG00000172466 [P17028-1] ENST00000589881; ENSP00000467655; ENSG00000172466 [P17028-2]
GeneIDⁱ	7572
KEGGⁱ	hsa:7572
UCSCⁱ	uc002kys.3 human [P17028-1]

Organism-specific databases

CTDⁱ	7572
DisGeNETⁱ	7572
EuPathDBⁱ	HostDB:ENSG00000172466.15
GeneCardsⁱ	ZNF24
HGNCⁱ	HGNC:13032 ZNF24
HPAⁱ	CAB025642 HPA024062
MIMⁱ	194534 gene
neXtProtⁱ	NX_P17028
OpenTargetsⁱ	ENSG00000172466
PharmGKBⁱ	PA37610
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00760000118881
HOGENOMⁱ	HOG000234619
HOVERGENⁱ	HBG066767
InParanoidⁱ	P17028
KOⁱ	K09230
OMAⁱ	TWNHLPD
OrthoDBⁱ	EOG091G09O3
PhylomeDBⁱ	P17028
TreeFamⁱ	TF338304

Miscellaneous databases

ChiTaRSⁱ	ZNF24 human
EvolutionaryTraceⁱ	P17028
GeneWikiⁱ	ZNF24
GenomeRNAiⁱ	7572
PMAP-CutDBⁱ	P17028
Protein Ontology More...PROⁱ	PR:P17028
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000172466 Expressed in 243 organ(s), highest expression level in globus pallidus
CleanExⁱ	HS_ZNF24
ExpressionAtlasⁱ	P17028 baseline and differential
Genevisibleⁱ	P17028 HS

Family and domain databases

CDDⁱ	cd07936 SCAN, 1 hit
Gene3Dⁱ	1.10.4020.10, 1 hit
InterProⁱ	View protein in InterPro IPR003309 SCAN_dom IPR038269 SCAN_sf IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF02023 SCAN, 1 hit PF00096 zf-C2H2, 4 hits
SMARTⁱ	View protein in SMART SM00431 SCAN, 1 hit SM00355 ZnF_C2H2, 4 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS50804 SCAN_BOX, 1 hit PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZNF24_HUMAN
Accessionⁱ	P17028Primary (citable) accession number: P17028 Secondary accession number(s): O14754 , Q53YE4, Q6ICR5, Q8IZN4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1990
	Last sequence update:	October 23, 2007
	Last modified:	November 7, 2018
	This is version 207 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - P17028 (ZNF24_HUMAN)

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Zinc finger protein 24

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ