UniProtKB - P17028 (ZNF24_HUMAN)
Protein
Zinc finger protein 24
Gene
ZNF24
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro.By similarity1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 251 – 273 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 279 – 301 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 307 – 329 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 335 – 357 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- identical protein binding Source: IntAct
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- myelination Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P17028 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 24Alternative name(s): Retinoic acid suppression protein A Short name: RSG-A Zinc finger and SCAN domain-containing protein 3 Zinc finger protein 191 Zinc finger protein KOX17 |
Gene namesi | Name:ZNF24 Synonyms:KOX17, ZNF191, ZSCAN3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000172466.15 |
HGNCi | HGNC:13032, ZNF24 |
MIMi | 194534, gene |
neXtProti | NX_P17028 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 286 | K → A: Partial cytoplasmic accumulation. 1 Publication | 1 | |
Mutagenesisi | 290 | R → A: Partial cytoplasmic accumulation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 7572 |
OpenTargetsi | ENSG00000172466 |
PharmGKBi | PA37610 |
Miscellaneous databases
Pharosi | P17028, Tbio |
Polymorphism and mutation databases
BioMutai | ZNF24 |
DMDMi | 160376173 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047352 | 1 – 368 | Zinc finger protein 24Add BLAST | 368 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 22 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 27 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 27 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 132 | PhosphoserineCombined sources | 1 | |
Modified residuei | 142 | PhosphoserineCombined sources | 1 | |
Cross-linki | 147 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 177 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 236 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 274 | PhosphoserineCombined sources | 1 | |
Cross-linki | 277 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 286 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 292 | PhosphoserineCombined sources | 1 | |
Modified residuei | 335 | PhosphotyrosineCombined sources | 1 | |
Cross-linki | 361 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 367 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Sumoylated.1 Publication
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P17028 |
jPOSTi | P17028 |
MassIVEi | P17028 |
MaxQBi | P17028 |
PaxDbi | P17028 |
PeptideAtlasi | P17028 |
PRIDEi | P17028 |
ProteomicsDBi | 53429 [P17028-1] 53430 [P17028-2] |
PTM databases
iPTMneti | P17028 |
PhosphoSitePlusi | P17028 |
SwissPalmi | P17028 |
Expressioni
Tissue specificityi
Expressed in many tissues except in heart.
Gene expression databases
Bgeei | ENSG00000172466, Expressed in globus pallidus and 255 other tissues |
ExpressionAtlasi | P17028, baseline and differential |
Genevisiblei | P17028, HS |
Organism-specific databases
HPAi | ENSG00000172466, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsP17028
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 113403, 98 interactors |
IntActi | P17028, 84 interactors |
MINTi | P17028 |
STRINGi | 9606.ENSP00000261332 |
Miscellaneous databases
RNActi | P17028, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P17028 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P17028 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 52 – 134 | SCAN boxPROSITE-ProRule annotationAdd BLAST | 83 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 251 – 301 | Necessary and sufficient for nuclear localizationAdd BLAST | 51 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 251 – 273 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 279 – 301 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 307 – 329 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 335 – 357 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161396 |
HOGENOMi | CLU_002678_49_3_1 |
InParanoidi | P17028 |
OMAi | TWNHLPD |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P17028 |
TreeFami | TF338304 |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P17028-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAQSVEEDS ILIIPTPDEE EKILRVKLEE DPDGEEGSSI PWNHLPDPEI
60 70 80 90 100
FRQRFRQFGY QDSPGPREAV SQLRELCRLW LRPETHTKEQ ILELVVLEQF
110 120 130 140 150
VAILPKELQT WVRDHHPENG EEAVTVLEDL ESELDDPGQP VSLRRRKREV
160 170 180 190 200
LVEDMVSQEE AQGLPSSELD AVENQLKWAS WELHSLRHCD DDGRTENGAL
210 220 230 240 250
APKQELPSAL ESHEVPGTLN MGVPQIFKYG ETCFPKGRFE RKRNPSRKKQ
260 270 280 290 300
HICDECGKHF SQGSALILHQ RIHSGEKPYG CVECGKAFSR SSILVQHQRV
310 320 330 340 350
HTGEKPYKCL ECGKAFSQNS GLINHQRIHT GEKPYECVQC GKSYSQSSNL
360
FRHQRRHNAE KLLNVVKV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EPL1 | K7EPL1_HUMAN | Zinc finger protein 24 | ZNF24 | 138 | Annotation score: | ||
K7EQP8 | K7EQP8_HUMAN | Zinc finger protein 24 | ZNF24 | 96 | Annotation score: | ||
K7EPZ8 | K7EPZ8_HUMAN | Zinc finger protein 24 | ZNF24 | 102 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 367 | K → E in AAB37275 (Ref. 1) Curated | 1 | |
Sequence conflicti | 367 | K → E in CAG29324 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012017 | 220 | N → S5 PublicationsCorresponds to variant dbSNP:rs2032729Ensembl. | 1 | |
Natural variantiVAR_012018 | 331 | G → W. Corresponds to variant dbSNP:rs3568Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039219 | 190 – 193 | DDDG → VIIP in isoform 2. 1 Publication | 4 | |
Alternative sequenceiVSP_039220 | 194 – 368 | Missing in isoform 2. 1 PublicationAdd BLAST | 175 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U68536 mRNA Translation: AAB37275.1 AF016052 Genomic DNA Translation: AAB70216.1 AF542097 mRNA Translation: AAN40767.1 AF038964 mRNA Translation: AAD19827.1 AK291246 mRNA Translation: BAF83935.1 BT006658 mRNA Translation: AAP35304.1 CR450328 mRNA Translation: CAG29324.1 AC116447 Genomic DNA No translation available. CH471088 Genomic DNA Translation: EAX01348.1 CH471088 Genomic DNA Translation: EAX01349.1 BC003566 mRNA Translation: AAH03566.1 BC016801 mRNA Translation: AAH16801.1 X52348 mRNA Translation: CAA36574.1 |
CCDSi | CCDS11912.1 [P17028-1] CCDS77175.1 [P17028-2] |
PIRi | I37956 |
RefSeqi | NP_001295052.1, NM_001308123.1 [P17028-2] NP_008896.2, NM_006965.3 [P17028-1] XP_005258398.1, XM_005258341.3 |
Genome annotation databases
Ensembli | ENST00000261332; ENSP00000261332; ENSG00000172466 [P17028-1] ENST00000399061; ENSP00000382015; ENSG00000172466 [P17028-1] ENST00000589881; ENSP00000467655; ENSG00000172466 [P17028-2] |
GeneIDi | 7572 |
KEGGi | hsa:7572 |
UCSCi | uc002kys.3, human [P17028-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U68536 mRNA Translation: AAB37275.1 AF016052 Genomic DNA Translation: AAB70216.1 AF542097 mRNA Translation: AAN40767.1 AF038964 mRNA Translation: AAD19827.1 AK291246 mRNA Translation: BAF83935.1 BT006658 mRNA Translation: AAP35304.1 CR450328 mRNA Translation: CAG29324.1 AC116447 Genomic DNA No translation available. CH471088 Genomic DNA Translation: EAX01348.1 CH471088 Genomic DNA Translation: EAX01349.1 BC003566 mRNA Translation: AAH03566.1 BC016801 mRNA Translation: AAH16801.1 X52348 mRNA Translation: CAA36574.1 |
CCDSi | CCDS11912.1 [P17028-1] CCDS77175.1 [P17028-2] |
PIRi | I37956 |
RefSeqi | NP_001295052.1, NM_001308123.1 [P17028-2] NP_008896.2, NM_006965.3 [P17028-1] XP_005258398.1, XM_005258341.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1X6E | NMR | - | A | 272-330 | [»] | |
3LHR | X-ray | 1.90 | A/B | 46-136 | [»] | |
SMRi | P17028 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113403, 98 interactors |
IntActi | P17028, 84 interactors |
MINTi | P17028 |
STRINGi | 9606.ENSP00000261332 |
PTM databases
iPTMneti | P17028 |
PhosphoSitePlusi | P17028 |
SwissPalmi | P17028 |
Polymorphism and mutation databases
BioMutai | ZNF24 |
DMDMi | 160376173 |
Proteomic databases
EPDi | P17028 |
jPOSTi | P17028 |
MassIVEi | P17028 |
MaxQBi | P17028 |
PaxDbi | P17028 |
PeptideAtlasi | P17028 |
PRIDEi | P17028 |
ProteomicsDBi | 53429 [P17028-1] 53430 [P17028-2] |
Protocols and materials databases
Antibodypediai | 8576, 248 antibodies |
DNASUi | 7572 |
Genome annotation databases
Ensembli | ENST00000261332; ENSP00000261332; ENSG00000172466 [P17028-1] ENST00000399061; ENSP00000382015; ENSG00000172466 [P17028-1] ENST00000589881; ENSP00000467655; ENSG00000172466 [P17028-2] |
GeneIDi | 7572 |
KEGGi | hsa:7572 |
UCSCi | uc002kys.3, human [P17028-1] |
Organism-specific databases
CTDi | 7572 |
DisGeNETi | 7572 |
EuPathDBi | HostDB:ENSG00000172466.15 |
GeneCardsi | ZNF24 |
HGNCi | HGNC:13032, ZNF24 |
HPAi | ENSG00000172466, Low tissue specificity |
MIMi | 194534, gene |
neXtProti | NX_P17028 |
OpenTargetsi | ENSG00000172466 |
PharmGKBi | PA37610 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161396 |
HOGENOMi | CLU_002678_49_3_1 |
InParanoidi | P17028 |
OMAi | TWNHLPD |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P17028 |
TreeFami | TF338304 |
Enzyme and pathway databases
PathwayCommonsi | P17028 |
Miscellaneous databases
BioGRID-ORCSi | 7572, 73 hits in 866 CRISPR screens |
ChiTaRSi | ZNF24, human |
EvolutionaryTracei | P17028 |
GeneWikii | ZNF24 |
GenomeRNAii | 7572 |
Pharosi | P17028, Tbio |
PROi | PR:P17028 |
RNActi | P17028, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172466, Expressed in globus pallidus and 255 other tissues |
ExpressionAtlasi | P17028, baseline and differential |
Genevisiblei | P17028, HS |
Family and domain databases
CDDi | cd07936, SCAN, 1 hit |
Gene3Di | 1.10.4020.10, 1 hit |
InterProi | View protein in InterPro IPR003309, SCAN_dom IPR038269, SCAN_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF02023, SCAN, 1 hit PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00431, SCAN, 1 hit SM00355, ZnF_C2H2, 4 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50804, SCAN_BOX, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZNF24_HUMAN | |
Accessioni | P17028Primary (citable) accession number: P17028 Secondary accession number(s): O14754 Q8IZN4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | October 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 223 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations