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UniProtKB - P17025 (ZN182_HUMAN)

Entry version 184 (08 May 2019)
Sequence version 2 (10 Jan 2006)
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Protein

Zinc finger protein 182

Gene

ZNF182

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri206 – 228C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 368C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 452C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri458 – 480C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 564C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri570 – 592C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri598 – 620C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 182
Alternative name(s):
Zinc finger protein 21
Zinc finger protein KOX14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF182
Synonyms:KOX14, ZNF21
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13001 ZNF182

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		314993 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P17025

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000147118

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37581

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF182

Domain mapping of disease mutations (DMDM)

More...DMDMi		85681865

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473451 – 639Zinc finger protein 182Add BLAST639

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P17025

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P17025

MaxQB - The MaxQuant DataBase

More...MaxQBi		P17025

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P17025

PeptideAtlas

More...PeptideAtlasi		P17025

PRoteomics IDEntifications database

More...PRIDEi		P17025

ProteomicsDB human proteome resource

More...ProteomicsDBi		53425
53426 [P17025-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P17025

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P17025

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000147118 Expressed in 200 organ(s), highest expression level in islet of Langerhans

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P17025 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA059574

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		113400, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000380165

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P17025

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 98KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 228C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 368C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri430 – 452C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri458 – 480C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri486 – 508C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri514 – 536C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri542 – 564C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri570 – 592C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri598 – 620C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162614

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P17025

KEGG Orthology (KO)

More...KOi		K09228

Identification of Orthologs from Complete Genome Data

More...OMAi		SIQRPHK

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P17025

TreeFam database of animal gene trees

More...TreeFami		TF350805

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 14 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 14 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P17025-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPASASGED SGSFYSWQKA KREQGLVTFE DVAVDFTQEE WQYLNPPQRT 
        60         70         80         90        100
LYRDVMLETY SNLVFVGQQV TKPNLILKLE VEECPAEGKI PFWNFPEVCQ 
       110        120        130        140        150
VDEQIERQHQ DDQDKCLLMQ VGFSDKKTII TKSARDCHEF GNILHLSTNL 
       160        170        180        190        200
VASIQRPDKH ESFGNNMVDN LDLFSRSSAE NKYDNGCAKL FFHTEYEKTN 
       210        220        230        240        250
PGMKPYGYKE CGKGLRRKKG LSLHQRIKNG EKPFECTACR KTFSKKSHLI 
       260        270        280        290        300
VHWRTHTGEK PFGCTECGKA FSQKSQLIIH LRTHTGERPF ECPECGKAFR 
       310        320        330        340        350
EKSTVIIHYR THTGEKPYEC NECGKAFTQK SNLIVHQKTH TGEKTYECTK 
       360        370        380        390        400
CGESFIQKLD LIIHHSTHTG KKPHECNECK KTFSDKSTLI IHQRTHTGEK 
       410        420        430        440        450
PHKCTECGKS FNEKSTLIVH QRTHTGEKPY ECDVCGKTFT QKSNLGVHQR 
       460        470        480        490        500
THSGEKPFEC NECEKAFSQK SYLMLHQRGH TGEKPYECNE CEKAFSQKSY 
       510        520        530        540        550
LIIHQRTHTE EKPYKCNECG KAFREKSKLI IHQRIHTGEK PYECPVCWKA 
       560        570        580        590        600
FSQKSQLIIH QRTHTGEKPY ACTECGKAFR EKSTFTVHQR THTGEKPYKC 
       610        620        630 
TECGKAFTQK SNLIVHQRTH AGKKAHGRGH TRKSKFMAH
Length:639
Mass (Da):73,646
Last modified:January 10, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6976EB14399390A5
GO
Isoform 2 (identifier: P17025-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MTPASASGEDSGSFYSWQKAKRE → MAKP

Note: No experimental confirmation available.
Show »
Length:620
Mass (Da):71,570
Checksum:i30F28986DF6A9331
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07783762N → S Found in a child with sporadic epilepsy; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs146965366Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0430781 – 23MTPAS…KAKRE → MAKP in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK122874 mRNA Translation: BAG53772.1
Z98304 Genomic DNA No translation available.
CH471164 Genomic DNA Translation: EAW59334.1
CH471164 Genomic DNA Translation: EAW59335.1
BC106875 mRNA Translation: AAI06876.1
BC114216 mRNA Translation: AAI14217.1
X52345 mRNA Translation: CAA36571.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35235.1 [P17025-2]
CCDS35236.1 [P17025-1]

Protein sequence database of the Protein Information Resource

More...PIRi		I37953 S10402

NCBI Reference Sequences

More...RefSeqi		NP_001007089.1, NM_001007088.1 [P17025-2]
NP_001171570.1, NM_001178099.1 [P17025-1]
NP_008893.1, NM_006962.1 [P17025-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000376943; ENSP00000366142; ENSG00000147118 [P17025-2]
ENST00000396965; ENSP00000380165; ENSG00000147118 [P17025-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7569

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7569

UCSC genome browser

More...UCSCi		uc004dis.4 human [P17025-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122874 mRNA Translation: BAG53772.1
Z98304 Genomic DNA No translation available.
CH471164 Genomic DNA Translation: EAW59334.1
CH471164 Genomic DNA Translation: EAW59335.1
BC106875 mRNA Translation: AAI06876.1
BC114216 mRNA Translation: AAI14217.1
X52345 mRNA Translation: CAA36571.1
CCDSiCCDS35235.1 [P17025-2]
CCDS35236.1 [P17025-1]
PIRiI37953 S10402
RefSeqiNP_001007089.1, NM_001007088.1 [P17025-2]
NP_001171570.1, NM_001178099.1 [P17025-1]
NP_008893.1, NM_006962.1 [P17025-1]

3D structure databases

SMRiP17025
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113400, 2 interactors
STRINGi9606.ENSP00000380165

PTM databases

iPTMnetiP17025
PhosphoSitePlusiP17025

Polymorphism and mutation databases

BioMutaiZNF182
DMDMi85681865

Proteomic databases

EPDiP17025
jPOSTiP17025
MaxQBiP17025
PaxDbiP17025
PeptideAtlasiP17025
PRIDEiP17025
ProteomicsDBi53425
53426 [P17025-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		7569
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376943; ENSP00000366142; ENSG00000147118 [P17025-2]
ENST00000396965; ENSP00000380165; ENSG00000147118 [P17025-1]
GeneIDi7569
KEGGihsa:7569
UCSCiuc004dis.4 human [P17025-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7569

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF182
HGNCiHGNC:13001 ZNF182
HPAiHPA059574
MIMi314993 gene
neXtProtiNX_P17025
OpenTargetsiENSG00000147118
PharmGKBiPA37581

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162614
HOGENOMiHOG000234617
InParanoidiP17025
KOiK09228
OMAiSIQRPHK
OrthoDBi1318335at2759
PhylomeDBiP17025
TreeFamiTF350805

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ZNF182

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7569

Protein Ontology

More...PROi		PR:P17025

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000147118 Expressed in 200 organ(s), highest expression level in islet of Langerhans
GenevisibleiP17025 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 14 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN182_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P17025
Secondary accession number(s): A2IDD7, Q3KP67, Q96QH7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: January 10, 2006
Last modified: May 8, 2019
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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