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UniProtKB - P17028 (ZNF24_HUMAN)

Entry version 226 (02 Jun 2021)
Sequence version 4 (23 Oct 2007)
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Protein

Zinc finger protein 24

Gene

ZNF24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity).

Has transcription repressor activity in vitro.

By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri251 – 273C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P17028

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 24
Alternative name(s):
Retinoic acid suppression protein A
Short name:
RSG-A
Zinc finger and SCAN domain-containing protein 3
Zinc finger protein 191
Zinc finger protein KOX17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF24
Synonyms:KOX17, ZNF191, ZSCAN3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13032, ZNF24

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		194534, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P17028

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000172466.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi286K → A: Partial cytoplasmic accumulation. 1 Publication1
Mutagenesisi290R → A: Partial cytoplasmic accumulation. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		7572

Open Targets

More...OpenTargetsi		ENSG00000172466

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37610

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P17028, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF24

Domain mapping of disease mutations (DMDM)

More...DMDMi		160376173

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473521 – 368Zinc finger protein 24Add BLAST368

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki22Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei132PhosphoserineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki177Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki236Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei274PhosphoserineCombined sources1
Cross-linki277Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei292PhosphoserineCombined sources1
Modified residuei335PhosphotyrosineCombined sources1
Cross-linki361Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki367Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P17028

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P17028

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P17028

MaxQB - The MaxQuant DataBase

More...MaxQBi		P17028

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P17028

PeptideAtlas

More...PeptideAtlasi		P17028

PRoteomics IDEntifications database

More...PRIDEi		P17028

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		53429 [P17028-1]
53430 [P17028-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P17028

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P17028

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P17028

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in many tissues except in heart.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000172466, Expressed in globus pallidus and 256 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P17028, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P17028, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000172466, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P17028
With#Exp.IntAct
APLP1 [P51693]2EBI-707773,EBI-74648
APOE [P02649]3EBI-707773,EBI-1222467
APP [P05067]3EBI-707773,EBI-77613
CCDC130 [P13994]7EBI-707773,EBI-716093
DDX6 [P26196]3EBI-707773,EBI-351257
DZIP3 [Q86Y13]5EBI-707773,EBI-948630
FAM161A [Q3B820]3EBI-707773,EBI-719941
LMO1 [P25800]5EBI-707773,EBI-8639312
LMO2 [P25791]4EBI-707773,EBI-739696
LMO2 - isoform 3 [P25791-3]3EBI-707773,EBI-11959475
MAP1LC3C [Q9BXW4]3EBI-707773,EBI-2603996
MID2 - isoform 2 [Q9UJV3-2]3EBI-707773,EBI-10172526
NEK6 - isoform 4 [Q9HC98-4]3EBI-707773,EBI-11750983
PGBD1 [Q96JS3]8EBI-707773,EBI-10290053
PRPF31 [Q8WWY3]3EBI-707773,EBI-1567797
SCAND1 [P57086]7EBI-707773,EBI-745846
TCAF1 [Q9Y4C2]3EBI-707773,EBI-750484
UBE2I [Q7KZS0]3EBI-707773,EBI-10180829
ZGPAT - isoform 2 [Q8N5A5-2]3EBI-707773,EBI-10183064
ZKSCAN4 [Q969J2]5EBI-707773,EBI-2818641
ZNF165 [P49910]3EBI-707773,EBI-741694
ZNF174 - isoform 2 [Q15697-2]4EBI-707773,EBI-11158827
ZNF232 [Q9UNY5]3EBI-707773,EBI-749023
itself4EBI-707773,EBI-707773
ZNF396 - isoform 3 [Q96N95-3]5EBI-707773,EBI-12328453
ZNF410 - isoform 3 [Q86VK4-3]3EBI-707773,EBI-11741890
ZNF444 - isoform 2 [Q8N0Y2-2]6EBI-707773,EBI-12010736
ZNF446 [Q9NWS9]4EBI-707773,EBI-3925851
ZNF446 - isoform 2 [Q9NWS9-2]13EBI-707773,EBI-740232
ZNF483 [Q6P088]3EBI-707773,EBI-10196963
ZNF620 [Q6ZNG0]3EBI-707773,EBI-4395669
ZSCAN12 [O43309]3EBI-707773,EBI-1210440
ZSCAN16 [Q9H4T2]3EBI-707773,EBI-723596
ZSCAN21 [Q9Y5A6]6EBI-707773,EBI-10281938
ZSCAN22 [P10073]6EBI-707773,EBI-10178224
ZSCAN23 [Q3MJ62]3EBI-707773,EBI-5667532
ZSCAN32 [Q9NX65]9EBI-707773,EBI-739949

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113403, 106 interactors

Protein interaction database and analysis system

More...IntActi		P17028, 88 interactors

Molecular INTeraction database

More...MINTi		P17028

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000261332

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P17028, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1368
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P17028

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P17028

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini52 – 134SCAN boxPROSITE-ProRule annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni251 – 301Necessary and sufficient for nuclear localizationAdd BLAST51

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri251 – 273C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161396

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_49_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P17028

Identification of Orthologs from Complete Genome Data

More...OMAi		TWNHLPD

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P17028

TreeFam database of animal gene trees

More...TreeFami		TF338304

Family and domain databases

Conserved Domains Database

More...CDDi		cd07936, SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P17028-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAQSVEEDS ILIIPTPDEE EKILRVKLEE DPDGEEGSSI PWNHLPDPEI 
        60         70         80         90        100
FRQRFRQFGY QDSPGPREAV SQLRELCRLW LRPETHTKEQ ILELVVLEQF 
       110        120        130        140        150
VAILPKELQT WVRDHHPENG EEAVTVLEDL ESELDDPGQP VSLRRRKREV 
       160        170        180        190        200
LVEDMVSQEE AQGLPSSELD AVENQLKWAS WELHSLRHCD DDGRTENGAL 
       210        220        230        240        250
APKQELPSAL ESHEVPGTLN MGVPQIFKYG ETCFPKGRFE RKRNPSRKKQ 
       260        270        280        290        300
HICDECGKHF SQGSALILHQ RIHSGEKPYG CVECGKAFSR SSILVQHQRV 
       310        320        330        340        350
HTGEKPYKCL ECGKAFSQNS GLINHQRIHT GEKPYECVQC GKSYSQSSNL 
       360 
FRHQRRHNAE KLLNVVKV
Length:368
Mass (Da):42,155
Last modified:October 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB890EDC512493E0E
GO
Isoform 2 (identifier: P17028-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-193: DDDG → VIIP
     194-368: Missing.

Show »
Length:193
Mass (Da):22,382
Checksum:iA6A9515C74EA57E0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EPL1K7EPL1_HUMAN
Zinc finger protein 24
ZNF24
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQP8K7EQP8_HUMAN
Zinc finger protein 24
ZNF24
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPZ8K7EPZ8_HUMAN
Zinc finger protein 24
ZNF24
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti367K → E in AAB37275 (Ref. 1) Curated1
Sequence conflicti367K → E in CAG29324 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_012017220N → S5 PublicationsCorresponds to variant dbSNP:rs2032729Ensembl.1
Natural variantiVAR_012018331G → W. Corresponds to variant dbSNP:rs3568Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039219190 – 193DDDG → VIIP in isoform 2. 1 Publication4
Alternative sequenceiVSP_039220194 – 368Missing in isoform 2. 1 PublicationAdd BLAST175

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U68536 mRNA Translation: AAB37275.1
AF016052 Genomic DNA Translation: AAB70216.1
AF542097 mRNA Translation: AAN40767.1
AF038964 mRNA Translation: AAD19827.1
AK291246 mRNA Translation: BAF83935.1
BT006658 mRNA Translation: AAP35304.1
CR450328 mRNA Translation: CAG29324.1
AC116447 Genomic DNA No translation available.
CH471088 Genomic DNA Translation: EAX01348.1
CH471088 Genomic DNA Translation: EAX01349.1
BC003566 mRNA Translation: AAH03566.1
BC016801 mRNA Translation: AAH16801.1
X52348 mRNA Translation: CAA36574.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11912.1 [P17028-1]
CCDS77175.1 [P17028-2]

Protein sequence database of the Protein Information Resource

More...PIRi		I37956

NCBI Reference Sequences

More...RefSeqi		NP_001295052.1, NM_001308123.1 [P17028-2]
NP_008896.2, NM_006965.3 [P17028-1]
XP_005258398.1, XM_005258341.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000261332; ENSP00000261332; ENSG00000172466 [P17028-1]
ENST00000399061; ENSP00000382015; ENSG00000172466 [P17028-1]
ENST00000589881; ENSP00000467655; ENSG00000172466 [P17028-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7572

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7572

UCSC genome browser

More...UCSCi		uc002kys.3, human [P17028-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68536 mRNA Translation: AAB37275.1
AF016052 Genomic DNA Translation: AAB70216.1
AF542097 mRNA Translation: AAN40767.1
AF038964 mRNA Translation: AAD19827.1
AK291246 mRNA Translation: BAF83935.1
BT006658 mRNA Translation: AAP35304.1
CR450328 mRNA Translation: CAG29324.1
AC116447 Genomic DNA No translation available.
CH471088 Genomic DNA Translation: EAX01348.1
CH471088 Genomic DNA Translation: EAX01349.1
BC003566 mRNA Translation: AAH03566.1
BC016801 mRNA Translation: AAH16801.1
X52348 mRNA Translation: CAA36574.1
CCDSiCCDS11912.1 [P17028-1]
CCDS77175.1 [P17028-2]
PIRiI37956
RefSeqiNP_001295052.1, NM_001308123.1 [P17028-2]
NP_008896.2, NM_006965.3 [P17028-1]
XP_005258398.1, XM_005258341.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X6ENMR-A272-330[»]
3LHRX-ray1.90A/B46-136[»]
SMRiP17028
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113403, 106 interactors
IntActiP17028, 88 interactors
MINTiP17028
STRINGi9606.ENSP00000261332

PTM databases

iPTMnetiP17028
PhosphoSitePlusiP17028
SwissPalmiP17028

Genetic variation databases

BioMutaiZNF24
DMDMi160376173

Proteomic databases

EPDiP17028
jPOSTiP17028
MassIVEiP17028
MaxQBiP17028
PaxDbiP17028
PeptideAtlasiP17028
PRIDEiP17028
ProteomicsDBi53429 [P17028-1]
53430 [P17028-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		8576, 257 antibodies

The DNASU plasmid repository

More...DNASUi		7572

Genome annotation databases

EnsembliENST00000261332; ENSP00000261332; ENSG00000172466 [P17028-1]
ENST00000399061; ENSP00000382015; ENSG00000172466 [P17028-1]
ENST00000589881; ENSP00000467655; ENSG00000172466 [P17028-2]
GeneIDi7572
KEGGihsa:7572
UCSCiuc002kys.3, human [P17028-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7572
DisGeNETi7572

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF24
HGNCiHGNC:13032, ZNF24
HPAiENSG00000172466, Low tissue specificity
MIMi194534, gene
neXtProtiNX_P17028
OpenTargetsiENSG00000172466
PharmGKBiPA37610
VEuPathDBiHostDB:ENSG00000172466.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000161396
HOGENOMiCLU_002678_49_3_1
InParanoidiP17028
OMAiTWNHLPD
OrthoDBi1318335at2759
PhylomeDBiP17028
TreeFamiTF338304

Enzyme and pathway databases

PathwayCommonsiP17028

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7572, 75 hits in 1018 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF24, human
EvolutionaryTraceiP17028

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZNF24

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7572
PharosiP17028, Tbio

Protein Ontology

More...PROi		PR:P17028
RNActiP17028, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000172466, Expressed in globus pallidus and 256 other tissues
ExpressionAtlasiP17028, baseline and differential
GenevisibleiP17028, HS

Family and domain databases

CDDicd07936, SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309, SCAN_dom
IPR038269, SCAN_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF02023, SCAN, 1 hit
PF00096, zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00431, SCAN, 1 hit
SM00355, ZnF_C2H2, 4 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50804, SCAN_BOX, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 4 hits
PS50157, ZINC_FINGER_C2H2_2, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZNF24_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17028
Secondary accession number(s): O14754
, Q53YE4, Q6ICR5, Q8IZN4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: October 23, 2007
Last modified: June 2, 2021
This is version 226 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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