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UniProtKB - P17025 (ZN182_HUMAN)
Protein
Zinc finger protein 182
Gene
ZNF182
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 206 – 228 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 234 – 256 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 262 – 284 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 290 – 312 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 318 – 340 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 346 – 368 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 374 – 396 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 402 – 424 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 430 – 452 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 458 – 480 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 486 – 508 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 514 – 536 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 542 – 564 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 570 – 592 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 598 – 620 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P17025 |
SignaLinki | P17025 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 182Alternative name(s): Zinc finger protein 21 Zinc finger protein KOX14 |
Gene namesi | Name:ZNF182 Synonyms:KOX14, ZNF21 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13001, ZNF182 |
MIMi | 314993, gene |
neXtProti | NX_P17025 |
VEuPathDBi | HostDB:ENSG00000147118 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7569 |
OpenTargetsi | ENSG00000147118 |
PharmGKBi | PA37581 |
Miscellaneous databases
Pharosi | P17025, Tbio |
Genetic variation databases
BioMutai | ZNF182 |
DMDMi | 85681865 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047345 | 1 – 639 | Zinc finger protein 182Add BLAST | 639 |
Proteomic databases
EPDi | P17025 |
jPOSTi | P17025 |
MassIVEi | P17025 |
MaxQBi | P17025 |
PaxDbi | P17025 |
PeptideAtlasi | P17025 |
PRIDEi | P17025 |
ProteomicsDBi | 53425 [P17025-1] 53426 [P17025-2] |
PTM databases
iPTMneti | P17025 |
PhosphoSitePlusi | P17025 |
Expressioni
Gene expression databases
Bgeei | ENSG00000147118, Expressed in secondary oocyte and 216 other tissues |
Genevisiblei | P17025, HS |
Organism-specific databases
HPAi | ENSG00000147118, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 113400, 4 interactors |
IntActi | P17025, 1 interactor |
STRINGi | 9606.ENSP00000380165 |
Miscellaneous databases
RNActi | P17025, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 98 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 619 – 639 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 206 – 228 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 234 – 256 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 262 – 284 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 290 – 312 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 318 – 340 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 346 – 368 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 374 – 396 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 402 – 424 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 430 – 452 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 458 – 480 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 486 – 508 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 514 – 536 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 542 – 564 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 570 – 592 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 598 – 620 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162614 |
HOGENOMi | CLU_002678_0_12_1 |
InParanoidi | P17025 |
OMAi | QDRYLLM |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P17025 |
TreeFami | TF350805 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 14 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P17025-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTPASASGED SGSFYSWQKA KREQGLVTFE DVAVDFTQEE WQYLNPPQRT
60 70 80 90 100
LYRDVMLETY SNLVFVGQQV TKPNLILKLE VEECPAEGKI PFWNFPEVCQ
110 120 130 140 150
VDEQIERQHQ DDQDKCLLMQ VGFSDKKTII TKSARDCHEF GNILHLSTNL
160 170 180 190 200
VASIQRPDKH ESFGNNMVDN LDLFSRSSAE NKYDNGCAKL FFHTEYEKTN
210 220 230 240 250
PGMKPYGYKE CGKGLRRKKG LSLHQRIKNG EKPFECTACR KTFSKKSHLI
260 270 280 290 300
VHWRTHTGEK PFGCTECGKA FSQKSQLIIH LRTHTGERPF ECPECGKAFR
310 320 330 340 350
EKSTVIIHYR THTGEKPYEC NECGKAFTQK SNLIVHQKTH TGEKTYECTK
360 370 380 390 400
CGESFIQKLD LIIHHSTHTG KKPHECNECK KTFSDKSTLI IHQRTHTGEK
410 420 430 440 450
PHKCTECGKS FNEKSTLIVH QRTHTGEKPY ECDVCGKTFT QKSNLGVHQR
460 470 480 490 500
THSGEKPFEC NECEKAFSQK SYLMLHQRGH TGEKPYECNE CEKAFSQKSY
510 520 530 540 550
LIIHQRTHTE EKPYKCNECG KAFREKSKLI IHQRIHTGEK PYECPVCWKA
560 570 580 590 600
FSQKSQLIIH QRTHTGEKPY ACTECGKAFR EKSTFTVHQR THTGEKPYKC
610 620 630
TECGKAFTQK SNLIVHQRTH AGKKAHGRGH TRKSKFMAH
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077837 | 62 | N → S Found in a child with sporadic epilepsy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs146965366Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043078 | 1 – 23 | MTPAS…KAKRE → MAKP in isoform 2. 1 PublicationAdd BLAST | 23 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK122874 mRNA Translation: BAG53772.1 Z98304 Genomic DNA No translation available. CH471164 Genomic DNA Translation: EAW59334.1 CH471164 Genomic DNA Translation: EAW59335.1 BC106875 mRNA Translation: AAI06876.1 BC114216 mRNA Translation: AAI14217.1 X52345 mRNA Translation: CAA36571.1 |
CCDSi | CCDS35235.1 [P17025-2] CCDS35236.1 [P17025-1] |
PIRi | I37953, S10402 |
RefSeqi | NP_001007089.1, NM_001007088.1 [P17025-2] NP_001171570.1, NM_001178099.1 [P17025-1] NP_008893.1, NM_006962.1 [P17025-1] |
Genome annotation databases
Ensembli | ENST00000376943.8; ENSP00000366142.4; ENSG00000147118.12 [P17025-2] ENST00000396965.5; ENSP00000380165.1; ENSG00000147118.12 |
GeneIDi | 7569 |
KEGGi | hsa:7569 |
MANE-Selecti | ENST00000376943.8; ENSP00000366142.4; NM_001007088.2; NP_001007089.1 [P17025-2] |
UCSCi | uc004dis.4, human [P17025-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK122874 mRNA Translation: BAG53772.1 Z98304 Genomic DNA No translation available. CH471164 Genomic DNA Translation: EAW59334.1 CH471164 Genomic DNA Translation: EAW59335.1 BC106875 mRNA Translation: AAI06876.1 BC114216 mRNA Translation: AAI14217.1 X52345 mRNA Translation: CAA36571.1 |
CCDSi | CCDS35235.1 [P17025-2] CCDS35236.1 [P17025-1] |
PIRi | I37953, S10402 |
RefSeqi | NP_001007089.1, NM_001007088.1 [P17025-2] NP_001171570.1, NM_001178099.1 [P17025-1] NP_008893.1, NM_006962.1 [P17025-1] |
3D structure databases
AlphaFoldDBi | P17025 |
SMRi | P17025 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 113400, 4 interactors |
IntActi | P17025, 1 interactor |
STRINGi | 9606.ENSP00000380165 |
PTM databases
iPTMneti | P17025 |
PhosphoSitePlusi | P17025 |
Genetic variation databases
BioMutai | ZNF182 |
DMDMi | 85681865 |
Proteomic databases
EPDi | P17025 |
jPOSTi | P17025 |
MassIVEi | P17025 |
MaxQBi | P17025 |
PaxDbi | P17025 |
PeptideAtlasi | P17025 |
PRIDEi | P17025 |
ProteomicsDBi | 53425 [P17025-1] 53426 [P17025-2] |
Protocols and materials databases
Antibodypediai | 21607, 112 antibodies from 18 providers |
DNASUi | 7569 |
Genome annotation databases
Ensembli | ENST00000376943.8; ENSP00000366142.4; ENSG00000147118.12 [P17025-2] ENST00000396965.5; ENSP00000380165.1; ENSG00000147118.12 |
GeneIDi | 7569 |
KEGGi | hsa:7569 |
MANE-Selecti | ENST00000376943.8; ENSP00000366142.4; NM_001007088.2; NP_001007089.1 [P17025-2] |
UCSCi | uc004dis.4, human [P17025-1] |
Organism-specific databases
CTDi | 7569 |
DisGeNETi | 7569 |
GeneCardsi | ZNF182 |
HGNCi | HGNC:13001, ZNF182 |
HPAi | ENSG00000147118, Low tissue specificity |
MIMi | 314993, gene |
neXtProti | NX_P17025 |
OpenTargetsi | ENSG00000147118 |
PharmGKBi | PA37581 |
VEuPathDBi | HostDB:ENSG00000147118 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162614 |
HOGENOMi | CLU_002678_0_12_1 |
InParanoidi | P17025 |
OMAi | QDRYLLM |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P17025 |
TreeFami | TF350805 |
Enzyme and pathway databases
PathwayCommonsi | P17025 |
SignaLinki | P17025 |
Miscellaneous databases
BioGRID-ORCSi | 7569, 14 hits in 723 CRISPR screens |
GeneWikii | ZNF182 |
GenomeRNAii | 7569 |
Pharosi | P17025, Tbio |
PROi | PR:P17025 |
RNActi | P17025, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147118, Expressed in secondary oocyte and 216 other tissues |
Genevisiblei | P17025, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 14 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN182_HUMAN | |
Accessioni | P17025Primary (citable) accession number: P17025 Secondary accession number(s): A2IDD7, Q3KP67, Q96QH7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1990 |
Last sequence update: | January 10, 2006 | |
Last modified: | May 25, 2022 | |
This is version 199 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families